In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 12, 2010, Pages 5021-5027

  Higgins, Paul G ^a   Schneiders, Thamarai ^b   Hamprecht, Axel ^a   Seifert, Harald ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; BACTERIAL ENZYME; CARBAPENEMASE; CIPROFLOXACIN; COLISTIN; COTRIMOXAZOLE; IMIPENEM; LEVOFLOXACIN; MEROPENEM; OXACILLINASE; PIPERACILLIN PLUS TAZOBACTAM; TIGECYCLINE; TOBRAMYCIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ACINETOBACTER BAUMANNII; ADEB GENE; ADEJ GENE; ADER GENE; ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BLAOXA 164 GENE; BLAOXA 58 GENE; CASE REPORT; GENE EXPRESSION; GENE MUTATION; HUMAN; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; VENTILATOR ASSOCIATED PNEUMONIA;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; BACTERIAL PROTEINS; CARBAPENEMS; DRUG RESISTANCE, BACTERIAL; FATAL OUTCOME; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 78649667671     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00598-10     Document Type: Article

References (29)

1. Allen, M. P., K. B. Zumbrennen, and W. R. McCleary. 2001. Genetic evidence that the α5 helix of the receiver domain of PhoB is involved in interdomain interactions. J. Bacteriol. 183:2204-2211.
2. Clinical and Laboratory Standards Institute. 2007. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 7th ed. Approved standard M7-A7. Clinical and Laboratory Standards Institute, Wayne, PA.
3. Damier-Piolle, L., S. Magnet, S. Bremont, T. Lambert, and P. Courvalin. 2008. AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. Antimicrob. Agents Chemother. 52:557-562.
4. Dijkshoorn, L., A. Nemec, and H. Seifert. 2007. An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nat. Rev. Microbiol. 5:939-951.
5. Healy, M., J. Huong, T. Bittner, M. Lising, S. Frye, S. Raza, R. Schrock, J. Manry, A. Renwick, R. Nieto, C. Woods, J. Versalovic, and J. R. Lupski. 2005. Microbial DNA typing by automated repetitive-sequence-based PCR. J. Clin. Microbiol. 43:199-207.
6. Heritier, C., L. Poirel, T. Lambert, and P. Nordmann. 2005. Contribution of acquired carbapenem-hydrolyzing oxacillinases to carbapenem resistance in Acinetobacter baumannii. Antimicrob. Agents Chemother. 49:3198-3202.
7. Higgins, P. G., H. Wisplinghoff, O. Krut, and H. Seifert. 2007. A PCR-based method to differentiate between Acinetobacter baumannii and Acinetobacter genomic species 13TU. Clin. Microbiol. Infect. 13:1199-1201.
8. Higgins, P. G., C. Dammhayn, M. Hackel, and H. Seifert. 2010. Global spread of carbapenem-resistant Acinetobacter baumannii. J. Antimicrob. Chemother. 65:233-238.
9. Higgins, P. G., H. Wisplinghoff, D. Stefanik, and H. Seifert. 2004. Selection of topoisomerase mutations and overexpression of adeB mRNA transcripts during an outbreak of Acinetobacter baumannii. J. Antimicrob. Chemother. 54:821-823.
10. Hornsey, M., M. J. Ellington, M. Doumith, C. P. Thomas, N. C. Gordon, D. W. Wareham, J. Quinn, K. Lolans, D. M. Livermore, and N. Woodford. 2010. AdeABC-mediated efflux and tigecycline MICs for epidemic clones of Acinetobacter baumannii. J. Antimicrob. Chemother. 65:1589-1593.
11. Hunger, M., R. Schmucker, V. Kishan, and W. Hillen. 1990. Analysis and nucleotide sequence of an origin of DNA replication in Acinetobacter calcoaceticus and its use for Escherichia coli shuttle plasmids. Gene 87:45-51.
12. Joyanes, P., M. D. Conejo, L. Martinez-Martinez, and E. J. Perea. 2001. Evaluation of the VITEK 2 system for the identification and susceptibility testing of three species of nonfermenting Gram-negative rods frequently isolated from clinical samples. J. Clin. Microbiol. 39:3247-3253.
13. Kulah, C., E. Aktas, F. Comert, N. Ozlu, I. Akyar, and H. Ankarali. 2009. Detecting imipenem resistance in Acinetobacter baumannii by automated systems (BD Phoenix, Microscan WalkAway, Vitek 2); high error rates with Microscan WalkAway. BMC Infect. Dis. 9:30.
14. Magnet, S., P. Courvalin, and T. Lambert. 2001. Resistance-nodulation- cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454. Antimicrob. Agents Chemother. 45:3375-3380.
15. Marchand, I., L. Damier-Piolle, P. Courvalin, and T. Lambert. 2004. Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system. Antimicrob. Agents Chemother. 48:3298-3304.
16. Mugnier, P. D., L. Poirel, and P. Nordmann. 2009. Functional analysis of insertion sequence ISAba1, responsible for genomic plasticity of Acinetobacter baumannii. J. Bacteriol. 191:2414-2418.
17. Nagasawa, S., S. Tokishita, H. Aiba, and T. Mizuno. 1992. A novel sensor-regulator protein that belongs to the homologous family of signal-transduction proteins involved in adaptive responses in Escherichia coli. Mol. Microbiol. 6:799-807.
18. Poirel, L., and P. Nordmann. 2006. Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin. Microbiol. Infect. 12:826-836.
19. OXA-58 in Acinetobacter baumannii. Antimicrob. Agents Chemother. 50:1442-1448.
20. Pournaras, S., A. Ikonomidis, A. Markogiannakis, A. N. Maniatis, and A. Tsakris. 2005. Heteroresistance to carbapenems in Acinetobacter baumannii. J. Antimicrob. Chemother. 55:1055-1056.
21. Ruzin, A., D. Keeney, and P. A. Bradford. 2007. AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex. J. Antimicrob. Chemother. 59:1001-1004.
22. Segal, H., S. Garny, and B. G. Elisha. 2005. Is ISABA-1 customized for Acinetobacter? FEMS Microbiol. Lett. 243:425-429.
23. Seifert, H., L. Dolzani, R. Bressan, T. van der Reijden, B. van Strijen, D. Stefanik, H. Heersma, and L. Dijkshoorn. 2005. Standardization and inter-laboratory reproducibility assessment of pulsed-field gel electrophoresis-generated fingerprints of Acinetobacter baumannii. J. Clin. Microbiol. 43:4328-4335.
24. Sola, M., F. X. Gomis-Ruth, L. Serrano, A. Gonzalez, and M. Coll. 1999. Three-dimensional crystal structure of the transcription factor PhoB receiver domain. J. Mol. Biol. 285:675-687.
25. Towner, K. J., K. Levi, and M. Vlassiadi. 2008. Genetic diversity of carbapenem-resistant isolates of Acinetobacter baumannii in Europe. Clin. Microbiol. Infect. 14:161-167.
26. Turton, J. F., M. E. Ward, N. Woodford, M. E. Kaufmann, R. Pike, D. M. Livermore, and T. L. Pitt. 2006. The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii. FEMS Microbiol. Lett. 258:72-77.
27. Walthers, D., V. K. Tran, and L. J. Kenney. 2003. Interdomain linkers of homologous response regulators determine their mechanism of action. J. Bacteriol. 185:317-324.
28. Woodford, N., M. J. Ellington, J. M. Coelho, J. F. Turton, M. E. Ward, S. Brown, S. G. B. Amyes, and D. M. Livermore. 2006. Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. Int. J. Antimicrob. Agents 27:351-353.
29. OXA-58 gene confers imipenem resistance to Acinetobacter baumannii isolates from a Lebanese hospital. Antimicrob. Agents Chemother. 52:4115-4120.