O-linked β-N-acetylglucosamine (O-GlcNAc) acts as a glucose sensor to epigenetically regulate the insulin gene in pancreatic beta cells

Journal of Biological Chemistry

Volumn 291, Issue 5, 2016, Pages 2107-2118

  Durning, Sean P ^a,c   Flanagan Steet, Heather ^a   Prasad, Nripesh ^b   Wells, Lance ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; GLUCOSE; GLUCOSE SENSORS; INSULIN; MOLECULAR INTERACTIONS; NUTRIENTS; TRANSCRIPTION;

BIOSYNTHETIC PATHWAY; ENZYMATIC MODIFICATION; GLUCOSE-STIMULATED INSULIN SECRETIONS; INTRACELLULAR PROTEINS; N-ACETYLGLUCOSAMINE; PANCREATIC BETA CELLS; PROTEIN MODIFICATIONS; TRANSCRIPTIONAL ACTIVATIONS;

PROTEINS;

GALACTOSE 1 PHOSPHATE URIDYLYLTRANSFERASE; GLUCOSE; HEXOSAMINE; HISTONE H3; INSULIN; MESSENGER RNA; N ACETYLGLUCOSAMINE;

ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE EXPRESSION; GENETIC REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INSULIN RELEASE; MOLECULAR MECHANICS; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PROCESSING; RNA SEQUENCE; TRANSCRIPTION INITIATION; ANIMAL; BIOLOGY; CELL LINE; CHEMISTRY; CONFOCAL MICROSCOPY; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; GENOME; HIGH THROUGHPUT SEQUENCING; INSULINOMA; METABOLISM; MOUSE;

ACETYLGLUCOSAMINE; ANIMALS; CELL LINE; COMPUTATIONAL BIOLOGY; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; GENOME; GLUCOSE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; INSULIN; INSULIN-SECRETING CELLS; INSULINOMA; MICE; MICROSCOPY, CONFOCAL; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, MESSENGER;

EID: 84957028316     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.693580     Document Type: Article

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