-
1
-
-
84924271853
-
Global cancer statistics, 2012
-
Torre L.A., et al. Global cancer statistics, 2012. CA Cancer J. Clin 2015, 65(2):87-108.
-
(2015)
CA Cancer J. Clin
, vol.65
, Issue.2
, pp. 87-108
-
-
Torre, L.A.1
-
2
-
-
77951220861
-
Chemotherapy for advanced gastric cancer
-
CD004064
-
Wagner A.D., et al. Chemotherapy for advanced gastric cancer. Cochrane Database Syst. Rev 2010, (3). CD004064.
-
(2010)
Cochrane Database Syst. Rev
, Issue.3
-
-
Wagner, A.D.1
-
3
-
-
84938701419
-
Sequential treatment with epirubicin, oxaliplatin and 5FU (EOF) followed by docetaxel, oxaliplatin and 5FU (DOF) in patients with advanced gastric or gastroesophageal cancer: a single-institution experience
-
Petrioli R., et al. Sequential treatment with epirubicin, oxaliplatin and 5FU (EOF) followed by docetaxel, oxaliplatin and 5FU (DOF) in patients with advanced gastric or gastroesophageal cancer: a single-institution experience. Cancer Chemother. Pharmacol 2015, 75(5):941-947.
-
(2015)
Cancer Chemother. Pharmacol
, vol.75
, Issue.5
, pp. 941-947
-
-
Petrioli, R.1
-
4
-
-
84899901507
-
Unmet needs and challenges in gastric cancer: the way forward
-
Lordick F., et al. Unmet needs and challenges in gastric cancer: the way forward. Cancer Treat. Rev 2014, 40(6):692-700.
-
(2014)
Cancer Treat. Rev
, vol.40
, Issue.6
, pp. 692-700
-
-
Lordick, F.1
-
5
-
-
77956262693
-
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial
-
Bang Y.J., et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010, 376(9742):687-697.
-
(2010)
Lancet
, vol.376
, Issue.9742
, pp. 687-697
-
-
Bang, Y.J.1
-
7
-
-
84867131579
-
Prognosis of metastatic gastric and gastroesophageal junction cancer by HER2 status: a European and USA International collaborative analysis
-
Janjigian Y.Y., et al. Prognosis of metastatic gastric and gastroesophageal junction cancer by HER2 status: a European and USA International collaborative analysis. Ann. Oncol 2012, 23(10):2656-2662.
-
(2012)
Ann. Oncol
, vol.23
, Issue.10
, pp. 2656-2662
-
-
Janjigian, Y.Y.1
-
8
-
-
84892852372
-
Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial
-
Fuchs C.S., et al. Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet 2014, 383(9911):31-39.
-
(2014)
Lancet
, vol.383
, Issue.9911
, pp. 31-39
-
-
Fuchs, C.S.1
-
9
-
-
84908139963
-
Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial
-
Wilke H., et al. Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial. Lancet Oncol 2014, 15(11):1224-1235.
-
(2014)
Lancet Oncol
, vol.15
, Issue.11
, pp. 1224-1235
-
-
Wilke, H.1
-
10
-
-
84951570516
-
Angiogenesis inhibitors in gastric and gastroesophageal junction cancer
-
Roviello G., et al. Angiogenesis inhibitors in gastric and gastroesophageal junction cancer. Gastric Cancer 2016, 19(1):31-41.
-
(2016)
Gastric Cancer
, vol.19
, Issue.1
, pp. 31-41
-
-
Roviello, G.1
-
11
-
-
84907270779
-
Comprehensive molecular characterization of gastric adenocarcinoma
-
Cancer Genome Atlas Research Network Comprehensive molecular characterization of gastric adenocarcinoma. Nature 2014, 513(7517):202-209.
-
(2014)
Nature
, vol.513
, Issue.7517
, pp. 202-209
-
-
-
12
-
-
79959208066
-
YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo
-
Tian S., et al. YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo. Cancer Sci 2011, 102(7):1374-1380.
-
(2011)
Cancer Sci
, vol.102
, Issue.7
, pp. 1374-1380
-
-
Tian, S.1
-
13
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm S.M., et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004, 64(19):7099-7109.
-
(2004)
Cancer Res
, vol.64
, Issue.19
, pp. 7099-7109
-
-
Wilhelm, S.M.1
-
14
-
-
0037699954
-
The biology of VEGF and its receptors
-
Ferrara N., Gerber H.P., LeCouter J. The biology of VEGF and its receptors. Nat. Med 2003, 9(6):669-676.
-
(2003)
Nat. Med
, vol.9
, Issue.6
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.P.2
LeCouter, J.3
-
15
-
-
34248386965
-
Challenges for patient selection with VEGF inhibitors
-
Longo R., Gasparini G. Challenges for patient selection with VEGF inhibitors. Cancer Chemother. Pharmacol 2007, 60(2):151-170.
-
(2007)
Cancer Chemother. Pharmacol
, vol.60
, Issue.2
, pp. 151-170
-
-
Longo, R.1
Gasparini, G.2
-
16
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin D.J., Ellis L.M. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J. Clin. Oncol 2005, 23(5):1011-1027.
-
(2005)
J. Clin. Oncol
, vol.23
, Issue.5
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
17
-
-
34548443831
-
Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition
-
Holmes K., et al. Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Cell. Signal 2007, 19(10):2003-2012.
-
(2007)
Cell. Signal
, vol.19
, Issue.10
, pp. 2003-2012
-
-
Holmes, K.1
-
18
-
-
3543131382
-
A naturally occurring soluble form of vascular endothelial growth factor receptor 2 detected in mouse and human plasma
-
Ebos J.M., et al. A naturally occurring soluble form of vascular endothelial growth factor receptor 2 detected in mouse and human plasma. Mol. Cancer Res 2004, 2(6):315-326.
-
(2004)
Mol. Cancer Res
, vol.2
, Issue.6
, pp. 315-326
-
-
Ebos, J.M.1
-
19
-
-
84905740234
-
VEGFr inhibitor YN968D1 xenograft dose response studies against human colon cancer Ls174t and HT29
-
Chen P., Iruela-Arispe I., Lou L., Sun P., Yuan K. VEGFr inhibitor YN968D1 xenograft dose response studies against human colon cancer Ls174t and HT29. Proc. Am. Assoc. Cancer Res 2006, 47. Abstract 1764.
-
(2006)
Proc. Am. Assoc. Cancer Res
, vol.47
-
-
Chen, P.1
Iruela-Arispe, I.2
Lou, L.3
Sun, P.4
Yuan, K.5
-
20
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship
-
Mendel D.B., et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin. Cancer Res 2003, 9(1):327-337.
-
(2003)
Clin. Cancer Res
, vol.9
, Issue.1
, pp. 327-337
-
-
Mendel, D.B.1
-
21
-
-
77957264446
-
Safety and pharmacokinetics of novel selective vascular endothelial growth factor receptor-2 inhibitor YN968D1 in patients with advanced malignancies
-
Li J., et al. Safety and pharmacokinetics of novel selective vascular endothelial growth factor receptor-2 inhibitor YN968D1 in patients with advanced malignancies. BMC Cancer 2010, 10:529.
-
(2010)
BMC Cancer
, vol.10
, pp. 529
-
-
Li, J.1
-
22
-
-
82355193008
-
A randomized, double-blind, multicenter, phase II, three-arm, placebo-control study of apatinib as third-line treatment in patients with metastatic gastric carcinoma
-
Li J., et al. A randomized, double-blind, multicenter, phase II, three-arm, placebo-control study of apatinib as third-line treatment in patients with metastatic gastric carcinoma. J. Clin. Oncol 2011, 29(Suppl.). Abstract 4019.
-
(2011)
J. Clin. Oncol
, vol.29
-
-
Li, J.1
-
23
-
-
84891373220
-
Apatinib for chemotherapy-refractory advanced metastatic gastric cancer: results from a randomized, placebo-controlled, parallel-arm, phase II trial
-
Li J., et al. Apatinib for chemotherapy-refractory advanced metastatic gastric cancer: results from a randomized, placebo-controlled, parallel-arm, phase II trial. J. Clin. Oncol 2013, 31(26):3219-3225.
-
(2013)
J. Clin. Oncol
, vol.31
, Issue.26
, pp. 3219-3225
-
-
Li, J.1
-
24
-
-
84907498840
-
Phase III study of apatinib in advanced gastric cancer: a randomized, double-blind, placebo-controlled trial
-
Suppl; abstr 4003
-
Qin S., et al. Phase III study of apatinib in advanced gastric cancer: a randomized, double-blind, placebo-controlled trial. J. Clin. Oncol 2014, 32(5s). Suppl; abstr 4003.
-
(2014)
J. Clin. Oncol
, vol.32
, Issue.5
-
-
Qin, S.1
-
25
-
-
0028929803
-
Angiogenesis in cancer, vascular, rheumatoid and other disease
-
Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med 1995, 1(1):27-31.
-
(1995)
Nat. Med
, vol.1
, Issue.1
, pp. 27-31
-
-
Folkman, J.1
-
26
-
-
0031037638
-
Correlation between expression of vascular endothelial growth factor and tumor vascularity, and patient outcome in human gastric carcinoma
-
Tanigawa N., et al. Correlation between expression of vascular endothelial growth factor and tumor vascularity, and patient outcome in human gastric carcinoma. J. Clin. Oncol 1997, 15(2):826-832.
-
(1997)
J. Clin. Oncol
, vol.15
, Issue.2
, pp. 826-832
-
-
Tanigawa, N.1
-
27
-
-
84937517268
-
Angiogenic inhibitors in gastric cancers and gastroesophageal junction carcinomas: a critical insight
-
Aprile G., et al. Angiogenic inhibitors in gastric cancers and gastroesophageal junction carcinomas: a critical insight. Crit. Rev. Oncol. Hematol 2015, 95(2):165-178.
-
(2015)
Crit. Rev. Oncol. Hematol
, vol.95
, Issue.2
, pp. 165-178
-
-
Aprile, G.1
-
29
-
-
2942590261
-
Vascular endothelial growth factor as a target for anticancer therapy
-
Ferrara N. Vascular endothelial growth factor as a target for anticancer therapy. Oncologist 2004, 9(Suppl. 1):2-10.
-
(2004)
Oncologist
, vol.9
, pp. 2-10
-
-
Ferrara, N.1
-
31
-
-
0029857184
-
Significance of vessel count and vascular endothelial growth factor and its receptor (KDR) in intestinal-type gastric cancer
-
Takahashi Y., et al. Significance of vessel count and vascular endothelial growth factor and its receptor (KDR) in intestinal-type gastric cancer. Clin. Cancer Res 1996, 2(10):1679-1684.
-
(1996)
Clin. Cancer Res
, vol.2
, Issue.10
, pp. 1679-1684
-
-
Takahashi, Y.1
-
32
-
-
79955534227
-
Docetaxel and irinotecan as second-line therapy for advanced oesophagogastric cancer
-
Hawkes E., et al. Docetaxel and irinotecan as second-line therapy for advanced oesophagogastric cancer. Eur. J. Cancer 2011, 47(8):1146-1151.
-
(2011)
Eur. J. Cancer
, vol.47
, Issue.8
, pp. 1146-1151
-
-
Hawkes, E.1
-
33
-
-
45549091227
-
Mitomycin C plus S-1 as second-line therapy in patients with advanced gastric cancer: a noncomparative phase II study
-
Park S.H., et al. Mitomycin C plus S-1 as second-line therapy in patients with advanced gastric cancer: a noncomparative phase II study. Anticancer Drugs 2008, 19(3):303-307.
-
(2008)
Anticancer Drugs
, vol.19
, Issue.3
, pp. 303-307
-
-
Park, S.H.1
-
34
-
-
70349388719
-
Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma
-
Rini B.I., Wilding G., Hudes G., Stadler W.M., Kim S., Tarazi J., et al. Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma. J. Clin. Oncol 2009, 27(27):4462-4468.
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.27
, pp. 4462-4468
-
-
Rini, B.I.1
Wilding, G.2
Hudes, G.3
Stadler, W.M.4
Kim, S.5
Tarazi, J.6
-
35
-
-
70249141675
-
Dasatinib in the treatment of chronic myeloid leukemia in accelerated phase after imatinib failure: the START a trial
-
Apperley J.F., Cortes J.E., Kim D.W., Roy L., Roboz G.J., Rosti G., et al. Dasatinib in the treatment of chronic myeloid leukemia in accelerated phase after imatinib failure: the START a trial. J. Clin. Oncol 2009, 27(21):3472-3479.
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.21
, pp. 3472-3479
-
-
Apperley, J.F.1
Cortes, J.E.2
Kim, D.W.3
Roy, L.4
Roboz, G.J.5
Rosti, G.6
-
36
-
-
84862777035
-
A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets
-
Deng N., et al. A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets. Gut 2012, 61(5):673-684.
-
(2012)
Gut
, vol.61
, Issue.5
, pp. 673-684
-
-
Deng, N.1
-
37
-
-
77957552916
-
Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for advanced esophagogastric cancer: dose-finding study for the prospective multicenter, randomized, phase II/III REAL-3 trial
-
Okines A.F., et al. Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for advanced esophagogastric cancer: dose-finding study for the prospective multicenter, randomized, phase II/III REAL-3 trial. J. Clin. Oncol 2010, 28(25):3945-3950.
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.25
, pp. 3945-3950
-
-
Okines, A.F.1
-
38
-
-
51449124276
-
Phase I study of epirubicin, cisplatin and capecitabine plus matuzumab in previously untreated patients with advanced oesophagogastric cancer
-
Rao S., et al. Phase I study of epirubicin, cisplatin and capecitabine plus matuzumab in previously untreated patients with advanced oesophagogastric cancer. Br. J. Cancer 2008, 99(6):868-874.
-
(2008)
Br. J. Cancer
, vol.99
, Issue.6
, pp. 868-874
-
-
Rao, S.1
-
39
-
-
33748987894
-
Pharmacodynamic studies of gefitinib in tumor biopsy specimens from patients with advanced gastric carcinoma
-
Rojo F., et al. Pharmacodynamic studies of gefitinib in tumor biopsy specimens from patients with advanced gastric carcinoma. J. Clin. Oncol 2006, 24(26):4309-4316.
-
(2006)
J. Clin. Oncol
, vol.24
, Issue.26
, pp. 4309-4316
-
-
Rojo, F.1
-
40
-
-
33750618860
-
Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127
-
Dragovich T., et al. Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127. J. Clin. Oncol 2006, 24(30):4922-4927.
-
(2006)
J. Clin. Oncol
, vol.24
, Issue.30
, pp. 4922-4927
-
-
Dragovich, T.1
-
41
-
-
77951635629
-
Multicenter phase II study of everolimus in patients with previously treated metastatic gastric cancer
-
Doi T., et al. Multicenter phase II study of everolimus in patients with previously treated metastatic gastric cancer. J. Clin. Oncol 2010, 28(11):1904-1910.
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.11
, pp. 1904-1910
-
-
Doi, T.1
-
42
-
-
84930819440
-
C-Met targeting in advanced gastric cancer: an open challenge
-
Marano L., et al. c-Met targeting in advanced gastric cancer: an open challenge. Cancer Lett 2015, 365(1):30-36.
-
(2015)
Cancer Lett
, vol.365
, Issue.1
, pp. 30-36
-
-
Marano, L.1
-
43
-
-
84983432305
-
A systematic review and meta-analysis of randomized trials on the role of targeted therapy in the management of advanced gastric cancer: evidence does not translate?
-
Ciliberto D., et al. A systematic review and meta-analysis of randomized trials on the role of targeted therapy in the management of advanced gastric cancer: evidence does not translate?. Cancer Biol. Ther 2015, 16(8):1148-1159.
-
(2015)
Cancer Biol. Ther
, vol.16
, Issue.8
, pp. 1148-1159
-
-
Ciliberto, D.1
|