Investigating voluntary medical male circumcision program efficiency gains through subpopulation prioritization: Insights from application to Zambia

PLoS ONE

Volumn 10, Issue 12, 2015, Pages

  Awad, Susanne F ^a   Sgaier, Sema K ^b,c   Tambatamba, Bushimbwa C ^d   Mohamoud, Yousra A ^a   Lau, Fiona K ^b   Reed, Jason B ^e   Njeuhmeli, Emmanuel ^f   Abu Raddad, Laith J ^a,g,h  

^a WEILL CORNELL MEDICAL COLLEGE   (Qatar)

^b BILL AND MELINDA GATES FOUNDATION   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d Ministry of Community Development Mother and Child Health   (Zambia)

^e US President's Emergency Plan for AIDS Relief   (United States)

^f UNITED STATES AGENCY FOR INTERNATIONAL DEVELOPMENT   (United States)

^g WEILL CORNELL MEDICAL COLLEGE   (United States)

^h HAMAD BIN KHALIFA UNIVERSITY   (Qatar)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGE; AGE DISTRIBUTION; ARTICLE; CHILD; CIRCUMCISION; CONCEPTUAL FRAMEWORK; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; FEASIBILITY STUDY; GEOGRAPHIC DISTRIBUTION; GEOGRAPHY; HEALTH CARE COST; HEALTH CARE PLANNING; HEALTH CARE POLICY; HEALTH ECONOMICS; HEALTH PROGRAM; HUMAN; HUMAN EXPERIMENT; MALE; MIDDLE AGED; NORMAL HUMAN; POPULATION RESEARCH; POPULATION SIZE; PREVALENCE; SCHOOL CHILD; SENSITIVITY ANALYSIS; SEXUAL TRANSMISSION; YOUNG ADULT; ZAMBIA; COST BENEFIT ANALYSIS; ECONOMICS; EPIDEMIC; HIV INFECTIONS; ORGANIZATION AND MANAGEMENT; PUBLIC HEALTH; SEXUAL BEHAVIOR; VOLUNTARY PROGRAM;

ADOLESCENT; ADULT; CHILD; CIRCUMCISION, MALE; COST-BENEFIT ANALYSIS; EFFICIENCY, ORGANIZATIONAL; EPIDEMICS; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; NATIONAL HEALTH PROGRAMS; PREVALENCE; SEXUAL BEHAVIOR; VOLUNTARY PROGRAMS; YOUNG ADULT; ZAMBIA;

EID: 84957074846     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0145729     Document Type: Article

References (61)

1. Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, Puren A. Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med. 2005;2(11):e298. PMID: 16231970.
2. Bailey RC, Moses S, Parker CB, Agot K, Maclean I, Krieger JN, et al. Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial. Lancet. 2007;369(9562):643-56. Epub 2007/02/27. doi: 10.1016/S0140-6736 (07) 60312-2 PMID: 17321310.
3. Gray RH, Kigozi G, Serwadda D, Makumbi F, Watya S, Nalugoda F, et al. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. Lancet. 2007;369(9562):657-66. Epub 2007/02/27. doi: 10.1016/S0140-6736 (07) 60313-4 PMID: 17321311.
4. Njeuhmeli E, Forsythe S, Reed J, Opuni M, Bollinger L, Heard N, et al. Voluntary medical male circumcision: modeling the impact and cost of expanding male circumcision for HIV prevention in eastern and southern Africa. PLoS Med. 2011;8(11):e1001132. Epub 2011/12/06. doi: 10.1371/journal.pmed. 1001132 PMID: 22140367; PubMed Central PMCID: PMC3226464.
5. WHO and Joint United Nations Programme on HIV/AIDS (UNAIDS). New data on male circumcision and HIV prevention: policy and programme implications. WHO/UNAIDS technical consultation on male circumcision and HIV prevention: research implications for policy and programming. Geneva, Switzerland: WHO. March 6-8, 2007.
6. Nagelkerke NJ, Moses S, de Vlas SJ, Bailey RC. Modelling the public health impact of male circumcision for HIV prevention in high prevalence areas in Africa. BMC Infect Dis. 2007;7:16. doi: 10.1186/1471-2334-7-16 PMID: 17355625; PubMed Central PMCID: PMC1832203.
7. Gray RH, Li X, Kigozi G, Serwadda D, Nalugoda F, Watya S, et al. The impact of male circumcision on HIV incidence and cost per infection prevented: a stochastic simulation model from Rakai, Uganda. AIDS. 2007;21(7):845-50. PMID: 17415039.
8. Williams BG, Lloyd-Smith JO, Gouws E, Hankins C, Getz WM, Hargrove J, et al. The potential impact of male circumcision on HIV in Sub-Saharan Africa. PLoS Med. 2006;3(7):e262. doi: 10.1371/journal. pmed.0030262 PMID: 16822094; PubMed Central PMCID: PMC1489185.
9. Hallett TB, Singh K, Smith JA, White RG, Abu-Raddad LJ, Garnett GP. Understanding the impact of male circumcision interventions on the spread of HIV in southern Africa. PLoS One. 2008;3(5):e2212. Epub 2008/05/22. doi: 10.1371/journal.pone.0002212 PMID: 18493593; PubMed Central PMCID: PMC2387228.
10. Alsallaq RA, Cash B, Weiss HA, Longini IM Jr., Omer SB, Wawer MJ, et al. Quantitative assessment of the role of male circumcision in HIV epidemiology at the population level. Epidemics. 2009;1(3):139-52. Epub 2009/09/01. doi: 10.1016/j.epidem.2009.08.001 PMID: 21352761.
11. White RG, Glynn JR, Orroth KK, Freeman EE, Bakker R, Weiss HA, et al. Male circumcision for HIV prevention in sub-Saharan Africa: who, what and when? AIDS. 2008;22(14):1841-50. Epub 2008/08/30. doi: 10.1097/QAD.0b013e32830e0137 PMID: 18753931.
12. World Health Organization (WHO). Joint strategic action framework to accelerate the scale-up of voluntary medical male circumcision for HIV prevention in Eastern and Southern Africa. Geneva: 2011.
13. Sgaier SK, Reed JB, Thomas A, Njeuhmeli E. Achieving the HIV prevention impact of voluntary medical male circumcision: lessons and challenges for managing programs. PLoS Med. 2014;11(5):e1001641. Epub 2014/05/08. doi: 10.1371/journal.pmed.1001641 PMID: 24800840; PubMed Central PMCID: PMC4011573.
14. Hogan DR, Baltussen R, Hayashi C, Lauer JA, Salomon JA. Cost effectiveness analysis of strategies to combat HIV/AIDS in developing countries. BMJ. 2005;331(7530):1431-7. Epub 2005/11/12. doi: 10. 1136/bmj.38643.368692.68 PMID: 16282380; PubMed Central PMCID: PMC1315644.
15. Abu-Raddad LJ, Longini IM Jr. No HIV stage is dominant in driving the HIV epidemic in sub-Saharan Africa. AIDS. 2008;22(9):1055-61. Epub 2008/06/04. doi: 10.1097/QAD.0b013e3282f8af84 PMID: 18520349.
16. Awad SF, Abu-Raddad LJ. Could there have been substantial declines in sexual risk behavior across sub-Saharan Africa in the mid-1990s? Epidemics. 2014;8:9-17. doi: 10.1016/j.epidem.2014.06.001 PMID: 25240899
17. Abu-Raddad LJ, Patnaik P, Kublin JG. Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan Africa. Science. 2006;314(5805):1603-6. Epub 2006/12/13. doi: 10.1126/science.1132338 PMID: 17158329.
18. Garnett GP, Anderson RM. Balancing sexual partnerships in an age and activity stratified model of HIV transmission in heterosexual populations. IMA J Math Appl Med Biol. 1994;11(3):161-92. Epub 1994/01/01. PMID: 7822888.
19. Garnett GP, Anderson RM. Factors controlling the spread of HIV in heterosexual communities in developing countries: patterns of mixing between different age and sexual activity classes. Philos Trans R Soc Lond B Biol Sci. 1993;342(1300):137-59. Epub 1993/10/29. doi: 10.1098/rstb.1993.0143 PMID: 7904355.
20. Cuadros DF, Crowley PH, Augustine B, Stewart SL, Garcia-Ramos G. Effect of variable transmission rate on the dynamics of HIV in sub-Saharan Africa. BMC Infect Dis. 2011;11:216. Epub 2011/08/13. doi: 10.1186/1471-2334-11-216 PMID: 21834977; PubMed Central PMCID: PMC3175213.
21. Handcock MS, Jones JH. Likelihood-based inference for stochastic models of sexual network formation. Theor Popul Biol. 2004;65(4):413-22. Epub 2004/05/12. doi: 10.1016/j.tpb.2003.09.006 PMID: 15136015.
22. Hamilton DT, Handcock MS, Morris M. Degree distributions in sexual networks: a framework for evaluating evidence. Sex Transm Dis. 2008;35(1):30-40. Epub 2008/01/25. PMID: 18217224.
23. Bansal S, Grenfell BT, Meyers LA. When individual behaviour matters: homogeneous and network models in epidemiology. J R Soc Interface. 2007;4(16):879-91. Epub 2007/07/21. doi: 10.1098/rsif. 2007.1100 PMID: 17640863; PubMed Central PMCID: PMC2394553.
24. Barrat A, Barthelemy M, Pastor-Satorras R, Vespignani A. The architecture of complex weighted networks. Proc Natl Acad Sci U S A. 2004;101(11):3747-52. Epub 2004/03/10. doi: 10.1073/pnas. 0400087101 PMID: 15007165; PubMed Central PMCID: PMC374315.
25. Boccaletti S, Latora V, Moreno Y, Chavez M, Hwang DU. Complex networks: Structure and dynamics. Physics Reports. 2006;424(4-5):175-308. doi: 10.1016/j.physrep. 2005.10.009
26. Watts DJ, Strogatz SH. Collective dynamics of 'small-world' networks. Nature. 1998;393(6684):440-2. Epub 1998/06/12. doi: 10.1038/30918 PMID: 9623998.
27. Barabási AL. Linked: how everything is connected to everything else and what it means for business, science and everyday life: London: First Plume Printing; 2003.
28. Liljeros F, Edling CR, Amaral LA, Stanley HE, Aberg Y. The web of human sexual contacts Promiscuous individuals are the vulnerable nodes to target in safe-sex campaigns. Nature. 2001;411(6840):907-8. Epub 2001/06/22. doi: 10.1038/35082140 PMID: 11418846.
29. Awad S, Cuadros D, Abu-Raddad L. Characterizing HIV prevalence distribution across sub-populations at variable levels of sexual behavior. International Journal of Infectious Diseases. 2012;16:e180-e1.
30. Gregson S, Nyamukapa CA, Garnett GP, Mason PR, Zhuwau T, Carael M, et al. Sexual mixing patterns and sex-differentials in teenage exposure to HIV infection in rural Zimbabwe. Lancet. 2002;359(9321):1896-903. Epub 2002/06/12. doi: 10.1016/S0140-6736 (02) 08780-9 PMID: 12057552.
31. Chemaitelly H, Cremin I, Shelton J, Hallett TB, Abu-Raddad LJ. Distinct HIV discordancy patterns by epidemic size in stable sexual partnerships in sub-Saharan Africa. Sex Transm Infect. 2012;88(1):51-7. Epub 2012/01/18. doi: 10.1136/sextrans-2011-050114 PMID: 22250180; PubMed Central PMCID: PMC3261749.
32. Westercamp N, Agot K, Jaoko W, Bailey RC. Risk compensation following male circumcision: results from a two-year prospective cohort study of recently circumcised and uncircumcised men in Nyanza Province, Kenya. AIDS Behav. 2014;18(9):1764-75. Epub 2014/07/23. doi: 10.1007/s10461-014-0846-4 PMID: 25047688.
33. Rosario IJ, Kasabwala K, Sadeghi-Nejad H. Circumcision as a strategy to minimize HIV transmission. Current urology reports. 2013;14(4):285-90. Epub 2013/06/19. doi: 10.1007/s11934-013-0343-8 PMID: 23775468.
34. UNAIDS. Political declaration on HIV and AIDS: Intensifying our efforts to eliminate HIV and AIDS. Geneva: UNAIDS: 2011.
35. UNAIDS. Global AIDS response progress reporting 2012: guidelines-construction of core indicators for monitoring the 2011 political declaration on HIV/AIDS. Geneva: UNAIDS: 2012.
36. UNAIDS. UNAIDS report on the global AIDS epidemic-2012. Annual UNAIDS report on the status of the AIDS epidemic and update on global initiatives to control it. Geneva: UNAIDS: 2012.
37. The MathWorks, Inc. MATLAB. The language of technical computing. 8.5.0.197613 (R2015a). Natick, MA, USA: ed: The MathWorks, Inc.; 2015.
38. UNAIDS. Epidemiological data, HIV estimates 1990-2013. 2013. Available: http://www.unaids.org/en/dataanalysis/datatools/aidsinfo.
39. Demographic and health surveys Calverton, MD: ICF Macro. Available: http://www.measuredhs.com/.
40. Central Statistical Office MoH, University of Zambia, Lusaka, Zambia, Tropical Diseases Research Centre, Ndola, Zambia and Macro International Inc. Calverton, Maryland, USA Zambia DHS, 2007-Final Report. Available: http://www.measuredhs.com/pubs/pdf/FR211/FR211[revised-05-12-2009].pdf. 2009.
41. Vandament L. Zambia 2011 HIV sentinel surveillance data from antenatal clinics. Country-level Data, Lusaka, Zambia 2013.
42. United Nations Department of Economic and Social Affairs, Population Division, Population Estimates and Projections Section. World population prospects, the 2012 revision. 2012. Available: http://esa.un.org/wpp/Excel-Data/population. htm
43. Vandament L. Program circumcision unit cost per actual VMMC program data from Zambia. Countrylevel data, Lusaka, Zambia 2013.
44. Drummond M, O'Brien B, Stoddart G, Torrance G. Methods for the economic evaluation of health care programmes. Oxford: Oxford University Press; 1999.
45. Lagarias JC, Reeds J. A., Wright M. H., and Wright P. E. Convergence Properties of the Nelder-Mead-Simplex Method in Low Dimensions. SIAM Journal of Optimization. 1998;9(1):112-47.
46. Haddix A, Teutsch S, Shaffer P, Dunet D. Prevention effectiveness: a guide to decision analysis and economic evaluation. Oxford: Oxford University Press; 1996.
47. Republic of Zambia Ministry of Health. Country Operational Plan for the Scale-up of Voluntary Medical Male Circumcision in Zambia, 2012-2015. Available: http://www.malecircumcision.org/country-updates/documents/Zambia-VMMC-operational-plan. pdf. 2012.
48. Sgaier SK. Performed voluntary medical male circumcision data for Zambia (2007-2014). Countrylevel data, Lusaka, Zambia. 2014.
49. Vandament L. Voluntary medical male circumcision forcast for Zambia. Country-level report. 2013.
50. Awad SF, Sgaier SK, Ncube G, Xaba S, Mugurungi OM, Mhangara MM, et al. A Reevaluation of the Voluntary Medical Male Circumcision Scale-Up Plan in Zimbabwe. PLoS One. 2015;10(10):e0140818. doi: 10.1371/journal.pone.0140818 PMID: 26529596.
51. UNAIDS. Ending the AIDS epidemic by 2030. Reducing sexual transmission Geneva: UNAIDS: 2014. Available: http://www.unaids.org/sites/default/files/media-asset/20140411-MeetingReport-Reducingsexualtransmission-en. pdf.
52. Chemaitelly H, Awad SF, Shelton JD, Abu-Raddad LJ. Sources of HIV incidence among stable couples in sub-Saharan Africa. Journal of the International AIDS Society. 2014;17:18765. Epub 2014/02/25. doi: 10.7448/IAS.17.1.18765 PMID: 24560339; PubMed Central PMCID: PMC3935448.
53. Chemaitelly H, Awad SF, Abu-Raddad LJ. The risk of HIV transmission within HIV-1 sero-discordant couples appears to vary across sub-Saharan Africa. Epidemics. 2014;6:1-9. Epub 2014/03/07. doi: 10.1016/j.epidem.2013.11.001 PMID: 24593916.
54. WHO. Global update on HIV treatment 2013: results, impact and opportunities: WHO report in partnership with UNICEF and UNAIDS. Geneva: WHO: 2013. Available: http://www.who.int/hiv/pub/progressreports/update2013/en/. Accessed 2015 Apr. 12.
55. Cleland J, Boerma JT, Carael M, Weir SS. Monitoring sexual behaviour in general populations: a synthesis of lessons of the past decade. Sex Transm Infect. 2004;80 Suppl 2:ii1-7. Epub 2004/12/02. doi: 10.1136/sti.2004.013151 PMID: 15572634; PubMed Central PMCID: PMC1765850.
56. Wawer MJ, Makumbi F, Kigozi G, Serwadda D, Watya S, Nalugoda F, et al. Circumcision in HIVinfected men and its effect on HIV transmission to female partners in Rakai, Uganda: a randomised controlled trial. Lancet. 2009;374(9685):229-37. Epub 2009/07/21. doi: 10.1016/S0140-6736 (09) 60998-3 PMID: 19616720; PubMed Central PMCID: PMC2905212.
57. Weiss HA, Hankins CA, Dickson K. Male circumcision and risk of HIV infection in women: a systematic review and meta-analysis. Lancet Infect Dis. 2009;9(11):669-77. Epub 2009/10/24. doi: 10.1016/S1473-3099 (09) 70235-X PMID: 19850225.
58. Hallett TB, Alsallaq RA, Baeten JM, Weiss H, Celum C, Gray R, et al. Will circumcision provide even more protection from HIV to women and men? New estimates of the population impact of circumcision interventions. Sex Transm Infect. 2011;87(2):88-93. Epub 2010/10/23. doi: 10.1136/sti.2010.043372 PMID: 20966458; PubMed Central PMCID: PMC3272710.
59. Baeten JM, Donnell D, Kapiga SH, Ronald A, John-Stewart G, Inambao M, et al. Male circumcision and risk of male-to-female HIV-1 transmission: a multinational prospective study in African HIV-1-serodiscordant couples. AIDS. 2010;24(5):737-44. Epub 2010/01/01. doi: 10.1097/QAD.0b013e32833616e0 PMID: 20042848; PubMed Central PMCID: PMC2919808.
60. Awad SF, Sgaier SK, Lau FK, Mohamoud YA, Tambatamba B, Reed JB, et al. Could circumcision of HIV positive males benefit voluntary medical male circumcision programs?: Mathematical modeling analysis. Under review. 2015.
61. Grund JM, Hennink MM. A qualitative study of sexual behavior change and risk compensation following adult male circumcision in urban Swaziland. AIDS Care. 2011;24(2):245-51. doi: 10.1080/09540121. 2011.596516 PMID: 21777079