메뉴 건너뛰기




Volumn 8, Issue 2, 2016, Pages 135-143

Role of inotuzumab ozogamicin in the treatment of relapsed/refractory acute lymphoblastic leukemia

Author keywords

acute lymphoblastic leukemia; antibody drug conjugate; inotuzumab; monoclonal antibody

Indexed keywords

INOTUZUMAB OZOGAMICIN; MONOCLONAL ANTIBODY;

EID: 84956957250     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.15.108     Document Type: Article
Times cited : (14)

References (48)
  • 1
    • 84930179795 scopus 로고    scopus 로고
    • Genomics in acute lymphoblastic leukaemia: Insights and treatment implications
    • Roberts KG, Mullighan CG. Genomics in acute lymphoblastic leukaemia: Insights and treatment implications. Nat. Rev. Clin. Oncol. 12(6), 344-357 (2015).
    • (2015) Nat. Rev. Clin. Oncol. , vol.12 , Issue.6 , pp. 344-357
    • Roberts, K.G.1    Mullighan, C.G.2
  • 2
    • 0033637892 scopus 로고    scopus 로고
    • Recent clinical trials in acute lymphocytic leukemia by the cancer and leukemia group B
    • x
    • Larson RA. Recent clinical trials in acute lymphocytic leukemia by the cancer and leukemia group B. Hematol. Oncol. Clin. North Am. 14(6), 1367-1379, x (2000).
    • (2000) Hematol. Oncol. Clin. North Am. , vol.14 , Issue.6 , pp. 1367-1379
    • Larson, R.A.1
  • 3
    • 10044259800 scopus 로고    scopus 로고
    • Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia
    • Kantarjian H, Thomas D, O'Brien S et al. Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia. Cancer 101(12), 2788-2801 (2004).
    • (2004) Cancer , vol.101 , Issue.12 , pp. 2788-2801
    • Kantarjian, H.1    Thomas, D.2    O'Brien, S.3
  • 4
    • 0033637411 scopus 로고    scopus 로고
    • Treatment of adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL)
    • ix
    • Gokbuget N, Hoelzer D, Arnold R et al. Treatment of adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL). Hematol. Oncol. Clin. North Am. 14(6), 1307-1325, ix (2000).
    • (2000) Hematol. Oncol. Clin. North Am. , vol.14 , Issue.6 , pp. 1307-1325
    • Gokbuget, N.1    Hoelzer, D.2    Arnold, R.3
  • 5
    • 33846869976 scopus 로고    scopus 로고
    • Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); An MRC UKALL12/ECOG 2993 study
    • Fielding AK, Richards SM, Chopra R et al. Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study. Blood 109(3), 944-950 (2007).
    • (2007) Blood , vol.109 , Issue.3 , pp. 944-950
    • Fielding, A.K.1    Richards, S.M.2    Chopra, R.3
  • 6
    • 79953727884 scopus 로고    scopus 로고
    • Augmented hyper-CVAD based on dose-intensified vincristine, dexamethasone, and asparaginase in adult acute lymphoblastic leukemia salvage therapy
    • Faderl S, Thomas DA, O'Brien S et al. Augmented hyper-CVAD based on dose-intensified vincristine, dexamethasone, and asparaginase in adult acute lymphoblastic leukemia salvage therapy. Clin. Lymphoma Myeloma Leuk. 11(1), 54-59 (2011).
    • (2011) Clin. Lymphoma Myeloma Leuk. , vol.11 , Issue.1 , pp. 54-59
    • Faderl, S.1    Thomas, D.A.2    O'Brien, S.3
  • 7
    • 2942567555 scopus 로고    scopus 로고
    • Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate
    • Thomas DA, Faderl S, Cortes J et al. Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate. Blood 103(12), 4396-4407 (2004).
    • (2004) Blood , vol.103 , Issue.12 , pp. 4396-4407
    • Thomas, D.A.1    Faderl, S.2    Cortes, J.3
  • 8
    • 77957191745 scopus 로고    scopus 로고
    • First report of Phase 2 study of dasatinib with hyper-CVAD for the frontline treatment of patients with Philadelphia chromosomepositive (Ph+) acute lymphoblastic leukemia
    • Ravandi F, O'Brien S, Thomas D et al. First report of Phase 2 study of dasatinib with hyper-CVAD for the frontline treatment of patients with Philadelphia chromosomepositive (Ph+) acute lymphoblastic leukemia. Blood 116(12), 2070-2077 (2010).
    • (2010) Blood , vol.116 , Issue.12 , pp. 2070-2077
    • Ravandi, F.1    O'Brien, S.2    Thomas, D.3
  • 9
    • 77955884680 scopus 로고    scopus 로고
    • Chemotherapy-phased imatinib pulses improve long-term outcome of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: Northern Italy Leukemia Group protocol 09/00
    • Bassan R, Rossi G, Pogliani EM et al. Chemotherapy-phased imatinib pulses improve long-term outcome of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: northern Italy Leukemia Group protocol 09/00. J. Clin. Oncol. 28(22), 3644-3652 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.22 , pp. 3644-3652
    • Bassan, R.1    Rossi, G.2    Pogliani, E.M.3
  • 10
    • 33645830511 scopus 로고    scopus 로고
    • Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia
    • Thomas DA, Faderl S, O'Brien S et al. Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia. Cancer 106(7), 1569-1580 (2006).
    • (2006) Cancer , vol.106 , Issue.7 , pp. 1569-1580
    • Thomas, D.A.1    Faderl, S.2    O'Brien, S.3
  • 11
    • 84869145679 scopus 로고    scopus 로고
    • Monoclonal antibody-based therapies: A new dawn in the treatment of acute lymphoblastic leukemia
    • Kantarjian H, Thomas D, Wayne AS, O'Brien S. Monoclonal antibody-based therapies: A new dawn in the treatment of acute lymphoblastic leukemia. J. Clin. Oncol. 30(31), 3876-3883 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.31 , pp. 3876-3883
    • Kantarjian, H.1    Thomas, D.2    Wayne, A.S.3    O'Brien, S.4
  • 12
    • 79957450612 scopus 로고    scopus 로고
    • Flow cytometric study of potential target antigens (CD19, CD20, CD22, CD33) for antibody-based immunotherapy in acute lymphoblastic leukemia: Analysis of 552 cases
    • Raponi S, De Propris MS, Intoppa S et al. Flow cytometric study of potential target antigens (CD19, CD20, CD22, CD33) for antibody-based immunotherapy in acute lymphoblastic leukemia: Analysis of 552 cases. Leuk. Lymphoma 52(6), 1098-1107 (2011).
    • (2011) Leuk. Lymphoma , vol.52 , Issue.6 , pp. 1098-1107
    • Raponi, S.1    De Propris, M.S.2    Intoppa, S.3
  • 13
    • 10744229449 scopus 로고    scopus 로고
    • Antibodytargeted chemotherapy with CMC-544: A CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies
    • DiJoseph JF, Armellino DC, Boghaert ER et al. Antibodytargeted chemotherapy with CMC-544: A CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies. Blood 103(5), 1807-1814 (2004).
    • (2004) Blood , vol.103 , Issue.5 , pp. 1807-1814
    • DiJoseph, J.F.1    Armellino, D.C.2    Boghaert, E.R.3
  • 14
    • 79551641737 scopus 로고    scopus 로고
    • Surface antigens analysis reveals significant expression of candidate targets for immunotherapy in adult acute lymphoid leukemia
    • Piccaluga PP, Arpinati M, Candoni A et al. Surface antigens analysis reveals significant expression of candidate targets for immunotherapy in adult acute lymphoid leukemia. Leuk. Lymphoma 52(2), 325-327 (2011).
    • (2011) Leuk. Lymphoma , vol.52 , Issue.2 , pp. 325-327
    • Piccaluga, P.P.1    Arpinati, M.2    Candoni, A.3
  • 15
    • 67649792047 scopus 로고    scopus 로고
    • CD22 and Siglec-G: B-cell inhibitory receptors with distinct functions
    • Nitschke L. CD22 and Siglec-G: B-cell inhibitory receptors with distinct functions. Immunol. Rev. 230(1), 128-143 (2009).
    • (2009) Immunol. Rev. , vol.230 , Issue.1 , pp. 128-143
    • Nitschke, L.1
  • 16
    • 0030993376 scopus 로고    scopus 로고
    • CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling
    • Tedder TF, Tuscano J, Sato S, Kehrl JH. CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. Annu. Rev. Immunol. 15, 481-504 (1997).
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 481-504
    • Tedder, T.F.1    Tuscano, J.2    Sato, S.3    Kehrl, J.H.4
  • 17
    • 84880797575 scopus 로고    scopus 로고
    • Targeting CD22 in B-cell malignancies: Current status and clinical outlook
    • Sullivan-Chang L, O'donnell RT, Tuscano JM. Targeting CD22 in B-cell malignancies: current status and clinical outlook. Biodrugs 27(4), 293-304 (2013).
    • (2013) Biodrugs , vol.27 , Issue.4 , pp. 293-304
    • Sullivan-Chang, L.1    O'Donnell, R.T.2    Tuscano, J.M.3
  • 18
    • 0036237495 scopus 로고    scopus 로고
    • Specifically targeting the CD22 receptor of human B-cell lymphomas with RNA damaging agents: A new generation of therapeutics
    • Hursey M, Newton DL, Hansen HJ et al. Specifically targeting the CD22 receptor of human B-cell lymphomas with RNA damaging agents: A new generation of therapeutics. Leuk. Lymphoma 43(5), 953-959 (2002).
    • (2002) Leuk. Lymphoma , vol.43 , Issue.5 , pp. 953-959
    • Hursey, M.1    Newton, D.L.2    Hansen, H.J.3
  • 19
    • 78049372729 scopus 로고    scopus 로고
    • Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B-cells in systemic lupus erythematosus
    • Daridon C, Blassfeld D, Reiter K et al. Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B-cells in systemic lupus erythematosus. Arthritis Res. Ther. 12(6), R204 (2010).
    • (2010) Arthritis Res. Ther. , vol.12 , Issue.6 , pp. R204
    • Daridon, C.1    Blassfeld, D.2    Reiter, K.3
  • 20
    • 84856710962 scopus 로고    scopus 로고
    • The novel calicheamicin-conjugated CD22 antibody inotuzumab ozogamicin (CMC-544) effectively kills primary pediatric acute lymphoblastic leukemia cells
    • De Vries JF, Zwaan CM, De Bie M et al. The novel calicheamicin-conjugated CD22 antibody inotuzumab ozogamicin (CMC-544) effectively kills primary pediatric acute lymphoblastic leukemia cells. Leukemia 26(2), 255-264 (2012).
    • (2012) Leukemia , vol.26 , Issue.2 , pp. 255-264
    • De Vries, J.F.1    Zwaan, C.M.2    De Bie, M.3
  • 22
    • 8944262198 scopus 로고    scopus 로고
    • Processing of antibodies bound to B-cell lymphomas and other hematological malignancies
    • Hanna R, Ong GL, Mattes MJ. Processing of antibodies bound to B-cell lymphomas and other hematological malignancies. Cancer Res. 56(13), 3062-3068 (1996).
    • (1996) Cancer Res. , vol.56 , Issue.13 , pp. 3062-3068
    • Hanna, R.1    Ong, G.L.2    Mattes, M.J.3
  • 23
    • 35548931579 scopus 로고    scopus 로고
    • Therapeutic potential of CD22-specific antibody-targeted chemotherapy using inotuzumab ozogamicin (CMC-544) for the treatment of acute lymphoblastic leukemia
    • Dijoseph JF, Dougher MM, Armellino DC, Evans DY, Damle NK. Therapeutic potential of CD22-specific antibody-targeted chemotherapy using inotuzumab ozogamicin (CMC-544) for the treatment of acute lymphoblastic leukemia. Leukemia 21(11), 2240-2245 (2007).
    • (2007) Leukemia , vol.21 , Issue.11 , pp. 2240-2245
    • Dijoseph, J.F.1    Dougher, M.M.2    Armellino, D.C.3    Evans, D.Y.4    Damle, N.K.5
  • 24
    • 79954448903 scopus 로고    scopus 로고
    • Preclinical anti-tumor activity of antibody-targeted chemotherapy with CMC-544 (inotuzumab ozogamicin), a CD22-specific immunoconjugate of calicheamicin, compared with non-targeted combination chemotherapy with CVP or CHOP
    • Dijoseph JF, Dougher MM, Evans DY, Zhou BB, Damle NK. Preclinical anti-tumor activity of antibody-targeted chemotherapy with CMC-544 (inotuzumab ozogamicin), a CD22-specific immunoconjugate of calicheamicin, compared with non-targeted combination chemotherapy with CVP or CHOP. Cancer Chemother. Pharmacol. 67(4), 741-749 (2011).
    • (2011) Cancer Chemother. Pharmacol. , vol.67 , Issue.4 , pp. 741-749
    • Dijoseph, J.F.1    Dougher, M.M.2    Evans, D.Y.3    Zhou, B.B.4    Damle, N.K.5
  • 25
    • 31544455876 scopus 로고    scopus 로고
    • Antitumor efficacy of a combination of CMC-544 (inotuzumab ozogamicin), a CD22-targeted cytotoxic immunoconjugate of calicheamicin, and rituximab against non-Hodgkin's B-cell lymphoma
    • Dijoseph JF, Dougher MM, Kalyandrug LB et al. Antitumor efficacy of a combination of CMC-544 (inotuzumab ozogamicin), a CD22-targeted cytotoxic immunoconjugate of calicheamicin, and rituximab against non-Hodgkin's B-cell lymphoma. Clin. Cancer. Res. 12(1), 242-249 (2006).
    • (2006) Clin. Cancer. Res. , vol.12 , Issue.1 , pp. 242-249
    • Dijoseph, J.F.1    Dougher, M.M.2    Kalyandrug, L.B.3
  • 26
    • 4544320025 scopus 로고    scopus 로고
    • Potent and specific antitumor efficacy of CMC-544, a CD22-targeted immunoconjugate of calicheamicin, against systemically disseminated B-cell lymphoma
    • Dijoseph JF, Goad ME, Dougher MM et al. Potent and specific antitumor efficacy of CMC-544, a CD22-targeted immunoconjugate of calicheamicin, against systemically disseminated B-cell lymphoma. Clin. Cancer. Res. 10(24), 8620-8629 (2004).
    • (2004) Clin. Cancer. Res. , vol.10 , Issue.24 , pp. 8620-8629
    • Dijoseph, J.F.1    Goad, M.E.2    Dougher, M.M.3
  • 27
    • 80054113954 scopus 로고    scopus 로고
    • Antibody-drug conjugates of calicheamicin derivative: Gemtuzumab ozogamicin and inotuzumab ozogamicin
    • Ricart AD. Antibody-drug conjugates of calicheamicin derivative: gemtuzumab ozogamicin and inotuzumab ozogamicin. Clin. Cancer. Res. 17(20), 6417-6427 (2011).
    • (2011) Clin. Cancer. Res. , vol.17 , Issue.20 , pp. 6417-6427
    • Ricart, A.D.1
  • 28
    • 84923019411 scopus 로고    scopus 로고
    • Antibody-based therapies in B-cell lineage acute lymphoblastic leukaemia
    • Le Jeune C, Thomas X. Antibody-based therapies in B-cell lineage acute lymphoblastic leukaemia. Eur. J. Haematol. 94(2), 99-108 (2015).
    • (2015) Eur. J. Haematol. , vol.94 , Issue.2 , pp. 99-108
    • Le Jeune, C.1    Thomas, X.2
  • 29
    • 0023820894 scopus 로고
    • Calicheamicin gamma 1I: An antitumor antibiotic that cleaves double-stranded DNA site specifically
    • Zein N, Sinha AM, Mcgahren WJ, Ellestad GA. Calicheamicin gamma 1I: An antitumor antibiotic that cleaves double-stranded DNA site specifically. Science 240(4856), 1198-1201 (1988).
    • (1988) Science , vol.240 , Issue.4856 , pp. 1198-1201
    • Zein, N.1    Sinha, A.M.2    Mcgahren, W.J.3    Ellestad, G.A.4
  • 30
    • 84861040649 scopus 로고    scopus 로고
    • Inotuzumab ozogamicin in the treatment of B-cell acute lymphoblastic leukemia
    • Thomas X. Inotuzumab ozogamicin in the treatment of B-cell acute lymphoblastic leukemia. Expert Opin. Invest. Drugs 21(6), 871-878 (2012).
    • (2012) Expert Opin. Invest. Drugs , vol.21 , Issue.6 , pp. 871-878
    • Thomas, X.1
  • 31
    • 0346034779 scopus 로고    scopus 로고
    • The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction
    • John B, Herrin BR, Raman C et al. The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction. J. Immunol. 170(7), 3534-3543 (2003).
    • (2003) J. Immunol. , vol.170 , Issue.7 , pp. 3534-3543
    • John, B.1    Herrin, B.R.2    Raman, C.3
  • 32
    • 84904354628 scopus 로고    scopus 로고
    • Novel targeted therapies in acute lymphoblastic leukemia
    • Portell CA, Advani AS. Novel targeted therapies in acute lymphoblastic leukemia. Leuk. Lymphoma 55(4), 737-748 (2014).
    • (2014) Leuk. Lymphoma , vol.55 , Issue.4 , pp. 737-748
    • Portell, C.A.1    Advani, A.S.2
  • 33
    • 84879591299 scopus 로고    scopus 로고
    • The antibody-drug conjugate: An enabling modality for natural product-based cancer therapeutics
    • Gerber HP, Koehn FE, Abraham RT. The antibody-drug conjugate: An enabling modality for natural product-based cancer therapeutics. Nat. Prod. Rep. 30(5), 625-639 (2013).
    • (2013) Nat. Prod. Rep. , vol.30 , Issue.5 , pp. 625-639
    • Gerber, H.P.1    Koehn, F.E.2    Abraham, R.T.3
  • 34
    • 0035874504 scopus 로고    scopus 로고
    • Targeting of the CD33-calicheamicin immunoconjugate Mylotarg (CMA-676) in acute myeloid leukemia: In vivo and in vitro saturation and internalization by leukemic and normal myeloid cells
    • Van Der Velden VH, Te Marvelde JG, Hoogeveen PG et al. Targeting of the CD33-calicheamicin immunoconjugate Mylotarg (CMA-676) in acute myeloid leukemia: In vivo and in vitro saturation and internalization by leukemic and normal myeloid cells. Blood 97(10), 3197-3204 (2001).
    • (2001) Blood , vol.97 , Issue.10 , pp. 3197-3204
    • Van Der Velden, V.H.1    Te Marvelde, J.G.2    Hoogeveen, P.G.3
  • 35
    • 2342572260 scopus 로고    scopus 로고
    • High CD33-antigen loads in peripheral blood limit the efficacy of gemtuzumab ozogamicin (Mylotarg) treatment in acute myeloid leukemia patients
    • Van Der Velden VH, Boeckx N, Jedema I et al. High CD33-antigen loads in peripheral blood limit the efficacy of gemtuzumab ozogamicin (Mylotarg) treatment in acute myeloid leukemia patients. Leukemia 18(5), 983-988 (2004).
    • (2004) Leukemia , vol.18 , Issue.5 , pp. 983-988
    • Van Der Velden, V.H.1    Boeckx, N.2    Jedema, I.3
  • 36
    • 84925259518 scopus 로고    scopus 로고
    • Inotuzumab ozogamicin in B-cell acute lymphoblastic leukemias and non-Hodgkin's lymphomas
    • Ohanian M, Kantarjian H, Guy D et al. Inotuzumab ozogamicin in B-cell acute lymphoblastic leukemias and non-Hodgkin's lymphomas. Expert Opin. Biol. Ther. 15(4), 601-611 (2015).
    • (2015) Expert Opin. Biol. Ther. , vol.15 , Issue.4 , pp. 601-611
    • Ohanian, M.1    Kantarjian, H.2    Guy, D.3
  • 37
    • 84869434807 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin: Time to resurrect?
    • Ravandi F, Estey EH, Appelbaum FR et al. Gemtuzumab ozogamicin: time to resurrect? J. Clin. Oncol. 30(32), 3921-3923 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.32 , pp. 3921-3923
    • Ravandi, F.1    Estey, E.H.2    Appelbaum, F.R.3
  • 38
    • 84939267428 scopus 로고    scopus 로고
    • Preclinical and clinical development of inotuzumab-ozogamicin in hematological malignancies
    • Shor B, Gerber HP, Sapra P. Preclinical and clinical development of inotuzumab-ozogamicin in hematological malignancies. Mol. Immunol. 67(2), 107-116 (2014).
    • (2014) Mol. Immunol. , vol.67 , Issue.2 , pp. 107-116
    • Shor, B.1    Gerber, H.P.2    Sapra, P.3
  • 39
    • 79952095577 scopus 로고    scopus 로고
    • Modern therapy of acute lymphoblastic leukemia
    • Bassan R, Hoelzer D. Modern therapy of acute lymphoblastic leukemia. J. Clin. Oncol. 29(5), 532-543 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.5 , pp. 532-543
    • Bassan, R.1    Hoelzer, D.2
  • 40
    • 77951648118 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non-Hodgkin's lymphoma: Results of a Phase i study
    • Advani A, Coiffier B, Czuczman MS et al. Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non-Hodgkin's lymphoma: results of a Phase I study. J. Clin. Oncol. 28(12), 2085-2093 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.12 , pp. 2085-2093
    • Advani, A.1    Coiffier, B.2    Czuczman, M.S.3
  • 41
    • 84880574025 scopus 로고    scopus 로고
    • Results of inotuzumab ozogamicin, a CD22 monoclonal antibody, in refractory and relapsed acute lymphocytic leukemia
    • Kantarjian H, Thomas D, Jorgensen J et al. Results of inotuzumab ozogamicin, a CD22 monoclonal antibody, in refractory and relapsed acute lymphocytic leukemia. Cancer 119(15), 2728-2736 (2013).
    • (2013) Cancer , vol.119 , Issue.15 , pp. 2728-2736
    • Kantarjian, H.1    Thomas, D.2    Jorgensen, J.3
  • 42
    • 84862786326 scopus 로고    scopus 로고
    • Inotuzumab ozogamicin, an anti-CD22-calecheamicin conjugate, for refractory and relapsed acute lymphocytic leukaemia: A Phase 2 study
    • Kantarjian H, Thomas D, Jorgensen J et al. Inotuzumab ozogamicin, an anti-CD22-calecheamicin conjugate, for refractory and relapsed acute lymphocytic leukaemia: A Phase 2 study. Lancet Oncol. 13(4), 403-411 (2012).
    • (2012) Lancet Oncol. , vol.13 , Issue.4 , pp. 403-411
    • Kantarjian, H.1    Thomas, D.2    Jorgensen, J.3
  • 44
    • 84877733104 scopus 로고    scopus 로고
    • Feasibility of allografting in patients with advanced acute lymphoblastic leukemia after salvage therapy with inotuzumab ozogamicin
    • Kebriaei P, Wilhelm K, Ravandi F et al. Feasibility of allografting in patients with advanced acute lymphoblastic leukemia after salvage therapy with inotuzumab ozogamicin. Clin. Lymphoma Myeloma Leuk. 13(3), 296-301 (2013).
    • (2013) Clin. Lymphoma Myeloma Leuk. , vol.13 , Issue.3 , pp. 296-301
    • Kebriaei, P.1    Wilhelm, K.2    Ravandi, F.3
  • 45
    • 84890875516 scopus 로고    scopus 로고
    • Initial experience with CMC-544 (inotuzumab ozogamicin) in pediatric patients with relapsed B-cell acute lymphoblastic leukemia
    • Rytting M, Triche L, Thomas D, O'Brien S, Kantarjian H. Initial experience with CMC-544 (inotuzumab ozogamicin) in pediatric patients with relapsed B-cell acute lymphoblastic leukemia. Pediatr. Blood Cancer 61(2), 369-372 (2014).
    • (2014) Pediatr. Blood Cancer , vol.61 , Issue.2 , pp. 369-372
    • Rytting, M.1    Triche, L.2    Thomas, D.3    O'Brien, S.4    Kantarjian, H.5
  • 46
    • 84923071079 scopus 로고    scopus 로고
    • Prognostic factors for outcome in patients with refractory and relapsed acute lymphocytic leukemia treated with inotuzumab ozogamicin, a CD22 monoclonal antibody
    • Jabbour E, O'Brien S, Huang X et al. Prognostic factors for outcome in patients with refractory and relapsed acute lymphocytic leukemia treated with inotuzumab ozogamicin, a CD22 monoclonal antibody. Am. J. Hematol. 90(3), 193-196 (2015).
    • (2015) Am. J. Hematol. , vol.90 , Issue.3 , pp. 193-196
    • Jabbour, E.1    O'Brien, S.2    Huang, X.3
  • 47
    • 84923051347 scopus 로고    scopus 로고
    • Weekly inotuzumab ozogamicin (InO) in adult patients with relapsed or refractory CD22-positive acute lymphoblastic leukemia (ALL)
    • Deangelo DJ, Stock W, Shustov AR et al. Weekly inotuzumab ozogamicin (InO) in adult patients with relapsed or refractory CD22-positive acute lymphoblastic leukemia (ALL). Blood 122(21), 3906a (2013).
    • (2013) Blood , vol.122 , Issue.21 , pp. 3906a
    • Deangelo, D.J.1    Stock, W.2    Shustov, A.R.3
  • 48
    • 84962743717 scopus 로고    scopus 로고
    • Inotuzumab ozogamicin in combination with low-intensity chemotherapy (mini-hyper-CVD) as frontline therapy for older patients (= 60 years) with acute lymphoblastic
    • Jabbour E, O'Brien S, Thomas DA et al. Inotuzumab ozogamicin in combination with low-intensity chemotherapy (mini-hyper-CVD) as frontline therapy for older patients (= 60 years) with acute lymphoblastic. Leukemia 124(21), a794 (2014).
    • (2014) Leukemia , vol.124 , Issue.21 , pp. a794
    • Jabbour, E.1    O'Brien, S.2    Thomas, D.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.