Effects of a common variant in the CD38 gene on social processing in an oxytocin challenge study: Possible links to autism

Neuropsychopharmacology

Volumn 37, Issue 6, 2012, Pages 1474-1482

  Sauer, Carina ^a   Montag, Christian ^b   Wörner, Christiane ^a   Kirsch, Peter ^a   Reuter, Martin ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

autism; CD38; imaging genetics; oxytocin; social processing

Indexed keywords

OXYTOCIN; PLACEBO;

ADULT; ALLELE; ARTICLE; AUTISM; BEHAVIOR CHANGE; BEHAVIOR GENETICS; CD38 GENE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FUSIFORM GYRUS; GENE; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; NERVE CELL; NORMAL HUMAN; PERCEPTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REACTION TIME; SINGLE NUCLEOTIDE POLYMORPHISM;

ADMINISTRATION, INTRANASAL; ADULT; AFFECT; ANTIGENS, CD31; AROUSAL; ATTENTION; AUTISTIC DISORDER; BRAIN; BRAIN MAPPING; CROSS-OVER STUDIES; FOLLOW-UP STUDIES; GENETIC VARIATION; GENOTYPE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; OXYGEN; OXYTOCIN; QUESTIONNAIRES; REACTION TIME; SOCIAL PERCEPTION; YOUNG ADULT;

EID: 84859769142     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2011.333     Document Type: Article

References (64)

1. Andari E, Duhamel JR, Zalla T, Herbrecht E, Leboyer M, Sirigu A (2010). Promoting social behavior with oxytocin in highfunctioning autism spectrum disorders. Proc Natl Acad Sci USA 107: 4389-4394.
2. Baskerville TA, Douglas AJ (2010). Dopamine and oxytocin interactions underlying behaviors: potential contributions to behavioral disorders. CNS Neurosci Ther 16: e92-123.
3. Baumgartner T, Heinrichs M, Vonlanthen A, Fischbacher U, Fehr E (2008). Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron 58: 639-650. (Pubitemid 351672358)
4. Bradley MM, Lang PJ (1994). Measuring emotion: the selfassessment manikin and the semantic differential. J Behav Ther Exp Psychiatry 25: 49-59. (Pubitemid 24214918)
5. Burt DR, Creese I, Snyder SH (1977). Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain. Science 196: 326-328. (Pubitemid 8076966)
6. Dalton KM, Nacewicz BM, Alexander AL, Davidson RJ (2007). Gaze-fixation, brain activation, and amygdala volume in unaffected siblings of individuals with autism. Biol Psychiatry 61: 512-520. (Pubitemid 46185335)
7. Dalton KM, Nacewicz BM, Johnstone T, Schaefer HS, Gernsbacher MA, Goldsmith HH et al (2005). Gaze fixation and the neural circuitry of face processing in autism. Nat Neurosci 8: 519-526. (Pubitemid 41007571)
8. De Dreu CK, Greer LL, Handgraaf MJ, Shalvi S, Van Kleef GA, Baas M et al (2010). The neuropeptide oxytocin regulates parochial altruism in intergroup conflict among humans. Science 328: 1408-1411.
9. De Dreu CK, Greer LL, Van Kleef GA, Shalvi S, Handgraaf MJ (2011). Oxytocin promotes human ethnocentrism. Proc Natl Acad Sci USA 108: 1262-1266.
10. Ditzen B, Schaer M, Gabriel B, Bodenmann G, Ehlert U, Heinrichs M (2009). Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict. Biol Psychiatry 65: 728-731.
11. Domes G, Heinrichs M, Glascher J, Buchel C, Braus DF, Herpertz SC (2007a). Oxytocin attenuates amygdala responses to emotional faces regardless of valence. Biol Psychiatry 62: 1187-1190. (Pubitemid 350029722)
12. Domes G, Heinrichs M, Michel A, Berger C, Herpertz SC (2007b). Oxytocin improves 'mind-reading' in humans. Biol Psychiatry 61: 731-733.
13. Ebstein RP, Mankuta D, Yirmiya N, Malavasi F (2011). Are retinoids potential therapeutic agents in disorders of Social cognition including autism? FEBS Lett 585: 1529-1536.
14. Ekman P, Friesen W (1976). Pictures of Facial Affect. Consulting Psychologists Press: Palo Alto.
15. Ewbank MP, Fox E, Calder AJ (2010). The interaction between gaze and facial expression in the amygdala and extended amygdala is modulated by anxiety. Front Hum Neurosci 4: 56.
16. Franke GH (2002). Die Symptom-Checkliste von Derogatis (SCL-90-R)FDeutsche Version. Beltz Test GmbH: Göttingen.
17. Freese JL, Amaral DG (2005). The organization of projections from the amygdala to visual cortical areas TE and V1 in the macaque monkey. J Comp Neurol 486: 295-317. (Pubitemid 40605036)
18. Freese JL, Amaral DG (2006). Synaptic organization of projections from the amygdala to visual cortical areas TE and V1 in the macaque monkey. J Comp Neurol 496: 655-667.
19. Gregory SG, Connelly JJ, Towers AJ, Johnson J, Biscocho D, Markunas CA et al (2009). Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Med 7: 62.
20. Guastella AJ, Einfeld SL, Gray KM, Rinehart NJ, Tonge BJ, Lambert TJ et al (2010). Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biol Psychiatry 67: 692-694.
21. Guastella AJ, Howard AL, Dadds MR, Mitchell P, Carson DS (2009). A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder. Psychoneuroendocrinology 34: 917-923.
22. Guastella AJ, Mitchell PB, Dadds MR (2008). Oxytocin increases gaze to the eye region of human faces. Biol Psychiatry 63: 3-5. (Pubitemid 350234895)
23. Hariri AR, Mattay VS, Tessitore A, Fera F, Smith WG, Weinberger DR (2002a). Dextroamphetamine modulates the response of the human amygdala. Neuropsychopharmacology 27: 1036-1040. (Pubitemid 35447640)
24. Hariri AR, Mattay VS, Tessitore A, Fera F, Weinberger DR (2003). Neocortical modulation of the amygdala response to fearful stimuli. Biol Psychiatry 53: 494-501. (Pubitemid 36331888)
25. Hariri AR, Tessitore A, Mattay VS, Fera F, Weinberger DR (2002b). The amygdala response to emotional stimuli: a comparison of faces and scenes. Neuroimage 17: 317-323.
26. Haxby JV, Hoffman EA, Gobbini MI (2000). The distributed human neural system for face perception. Trends Cogn Sci 4: 223-233. (Pubitemid 30332148)
27. Haxby JV, Hoffman EA, Gobbini MI (2002). Human neural systems for face recognition and social communication. Biol Psychiatry 51: 59-67. (Pubitemid 34093794)
28. Heinrichs M, Baumgartner T, Kirschbaum C, Ehlert U (2003). Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol Psychiatry 54: 1389-1398. (Pubitemid 37522163)
29. Higashida H, Lopatina O, Yoshihara T, Pichugina YA, Soumarokov AA, Munesue T et al (2010). Oxytocin signal and social behaviour: comparison among adult and infant oxytocin, oxytocin receptor and CD38 gene knockout mice. J Neuroendocrinol 22: 373-379.
30. Hoffman KL, Gothard KM, Schmid MC, Logothetis NK (2007). Facial-expression and gaze-selective responses in the monkey amygdala. Curr Biol 17: 766-772. (Pubitemid 46635115)
31. Hollander E, Bartz J, Chaplin W, Phillips A, Sumner J, Soorya L et al (2007). Oxytocin increases retention of social cognition in autism. Biol Psychiatry 61: 498-503. (Pubitemid 46185336)
32. Huber D, Veinante P, Stoop R (2005). Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science 308: 245-248. (Pubitemid 40558858)
33. Itier RJ, Batty M (2009). Neural bases of eye and gaze processing: the core of social cognition. Neurosci Biobehav Rev 33: 843-863.
34. Jacob S, Brune CW, Carter CS, Leventhal BL, Lord C, Cook Jr EH (2007). Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism. Neurosci Lett 417: 6-9. (Pubitemid 46517832)
35. Jemel B, Mottron L, Dawson M (2006). Impaired face processing in autism: fact or artifact? J Autism Dev Disord 36: 91-106.
36. Jin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatina O et al (2007). CD38 is critical for social behaviour by regulating oxytocin secretion. Nature 446: 41-45. (Pubitemid 46348037)
37. Kanwisher N, Yovel G (2006). The fusiform face area: a cortical region specialized for the perception of faces. Philos Trans R Soc Lond B Biol Sci 361: 2109-2128. (Pubitemid 46025883)
38. Kawashima R, Sugiura M, Kato T, Nakamura A, Hatano K, Ito K et al (1999). The human amygdala plays an important role in gaze monitoring. A PET study. Brain 122(Part 4): 779-783. (Pubitemid 29158783)
39. Kirsch P, Esslinger C, Chen Q, Mier D, Lis S, Siddhanti S et al (2005). Oxytocin modulates neural circuitry for social cognition and fear in humans. J Neurosci 25: 11489-11493. (Pubitemid 43083720)
40. Kleinhans NM, Johnson LC, Richards T, Mahurin R, Greenson J, Dawson G et al (2009). Reduced neural habituation in the amygdala and social impairments in autism spectrum disorders. Am J Psychiatry 166: 467-475.
41. Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E (2005). Oxytocin increases trust in humans. Nature 435: 673-676. (Pubitemid 40825511)
42. Lang PJ, Bradley MM, Cuthbert BN (2008). International Affective Picture System (IAPS): Affective Ratings of Pictures and Instruction Manual. Technical Report A-8. University of Florida, Gainesville, FL.
43. Laux L, Glanzmann P, Schaffner P, Spielberger CD (1981). State-Trait-Angstinventar (STAI). Beltz Test GmbH: Göttingen.
44. Lee HJ, Macbeth AH, Pagani JH, Young III WS (2009). Oxytocin: the great facilitator of life. Prog Neurobiol 88: 127-151.
45. Lerer E, Levi S, Israel S, Yaari M, Nemanov L, Mankuta D et al (2010). Low CD38 expression in lymphoblastoid cells and haplotypes are both associated with autism in a family-based study. Autism Res 3: 293-302.
46. Lerer E, Levi S, Salomon S, Darvasi A, Yirmiya N, Ebstein RP (2008). Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition. Mol Psychiatry 13: 980-988.
47. Loup F, Tribollet E, Dubois-Dauphin M, Dreifuss JJ (1991). Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain. An autoradiographic study. Brain Res 555: 220-232.
48. Meyer-Lindenberg A, Domes G, Kirsch P, Heinrichs M (2011). Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat Rev Neurosci 12: 524-538.
49. Meyer-Lindenberg A, Weinberger DR (2006). Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat Rev Neurosci 7: 818-827. (Pubitemid 44435264)
50. Morris JP, Pelphrey KA, McCarthy G (2007). Controlled scanpath variation alters fusiform face activation. Soc Cogn Affect Neurosci 2: 31-38. (Pubitemid 47090791)
51. Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K et al (2010). Two genetic variants of CD38 in subjects with autism spectrum disorder and controls. Neurosci Res 67: 181-191.
52. Petrovic P, Kalisch R, Singer T, Dolan RJ (2008). Oxytocin attenuates affective evaluations of conditioned faces and amygdala activity. J Neurosci 28: 6607-6615.
53. Riebold M, Mankuta D, Lerer E, Israel S, Zhong S, Nemanov L et al (2011). All-trans retinoic acid upregulates reduced CD38 transcription in lymphoblastoid cell lines from autism spectrum disorder. Mol Med 17: 799-806.
54. Schorscher-Petcu A, Dupre A, Tribollet E (2009). Distribution of vasopressin and oxytocin binding sites in the brain and upper spinal cord of the common marmoset. Neurosci Lett 461: 217-222.
55. Schultz RT (2005). Developmental deficits in social perception in autism: the role of the amygdala and fusiform face area. Int J Dev Neurosci 23: 125-141. (Pubitemid 40313547)
56. Schwenkmezger P, Hodapp V, Spielberger CD (1992). State-Trait-Ä rgerausdrucks-Inventar (STAXI). Verlag Hans Huber: Bern.
57. Skuse DH, Gallagher L (2009). Dopaminergic-neuropeptide interactions in the social brain. Trends Cogn Sci 13: 27-35.
58. Steyer R, Schwenkmezger P, Notz P, Eid M (1997). Der Mehrdimensionale Befindlichkeitsfragebogen (MDBF). Hogrefe: Göttingen.
59. Straube T, Langohr B, Schmidt S, Mentzel HJ, Miltner WH (2010). Increased amygdala activation to averted vs direct gaze in humans is independent of valence of facial expression. Neuroimage 49: 2680-2686.
60. Tost H, Kolachana B, Hakimi S, Lemaitre H, Verchinski BA, Mattay VS et al (2010). A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proc Natl Acad Sci USA 107: 13936-13941.
61. Verhoeven JS, De Cock P, Lagae L, Sunaert S (2010). Neuroimaging of autism. Neuroradiology 52: 3-14.
62. Wermter AK, Kamp-Becker I, Hesse P, Schulte-Korne G, Strauch K, Remschmidt H (2010). Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high-functioning level. Am J Med Genet B Neuropsychiatr Genet 153B: 629-639.
63. Wu S, Jia M, Ruan Y, Liu J, Guo Y, Shuang M et al (2005). Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Biol Psychiatry 58: 74-77. (Pubitemid 40909939)
64. Yrigollen CM, Han SS, Kochetkova A, Babitz T, Chang JT, Volkmar FR et al (2008). Genes controlling affiliative behavior as candidate genes for autism. Biol Psychiatry 63: 911-916.