Myocardial Regional Interstitial Fibrosis is Associated with Left Intra-Ventricular Dyssynchrony in Patients with Heart Failure: A Cardiovascular Magnetic Resonance Study

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Lin, Lian Yu ^a   Wu, Cho Kai ^a   Juang, Jyh Ming Jimmy ^a   Wang, Yi Chih ^a   Su, Mao Yuan Marine ^a   Lai, Ling Ping ^a   Hwang, Juey Jen ^a   Chiang, Fu Tien ^a   Tseng, Wen Yih Issac ^a,b   Lin, Jiunn Lee ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; COMPLICATION; DIAGNOSTIC IMAGING; ETIOLOGY; FEMALE; HEART FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE FIBROSIS; HEART VENTRICLE; HUMAN; MALE; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY;

AGED; ENDOMYOCARDIAL FIBROSIS; FEMALE; HEART FAILURE; HEART VENTRICLES; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT;

EID: 84957538066     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep20711     Document Type: Article

References (33)

1. Abraham, T. P., Lardo, A. C. & Kass, D. A. Myocardial dyssynchrony and resynchronization. Heart Fail Clin. 2, 179-192 (2006).
2. Bader, H. et al. Intra-left ventricular electromechanical asynchrony. A new independent predictor of severe cardiac events in heart failure patients. J Am Coll Cardiol. 43, 248-256 (2004).
3. Penicka, M. et al. Severe left ventricular dyssynchrony is associated with poor prognosis in patients with moderate systolic heart failure undergoing coronary artery bypass grafting. J Am Coll Cardiol. 50, 1315-1323 (2007).
4. Maruskova, M., Gregor, P., Bartunek, J., Tintera, J. & Penicka, M. Myocardial viability and cardiac dyssynchrony as strong predictors of perioperative mortality in high-risk patients with ischemic cardiomyopathy having coronary artery bypass surgery. J Thorac Cardiovasc Surg. 138, 62-68 (2009).
5. Tigen, K. et al. Diffuse late gadolinium enhancement by cardiovascular magnetic resonance predicts significant intraventricular systolic dyssynchrony in patients with non-ischemic dilated cardiomyopathy. J Am Soc Echocardiogr. 23, 416-422 (2010).
6. Crendal, E., Dutheil, F., Naughton, G., McDonald, T. & Obert P. Increased myocardial dysfunction, dyssynchrony, and epicardial fat across the lifespan in healthy males. BMC Cardiovasc Disord. 14, 95-104 (2014).
7. Mewton, N., Liu, C. Y., Croisille, P., Bluemke, D. & Lima, J. A. Assessment of myocardial fibrosis with cardiovascular magnetic resonance. J Am Coll Cardiol. 57, 891-903 (2011).
8. Iles, L. et al. Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping. J Am Coll Cardiol. 52, 1574-1580 (2008).
9. Mascherbauer, J. et al. Cardiac magnetic resonance postcontrast T1 time is associated with outcome in patients with heart failure and preserved ejection fraction. Circ Cardiovasc Imaging. 6, 1056-1065 (2013).
10. Liu, C. Y. et al. Evaluation of age-related interstitial myocardial fibrosis with cardiac magnetic resonance contrast-enhanced T1 mapping: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol, 62, 1280-1287, 2013
11. Conrad, C. H. et al. Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat. Circulation. 91, 161-170 (1995).
12. Oshinski, J. N., Yang, Z., Jones, J. R., Mata, J. F. & French, B. A. Imaging time after Gd-DTPA injection is critical in using delayed enhancement to determine infarct size accurately with magnetic resonance imaging. Circulation. 104, 2838-2842 (2001).
13. Lee, J. J. et al. Myocardial T1 and extracellular volume fraction mapping at 3 tesla. J Cardiovasc Magn Reson. 13, 75 (2011).
14. Kirk, J. A. & Kass, D. A. Electromechanical dyssynchrony and resynchronization of the failing heart. Circ Res. 113, 765-76 (2013).
15. Leong, D. P. et al. Effects of myocardial fibrosis and ventricular dyssynchrony on response to therapy in new-presentation idiopathic dilated cardiomyopathy: insights from cardiovascular magnetic resonance and echocardiography. Eur Heart J. 33, 640-648 (2012).
16. Lin, J. M. et al. Left ventricular extracellular matrix remodeling in dogs with right ventricular apical pacing. J Cardiovasc Electrophysiol. 21, 1142-1149 (2010).
17. Lin, J. M., Lai, L. P., Chou, N. K. & Lin, J. L. Spatial heterogeneity of protein expression induced by dyssynchronous right ventricular pacing in the left ventricle of dogs with preserved systolic function. J Card Fail. 16, 700-706 (2010).
18. Korosoglou, G. et al. Evidence of left ventricular contractile asynchrony by echocardiographic phase imaging in patients with type 2 diabetes mellitus and without clinically evident heart disease. Am J Cardiol. 98, 1525-1530 (2006).
19. Yang, B., Chettiveettil, D., Jones, F., Aguero, M. & Lewis, J. F. Left ventricular dyssynchrony in hypertensive patients without congestive heart failure. Clin Cardiol. 31, 597-601 (2008).
20. Ng, A. C. et al. Association between diffuse myocardial fibrosis by cardiac magnetic resonance contrast-enhanced T1 mapping and subclinical myocardial dysfunction in diabetic patients: A pilot study. Circ Cardiovasc Imaging. 5, 51-59 (2012).
21. Kuruvilla, S. et al. Increased extracellular volume and altered mechanics are associated with LVH in hypertensive heart disease, not hypertension alone. JACC Cardiovasc Imaging. 8, 172-180 (2015).
22. Crendal, E., Dutheil, F., Naughton, G., McDonald, T. & Obert, P. Increased myocardial dysfunction, dyssynchrony, and epicardial fat across the lifespan in healthy males. BMC Cardiovasc Disord. 14, 95-104 (2014).
23. Rosen, B. D. et al. Age, increased left ventricular mass, and lower regional myocardial perfusion are related to greater extent of myocardial dyssynchrony in asymptomatic individuals: The multi-ethnic study of atherosclerosis. Circulation. 120, 859-866 (2009).
24. Su, M. Y. et al. CMR-verified diffuse myocardial fibrosis is associated with diastolic dysfunction in HFpEF. JACC Cardiovasc Imaging. 7, 991-997 (2014).
25. Delgado, V. et al. Relative merits of left ventricular dyssynchrony, left ventricular lead position, and myocardial scar to predict longterm survival of ischemic heart failure patients undergoing cardiac resynchronization therapy. Circulation. 123, 70-78 (2011).
26. Ugander, M. et al. Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology. Eur Heart J. 33, 1268-1278 (2012).
27. Mischi, M. et al. Quantification of regional left ventricular dyssynchrony by magnetic resonance imaging. IEEE Trans Biomed Eng. 55, 985-995 (2008).
28. Delgado, V. et al. Assessment of left ventricular dyssynchrony by speckle tracking strain imaging comparison between longitudinal, circumferential, and radial strain in cardiac resynchronization therapy. J Am Coll Cardiol. 51, 1944-1952 (2008).
29. Mottram, P. M. et al. Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure. Circulation. 110, 558-565 (2004).
30. Sohn, D. W. et al. Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function. J Am Coll Cardiol. 30, 474-480 (1997).
31. Kellman, P., Arai, A. E., McVeigh, E. R. & Aletras, A. H. Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement. Magn Reson Med. 47, 372-383 (2002).
32. Wong, T. C. et al. Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and shortterm mortality. Circulation. 126, 1206-1216 (2012).
33. Tseng, W. Y., Liao, T. Y. & Wang, J. L. Normal systolic and diastolic functions of the left ventricle and left atrium by cine magnetic resonance imaging. Journal of cardiovascular magnetic resonance. J Cardiovasc Magn reson. 4, 443-457 (2002).