A pilot study of gray matter volume changes associated with paroxetine treatment and response in social anxiety disorder

Psychiatry Research - Neuroimaging

Volumn 231, Issue 3, 2015, Pages 279-285

  Talati, Ardesheer ^a,b   Pantazatos, Spiro P ^a,b   Hirsch, Joy ^c   Schneier, Franklin ^a,b  

^a NewYork Presbyterian Hospital   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Caudate; Cerebellum; Paroxetine; Social anxiety; Structural MRI; Thalamus

Indexed keywords

PAROXETINE; SEROTONIN UPTAKE INHIBITOR;

ADULT; ARTICLE; BRAIN REGION; BRAIN SIZE; CAUDATE NUCLEUS; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DSM-IV; FEMALE; GENERALIZED ANXIETY DISORDER; GRAY MATTER; HUMAN; IMAGE SUBTRACTION; LIEBOWITZ SOCIAL ANXIETY SCALE; MALE; MESENCEPHALON; NEUROANATOMY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PILOT STUDY; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; PUTAMEN; RIGHT HEMISPHERE; SOCIAL PHOBIA; THALAMUS; TREATMENT DURATION; TREATMENT RESPONSE; VOXEL BASED MORPHOMETRY; ANATOMY AND HISTOLOGY; DRUG EFFECTS; PHOBIC DISORDERS; PROCEDURES; TREATMENT OUTCOME;

ADULT; FEMALE; GRAY MATTER; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PAROXETINE; PHOBIC DISORDERS; PILOT PROJECTS; SEROTONIN UPTAKE INHIBITORS; TREATMENT OUTCOME;

EID: 84930375271     PISSN: 09254927     EISSN: 18727506     Source Type: Journal    
DOI: 10.1016/j.pscychresns.2015.01.008     Document Type: Article

References (60)

1. Andrews-Hanna J.R., Reidler J.S., Sepulcre J., Poulin R., Buckner R.L. Functional-anatomic fractionation of the brain[U+05F3]s default network. Neuron 2010, 65:550-562.
2. Arnold Anteraper S., Triantafyllou C., Sawyer A.T., Hofmann S.G., Gabrieli J.D., Whitfield-Gabrieli S. Hyper-connectivity of subcortical resting-state networks in social anxiety disorder. Brain Connections 2014, 4:81-90.
3. Ashburner J., Friston K.J. Voxel-based morphometry-the methods. Neuroimage 2000, 11:805-821.
4. Ashburner J., Friston K.J. Why voxel-based morphometry should be used. Neuroimage 2001, 14:1238-1243.
5. Baldacara L., Borgio J.G., Lacerda A.L., Jackowski A.P. Cerebellum and psychiatric disorders. Revista Brasileira de Psiquiatria 2008, 30:281-289.
6. Berns G.S., Cohen J.D., Mintun M.A. Brain regions responsive to novelty in the absence of awareness. Science 1997, 276:1272-1275.
7. Bienvenu O.J., Samuels J.F., Wuyek L.A., Liang K.Y., Wang Y., Grados M.A., Cullen B.A., Riddle M.A., Greenberg B.D., Rasmussen S.A., Fyer A.J., Pinto A., Rauch S.L., Pauls D.L., McCracken J.T., Piacentini J., Murphy D.L., Knowles J.A., Nestadt G. Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective. Psychological Medicine 2011, 42(1):1-13.
8. Bruhl A.B., Delsignore A., Komossa K., Weidt S. Neuroimaging in social anxiety disorder - a meta-analytic review resulting in a new neurofunctional model. Neuroscience and Biobehavioral Reviews 2014, 47C:260-280.
9. Bruhl A.B., Hanggi J., Baur V., Rufer M., Delsignore A., Weidt S., Jancke L., Herwig U. Increased cortical thickness in a frontoparietal network in social anxiety disorder. Human Brain Mapping 2014, 35(7):2966-2977.
10. Bruhl A.B., Rufer M., Delsignore A., Kaffenberger T., Jancke L., Herwig U. Neural correlates of altered general emotion processing in social anxiety disorder. Brain Research 2011, 1378:72-83.
11. Cassimjee N., Fouche J.P., Burnett M., Lochner C., Warwick J., Dupont P., Stein D.J., Cloete K.J., Carey P.D. Changes in regional brain volumes in social anxiety disorder following 12 weeks of treatment with escitalopram. Metabolic Brain Disease 2010, 25:369-374.
12. Cohen J. Statistical Power Analysis for the Behavioral Sciences 1988, Academic Press, New York. third ed.
13. Crum W.R., Griffin L.D., Hill D.L., Hawkes D.J. Zen and the art of medical image registration: correspondence, homology, and quality. Neuroimage 2003, 20:1425-1437.
14. Draganski B., Gaser C., Busch V., Schuierer G., Bogdahn U., May A. Neuroplasticity: changes in grey matter induced by training. Nature 2004, 427:311-312.
15. Draganski B., Gaser C., Kempermann G., Kuhn H.G., Winkler J., Buchel C., May A. Temporal and spatial dynamics of brain structure changes during extensive learning. The Journal of Neuroscience 2006, 26:6314-6317.
16. Etkin A., Wager T.D. Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. American Journal of Psychiatry 2007, 164:1476-1488.
17. Ferrari M.C., Busatto G.F., McGuire P.K., Crippa J.A. Structural magnetic resonance imaging in anxiety disorders: an update of research findings. Revista Brasileira de Psiquiatria 2008, 30:251-264.
18. Filho A.S., Hetem L.A., Ferrari M.C., Trzesniak C., Martin-Santos R., Borduqui T., de Lima Osorio F., Loureiro S.R., Busatto Filho G., Zuardi A.W., Crippa J.A. Social anxiety disorder: what are we losing with the current diagnostic criteria?. Acta Psychiatrica Scandinavica 2010, 121:216-226.
19. First M.B., Spitzer R.L., Gibbon M., Willians J.B.W. Structured Clinical Interview for DSM-IV Axis 1 Disorders 1997, American Psychiatric Press, Washington, DC.
20. Freitas-Ferrari M.C., Hallak J.E., Trzesniak C., Filho A.S., Machado-de-Sousa J.P., Chagas M.H., Nardi A.E., Crippa J.A. Neuroimaging in social anxiety disorder: a systematic review of the literature. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2010, 34:565-580.
21. Frick A., Howner K., Fischer H., Eskildsen S.F., Kristiansson M., Furmark T. Cortical thickness alterations in social anxiety disorder. Neuroscience Letters 2013, 536:52-55.
22. Frick A., Howner K., Fischer H., Kristiansson M., Furmark T. Altered fusiform connectivity during processing of fearful faces in social anxiety disorder. Translational Psychiatry 2013, 3:e312.
23. Furmark T., Tillfors M., Marteinsdottir I., Fischer H., Pissiota A., Langstrom B., Fredrikson M. Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy. Archives of General Psychiatry 2002, 59:425-433.
24. Gaebler M., Daniels J.K., Lamke J.P., Fydrich T., Walter H. Heart rate variability and its neural correlates during emotional face processing in social anxiety disorder. Biological Psychology 2013, 94:319-330.
25. Gimenez M., Ortiz H., Soriano-Mas C., Lopez-Sola M., Farre M., Deus J., Martin-Santos R., Fernandes S., Fina P., Bani M., Zancan S., Pujol J., Merlo-Pich E. Functional effects of chronic paroxetine versus placebo on the fear, stress and anxiety brain circuit in social anxiety disorder: initial validation of an imaging protocol for drug discovery. European Neuropsychopharmacology. 2013, 24(1):105-116.
26. Gimenez, et al. Functional effects of chronic paroxetine versus placebo on the fear, stress and anxiety brain circuit in aocial anxiety disorder: initial validation of an imaging protocol for drug discovery. Eur. Neuropsychopharmacol. 2014, 24(1):105-116. 10.1016/j.euroneuro.2013.09.004. PMID: 24332890.
27. Goldin P.R., Ziv M., Jazaieri H., Hahn K., Heimberg R., Gross J.J. Impact of cognitive behavioral therapy for social anxiety disorder on the neural dynamics of cognitive reappraisal of negative self-beliefs: randomized clinical trial. JAMA Psychiatry 2013, 70:1048-1056.
28. Grant B.F., Hasin D.S., Stinson F.S., Dawson D.A., Patricia Chou S., June Ruan W., Huang B. Co-occurrence of 12-month mood and anxiety disorders and personality disorders in the US: results from the national epidemiologic survey on alcohol and related conditions. Journal of Psychiatric Research 2005, 39:1-9.
29. Grieve K.L., Acuna C., Cudeiro J. The primate pulvinar nuclei: vision and action. Trends in Neurosciences 2000, 23:35-39.
30. Hayasaka S., Phan K.L., Liberzon I., Worsley K.J., Nichols T.E. Nonstationary cluster-size inference with random field and permutation methods. Neuroimage 2004, 22:676-687.
31. Heimberg R.G., Horner K.J., Juster H.R., Safren S.A., Brown E.J., Schneier F.R., Liebowitz M.R. Psychometric properties of the Liebowitz Social Anxiety Scale. Psychological Medicine 1999, 29:199-212.
32. Hofmann S.G. Can fMRI be used to predict the course of treatment for social anxiety disorder?. Expert Review of Neurotherapeutics 2013, 13:123-125.
33. Kazui H., Mori E., Hashimoto M., Hirono N. Phobia after bilateral thalamic hemorrhage. Cerebrovascular Diseases 2001, 12:283-284.
34. Keller S.S., Wilke M., Wieshmann U.C., Sluming V.A., Roberts N. Comparison of standard and optimized voxel-based morphometry for analysis of brain changes associated with temporal lobe epilepsy. Neuroimage 2004, 23:860-868.
35. Kessler R.C., Chiu W.T., Demler O., Merikangas K.R., Walters E.E. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry 2005, 62:617-627.
36. Kim S., Matyas F., Lee S., Acsady L., Shin H.S. Lateralization of observational fear learning at the cortical but not thalamic level in mice. Proceedings of the National Academy of Sciences of the United States of America 2012, 109:15497-15501.
37. Klumpp H., Angstadt M., Nathan P.J., Phan K.L. Amygdala reactivity to faces at varying intensities of threat in generalized social phobia: an event-related functional MRI study. Psychiatry Research: Neuroimaging 2010, 183:167-169.
38. Klumpp H., Fitzgerald D.A., Phan K.L. Neural predictors and mechanisms of cognitive behavioral therapy on threat processing in social anxiety disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2013, 45:83-91.
39. LeDoux J.E. The Emotional Brain: The Mysterious Underpinnings of Emotional Life 1996, Simon & Schuster, New York.
40. Liebowitz M.R. Social phobia. Modern Problems of Pharmacopsychiatry 1987, 22:141-173.
41. Linares I.M., Trzesniak C., Chagas M.H., Hallak J.E., Nardi A.E., Crippa J.A. Neuroimaging in specific phobia disorder: a systematic review of the literature. Revista Brasileira de Psiquiatria 2012, 34:101-111.
42. Lorberbaum J.P., Kose S., Johnson M.R., Arana G.W., Sullivan L.K., Hamner M.B., Ballenger J.C., Lydiard R.B., Brodrick P.S., Bohning D.E., George M.S. Neural correlates of speech anticipatory anxiety in generalized social phobia. Neuroreport 2004, 15:2701-2705.
43. Mansson K.N., Carlbring P., Frick A., Engman J., Olsson C.J., Bodlund O., Furmark T., Andersson G. Altered neural correlates of affective processing after internet-delivered cognitive behavior therapy for social anxiety disorder. Psychiatry Research: Neuroimaging 2013, 214:229-237.
44. Phan K.L., Coccaro E.F., Angstadt M., Kreger K.J., Mayberg H.S., Liberzon I., Stein M.B. Corticolimbic brain reactivity to social signals of threat before and after sertraline treatment in generalized social phobia. Biological Psychiatry 2013, 73:329-336.
45. Pietrini F., Godini L., Lazzeretti L., Benni L., Pracucci C., Talamba G.A., Faravelli C. Neuroimaging and neurobiology of social anxiety. Rivista di Psichiatria 2010, 45:349-360.
46. Pollack M.H., Jensen J.E., Simon N.M., Kaufman R.E., Renshaw P.F. High-field MRS study of GABA, glutamate and glutamine in social anxiety disorder: response to treatment with levetiracetam. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2008, 32:739-743.
47. Saxena S., Brody A.L., Ho M.L., Alborzian S., Maidment K.M., Zohrabi N., Ho M.K., Huang S.C., Wu H.M., Baxter L.R. Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression. Archives of General Psychiatry 2002, 59:250-261.
48. Schneier F.R., Pomplun M., Sy M., Hirsch J. Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder. Psychiatry Research: Neuroimaging 2011, 194:271-278.
49. Silver M., Montana G., Nichols T.E. False positives in neuroimaging genetics using voxel-based morphometry data. Neuroimage 2011, 54:992-1000.
50. Stathis P., Panourias I.G., Themistocleous M.S., Sakas D.E. Connections of the basal ganglia with the limbic system: implications for neuromodulation therapies of anxiety and affective disorders. Acta Neurochirurgica 2007, Suppl. 97:S575-S586.
51. Stein D.J., Andersen E.W., Lader M. Escitalopram versus paroxetine for social anxiety disorder: an analysis of efficacy for different symptom dimensions. European Neuropsychopharmacology 2006, 16:33-38.
52. Stein D.J., Craske M.G., Friedman M.J., Phillips K.A. Meta-structure issues for the DSM-5: how do anxiety disorders, obsessive-compulsive and related disorders, post-traumatic disorders, and dissociative disorders fit together?. Current Psychiatry Reports 2011, 13:248-250.
53. Stein M.B., Stein D.J. Social anxiety disorder. Lancet 2008, 371:1115-1125.
54. Syal S., Hattingh C.J., Fouche J.P., Spottiswoode B., Carey P.D., Lochner C., Stein D.J. Grey matter abnormalities in social anxiety disorder: a pilot study. Metabolic Brain Disease 2012, 27:299-309.
55. Talati A., Pantazatos S.P., Schneier F.R., Weissman M.M., Hirsch J. Gray matter abnormalities in social anxiety disorder: primary, replication, and specificity studies. Biological Psychiatry 2013, 73:75-84.
56. Tillfors M., Furmark T., Marteinsdottir I., Fischer H., Pissiota A., Langstrom B., Fredrikson M. Cerebral blood flow in subjects with social phobia during stressful speaking tasks: a PET study. American Journal of Psychiatry 2001, 158:1220-1226.
57. van der Wee N.J., van Veen J.F., Stevens H., van Vliet I.M., van Rijk P.P., Westenberg H.G. Increased serotonin and dopamine transporter binding in psychotropic medication-naive patients with generalized social anxiety disorder shown by 123I-beta-(4-iodophenyl)-tropane SPECT. Journal of Nuclear Medicine 2008, 49:757-763.
58. Warwick J.M., Carey P., Jordaan G.P., Dupont P., Stein D.J. Resting brain perfusion in social anxiety disorder: a voxel-wise whole brain comparison with healthy control subjects. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2008, 32:1251-1256.
59. Weissman M.M., Bland R.C., Canino G.J., Greenwald S., Lee C.K., Newman S.C., Rubio-Stipec M., Wickramaratne P.J. The cross-national epidemiology of social phobia: a preliminary report. International Clinical Psychopharmacology 1996, 11(Suppl. 3):S9-S14.
60. Whitfield-Gabrieli S., Moran J.M., Nieto-Castanon A., Triantafyllou C., Saxe R., Gabrieli J.D. Associations and dissociations between default and self-reference networks in the human brain. Neuroimage 2011, 55:225-232.