AdeR protein regulates adeABC expression by binding to a direct-repeat motif in the intercistronic spacer

Microbiological Research

Volumn 183, Issue , 2016, Pages 60-67

  Chang, Tein Yao ^a,b   Huang, Bo Jun ^a,b   Sun, Jun Ren ^a,b   Perng, Cherng Lih ^b   Chan, Ming Chin ^b   Yu, Cheng Ping ^a   Chiueh, Tzong Shi ^a,b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

Acinetobacter baumannii; AdeABC efflux pump; AdeR; Two component system

Indexed keywords

BINDING ENERGY; BINS; ELECTROPHORESIS;

ADER; BAUMANNII; BINDING AFFINITIES; BINDING PROTEINS; BIOLOGICAL CHARACTERISTIC; EFFLUX PUMPS; TWO COMPONENT SYSTEMS; TWO-COMPONENT REGULATORY SYSTEMS;

PROTEINS;

BACTERIUM; BIOASSAY; CANCER; GENE EXPRESSION; PROTEIN;

ACINETOBACTER BAUMANNII;

ANTIINFECTIVE AGENT; BACTERIAL DNA; CARRIER PROTEIN; MINOCYCLINE; TIGECYCLINE;

ACINETOBACTER BAUMANNII; ANALOGS AND DERIVATIVES; ANTIBIOTIC RESISTANCE; BIOSYNTHESIS; CHROMOSOMAL MAPPING; DRUG EFFECTS; ELECTROPHORESIS; GENE DELETION; GENETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; MUTATION; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; OPERON; PROCEDURES; PROTEIN MOTIF; SEQUENCE ANALYSIS;

ACINETOBACTER BAUMANNII; AMINO ACID MOTIFS; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; CHROMOSOME MAPPING; DNA, BACTERIAL; ELECTROPHORESIS; GENE DELETION; MEMBRANE TRANSPORT PROTEINS; MICROBIAL SENSITIVITY TESTS; MINOCYCLINE; MUTATION; OPERON; REPETITIVE SEQUENCES, NUCLEIC ACID; SEQUENCE ANALYSIS; TETRACYCLINE RESISTANCE;

EID: 84957057136     PISSN: 09445013     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.micres.2015.11.010     Document Type: Article

References (42)

1. Adams M.D., Chan E.R., Molyneaux N.D., Bonomo R.A. Genomewide analysis of divergence of antibiotic resistance determinants in closely related isolates of Acinetobacter baumannii. Antimicrob. Agents Chemother. 2010, 54(9):3569-3577.
2. Aguirre A., Lejona S., Vescovi E.G., Soncini F.C. Phosphorylated PmrA interacts with the promoter region of ugd in Salmonella enterica serovar typhimurium. J. Bacteriol. 2000, 182(13):3874-3876.
3. Capra E.J., Laub M.T. Evolution of two-component signal transduction systems. Annu. Rev. Microbiol. 2012, 66:325-347.
4. Chen Q., Li X., Zhou H., Jiang Y., Chen Y., Hua X., Yu Y. Decreased susceptibility to tigecycline in Acinetobacter baumannii mediated by a mutation in trm encoding SAM-dependent methyltransferase. J. Antimicrob. Chemother. 2014, 69(1):72-76.
5. Cheung J., Hendrickson W.A. Sensor domains of two-component regulatory systems. Curr. Opin. Microbiol. 2010, 13(2):116-123.
6. Cortez-Cordova J., Kumar A. Activity of the efflux pump inhibitor phenylalanine-arginine beta-naphthylamide against the AdeFGH pump of Acinetobacter baumannii. Int. J. Antimicrob. Agents 2011, 37(5):420-424.
7. Coyne S., Guigon G., Courvalin P., Perichon B. Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray. Antimicrob. Agents Chemother. 2010, 54(1):333-340.
8. Coyne S., Rosenfeld N., Lambert T., Courvalin P., Perichon B. Overexpression of resistance-nodulation-cell division pump AdeFGH confers multidrug resistance in Acinetobacter baumannii. Antimicrob. Agents Chemother. 2010, 54(10):4389-4393.
9. Coyne S., Courvalin P., Perichon B. Efflux-mediated antibiotic resistance in Acinetobacter spp. Antimicrob. Agents Chemother. 2011, 55(3):947-953.
10. Damier-Piolle L., Magnet S., Bremont S., Lambert T., Courvalin P. AdeIJK a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. Antimicrob. Agents Chemother. 2008, 52(2):557-562.
11. Gordon N.C., Wareham D.W. A review of clinical and microbiological outcomes following treatment of infections involving multidrug-resistant Acinetobacter baumannii with tigecycline. J. Antimicrob. Chemother. 2009, 63(4):775-780.
12. Guerrero P., Collao B., Alvarez R., Salinas H., Morales E.H., Calderon I.L., Saavedra C.P., Gil F. Salmonella enterica serovar Typhimurium BaeSR two-component system positively regulates sodA in response to ciprofloxacin. Microbiology 2013, 159(Pt. 10):2049-2057.
13. Higgins P.G., Schneiders T., Hamprecht A., Seifert H. In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient. Antimicrob. Agents Chemother. 2010, 54(12):5021-5027.
14. Hoch J.A. Two-component and phosphorelay signal transduction. Curr. Opin. Microbiol. 2000, 3(2):165-170.
15. Horng Y.T., Chang K.C., Liu Y.N., Lai H.C., Soo P.C. The RssB/RssA two-component system regulates biosynthesis of the tripyrrole antibiotic, prodigiosin, in Serratia marcescens. Int. J. Med. Microbiol.: IJMM 2010, 300(5):304-312.
16. Hornsey M., Ellington M.J., Doumith M., Thomas C.P., Gordon N.C., Wareham D.W., Quinn J., Lolans K., Livermore D.M., Woodford N. AdeABC-mediated efflux and tigecycline MICs for epidemic clones of Acinetobacter baumannii. J. Antimicrob. Chemother. 2010, 65(8):1589-1593.
17. Hornsey M., Loman N., Wareham D.W., Ellington M.J., Pallen M.J., Turton J.F., Underwood A., Gaulton T., Thomas C.P., Doumith M., Livermore D.M., Woodford N. Whole-genome comparison of two Acinetobacter baumannii isolates from a single patient, where resistance developed during tigecycline therapy. J. Antimicrob. Chemother. 2011, 66(7):1499-1503.
18. Iredell J., Thomas L., Power D., Mendes E. Tigecycline resistance in Australian antibiotic-resistant gram-negative bacteria. J. Antimicrob. Chemother. 2007, 59(4):816-818.
19. Leblanc S.K., Oates C.W., Raivio T.L. Characterization of the induction and cellular role of the BaeSR two-component envelope stress response of Escherichia coli. J. Bacteriol. 2011, 193(13):3367-3375.
20. Lin M.F., Lin Y.Y., Yeh H.W., Lan C.Y. Role of the BaeSR two-component system in the regulation of Acinetobacter baumannii adeAB genes and its correlation with tigecycline susceptibility. BMC Microbiol. 2014, 14(1):119.
21. Lopes B.S., Amyes S.G. Insertion sequence disruption of adeR and ciprofloxacin resistance caused by efflux pumps and gyrA and parC mutations in Acinetobacter baumannii. Int. J. Antimicrob. Agents 2013, 41(2):117-121.
22. Magnet S., Courvalin P., Lambert T. Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454. Antimicrob. Agents Chemother. 2001, 45(12):3375-3380.
23. Maragakis L.L., Perl T.M. Acinetobacter baumannii: epidemiology, antimicrobial resistance, and treatment options. Clin. Infect. Dis. 2008, 46(8):1254-1263.
24. Marchand I., Damier-Piolle L., Courvalin P., Lambert T. Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system. Antimicrob. Agents Chemother. 2004, 48(9):3298-3304.
25. Muller C., Plesiat P., Jeannot K. A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 2011, 55(3):1211-1221.
26. Navon-Venezia S., Leavitt A., Carmeli Y. High tigecycline resistance in multidrug-resistant Acinetobacter baumannii. J. Antimicrob. Chemother. 2007, 59(4):772-774.
27. Orsi G.B., Franchi C., Giordano A., Rocco M., Ferraro F., Mancini C., Venditti M. Multidrug-resistant Acinetobacter baumannii outbreak in an intensive care unit. J. Chemother. 2008, 20(2):219-244.
28. Peleg A.Y., Adams J., Paterson D.L. Tigecycline efflux as a mechanism for nonsusceptibility in Acinetobacter baumannii. Antimicrob. Agents Chemother. 2007, 51(6):2065-2069.
29. Peleg A.Y., Seifert H., Paterson D.L. Acinetobacter baumannii: emergence of a successful pathogen. Clin. Microbiol. Rev. 2008, 21(3):538-582.
30. Richmond G.E., Chua K.L., Piddock L.J. Efflux in Acinetobacter baumannii can be determined by measuring accumulation of H33342 (bis-benzamide). J. Antimicrob. Chemother. 2013, 68(7):1594-1600.
31. Rumbo C., Gato E., Lopez M., Ruiz de Alegria C., Fernandez-Cuenca F., Martinez-Martinez L., Vila J., Pachon J., Cisneros J.M., Rodriguez-Bano J., Pascual A., Bou G., Tomas M. Spanish Group of Nosocomial I, Mechanisms of A, Resistance to A, Spanish Society of Clinical M, Infectious D, Spanish Network for Research in Infectious D. Contribution of efflux pumps, porins, and beta-lactamases to multidrug resistance in clinical isolates of Acinetobacter baumannii. Antimicrob. Agents Chemother. 2013, 57(11):5247-5257.
32. Ruzin A., Keeney D., Bradford P.A. AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex. J. Antimicrob. Chemother. 2007, 59(5):1001-1004.
33. Ruzin A., Immermann F.W., Bradford P.A. RT-PCR and statistical analyses of adeABC expression in clinical isolates of Acinetobacter calcoaceticus-Acinetobacter baumannii complex. Microb. Drug Resist. 2010, 16(2):87-89.
34. Segal H., Garny S., Elisha B.G. Is IS(ABA-1) customized for Acinetobacter?. FEMS Microbiol. Lett. 2005, 243(2):425-429.
35. Stauff D.L., Torres V.J., Skaar E.P. Signaling and DNA-binding activities of the Staphylococcus aureus HssR-HssS two-component system required for heme sensing. J. Biol. Chem. 2007, 282(36):26111-26121.
36. Sun F., Li C., Jeong D., Sohn C., He C., Bae T. In the Staphylococcus aureus two-component system sae, the response regulator SaeR binds to a direct repeat sequence and DNA binding requires phosphorylation by the sensor kinase SaeS. J. Bacteriol. 2010, 192(8):2111-2127.
37. Sun J.R., Perng C.L., Chan M.C., Morita Y., Lin J.C., Su C.M., Wang W.Y., Chang T.Y., Chiueh T.S. A truncated AdeS kinase protein generated by ISAba1 insertion correlates with tigecycline resistance in Acinetobacter baumannii. PLoS One 2012, 7(11):e49534.
38. Turton J.F., Ward M.E., Woodford N., Kaufmann M.E., Pike R., Livermore D.M., Pitt T.L. The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii. FEMS Microbiol. Lett. 2006, 258(1):72-77.
39. West A.H., Stock A.M. Histidine kinases and response regulator proteins in two-component signaling systems. Trends Biochem. Sci. 2001, 26(6):369-376.
40. Wieczorek P., Sacha P., Hauschild T., Zorawski M., Krawczyk M., Tryniszewska E. Multidrug resistant Acinetobacter baumannii-the role of AdeABC (RND family) efflux pump in resistance to antibioticsFolia histochemica et cytobiologica/Polish Academy of Sciences. Pol. Histochem. Cytochem. Society 2008, 46(3):257-267.
41. Yahav D., Lador A., Paul M., Leibovici L. Efficacy and safety of tigecycline: a systematic review and meta-analysis. J. Antimicrob. Chemother. 2011, 66(9):1963-1971.
42. Yoon E.J., Courvalin P., Grillot-Courvalin C. RND-type efflux pumps in multidrug-resistant clinical isolates of Acinetobacter baumannii: major role for AdeABC overexpression and AdeRS mutations. Antimicrob. Agents Chemother. 2013, 57(7):2989-2995.