Nobiletin, a polymethoxy flavonoid, suppresses bone resorption by inhibiting NFκB-dependent prostaglandin E synthesis in osteoblasts and prevents bone loss due to estrogen deficiency

Journal of Pharmacological Sciences

Volumn 115, Issue 1, 2011, Pages 89-93

  Harada, Suguru ^a   Tominari, Tsukasa ^a   Matsumoto, Chiho ^a   Hirata, Michiko ^a   Takita, Morichika ^a   Inada, Masaki ^a   Miyaura, Chisato ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

Bone resorption; Osteoporosis; Polymethoxy flavonoid

Indexed keywords

CYCLOOXYGENASE 2; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; NOBILETIN; PROSTAGLANDIN E2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MASS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ESTROGEN DEFICIENCY; FEMALE; FEMUR; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEWBORN; NONHUMAN; OSTEOBLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; OSTEOPOROSIS; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

EID: 79952373608     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.10193SC     Document Type: Article

References (17)

1. Raisz LG, Vanderhoek JY, Simmons HA, Kream BE, Nicolaou KC. Prostaglandin synthesis by fetal rat bone in vitro: evidence for a role of prostacyclin. Prostaglandins. 1979;17:905-914. (Pubitemid 10221956)
2. Miyaura C, Inada M, Suzawa T, Sugimoto Y, Ushikubi F, Ichikawa A, et al. Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice. J Biol Chem. 2000;275:19819-19823. (Pubitemid 30441583)
3. Akao Y, itoh T, Ohguchi K, Iinuma M, Nozawa Y. Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells. Bioorg Med Chem. 2008;16:2803-2810.
4. Murakami A, Shigemori T, Ohigashi H. Zingiberaceous and citrus constituents, 1′-acetoxychavicol acetate, zerumbone, auraptene, and nobiletin, suppress lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 murine macrophages through different modes of action. J Nutr. 2005;135:2987S-2992S.
5. Wu YQ, Zhou CH, Tao J, Li SN. Antagonistic effects of nobiletin, a polymethoxy flavonoid, on eosinophilic airway inflammation of asthmatic rats and relevant mechanisms. Life Sci. 2006;78: 2689-2696.
6. Murakami A, Song M, Katsumata S, Uehara M, Suzuki K, Ohigashi H. Citrus nobiletin suppresses bone loss in ovariectomized ddY mice and collagen-induced arthritis in DBA/1J mice: possible involvement of receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis regulation. Biofactors. 2007;30:179-192. (Pubitemid 352038454)
7. Miyaura C, Kusano K, Masuzawa T, Chaki O, Onoe Y, Aoyagi M, et al. Endogenous bone-resorbing factors in estrogen deficiency: cooperative effects of IL-1 and IL-6. J Bone Miner Res. 1995;10:1365-1373.
8. Kawaguchi H, Pilbeam CC, Vargas SJ, Morse EE, Lorenzo JA, Raisz LG. Ovariectomy enhances and estrogen replacement inhibits the activity of bone marrow factors that stimulate prostaglandin production in cultured mouse calvariae. J Clin Invest. 1995;96:539-548.
9. Yamamoto K, Arakawa T, Ueda N. Transcriptional roles of nuclear factor κ B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J Biol Chem. 1995;270:31315-31320.
10. Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, et al. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science. 1992;247:88-91.
11. Kimble RB, Bain S, Pacifici R. The functional block of TNF but not of IL-6 prevents bone loss in ovariectomized mice. J Bone Miner Res. 1997;12:935-941. (Pubitemid 27225004)
12. Okada Y, Lorenzo JA, Freeman AM, Tomita M, Morham SG, Raisz LG, et al. Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture. J Clin Invest. 2000;105:823-832. (Pubitemid 30164121)
13. Gregory LS, Kelly WL, Reid RC, Fairlie DP, Forwood MR. Inhibitors of cyclo-oxygenase-2 and secretory phospholipase A2 preserve bone architecture following ovariectomy in adult rats. Bone. 2006;39:134-142. (Pubitemid 43831782)
14. Kim HP, Son KH, Chang HW, Kang SS. Anti-inflammatory plant flavonoids and cellular action mechanisms. J Pharmacol Sci. 2004;96:229-245. (Pubitemid 40013328)
15. Ishimi Y, Miyaura C, Ohmura M, Onoe Y, Sato T, Uchiyama Y, et al. Selective effects of genistein, a soybean isoflavone, on Blymphopoiesis and bone loss caused by estrogen deficiency. Endocrinology. 1999;140:1893-1900. (Pubitemid 29149263)
16. Chiba H, Uehara M, Wu J, Wang X, Masuyama R, Suzuki K, et al. Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice. J Nutr. 2003;133:1892-1897. (Pubitemid 36666531)
17. Norimatsu H, Mori S, Uesato T, Yoshikawa T, Katsuyama N. Bone mineral density of the spine and proximal femur in normal and osteoporotic subjects in Japan. Bone Miner. 1989;5:213-222. (Pubitemid 19027444)