Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways

Phytotherapy Research

Volumn 30, Issue 2, 2016, Pages 214-221

  Lien, Li Ming ^a,b   Wang, Meng Jiy ^c,d   Chen, Ray Jade ^a,e   Chiu, Hou Chang ^b,f   Wu, Jia Lun ^b   Shen, Ming Yi ^g   Chou, Duen Suey ^d   Sheu, Joen Rong ^d   Lin, Kuan Hung ^b,d   Lu, Wan Jung ^d,e  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^g CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Akt; cell cycle; glioblastoma multiforme; MAPKs; nobiletin

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NOBILETIN; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR E2F1; CDK2 PROTEIN, HUMAN; CDK4 PROTEIN, HUMAN; E2F1 PROTEIN, HUMAN; FLAVONE DERIVATIVE;

ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENZYME REPRESSION; GLIOMA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MTT ASSAY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STAINING; WESTERN BLOTTING; APOPTOSIS; CELL CYCLE CHECKPOINT; CELL MOTION; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; CITRUS; DRUG EFFECTS; GLIOMA; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CITRUS; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; E2F1 TRANSCRIPTION FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONES; GLIOMA; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84956958860     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5517     Document Type: Article

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