Promising evidence and remaining issues regarding the clinical application of oxytocin in autism spectrum disorders

Psychiatry and Clinical Neurosciences

Volumn 70, Issue 2, 2016, Pages 89-99

  Yamasue, Hidenori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

autism; neuropeptide; oxytocin; pervasive developmental disorders; social behavior

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; N ACETYLASPARTIC ACID; OXYTOCIN; PLACEBO;

ANXIETY; ARTICLE; AUTISM; BRAIN FUNCTION; CHILD PARENT RELATION; COMPULSION; CONTINUOUS INFUSION; COOPERATION; CORPUS STRIATUM; DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; DRUG TOLERABILITY; EMOTION; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; LONG TERM CARE; LOW DRUG DOSE; MEDIAL PREFRONTAL CORTEX; MENTAL STRESS; MENTAL TASK; MIDDLE FRONTAL GYRUS; NONHUMAN; NUCLEUS ACCUMBENS; ORBITAL CORTEX; PREMOTOR CORTEX; PROTON NUCLEAR MAGNETIC RESONANCE; PSYCHOMETRY; RANDOMIZED CONTROLLED TRIAL (TOPIC); READING THE MIND IN THE EYES TEST; RELIABILITY; REPETITIVE BEHAVIOR SCALE REVISED; RISK FACTOR; SINGLE DRUG DOSE; SOCIAL BEHAVIOR; SOCIAL COGNITION; SOCIAL INTERACTION; SOCIAL MEMORY; SOCIAL RECOGNITION; SUPERIOR TEMPORAL SULCUS; SYMPTOMATOLOGY; TREATMENT DURATION; WORLD HEALTH ORGANIZATION QAULITY OF LIFE QUESTIONNAIRE; AUTISM SPECTRUM DISORDER; HUMAN RELATION; INTRANASAL DRUG ADMINISTRATION; PSYCHOLOGY; TREATMENT OUTCOME;

ADMINISTRATION, INTRANASAL; AUTISM SPECTRUM DISORDER; HUMANS; INTERPERSONAL RELATIONS; OXYTOCIN; SOCIAL BEHAVIOR; TREATMENT OUTCOME;

EID: 84957631207     PISSN: 13231316     EISSN: 14401819     Source Type: Journal    
DOI: 10.1111/pcn.12364     Document Type: Article

References (46)

1. Yamasue H, Kuwabara H, Kawakubo Y, Kasai K., Oxytocin, sexually dimorphic features of the social brain, and autism. Psychiatry Clin. Neurosci. 2009; 63: 129-140.
2. Yamasue H, Yee JR, Hurlemann R, et al. Integrative approaches utilizing oxytocin to enhance prosocial behavior: From animal and human social behavior to autistic social dysfunction. J. Neurosci. 2012; 32: 14109-14117.
3. Young LJ, Barrett CE., Neuroscience. Can oxytocin treat autism? Science 2015; 347: 825-826.
4. Preti A, Melis M, Siddi S, Vellante M, Doneddu G, Fadda R., Oxytocin and autism: A systematic review of randomized controlled trials. J. Child Adolesc. Psychopharmacol. 2014; 24: 54-68.
5. Hollander E, Novotny S, Hanratty M, et al. Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger's disorders. Neuropsychopharmacology 2003; 28: 193-198.
6. Hollander E, Bartz J, Chaplin W, et al. Oxytocin increases retention of social cognition in autism. Biol. Psychiatry 2007; 61: 498-503.
7. Guastella A, Einfeld S, Gray K, et al. Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biol. Psychiatry 2010; 67: 692-694.
8. Andari E, Duhamel J, Zalla T, Herbrecht E, Leboyer M, Sirigu A., Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proc. Natl. Acad. Sci. USA 2010; 107: 4389-4394.
9. Auyeung B, Lombardo MV, Heinrichs M, et al. Oxytocin increases eye contact during a real-time, naturalistic social interaction in males with and without autism. Transl. Psychiatry 2015; 5: e507.
10. Gordon I, Vander, Wyk BC, Bennett RH, et al. Oxytocin enhances brain function in children with autism. Proc. Natl. Acad. Sci. USA 2013; 110: 20953-20958.
11. Domes G, Heinrichs M, Kumbier E, Grossmann A, Hauenstein K, Herpertz SC., Effects of intranasal oxytocin on the neural basis of face processing in autism spectrum disorder. Biol. Psychiatry 2013; 74: 164-171.
12. Domes G, Kumbier E, Heinrichs M, Herpertz SC., Oxytocin promotes facial emotion recognition and amygdala reactivity in adults with Asperger syndrome. Neuropsychopharmacology 2014; 39: 698-706.
13. Watanabe T, Abe O, Kuwabara H, et al. Mitigation of sociocommunicational deficits of autism through oxytocin-induced recovery of medial prefrontal activity: A randomized trial. JAMA Psychiatry 2014; 71: 166-175.
14. Aoki Y, Watanabe T, Abe O, et al. Oxytocin's neurochemical effects in the medial prefrontal cortex underlie recovery of task-specific brain activity in autism: A randomized controlled trial. Mol. Psychiatry 2015; 20: 447-453.
15. Aoki Y, Yahata N, Watanabe T, et al. Oxytocin improves behavioural and neural deficits in inferring others' social emotions in autism. Brain 2014; 137: 3073-3086.
16. Baron-Cohen S, Wheelwright S, Hill J, Raste Y, Plumb I., The 'Reading the Mind in the Eyes' test, revised version: A study with normal adults, and adults with Asperger's syndrome or high-functioning autism. J. Child Psychol. Psychiatry 2001; 42: 241-251.
17. Yamasue H., Function and structure in social brain regions can link oxytocin-receptor genes with autistic social behavior. Brain Dev. 2013; 35: 111-118.
18. Yamasue H., Using endophenotypes to examine molecules related to candidate genes as novel therapeutics: The 'endophenotype-associated surrogate endpoint (EASE)' concept. Neurosci. Res. 2015; 99: 1-7.
19. Watanabe T, Yahata N, Kawakubo Y, et al. Network structure underlying resolution of conflicting non-verbal and verbal social information. Soc. Cogn. Affect. Neurosci. 2014; 9: 767-775.
20. Watanabe T, Yahata N, Abe O, et al. Diminished medial prefrontal activity behind autistic social judgments of incongruent information. PLoS ONE 2012; 7: e39561.
21. Aoki Y, Abe O, Yahata N, et al. Absence of age-related prefrontal NAA change in adults with autism spectrum disorders. Transl. Psychiatry 2012; 2: e178.
22. Aoki Y, Yamasue H., Reply: Does imitation act as an oxytocin nebulizer in autism spectrum disorder? Brain 2015. doi: 10.1093/brain/awv061
23. Anagnostou E, Soorya L, Chaplin W, et al. Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: A randomized controlled trial. Mol. Autism 2012; 3: 16.
24. Dadds MR, MacDonald E, Cauchi A, Williams K, Levy F, Brennan J., Nasal oxytocin for social deficits in childhood autism: A randomized controlled trial. J. Autism Dev. Disord. 2014; 44: 521-531.
25. Guastella AJ, Gray KM, Rinehart NJ, et al. The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: A randomized controlled trial. J. Child Psychol. Psychiatry 2015; 56: 444-452.
26. Watanabe T, Kuroda M, Kuwabara H, et al. Clinical and neural effects of six-week administration of oxytocin on core symptoms of autism. Brain 2015. doi: 10.1093/brain/awv249
27. Munesue T, Yokoyama S, Nakamura K, et al. Two genetic variants of CD38 in subjects with autism spectrum disorder and controls. Neurosci. Res. 2010; 67: 181-191.
28. Kosaka H, Munesue T, Ishitobi M, et al. Long-term oxytocin administration improves social behaviors in a girl with autistic disorder. BMC Psychiatry 2012; 12: 110.
29. Tachibana M, Kagitani-Shimono K, Mohri I, et al. Long-term administration of intranasal oxytocin is a safe and promising therapy for early adolescent boys with autism spectrum disorders. J. Child Adolesc. Psychopharmacol. 2013; 23: 123-127.
30. Lord C, Rutter M, Le, Couteur A., Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J. Autism Dev. Disord. 1994; 24: 659-685.
31. Lord C, Risi S, Lambrecht L, et al. The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. J. Autism Dev. Disord. 2000; 30: 205-223.
32. Bales KL, Perkeybile AM, Conley OG, et al. Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles. Biol. Psychiatry 2013; 74: 180-188.
33. Bales KL, Solomon M, Jacob S, et al. Long-term exposure to intranasal oxytocin in a mouse autism model. Transl. Psychiatry 2014; 4: e480.
34. Young LJ., When too much of a good thing is bad: Chronic oxytocin, development, and social impairments. Biol. Psychiatry 2013; 74: 160-161.
35. Hammock EAD., Developmental perspectives on oxytocin and vasopressin. Neuropsychopharmacology 2015; 40: 24-42.
36. Huang H, Huang H, Michetti C, et al. Chronic and acute intranasal oxytocin produce divergent social effects in mice. Neuropsychopharmacology 2014; 39: 1102-1114.
37. Kirkpatrick MG, Francis SM, Lee R, de Wit H, Jacob S., Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans. Psychoneuroendocrinology 2014; 46: 23-31.
38. Kirkpatrick MG, Lee R, Wardle MC, Jacob S, de Wit H., Effects of MDMA and intranasal oxytocin on social and emotional processing. Neuropsychopharmacology 2014; 39: 1654-1663.
39. Cardoso C, Orlando MA, Brown CA, Ellenbogen MA., Oxytocin and enhancement of the positive valence of social affiliation memories: An autobiographical memory study. Soc Neurosci 2014; 9: 186-195.
40. Cardoso C, Ellenbogen MA, Orlando MA, Bacon SL, Joober R., Intranasal oxytocin attenuates the cortisol response to physical stress: A dose-response study. Psychoneuroendocrinology 2013; 38: 399-407.
41. Chini B, Chini B, Leonzino M, et al. Learning about oxytocin: Pharmacologic and behavioral issues. Biol. Psychiatry 2014; 76: 360-366.
42. Peters S, Slattery DA, Uschold-Schmidt N, Reber SO, Neumann ID., Dose-dependent effects of chronic central infusion of oxytocin on anxiety, oxytocin receptor binding and stress-related parameters in mice. Psychoneuroendocrinology 2014; 42: 225-236.
43. Quintana DS, Alvares GA, Hickie IB, Guastella AJ., Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model. Neurosci. Biobehav. Rev. 2015; 49: 182-192.
44. Sauer C, Montag C, Reuter M, Kirsch P., Imaging oxytocin × dopamine interactions: An epistasis effect of CD38 and COMT gene variants influences the impact of oxytocin on amygdala activation to social stimuli. Front. Neurosci. 2013; 7: 45.
45. Sauer C, Montag C, Wörner C, Kirsch P, Reuter M., Effects of a common variant in the CD38 gene on social processing in an oxytocin challenge study: Possible links to autism. Neuropsychopharmacology 2012; 37: 1474-1482.
46. Montag C, Sauer C, Reuter M, Kirsch P., An interaction between oxytocin and a genetic variation of the oxytocin receptor modulates amygdala activity toward direct gaze: Evidence from a pharmacological imaging genetics study. Eur. Arch. Psychiatry Clin. Neurosci. 2013; 263: S169-S175.