Monoclonal anti-interleukin-5 treatment suppresses eosinophil but not T-cell functions

European Respiratory Journal

Volumn 21, Issue 5, 2003, Pages 799-803

  Buttner C ^a   Lun, Andreas ^a   Splettstoesser, T ^a   Kunkel, G ^a   Renz, H ^b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Asthma; Eosinophils; Interleukin 5; Lymphocytes; Treatment

Indexed keywords

BECLOMETASONE DIPROPIONATE; BUDESONIDE; CD4 ANTIGEN; CORTICOSTEROID DERIVATIVE; CYTOKINE; EOSINOPHIL CATIONIC PROTEIN; FLUTICASONE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 5 ANTIBODY; MEPOLIZUMAB; MONOCLONAL ANTIBODY; PLACEBO; SALBUTAMOL;

ADULT; ARTICLE; ASTHMA; CELL COUNT; CELL DIFFERENTIATION; CELL MATURATION; CELL SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG INFUSION; DRUG MECHANISM; EOSINOPHIL; FEMALE; FORCED EXPIRATORY VOLUME; HELPER CELL; HUMAN; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

ADULT; ANTIBODIES, MONOCLONAL; ASTHMA; BLOOD PROTEINS; DOUBLE-BLIND METHOD; EOSINOPHIL GRANULE PROTEINS; EOSINOPHILS; FEMALE; HUMANS; INTERLEUKIN-5; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RIBONUCLEASES; T-LYMPHOCYTES;

EID: 0037718532     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.03.00027302     Document Type: Article

References (29)

1. De Monchy JG, Kauffman HF, Venge P, et al. Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions. Am Rev Respir Dis 1985; 131: 373-376.
2. Beasley R, Roche WR, Roberts JA, Holgate ST. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 1989; 139: 806-817.
3. Robinson DS, Ying S, Bentley AM, et al. Relationship among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway metacholine responsiveness in atopic asthma. J Allergy Clin Immunol 1993; 92: 397-403.
4. Chung KF, Barnes PJ. Cytokines in asthma. Thorax 1999; 54: 825-857.
5. Sanderson CJ. Interleukin-5: an eosinophil growth and activation factor. Dev Biol Stand 1988; 69: 23-29.
6. Wang JM, Rambaldi A, Biondi A, Chen ZG, Sanderson CJ, Mantovani A. Recombinant human interleukin 5 is a selective eosinophil chemoattractant. Eur J Immunol 1989; 19: 701-705.
7. Foster PS, Hogan SP, Ramsay AJ, Matthaei KI, Young IG. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity and lung damage in a mouse asthma model. J Exp Med 1996; 183: 195-201.
8. Yamaguchi Y, Suda T, Suda J, et al. Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors. J Exp Med 1988; 167: 43-56.
9. Hogan SP, Mould A, Kikutani H, Ramsay AJ, Foster PS. Aeroallergen-induced eosinophilic inflammation, lung damage and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins. J Clin Invest 1997; 99: 1329-1339.
10. Broide DH, Paine MM, Firestein GS. Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation. J Clin Invest 1992; 90: 1414-1424.
11. Hallden G, Hellman C, Gronneberg R, Lundahl J. Increased levels of IL-5 positive peripheral blood eosinophils and lymphocytes in mild asthmatics after allergen inhalation. Clin Exp Allergy 1999; 29: 595-603.
12. Corrigan CJ, Haczku A, Gemou-Engesaeth V, et al. CD4 T-lymphocyte activation in asthma is accompanied by increased serum concentrations in interleukin-5. Am Rev Respir Dis 1993; 147: 540-547.
13. Humbert M, Corrigan CJ, Kimmitt P, Till SJ, Kay AB, Durham SR. Relationship between IL-4 and IL-5 mRNA expression and disease severity in atopic asthma. Am J Respir Crit Care Med 1997; 156: 704-708.
14. van der Veen MJ, van Neerven RJJ, de Jong EC, Aalberse RC, Jansen HM, van der Zee JS. The late asthmatic response is associated with baseline allergen-specific proliferative responsiveness of peripheral T lymphocytes in vitro and serum interleukin-5. Clin Exp Allergy 1999; 29: 217-227.
15. Shi HZ, Xiao C-Q, Zhong D, et al. Effect of inhaled interleukin-5 on airway hyperreactivity and eosinophilia in asthmatics. Am J Respir Crit Care Med 1998; 157: 204-209.
16. Kung TT, Stelts DM, Zurcher JA, et al. Involvement of IL-5 in a murine model of allergic pulmonary inflammation: prophylactic and therapeutic effect of an anti-IL-5 antibody. Am J Respir Cell Mol Biol 1995; 13: 360-365.
17. Mauser PJ, Pitman AM, Fernandez X, et al. Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma. Am Rev Respir Dis 1993; 148: 1623-1627.
18. Mauser PJ, Pitman A, Fernandez X, et al. Effects of an antibody to interleukin 5 in a monkey model of asthma. Am J Respir Crit Care Med 1995; 152: 467-472.
19. Egan RW, Athwahl D, Chou CC, et al. Inhibition of pulmonary eosinophilia and hyperreactivity by antibodies to interleukin 5. Int Arch Allergy Immunol 1995; 107: 321-322.
20. Leckie MJ, ten Brinke A, Khan J, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-reponsiveness, and the late asthmatic response. Lancet 2000; 356: 2144-2148.
21. Salcedo M, Hoglund P, Ljungren HG. Natural killer cell interaction with murine allogenic MHC class I molecules. Transplantation 1995; 60: 281-286.
22. Meissner N, Kussebi F, Jung T, et al. A subset of CD8+ T cells from allergic patients produce IL-4 and stimulate IgE production in vitro. Clin Exp Allergy 1997; 27: 1402-1411.
23. Corry DB, Kheramand F. Induction and regulation of the IgE response. Nature 1999; 402: Suppl. 6760, B18-B23.
24. Robinson DS, Hamid Q, Yin S, et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992; 326: 298-304.
25. Bousquet J, Chanez P, Lacoste JY, et al. Eosinophilic inflammation in asthma. N Engl J Med 1990; 323: 1033-1039.
26. Corry DB, Folkesson HG, Warnock ML, et al. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med 1996; 183: 109-117.
27. Holgate T. The epidemic of allergy and asthma. Nature 1999; 402: Suppl. 6760, B2-B4.
28. Mould AW, Ramsay AJ, Matthaei KI, Young IG, Rothenberg ME, Foster PS. The effect of IL-5 and eotaxin expression in the lung on eosinophil trafficking and degranulation and the induction of bronchial hyperreactivity. J Immunol 2000; 164: 2142-2150.
29. Zhu Z, Homer RJ, Wang Z, et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities and eotaxin production. J Clin Invest 1999; 103: 779-788.