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Volumn 23, Issue 3, 2016, Pages 542-552

C-Abl-p38α signaling plays an important role in MPTP-induced neuronal death

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ABELSON KINASE; IMATINIB; MITOGEN ACTIVATED PROTEIN KINASE 14; PROTEIN BINDING;

EID: 84957566137     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2015.135     Document Type: Article
Times cited : (59)

References (32)
  • 1
    • 33745847479 scopus 로고    scopus 로고
    • Diagnosis and treatment of Parkinson disease: Molecules to medicine
    • Savitt JM, Dawson VL, Dawson TM. Diagnosis and treatment of Parkinson disease: molecules to medicine. J Clin Invest 2006; 116: 1744-1754.
    • (2006) J Clin Invest , vol.116 , pp. 1744-1754
    • Savitt, J.M.1    Dawson, V.L.2    Dawson, T.M.3
  • 2
    • 69149089036 scopus 로고    scopus 로고
    • Molecular pathogenesis of Parkinson disease: Insights from genetic studies
    • Gasser T. Molecular pathogenesis of Parkinson disease: insights from genetic studies. Exp Rev Mol Med 2009; 11: e22.
    • (2009) Exp Rev Mol Med , vol.11 , pp. e22
    • Gasser, T.1
  • 3
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron 2003; 39: 889-909.
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 4
    • 0020680904 scopus 로고
    • Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston JW, Ballard P, Tetrud JW, Irwin I. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983; 219: 979-980.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 5
    • 56149111255 scopus 로고    scopus 로고
    • Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells
    • Sirvent A, Benistant C, Roche S. Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells. Biol Cell 2008; 100: 617-631.
    • (2008) Biol Cell , vol.100 , pp. 617-631
    • Sirvent, A.1    Benistant, C.2    Roche, S.3
  • 6
    • 79959960788 scopus 로고    scopus 로고
    • The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death
    • Xiao L, Chen D, Hu P, Wu J, Liu W, Zhao Y et al. The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death. J Neurosci 2011; 31: 9611-9619.
    • (2011) J Neurosci , vol.31 , pp. 9611-9619
    • Xiao, L.1    Chen, D.2    Hu, P.3    Wu, J.4    Liu, W.5    Zhao, Y.6
  • 7
    • 84860745715 scopus 로고    scopus 로고
    • Regulation of neuronal cell death by c-Abl-Hippo/MST2 signaling pathway
    • Liu W, Wu J, Xiao L, Bai Y, Qu A, Zheng Z et al. Regulation of neuronal cell death by c-Abl-Hippo/MST2 signaling pathway. PLoS One 2012; 7: e36562.
    • (2012) PLoS One , vol.7 , pp. e36562
    • Liu, W.1    Wu, J.2    Xiao, L.3    Bai, Y.4    Qu, A.5    Zheng, Z.6
  • 9
    • 78049275348 scopus 로고    scopus 로고
    • Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
    • Ko HS, Lee Y, Shin JH, Karuppagounder SS, Gadad BS, Koleske AJ et al. Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. Proc Natl Acad Sci USA 2010; 107: 16691-16696.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 16691-16696
    • Ko, H.S.1    Lee, Y.2    Shin, J.H.3    Karuppagounder, S.S.4    Gadad, B.S.5    Koleske, A.J.6
  • 10
    • 78650881155 scopus 로고    scopus 로고
    • Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: Implications for Parkinson's disease
    • Imam SZ, Zhou Q, Yamamoto A, Valente AJ, Ali SF, Bains M et al. Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease. J Neurosci 2011; 31: 157-163.
    • (2011) J Neurosci , vol.31 , pp. 157-163
    • Imam, S.Z.1    Zhou, Q.2    Yamamoto, A.3    Valente, A.J.4    Ali, S.F.5    Bains, M.6
  • 11
    • 84899894003 scopus 로고    scopus 로고
    • C-Abl phosphorylates alpha-synuclein and regulates its degradation: Implication for alphasynuclein clearance and contribution to the pathogenesis of Parkinson's disease
    • Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S et al. c-Abl phosphorylates alpha-synuclein and regulates its degradation: implication for alphasynuclein clearance and contribution to the pathogenesis of Parkinson's disease. Hum Mol Genet 2014; 23: 2858-2879.
    • (2014) Hum Mol Genet , vol.23 , pp. 2858-2879
    • Mahul-Mellier, A.L.1    Fauvet, B.2    Gysbers, A.3    Dikiy, I.4    Oueslati, A.5    Georgeon, S.6
  • 12
    • 84881250979 scopus 로고    scopus 로고
    • Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of alpha-synuclein in Parkinson's disease models
    • Hebron ML, Lonskaya I, Moussa CE. Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of alpha-synuclein in Parkinson's disease models. Hum Mol Genet 2013; 22: 3315-3328.
    • (2013) Hum Mol Genet , vol.22 , pp. 3315-3328
    • Hebron, M.L.1    Lonskaya, I.2    Moussa, C.E.3
  • 13
    • 84878549593 scopus 로고    scopus 로고
    • Neuroprotective efficacy of a new brain-penetrating C-Abl inhibitor in a murine Parkinson's disease model
    • Imam SZ, Trickler W, Kimura S, Binienda ZK, Paule MG, Slikker W Jr et al. Neuroprotective efficacy of a new brain-penetrating C-Abl inhibitor in a murine Parkinson's disease model. PLoS One 2013; 8: e65129.
    • (2013) PLoS One , vol.8 , pp. e65129
    • Imam, S.Z.1    Trickler, W.2    Kimura, S.3    Binienda, Z.K.4    Paule, M.G.5    Slikker, W.6
  • 14
    • 84899892500 scopus 로고    scopus 로고
    • The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease
    • Karuppagounder SS, Brahmachari S, Lee Y, Dawson VL, Dawson TM, Ko HS. The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease. Sci Rep 2014; 4: 4874.
    • (2014) Sci Rep , vol.4 , pp. 4874
    • Karuppagounder, S.S.1    Brahmachari, S.2    Lee, Y.3    Dawson, V.L.4    Dawson, T.M.5    Ko, H.S.6
  • 15
    • 0344520475 scopus 로고    scopus 로고
    • Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux
    • Dai H, Marbach P, Lemaire M, Hayes M, Elmquist WF. Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux. J Pharmacol Exp Ther 2003; 304: 1085-1092.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 1085-1092
    • Dai, H.1    Marbach, P.2    Lemaire, M.3    Hayes, M.4    Elmquist, W.F.5
  • 16
    • 84899894003 scopus 로고    scopus 로고
    • C-Abl phosphorylates alpha-syn and regulates its degradation implication for alpha-syn clearance and contribution to the pathogenesis of Parkinson's Disease
    • Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S et al. c-Abl phosphorylates alpha-syn and regulates its degradation, implication for alpha-syn clearance and contribution to the pathogenesis of Parkinson's Disease. Hum Mol Genet 2014; 23: 2858-2879.
    • (2014) Hum Mol Genet , vol.23 , pp. 2858-2879
    • Mahul-Mellier, A.L.1    Fauvet, B.2    Gysbers, A.3    Dikiy, I.4    Oueslati, A.5    Georgeon, S.6
  • 17
    • 0037630403 scopus 로고    scopus 로고
    • Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response
    • Cao C, Leng Y, Li C, Kufe D. Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response. J Biol Chem 2003; 278: 12961-12967.
    • (2003) J Biol Chem , vol.278 , pp. 12961-12967
    • Cao, C.1    Leng, Y.2    Li, C.3    Kufe, D.4
  • 18
    • 0028889810 scopus 로고
    • Tyrosine phosphorylation and activation of focal adhesion kinase (p125FAK) by BCR-ABL oncoprotein
    • Gotoh A, Miyazawa K, Ohyashiki K, Tauchi T, Boswell HS, Broxmeyer HE et al. Tyrosine phosphorylation and activation of focal adhesion kinase (p125FAK) by BCR-ABL oncoprotein. Exp Hematol 1995; 23: 1153-1159.
    • (1995) Exp Hematol , vol.23 , pp. 1153-1159
    • Gotoh, A.1    Miyazawa, K.2    Ohyashiki, K.3    Tauchi, T.4    Boswell, H.S.5    Broxmeyer, H.E.6
  • 19
    • 0037341849 scopus 로고    scopus 로고
    • C-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14
    • Sanguinetti AR, Mastick CC. c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14. Cell Signal 2003; 15: 289-298.
    • (2003) Cell Signal , vol.15 , pp. 289-298
    • Sanguinetti, A.R.1    Mastick, C.C.2
  • 20
    • 26444452643 scopus 로고    scopus 로고
    • Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway
    • Burton EA, Oliver TN, Pendergast AM. Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway. Mol Cell Biol 2005; 25: 8834-8843.
    • (2005) Mol Cell Biol , vol.25 , pp. 8834-8843
    • Burton, E.A.1    Oliver, T.N.2    Pendergast, A.M.3
  • 21
    • 79960728952 scopus 로고    scopus 로고
    • P38alpha MAP kinase dimers with swapped activation segments and a novel catalytic loop conformation
    • Rothweiler U, Aberg E, Johnson KA, Hansen TE, Jorgensen JB, Engh RA. p38alpha MAP kinase dimers with swapped activation segments and a novel catalytic loop conformation. J Mol Biol 2011; 411: 474-485.
    • (2011) J Mol Biol , vol.411 , pp. 474-485
    • Rothweiler, U.1    Aberg, E.2    Johnson, K.A.3    Hansen, T.E.4    Jorgensen, J.B.5    Engh, R.A.6
  • 23
    • 0032100191 scopus 로고    scopus 로고
    • Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1 2 3,6-tetrahydropyridine (MPTP)
    • Kohutnicka M, Lewandowska E, Kurkowska-Jastrzebska I, Czlonkowski A, Czlonkowska A. Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Immunopharmacology 1998; 39: 167-180.
    • (1998) Immunopharmacology , vol.39 , pp. 167-180
    • Kohutnicka, M.1    Lewandowska, E.2    Kurkowska-Jastrzebska, I.3    Czlonkowski, A.4    Czlonkowska, A.5
  • 24
    • 0347132269 scopus 로고    scopus 로고
    • Regulation of the c-Abl and Bcr-Abl tyrosine kinases
    • Hantschel O, Superti-Furga G. Regulation of the c-Abl and Bcr-Abl tyrosine kinases. Nat Rev Mol Cell Biol 2004; 5: 33-44.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 33-44
    • Hantschel, O.1    Superti-Furga, G.2
  • 25
    • 0034018326 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor STI571, like interferon-alpha, preferentially reduces the capacity for amplification of granulocyte-macrophage progenitors from patients with chronic myeloid leukemia
    • Marley SB, Deininger MW, Davidson RJ, Goldman JM, Gordon MY. The tyrosine kinase inhibitor STI571, like interferon-alpha, preferentially reduces the capacity for amplification of granulocyte-macrophage progenitors from patients with chronic myeloid leukemia. Exp Hematol 2000; 28: 551-557.
    • (2000) Exp Hematol , vol.28 , pp. 551-557
    • Marley, S.B.1    Deininger, M.W.2    Davidson, R.J.3    Goldman, J.M.4    Gordon, M.Y.5
  • 28
    • 77949909616 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase enhances MST1-mediated pro-apoptotic signaling through phosphorylation at serine 82
    • Bi W, Xiao L, Jia Y, Wu J, Xie Q, Ren J et al. c-Jun N-terminal kinase enhances MST1-mediated pro-apoptotic signaling through phosphorylation at serine 82. J Biol Chem 2010; 285: 6259-6264.
    • (2010) J Biol Chem , vol.285 , pp. 6259-6264
    • Bi, W.1    Xiao, L.2    Jia, Y.3    Wu, J.4    Xie, Q.5    Ren, J.6
  • 29
    • 19644367000 scopus 로고    scopus 로고
    • Activation and signaling of the p38 MAP kinase pathway
    • Zarubin T, Han J. Activation and signaling of the p38 MAP kinase pathway. Cell Res 2005; 15: 11-18.
    • (2005) Cell Res , vol.15 , pp. 11-18
    • Zarubin, T.1    Han, J.2
  • 30
    • 0031916832 scopus 로고    scopus 로고
    • Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
    • Enslen H, Raingeaud J, Davis RJ. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J Biol Chem 1998; 273: 1741-1748.
    • (1998) J Biol Chem , vol.273 , pp. 1741-1748
    • Enslen, H.1    Raingeaud, J.2    Davis, R.J.3
  • 31
    • 67650138623 scopus 로고    scopus 로고
    • T cell receptor-mediated activation of p38{alpha} by mono-phosphorylation of the activation loop results in altered substrate specificity
    • Mittelstadt PR, Yamaguchi H, Appella E, Ashwell JD. T cell receptor-mediated activation of p38{alpha} by mono-phosphorylation of the activation loop results in altered substrate specificity. J Biol Chem 2009; 284: 15469-15474.
    • (2009) J Biol Chem , vol.284 , pp. 15469-15474
    • Mittelstadt, P.R.1    Yamaguchi, H.2    Appella, E.3    Ashwell, J.D.4
  • 32
    • 34347259269 scopus 로고    scopus 로고
    • Protocol for the MPTP mouse model of Parkinson's disease
    • Jackson-Lewis V, Przedborski S. Protocol for the MPTP mouse model of Parkinson's disease. Nat Protoc 2007; 2: 141-151.
    • (2007) Nat Protoc , vol.2 , pp. 141-151
    • Jackson-Lewis, V.1    Przedborski, S.2


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