Neuroplasticity in response to cognitive behavior therapy for social anxiety disorder

Translational Psychiatry

Volumn 6, Issue , 2016, Pages

  Mansson K N T ^a,b   Salami, A ^c,d   Frick, A ^e   Carlbring, P ^f   Andersson, G ^a,c   Furmark, T ^e   Boraxbekk, C J ^d,g  

^a LINKÖPING UNIVERSITY   (Sweden)

^b PRIMA Barn Och Vuxenpsykiatri ^*  (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UMEÅ UNIVERSITY   (Sweden)

^e UPPSALA UNIVERSITY   (Sweden)

^f STOCKHOLM UNIVERSITY   (Sweden)

^g UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AMYGDALOID NUCLEUS; ANTICIPATORY ANXIETY; ARTICLE; ATTENTIONAL BIAS; BOLD SIGNAL; BRAIN ANALYSIS; BRAIN SIZE; CLINICAL ARTICLE; COGNITIVE THERAPY; CONTROLLED STUDY; FEMALE; GRAY MATTER; HUMAN; MALE; NERVE CELL PLASTICITY; NERVE POTENTIAL; NEUROIMAGING; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; SOCIAL PHOBIA; TREATMENT OUTCOME; ADOLESCENT; ANXIETY DISORDERS; BRAIN; BRAIN MAPPING; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; YOUNG ADULT;

ADOLESCENT; ADULT; ANXIETY DISORDERS; BRAIN; BRAIN MAPPING; COGNITIVE THERAPY; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEURONAL PLASTICITY; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84957583302     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2015.218     Document Type: Article

References (72)

1. Kühn S, Gleich T, Lorenz RC, Lindenberger U, Gallinat J. Playing Super Mario induces structural brain plasticity: gray matter changes resulting from training with a commercial video game. Mol Psychiatry 2014; 19: 265-271.
2. Trabalza A, Colazingari S, Sgobio C, Bevilacqua A. Contextual learning increases dendrite complexity and EphrinB2 levels in hippocampal mouse neurons. Behav Brain Res 2012; 227: 175-183.
3. Sztainberg Y, Kuperman Y, Tsoory M, Lebow M, Chen A. The anxiolytic effect of environmental enrichment is mediated via amygdalar CRF receptor type 1. Mol Psychiatry 2010; 15: 905-917.
4. Lövdén M, Wenger E, Mårtensson J, Lindenberger U, Bäckman L. Structural brain plasticity in adult learning and development. Neurosci Biobehav Rev 2013; 37: 2296-2310.
5. Maass A, Duzel S, Goerke M, Becke A, Sobieray U, Neumann K et al. Vascular hippocampal plasticity after aerobic exercise in older adults. Mol Psychiatry 2015; 20: 585-593.
6. Arnone D, McKie S, Elliott R, Juhasz G, Thomas EJ, Downey D et al. State-dependent changes in hippocampal grey matter in depression. Mol Psychiatry 2013; 18: 1265-1272.
7. Ghosh S, Laxmi TR, Chattarji S. Functional connectivity from the amygdala to the hippocampus grows stronger after stress. J Neurosci 2013; 33: 7234-7244.
8. Maren S, Quirk GJ. Neuronal signalling of fear memory. Nat Rev Neurosci 2004; 5: 844-852.
9. Poldrack RA. Imaging brain plasticity: conceptual and methodological issues - a theoretical review. NeuroImage 2000; 12: 1-13.
10. Sui J, Huster R, Yu Q, Segall JM, Calhoun VD. Function-structure associations of the brain: evidence from multimodal connectivity and covariance studies. NeuroImage 2014; 102: 11-23.
11. Nyberg L, Salami A, Andersson M, Eriksson J, Kalpouzos G, Kauppi K et al. Longitudinal evidence for diminished frontal cortex function in aging. Proc Natl Acad Sci USA 2010; 107: 22682-22686.
12. Salami A, Eriksson J, Nyberg L. Opposing effects of aging on large-scale brain systems for memory encoding and cognitive control. J Neurosci 2012; 32: 10749-10757.
13. Redlich R, Grotegerd D, Opel N, Kaufmann C, Zwitserlood P, Kugel H et al. Are you gonna leave me? Separation anxiety is associated with increased amygdala responsiveness and volume. Soc Cogn Affect Neurosci 2015; 10: 278-284.
14. LeDoux J. The emotional brain, fear, and the amygdala. Cell Mol Neurobiol 2003; 23: 727-738.
15. Etkin A, Wager TD. Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am J Psychiatry 2007; 164: 1476-1488.
16. Freitas-Ferrari MC, Hallak JEC, Trzesniak C, Filho AS, Machado-De-Sousa JP, Chagas MHN et al. Neuroimaging in social anxiety disorder: a systematic review of the literature. Prog Neuropsychopharmacol Biol Psychiatry 2010; 34: 565-580.
17. Shin LM, Liberzon I. The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacol 2009; 35: 169-191.
18. Li L, Wu M, Liao Y, Ouyang L, Du M, Lei D et al. Grey matter reduction associated with posttraumatic stress disorder and traumatic stress. Neurosci Biobehav Rev 2014; 43: 163-172.
19. Talati A, Pantazatos SP, Schneier FR, Weissman MM, Hirsch J. Gray matter abnormalities in social anxiety disorder: primary, replication, and specificity studies. Biol Psychiatry 2013; 73: 75-84.
20. van Tol MJ, van der Wee NJ, van den Heuvel OA, Nielen MM, Demenescu LR, Aleman A et al. Regional brain volume in depression and anxiety disorders. Arch Gen Psychiatry 2010; 67: 1002-1011.
21. Radua J, van den Heuvel OA, Surguladze S, Mataix-Cols D. Meta-analytical comparison of voxel-based morphometry studies in obsessive-compulsive disorder vs other anxiety disorders. Arch Gen Psychiatry 2010; 67: 701-711.
22. Irle E, Ruhleder M, Lange C, Seidler-Brandler U, Salzer S, Dechent P et al. Reduced amygdalar and hippocampal size in adults with generalized social phobia. J Psychiatry Neurosci 2010; 35: 126-131.
23. Frick A, Gingnell M, Marquand AF, Howner K, Fischer H, Kristiansson M et al. Classifying social anxiety disorder using multivoxel pattern analyses of brain function and structure. Behav Brain Res 2014; 259: 330-335.
24. Frick A, Howner K, Fischer H, Eskildsen SF, Kristiansson M, Furmark T. Cortical thickness alterations in social anxiety disorder. Neurosci Lett 2013; 536: 52-55.
25. Brühl AB, Delsignore A, Komossa K, Weidt S. Neuroimaging in social anxiety disorder-a meta-analytic review resulting in a new neurofunctional model. Neurosci Biobehav Rev 2014; 47: 260-280.
26. Liao W, Xu Q, Mantini D, Ding J, Machado-de-Sousa JP, Hallak JE et al. Altered gray matter morphometry and resting-state functional and structural connectivity in social anxiety disorder. Brain Res 2011; 1388: 167-177.
27. Månsson KNT, Carlbring P, Frick A, Engman J, Olsson C-J, Bodlund O et al. Altered neural correlates of affective processing after internet-delivered cognitive behavior therapy for social anxiety disorder. Psychiatry Res 2013; 214: 229-237.
28. Furmark T, Tillfors M, Marteinsdottir I, Fischer H, Pissiota A, Langstrom B et al. Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy. Arch Gen Psychiatry 2002; 59: 425-433.
29. Lueken U, Straube B, Konrad C, Wittchen HU, Strohle A, Wittmann A et al. Neural substrates of treatment response to cognitive-behavioral therapy in panic disorder with agoraphobia. Am J Psychiatry 2013; 170: 1345-1355.
30. Goldin PR, Ziv M, Jazaieri H, Hahn K, Heimberg R, Gross JJ. Impact of cognitive behavioral therapy for social anxiety disorder on the neural dynamics of cognitive reappraisal of negative self-beliefs: randomized clinical trial. JAMA Psychiatry 2013; 70: 1048-1056.
31. Linden DEJ. How psychotherapy changes the brain - the contribution of functional neuroimaging. Mol Psychiatry 2006; 11: 528-538.
32. Phan KL, Coccaro EF, Angstadt M, Kreger KJ, Mayberg HS, Liberzon I et al. Corticolimbic brain reactivity to social signals of threat before and after sertraline treatment in generalized social phobia. Biol Psychiatry 2013; 73: 329-336.
33. Mahan AL, Ressler KJ. Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder. Trends Neurosci 2012; 35: 24-35.
34. Cassimjee N, Fouche J-P, Burnett M, Lochner C, Warwick J, Dupont P et al. Changes in regional brain volumes in social anxiety disorder following 12 weeks of treatment with escitalopram. Metab Brain Dis 2010; 25: 369-374.
35. Talati A, Pantazatos SP, Hirsch J, Schneier F. A pilot study of gray matter volume changes associated with paroxetine treatment and response in social anxiety disorder. Psychiatry Res 2015; 231: 279-285.
36. Schienle A, Wabnegger A, Scharmüller W. Effects of cognitive behavior therapy on regional brain volume in spider-phobic patients: preliminary results. J Anxiety Disord 2014; 28: 276-279.
37. Blair K, Geraci M, Devido J, McCaffrey D, Chen G, Vythilingam M et al. Neural response to self- and other referential praise and criticism in generalized social phobia. Arch Gen Psychiatry 2008; 65: 1176-1184.
38. First M, Gibbon M, Spitzer R, Williams J. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). American Psychiatric Press: Washington, DC, 1997.
39. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998; 59: 22-33.
40. Baker SL, Heinrichs N, Kim HJ, Hofmann SG. The liebowitz social anxiety scale as a self-report instrument: a preliminary psychometric analysis. Behav Res Ther 2002; 40: 701-715.
41. Svanborg P, Asberg M. A new self-rating scale for depression and anxiety states based on the comprehensive psychopathological rating scale. Acta Psychiatr Scand 1994; 89: 21-28.
42. Månsson KN, Frick A, Boraxbekk CJ, Marquand AF, Williams SC, Carlbring P et al. Predicting long-term outcome of Internet-delivered cognitive behavior therapy for social anxiety disorder using fMRI and support vector machine learning. Transl Psychiatry 2015; 5: e530.
43. Zaider TI, Heimberg RG, Fresco DM, Schneier FR, Liebowitz MR. Evaluation of the Clinical Global Impression Scale among individuals with social anxiety disorder. Psychol Med 2003; 33: 611-622.
44. Furmark T, Appel L, Michelgard A, Wahlstedt K, Ahs F, Zancan S et al. Cerebral blood flow changes after treatment of social phobia with the neurokinin-1 antagonist GR205171, citalopram, or placebo. Biol Psychiatry 2005; 58: 132-142.
45. Andersson G, Carlbring P, Furmark T. Group SOFIER Therapist experience and knowledge acquisition in internet-delivered CBT for social anxiety disorder: a randomized controlled trial. PLoS One 2012; 7: e37411.
46. Boettcher J, Carlbring P, Renneberg B, Berger T. Internet-based interventions for social anxiety disorder - an overview. Verhaltenstherapie 2013; 23: 160-168.
47. Andersson G, Cuijpers P, Carlbring P, Riper H, Hedman E. Guided Internet-based vs. face-to-face cognitive behavior therapy for psychiatric and somatic disorders: a systematic review and meta-analysis. World Psychiatry 2014; 13: 288-295.
48. MacLeod C, Mathews A. Cognitive bias modification approaches to anxiety. Annu Rev Clin Psychol 2012; 8: 189-217.
49. Carlbring P, Apelstrand M, Sehlin H, Amir N, Rousseau A, Hofmann SG et al. Internet-delivered attention bias modification training in individuals with social anxiety disorder - a double blind randomized controlled trial. BMC Psychiatry 2012; 12: 66.
50. Amir N, Beard C, Taylor CT, Klumpp H, Elias J, Burns M et al. Attention training in individuals with generalized social phobia: a randomized controlled trial. J Consult Clin Psychol 2009; 77: 961-973.
51. Linetzky M, Pergamin-Hight L, Pine DS, Bar-Haim Y. Quantitative evaluation of the clinical efficacy of attention bias modification treatment for anxiety disorders. Depress Anxiety 2015; 32: 383-391.
52. Miskovic V, Schmidt LA. Social fearfulness in the human brain. Neurosci Biobehav Rev 2012; 36: 459-478.
53. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. NeuroImage 2003; 19: 1233-1239.
54. Shrout PE, Bolger N. Mediation in experimental and nonexperimental studies: new procedures and recommendations. Psychol Methods 2002; 7: 422-445.
55. Casanova R, Srikanth R, Baer A, Laurienti PJ, Burdette JH, Hayasaka S et al. Biological parametric mapping: a statistical toolbox for multimodality brain image analysis. NeuroImage 2007; 34: 137-143.
56. Northoff G, Heinzel A, de Greck M, Bermpohl F, Dobrowolny H, Panksepp J. Self-referential processing in our brain - A meta-analysis of imaging studies on the self. NeuroImage 2006; 31: 440-457.
57. Zhang W, Yang X, Lui S, Meng Y, Yao L, Xiao Y et al. Diagnostic prediction for social anxiety disorder via multivariate pattern analysis of the regional homogeneity. Biomed Res Int 2015; 2015: 763965.
58. Felmingham K, Kemp A, Williams L, Das P, Hughes G, Peduto A et al. Changes in anterior cingulate and amygdala after cognitive behavior therapy of posttraumatic stress disorder. Psychol Sci 2007; 18: 127-129.
59. Faria V, Ahs F, Appel L, Linnman C, Bani M, Bettica P et al. Amygdala-frontal couplings characterizing SSRI and placebo response in social anxiety disorder. Int J Neuropsychopharmacol 2014; 17: 1149-1157.
60. Faria V, Appel L, Ahs F, Linnman C, Pissiota A, Frans O et al. Amygdala subregions tied to SSRI and placebo response in patients with social anxiety disorder. Neuropsychopharmacology 2012; 37: 2222-2232.
61. Klumpp H, Fitzgerald DA, Phan KL. Neural predictors and mechanisms of cognitive behavioral therapy on threat processing in social anxiety disorder. Prog Neuropsychopharmacol Biol Psychiatry 2013; 45: 83-91.
62. Alvarez VA, Sabatini BL. Anatomical and physiological plasticity of dendritic spines. Annu Rev Neurosci 2007; 30: 79-97.
63. Nikonenko I, Jourdain P, Alberi S, Toni N, Muller D. Activity-induced changes of spine morphology. Hippocampus 2002; 12: 585-591.
64. Duvarci S, Pare D. Amygdala microcircuits controlling learned fear. Neuron 2014; 82: 966-980.
65. Wang YC, Ho UC, Ko MC, Liao CC, Lee LJ. Differential neuronal changes in medial prefrontal cortex, basolateral amygdala and nucleus accumbens after post-weaning social isolation. Brain Struct Funct 2012; 217: 337-351.
66. Ghosh S, Chattarji S. Neuronal encoding of the switch from specific to generalized fear. Nat Neurosci 2015; 18: 112-120.
67. Suvrathan A, Bennur S, Ghosh S, Tomar A, Anilkumar S, Chattarji S. Stress enhances fear by forming new synapses with greater capacity for long-term potentiation in the amygdala. Philos Trans R Soc Lond B Biol Sci 2014; 369: 20130151.
68. Heinrichs SC, Leite-Morris KA, Guy MD, Goldberg LR, Young AJ, Kaplan GB. Dendritic structural plasticity in the basolateral amygdala after fear conditioning and its extinction in mice. Behav Brain Res 2013; 248: 80-84.
69. Vetere G, Restivo L, Novembre G, Aceti M, Lumaca M, Ammassari-Teule M. Extinction partially reverts structural changes associated with remote fear memory. Learn Memory 2011; 18: 554-557.
70. Milad MR, Rosenbaum BL, Simon NM. Neuroscience of fear extinction: implications for assessment and treatment of fear-based and anxiety related disorders. Behav Res Ther 2014; 62: 17-23.
71. Mattsson N, Insel PS, Aisen PS, Jagust W, Mackin S, Weiner M et al. Brain structure and function as mediators of the effects of amyloid on memory. Neurology 2015; 84: 1136-1144.
72. Saxena S, Gorbis E, O'Neill J, Baker SK, Mandelkern MA, Maidment KM et al. Rapid effects of brief intensive cognitive-behavioral therapy on brain glucose metabolism in obsessive-compulsive disorder. Mol Psychiatry 2009; 14: 197-205.