Oxytocin infusion reduces repetitive behaviors in adults with autistic and asperger’s disorders

Neuropsychopharmacology

Volumn 28, Issue 1, 2003, Pages 193-198

  Hollander, Eric ^a   Novotny, Sherie ^a   Hanratty, Margaret ^a   Yaffe, Rona ^a   DeCaria, Concetta M ^a   Aronowitz, Bonnie R ^a   Mosovich, Serge ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Asperger's disorder; Autism; Obsessive compulsive behaviors; Oxytocin; Peptide

Indexed keywords

OXYTOCIN;

ADULT; ARTICLE; ASPERGER SYNDROME; AUTISM; BLOOD PRESSURE; BODY TEMPERATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; PSYCHOLOGICAL ASPECT; PSYCHOLOGICAL RATING SCALE; PULSE RATE; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADULT; ASPERGER SYNDROME; AUTISTIC DISORDER; BLOOD PRESSURE; BODY TEMPERATURE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; OXYTOCIN; PSYCHIATRIC STATUS RATING SCALES; PULSE; TREATMENT OUTCOME;

EID: 0037209159     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/sj.npp.1300021     Document Type: Article

References (57)

1. Altemus M, Jacobson KR, Debellis M, Kling M, Pigott T, Murphy DLet al(1999). Normal CSF oxytocin and NPY levels in OCD.Biol. Psychiatry45: 931-933.
2. Ansseau M, Legros JJ, Mormont C, Cerfontain JL, Papart P(1987). Intranasal oxytocin in obsessive-compulsive disorder.Psychoneuroendocrinology12: 231-236.
3. Banks WA, Kastin AJ, Horvath A, Michals EA (1987). Carriermediated transport of vasopressin across the blood-brain barrier of the mouse.J Neurosci Res18: 326-332.
4. Brown R, King MG (1984). Arginine vasotocin and aggression in rats.Peptides5: 1135-1138.
5. Burbach JPH, Bohus B, Kovacs GL, Van Nispen JW, Grven HM, de Wied D (1983a). Oxytocin is a precursor of potent behaviourallyactive neuropeptide.Eur J Pharmacol94: 125-131.
6. Burbach JPH, Kovacs GL, de Wied D, Van Nispen JW, Greven HM (1983b). A major metabolite of arginine-vasopressin in the brainis a highly potent neuropeptide.Science221: 1310-1312.
7. Carter CS, Williams JR, Witt DM, Insel TR (1992). Oxytocin and social bonding.Ann NY AcadSci652: 204-211.
8. Cook EHJ (1998). Genetics of autism.Mental Retardation DevDisabil Res Rev4: 113-120.
9. Den Boer JA, Westenberg HGM (1992). Oxytocin in obsessive compulsive disorder.Peptides13: 1083-1085.
10. deWied D (1976). Behavioral effects of intraventricularly administered vasopressin and vasopressin fragments.Life Sci19: 685-690.
11. deWied D, Diamant M, Fodor M (1993). Central nervous system effects of the neurohypophyseal hormones and related peptides.Front Neuroendocrinol14: 251-302.
12. de Wied D, Gaffori O, Burbach JPH, Kavacs GL, van Ree JM (1987). Structure activity relationship studies with c-terminal fragmentsof vasopressin and oxytocin on avoidance behaviors of rats.JPharmacolExpTher241: 268-274.
13. deWied D, Greven HM, Lande S, Witter A (1972). Dissociation of the behavioral and endocrine effects of lysine vasopressin bytryptic digestion.Br J Pharmacol45: 118-122.
14. deWied D, Versteeg DH (1979). Neurohypophyseal principles and memory.Fed Proc38: 2348-2454.
15. Drago F, Pedersen CA, Caldwell JD, PrangeJr AJ (1986). Oxytocin potently enhances novelty-induced grooming behavior in therat.Brain Res368: 287-295.
16. Epperson CN, McDougle CJ, Price LH (1996). Intranasal oxytocin in obsessive-compulsive disorder.Biol Psychiatry40: 547-549.
17. Ermisch A, Landgraf R (1990). Vasopressin-blood-brain barrier-brain performance.Circulating Regulatory Factors andNeuroendocrine Function.Plenum Press: New York, pp 71-89.
18. Ermisch A, Landgraf R, Brust P, Kretzschmar R, Hess J (1988). Peptide receptors of the cerebral capillary endothelium and thetransport of amino acids across the blood-brain barrier. In:Rakic L, Begley DJ, Davson H, Zlokovic BV (eds).Peptide andAmino Acid Transport Mechanisms in the Central NervousSystem. Stockton Press: New York, pp 41-53.
19. Ermisch A, Brust P, Kretzchmar R, Ruhle H-J (1993). Peptides and the blood-brain barrier.Physiol Rev73: 489-527.
20. Ferguson JN, Young LJ, Hearn EF, Matzuk MM, Insel TR, Winslow JT (2000).Social amnesia in mice lacking the oxytocin gene.NatGenet25: 284-288.
21. Green LA, Fein D, Modahl C, Feinstein C, Waterhouse L, Morris M (2001). Oxytocin and autistic disorder: alteration in peptideforms.Biol Psychiatry50: 609-613.
22. Hollander E, DelGiudice-Asch G, Simon L, Schmeidler J, Cart-wright C, DeCaria CMet al(1999). B lymphocyte antigen D8/17 and repetitive behaviors in autism.Am J Psychiatry156: 317-320.
23. Hollander E, Novotny S, Allen A, Aronowitz B, Cartwright C, DeCaria C (2000). The relationship between repetitive behaviorsand growth hormone response to sumatriptan challenge in adultautistic disorder.Neuropsychopharmacology22: 163-167.
24. Insel TR, Hulihan TJ (1995). A gender-specific mechanism for pair bonding: oxytocin and partner preference formation in mono-gamous voles.BehavNeurosci109: 782-789.
25. Insel TR, O’Brien DJ, Leckman JF (1999). Oxytocin, vasopressin, and autism: is there a connection.Biol. Psychiatry45: 145-157.
26. Insel TR, Winslow JT (1991). Central administration of oxytocin modulates the infant rat’s response to social isolation.Eur JPharmacol.203: 149-152.
27. Insel TR, Winslow JT (1998). Serotonin and neuropeptides in affiliative behaviors.Biol Psychiatry443: 207-219.
28. Insel TR, Young LJ (2001). The neurobiology of attachment.Nature Reviews Neuroscience2: 129-136.
29. Johnson AE, Coirini H, Insel TR, McEwen BS (1990). The regulation of oxytocin receptor binding in the ventromedialhypothalamic nucleus by testosterone and its metabolites.Endocrinology128: 891-896.
30. Kretzchmar R, Landgraf R, Gjedde A, Ermisch A (1986). Vasopressin binds to microvessels from rat hippocampus.BrainRes380: 325-330.
31. Landgraf R, Hess J, Hartmann E (1977). Effect of oxytocin on regional 3H-orotic acid uptake in rat brain.Endokrinologie70:45-52.
32. Landgraf R, Hess J, Ermisch A (1978). The influence of vasopressin on the regional uptake of [3H] orotic acid by the rat brain.ActaBiol Med Ger37: 655-658.
33. Leckman JF, Goodman WK, North WG, Chappell PB, Price LH, Pauls DLet al(1994). Elevated cerebrospinal fluid levels ofoxytocin in obsessive-compulsive disorder Comparison withTourette’s syndrome and healthy controls.Arch Gen Psychiatry51: 782-792.
34. Lord C, Rutter M, LeCouteur A (1994). Autism Diagnostic Interview-Revised: a revised version of a diagnostic scale forcaregivers of individuals with possible pervasive developmentaldisorders.J Autism Develop Disorders24: 659-685.
35. Martin A, State M, Anderson GM, Kaye WM, Hanchett JM, McConaha CWet al(1998). Cerebrospinal fluid levels ofoxytocin in Prader-Willi syndrome: a preliminary report.BiolPsychiatry44: 1349-1352.
36. Meisenberg G, Simmons WH (1983a). Centrally mediated effects of neurohypophyseal hormones.NeurosciBiobehav Rev7: 263-280.
37. Meisenberg G, Simmons WH (1983b). Peptides and the blood-brain barrier.Life Sci32: 2611-2623.
38. Modahl C, Green L, Fein D, Morris M, Waterhouse L, Feinstein C, Levin H (1998). Plasma oxytocin levels in autistic children.BiolPsychiatry43: 270-277.
39. Nelson E, Alberts JR (1997). Oxytocin-induced paw sucking in infant rats.Ann NY AcadSci807: 543-545.
40. Nelson E, Panksepp J (1996). Oxytocin mediates acquisition of maternally associated odor preferences in preweanling rat pups.BehavNeurosci110: 583-592.
41. Nishimori K, Young LJ, Guo Q, Wang Z, Insel TR, Matzuk MM (1996). Oxytocin is required for nursing but is not essential forparturition or reproductive behavior.Proc Nat AcadSci USA93:11699-11704.
42. Panksepp J (1992). Oxytocin effects on emotional processes: separation distress, social bonding, and relationships topsychiatric disorders. In: Pedersen C, Caldwell J, Jirikowski G, Insel T (eds).Oxytocin in Maternal Sexual and SocialProcesses.Vol, 652. New York Academy of Sciences, New York,243-252.
43. Popik P, Van Ree JM (1992). Long term facilitation of social recognition in rats by vasopressin related peptides: a structure-activity study.Life Sci50: 567-572.
44. Popik P, Vetulani J, van Ree JM (1992a). Low doses of oxytocin facilitate social recognition in rats.Psychopharmacology106: 7174.
45. Popik P, Vos P, van Ree J (1992b). Neurohypophyseal hormone receptors in the septum are implicated in social recognition inthe rat.BehavPharmacol3: 351-358.
46. Rainbow TC, Flexner JB, Flexner LB, Hoffman PL, Walter R (1979). Distribution, survival and biological effects in mice of abehaviorally active, enzymatically stable peptide: pharmacoki-netics of cyclo-(Leu-Gly) and puromycin-induced amnesia.PharmacolBiochemBehav10: 787-793.
47. Salzberg AD, Swedo SE (1992). Oxytocin and vasopressin in obsessive-compulsive disorder.Am J Psychiatry149: 713-714.
48. Shapiro LE, Insel TR (1989). Ontogeny of oxytocin receptors in rat forebrain: a quantitative study.Synapse4: 259-266.
49. Swedo SE, Leonard HL, Kruesi MJ, Rettew DC, Listwak SJ, Berrettini Wet al(1992). Cerebrospinal fluid neurochemistry inchildren and adolescents with obsessive-compulsive disorder.Arch Gen Psychiatry49: 29-36.
50. Tanabe S, Shishido Y, Furushiro M, Kado K, Hashimoto S, Yokokura T, Ohsawa T (1997). Facilitation of passive avoid-ance response by newly synthesized cationized argininevasopressin fragment 4-9 in rats.PharmacolBiochemBehav57: 251-256.
51. vanWimersmaGreidanus TB, Kroodsma JM, Pot MLH, Stevens M, Maigret C (1990). Neurohypophyseal hormones and excessivegrooming behavior.Eur J Pharmacol187: 1-8.
52. Walter R, Hoffman PL, Flexner JB, Flexner LB (1975).Proc Nat AcadSci USA72: 4180-4184.
53. Winslow DM, Insel TR (1991). Social status in the pairs of male squirrel monkeys determines the behavioral response to centraloxytocin administration.J Neurosci11: 2032-2038.
54. Winslow JT, Hastings N, Carter CS, Harbaugh CR, Insel TR (1993). A role for central vasopressin in pair bonding in monogamousprairie voles.Nature365: 545-548.
55. Witt DM, Winslow JT, Insel TR (1992). Enhanced social interactions in rats following chronic, centrally infused oxytocin.Pharmacol, BiochemBehav43: 855-861.
56. Young LJ, Winslow JT, Wang Z, Gingrich B, Guo Q, Matzuk MMet al(1997). Gene targeting approaches to neuroendocrinology:oxytocin, maternal behavior, and affiliation.Hormones Behav31:221-231.
57. Zlokovic BV, Hyman S, McComb JG, Lipovac MN, Tang G, Davson H (1990). Kinetics of arginine-vasopressin uptake at the blood-brain barrier.BiochimBiophysActa1025: 191-198.