-
1
-
-
33745847479
-
Diagnosis and treatment of Parkinson disease: Molecules to medicine
-
Savitt JM, Dawson VL, Dawson TM. Diagnosis and treatment of Parkinson disease: molecules to medicine. J Clin Invest 2006; 116: 1744-1754.
-
(2006)
J Clin Invest
, vol.116
, pp. 1744-1754
-
-
Savitt, J.M.1
Dawson, V.L.2
Dawson, T.M.3
-
2
-
-
69149089036
-
Molecular pathogenesis of Parkinson disease: Insights from genetic studies
-
Gasser T. Molecular pathogenesis of Parkinson disease: insights from genetic studies. Exp Rev Mol Med 2009; 11: e22.
-
(2009)
Exp Rev Mol Med
, vol.11
, pp. e22
-
-
Gasser, T.1
-
3
-
-
0141741347
-
Parkinson's disease: Mechanisms and models
-
Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron 2003; 39: 889-909.
-
(2003)
Neuron
, vol.39
, pp. 889-909
-
-
Dauer, W.1
Przedborski, S.2
-
4
-
-
0020680904
-
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
-
Langston JW, Ballard P, Tetrud JW, Irwin I. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983; 219: 979-980.
-
(1983)
Science
, vol.219
, pp. 979-980
-
-
Langston, J.W.1
Ballard, P.2
Tetrud, J.W.3
Irwin, I.4
-
5
-
-
56149111255
-
Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells
-
Sirvent A, Benistant C, Roche S. Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells. Biol Cell 2008; 100: 617-631.
-
(2008)
Biol Cell
, vol.100
, pp. 617-631
-
-
Sirvent, A.1
Benistant, C.2
Roche, S.3
-
6
-
-
79959960788
-
The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death
-
Xiao L, Chen D, Hu P, Wu J, Liu W, Zhao Y et al. The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death. J Neurosci 2011; 31: 9611-9619.
-
(2011)
J Neurosci
, vol.31
, pp. 9611-9619
-
-
Xiao, L.1
Chen, D.2
Hu, P.3
Wu, J.4
Liu, W.5
Zhao, Y.6
-
7
-
-
84860745715
-
Regulation of neuronal cell death by c-Abl-Hippo/MST2 signaling pathway
-
Liu W, Wu J, Xiao L, Bai Y, Qu A, Zheng Z et al. Regulation of neuronal cell death by c-Abl-Hippo/MST2 signaling pathway. PLoS One 2012; 7: e36562.
-
(2012)
PLoS One
, vol.7
, pp. e36562
-
-
Liu, W.1
Wu, J.2
Xiao, L.3
Bai, Y.4
Qu, A.5
Zheng, Z.6
-
8
-
-
79958765866
-
C-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice
-
Cancino GI, Perez de Arce K, Castro PU, Toledo EM, von Bernhardi R, Alvarez AR. c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice. Neurobiol Aging 2011; 32: 1249-1261.
-
(2011)
Neurobiol Aging
, vol.32
, pp. 1249-1261
-
-
Cancino, G.I.1
Perez De Arce, K.2
Castro, P.U.3
Toledo, E.M.4
Von Bernhardi, R.5
Alvarez, A.R.6
-
9
-
-
78049275348
-
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
-
Ko HS, Lee Y, Shin JH, Karuppagounder SS, Gadad BS, Koleske AJ et al. Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. Proc Natl Acad Sci USA 2010; 107: 16691-16696.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 16691-16696
-
-
Ko, H.S.1
Lee, Y.2
Shin, J.H.3
Karuppagounder, S.S.4
Gadad, B.S.5
Koleske, A.J.6
-
10
-
-
78650881155
-
Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: Implications for Parkinson's disease
-
Imam SZ, Zhou Q, Yamamoto A, Valente AJ, Ali SF, Bains M et al. Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease. J Neurosci 2011; 31: 157-163.
-
(2011)
J Neurosci
, vol.31
, pp. 157-163
-
-
Imam, S.Z.1
Zhou, Q.2
Yamamoto, A.3
Valente, A.J.4
Ali, S.F.5
Bains, M.6
-
11
-
-
84899894003
-
C-Abl phosphorylates alpha-synuclein and regulates its degradation: Implication for alphasynuclein clearance and contribution to the pathogenesis of Parkinson's disease
-
Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S et al. c-Abl phosphorylates alpha-synuclein and regulates its degradation: implication for alphasynuclein clearance and contribution to the pathogenesis of Parkinson's disease. Hum Mol Genet 2014; 23: 2858-2879.
-
(2014)
Hum Mol Genet
, vol.23
, pp. 2858-2879
-
-
Mahul-Mellier, A.L.1
Fauvet, B.2
Gysbers, A.3
Dikiy, I.4
Oueslati, A.5
Georgeon, S.6
-
12
-
-
84881250979
-
Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of alpha-synuclein in Parkinson's disease models
-
Hebron ML, Lonskaya I, Moussa CE. Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of alpha-synuclein in Parkinson's disease models. Hum Mol Genet 2013; 22: 3315-3328.
-
(2013)
Hum Mol Genet
, vol.22
, pp. 3315-3328
-
-
Hebron, M.L.1
Lonskaya, I.2
Moussa, C.E.3
-
13
-
-
84878549593
-
Neuroprotective efficacy of a new brain-penetrating C-Abl inhibitor in a murine Parkinson's disease model
-
Imam SZ, Trickler W, Kimura S, Binienda ZK, Paule MG, Slikker W Jr et al. Neuroprotective efficacy of a new brain-penetrating C-Abl inhibitor in a murine Parkinson's disease model. PLoS One 2013; 8: e65129.
-
(2013)
PLoS One
, vol.8
, pp. e65129
-
-
Imam, S.Z.1
Trickler, W.2
Kimura, S.3
Binienda, Z.K.4
Paule, M.G.5
Slikker, W.6
-
14
-
-
84899892500
-
The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease
-
Karuppagounder SS, Brahmachari S, Lee Y, Dawson VL, Dawson TM, Ko HS. The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease. Sci Rep 2014; 4: 4874.
-
(2014)
Sci Rep
, vol.4
, pp. 4874
-
-
Karuppagounder, S.S.1
Brahmachari, S.2
Lee, Y.3
Dawson, V.L.4
Dawson, T.M.5
Ko, H.S.6
-
15
-
-
0344520475
-
Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux
-
Dai H, Marbach P, Lemaire M, Hayes M, Elmquist WF. Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux. J Pharmacol Exp Ther 2003; 304: 1085-1092.
-
(2003)
J Pharmacol Exp Ther
, vol.304
, pp. 1085-1092
-
-
Dai, H.1
Marbach, P.2
Lemaire, M.3
Hayes, M.4
Elmquist, W.F.5
-
16
-
-
84899894003
-
C-Abl phosphorylates alpha-syn and regulates its degradation implication for alpha-syn clearance and contribution to the pathogenesis of Parkinson's Disease
-
Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S et al. c-Abl phosphorylates alpha-syn and regulates its degradation, implication for alpha-syn clearance and contribution to the pathogenesis of Parkinson's Disease. Hum Mol Genet 2014; 23: 2858-2879.
-
(2014)
Hum Mol Genet
, vol.23
, pp. 2858-2879
-
-
Mahul-Mellier, A.L.1
Fauvet, B.2
Gysbers, A.3
Dikiy, I.4
Oueslati, A.5
Georgeon, S.6
-
17
-
-
0037630403
-
Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response
-
Cao C, Leng Y, Li C, Kufe D. Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response. J Biol Chem 2003; 278: 12961-12967.
-
(2003)
J Biol Chem
, vol.278
, pp. 12961-12967
-
-
Cao, C.1
Leng, Y.2
Li, C.3
Kufe, D.4
-
18
-
-
0028889810
-
Tyrosine phosphorylation and activation of focal adhesion kinase (p125FAK) by BCR-ABL oncoprotein
-
Gotoh A, Miyazawa K, Ohyashiki K, Tauchi T, Boswell HS, Broxmeyer HE et al. Tyrosine phosphorylation and activation of focal adhesion kinase (p125FAK) by BCR-ABL oncoprotein. Exp Hematol 1995; 23: 1153-1159.
-
(1995)
Exp Hematol
, vol.23
, pp. 1153-1159
-
-
Gotoh, A.1
Miyazawa, K.2
Ohyashiki, K.3
Tauchi, T.4
Boswell, H.S.5
Broxmeyer, H.E.6
-
19
-
-
0037341849
-
C-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14
-
Sanguinetti AR, Mastick CC. c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14. Cell Signal 2003; 15: 289-298.
-
(2003)
Cell Signal
, vol.15
, pp. 289-298
-
-
Sanguinetti, A.R.1
Mastick, C.C.2
-
20
-
-
26444452643
-
Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway
-
Burton EA, Oliver TN, Pendergast AM. Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway. Mol Cell Biol 2005; 25: 8834-8843.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 8834-8843
-
-
Burton, E.A.1
Oliver, T.N.2
Pendergast, A.M.3
-
21
-
-
79960728952
-
P38alpha MAP kinase dimers with swapped activation segments and a novel catalytic loop conformation
-
Rothweiler U, Aberg E, Johnson KA, Hansen TE, Jorgensen JB, Engh RA. p38alpha MAP kinase dimers with swapped activation segments and a novel catalytic loop conformation. J Mol Biol 2011; 411: 474-485.
-
(2011)
J Mol Biol
, vol.411
, pp. 474-485
-
-
Rothweiler, U.1
Aberg, E.2
Johnson, K.A.3
Hansen, T.E.4
Jorgensen, J.B.5
Engh, R.A.6
-
22
-
-
0034741267
-
A CamKIIalpha iCre BAC allows brain-specific gene inactivation
-
Casanova E, Fehsenfeld S, Mantamadiotis T, Lemberger T, Greiner E, Stewart AF et al. A CamKIIalpha iCre BAC allows brain-specific gene inactivation. Genesis 2001; 31: 37-42.
-
(2001)
Genesis
, vol.31
, pp. 37-42
-
-
Casanova, E.1
Fehsenfeld, S.2
Mantamadiotis, T.3
Lemberger, T.4
Greiner, E.5
Stewart, A.F.6
-
23
-
-
0032100191
-
Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1 2 3,6-tetrahydropyridine (MPTP)
-
Kohutnicka M, Lewandowska E, Kurkowska-Jastrzebska I, Czlonkowski A, Czlonkowska A. Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Immunopharmacology 1998; 39: 167-180.
-
(1998)
Immunopharmacology
, vol.39
, pp. 167-180
-
-
Kohutnicka, M.1
Lewandowska, E.2
Kurkowska-Jastrzebska, I.3
Czlonkowski, A.4
Czlonkowska, A.5
-
24
-
-
0347132269
-
Regulation of the c-Abl and Bcr-Abl tyrosine kinases
-
Hantschel O, Superti-Furga G. Regulation of the c-Abl and Bcr-Abl tyrosine kinases. Nat Rev Mol Cell Biol 2004; 5: 33-44.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 33-44
-
-
Hantschel, O.1
Superti-Furga, G.2
-
25
-
-
0034018326
-
The tyrosine kinase inhibitor STI571, like interferon-alpha, preferentially reduces the capacity for amplification of granulocyte-macrophage progenitors from patients with chronic myeloid leukemia
-
Marley SB, Deininger MW, Davidson RJ, Goldman JM, Gordon MY. The tyrosine kinase inhibitor STI571, like interferon-alpha, preferentially reduces the capacity for amplification of granulocyte-macrophage progenitors from patients with chronic myeloid leukemia. Exp Hematol 2000; 28: 551-557.
-
(2000)
Exp Hematol
, vol.28
, pp. 551-557
-
-
Marley, S.B.1
Deininger, M.W.2
Davidson, R.J.3
Goldman, J.M.4
Gordon, M.Y.5
-
27
-
-
0034738962
-
SPAK, a STE20/SPS1-related kinase that activates the p38 pathway
-
Johnston AM, Naselli G, Gonez LJ, Martin RM, Harrison LC, DeAizpurua HJ. SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene 2000; 19: 4290-4297.
-
(2000)
Oncogene
, vol.19
, pp. 4290-4297
-
-
Johnston, A.M.1
Naselli, G.2
Gonez, L.J.3
Martin, R.M.4
Harrison, L.C.5
DeAizpurua, H.J.6
-
28
-
-
77949909616
-
C-Jun N-terminal kinase enhances MST1-mediated pro-apoptotic signaling through phosphorylation at serine 82
-
Bi W, Xiao L, Jia Y, Wu J, Xie Q, Ren J et al. c-Jun N-terminal kinase enhances MST1-mediated pro-apoptotic signaling through phosphorylation at serine 82. J Biol Chem 2010; 285: 6259-6264.
-
(2010)
J Biol Chem
, vol.285
, pp. 6259-6264
-
-
Bi, W.1
Xiao, L.2
Jia, Y.3
Wu, J.4
Xie, Q.5
Ren, J.6
-
29
-
-
19644367000
-
Activation and signaling of the p38 MAP kinase pathway
-
Zarubin T, Han J. Activation and signaling of the p38 MAP kinase pathway. Cell Res 2005; 15: 11-18.
-
(2005)
Cell Res
, vol.15
, pp. 11-18
-
-
Zarubin, T.1
Han, J.2
-
30
-
-
0031916832
-
Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
-
Enslen H, Raingeaud J, Davis RJ. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J Biol Chem 1998; 273: 1741-1748.
-
(1998)
J Biol Chem
, vol.273
, pp. 1741-1748
-
-
Enslen, H.1
Raingeaud, J.2
Davis, R.J.3
-
31
-
-
67650138623
-
T cell receptor-mediated activation of p38{alpha} by mono-phosphorylation of the activation loop results in altered substrate specificity
-
Mittelstadt PR, Yamaguchi H, Appella E, Ashwell JD. T cell receptor-mediated activation of p38{alpha} by mono-phosphorylation of the activation loop results in altered substrate specificity. J Biol Chem 2009; 284: 15469-15474.
-
(2009)
J Biol Chem
, vol.284
, pp. 15469-15474
-
-
Mittelstadt, P.R.1
Yamaguchi, H.2
Appella, E.3
Ashwell, J.D.4
-
32
-
-
34347259269
-
Protocol for the MPTP mouse model of Parkinson's disease
-
Jackson-Lewis V, Przedborski S. Protocol for the MPTP mouse model of Parkinson's disease. Nat Protoc 2007; 2: 141-151.
-
(2007)
Nat Protoc
, vol.2
, pp. 141-151
-
-
Jackson-Lewis, V.1
Przedborski, S.2
|