Processing of antibodies bound to B-cell lymphomas and other hematological malignancies

Cancer Research

Volumn 56, Issue 13, 1996, Pages 3062-3068

  Hanna, Rafik ^a   Ong, Gaik Lin ^a   Mattes, M Jules ^a  

^a CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CD20 ANTIGEN; CD22 ANTIGEN; FC RECEPTOR; IODINE 125; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY;

ANTIBODY AFFINITY; ANTIGEN BINDING; ARTICLE; B CELL LYMPHOMA; CANCER IMMUNOTHERAPY; CATABOLISM; CELL SURFACE; CONTROLLED STUDY; CROSS LINKING; DISSOCIATION; HISTOLOGY; HUMAN; HUMAN CELL; INTERNALIZATION; MYELOID LEUKEMIA; MYELOMA; PRIORITY JOURNAL; T CELL LEUKEMIA;

ANIMALS; ANTIBODIES, MONOCLONAL; CROSS-LINKING REAGENTS; HEMATOLOGIC DISEASES; HUMANS; LEUKEMIA, MYELOID; LEUKEMIA, T-CELL; LYMPHOMA, B-CELL; MULTIPLE MYELOMA; RATS; REPRODUCIBILITY OF RESULTS; TUMOR CELLS, CULTURED;

EID: 8944262198     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Kyriakos, R. J., Shih, L. B., Ong, G. L., Patel, K., Goldenberg, D M., and Mattes, M. J. The fate of antibodies bound to the surface of tumor cells in vtiro. Cancer Res., 52: 835-842, 1992
2. Mattes, M J., Griffiths, G L., Diril, H., Goldenberg, D. M., Ong, G. L., and Shih, L B. Processing of antibody-radioisotope conjugates after binding to the surface of tumor cells Cancer (Phila.), 73. 787-793, 1994
3. 131I]anti-B1 (anti-CD20) antibody. N. Engl. J. Med., 329: 459-465, 1993.
4. Press, O W., Eary, J. F., Appelbaum, F. R., Martin, P. J., Badger, C. C., Nelp, W. B., Glenn, S., Butchko, G., Fisher, D , Porter, B., Matthews, D. C , Fisher, L D., and Bernstein, I. D Radiolabeled-antibody therapy of B-cell lymphoma with autologous bone marrow support N Engl J. Med., 329. 1219-1224, 1993.
5. Amlot, P. L., Stone, M. J., Cunningham, D., Fay, J., Newman, J , Collins, R., May, R. D , McCarthy, M., Richardson, J., Ghetie, V , Ramilo, O., Thorpe, P. E , Uhr, J. W., and Vitetta, E S. A phase 1 study of anti-CD22 deglycosylated ricin A chain immunotoxin in the treatment of B cell lymphomas resistant to conventional therapy Blood, 82: 2624-2633, 1993
6. 131I-Lym-1 as a model Cancer (Pnila.), 73: 1038-1048, 1994
7. Goldenberg, D. M., Horowitz, J A., Sharkey, R. M., Hall, T. C., Murthy, S , Goldenberg, H , Lee, R. E., Stein, R., Siegel, J. A , Izon, D O , Burger, K , Swayne, L C., Belisle, E., Hansen, H. J., and Pinsky, C. M. Targeting, dosimetry, and radioimmunotherapy of B-cell lymphomas with iodine-131-labeled LL2 monoclonal antibody J. Clin. Oncol. 9: 548-564, 1991.
8. Press, O. W , Farr, A G., Borroz, K I., Anderson, S. K , and Martin, P. J. Endocytosis and degradation of monoclonal antibodies targeting human B-cell malignancies. Cancer Res., 49: 4906-4912, 1989.
9. Vervoordeldonk, S. F., Merle, P. A., van Leeuwen, E. F., van dem Borne, A. E. G. Kr., and Slaper-Cortenbach, I. C. M. Preclinical studies with radiolabeled monoclonal antibodies for treatment of patients with B-cell malignancies. Cancer (Phila.), 73: 1006-1011, 1993.
10. Mattes, M. J , Cairncross, J G , Old, L J., and Lloyd, K O Monoclonal antibodies to three widely distributed human cell surface antigens. Hybridoma, 2: 253-264, 1983.
11. Beckwith, M , Longo, D. L , O'Connell, C D., Moratz, C. M , and Urba, W. J. Phorbol ester-induced, cell-cycle-specific, growth inhibition of human B-lymphoma cell lines. J. Natl. Cancer Inst., 82: 501-509, 1990.
12. Clark, E. A., Shu, G., and Ledbetter, J. A. Role of the Bp356 cell surface polypeptide in human B cell activation. Proc. Natl. Acad. Sci. USA, 82: 1766-1770, 1985.
13. Pawlak-Byczkowska, E. J., Hansen, H. J., Dion, A. S , and Goldenberg, D. M. Two new monoclonal antibodies, EPB-1 and EPB-2, reactive with human lymphomas. Cancer Res., 49: 4568-4577, 1989.
14. Stein, R., Belisle, E., Hansen, H. J , and Goldenberg, D. M. Epitope specificity of the anti-(B cell lymphoma) monoclonal antibody, LL2. Cancer Immunol. Immunother., 37: 293-298, 1993
15. Epstein, A. L., Marder, R J., Winter, J. N., Stathopoulos, E., Chen, F. M , Parker, J W., and Taylor, C R. Two new monoclonal antibodies, Lym-1 and Lym-2, reactive with human B-lymphocytes and derived tumors, with immunodiagnostic and immunotherapeutic potential. Cancer Res , 47: 830-840, 1987.
16. Geissler, F , Anderson, S. K , Venkatesan, P , and Press, O Intracellular catabolism of radiolabeled anti-μ antibodies by malignant B-cells Cancer Res., 52: 2907-2915, 1992.
17. Geissler, F , Anderson, S. K , and Press, O. Intracellular catabolism of radiolabeled anti-CD3 antibodies by leukemic T cells. Cell. Immunol., 137: 96-110, 1991
18. Press, O W., Howell-Clark, J., Anderson, S , and Bernstein, I Retention of B-cell-specific monoclonal antibodies by human lymphoma cells Blood, 83. 1390-1397, 1994.
19. Mattes, M. J., Lloyd, K. O., and Lewis, J L., Jr. Binding parameters of monoclonal antibodies reactins with ovarian carcinoma ascites cells. Cancer Immunol. Immunother , 28: 199-207, 1989
20. Segal, D M , and Hurwitz, E. Binding of affinity cross-linked oligomers of IgG to cells bearing Fc receptors. J Immunol , 118: 1338-1347, 1977
21. Lansdorp, P. M., Aalberse, R. C., Bos, R., Schutter, W. G., and Van Bruggen, E F. J Cyclic tetramolecular complexes of monoclonal antibodies: a new type of cross-linking reagent Eur. J. Immunol , 16. 679-683, 1986.
22. Hopkins, C. R., and Trowbridge, I. S. Internalization and processing of transferrin and the transform receptor in human carcinoma A431 cells. J Cell Biol., 97: 508-521, 1983
23. Ong G. L , Marria, V., and Mattes, M. J. The fate of antibodies and their radiolabels bound to tumor cells in vitro, the effect of cross-linking at the cell surface and of anti-idiotype antibodies. Cancer Immunol Immunother., 39: 325-331, 1994.
24. Pulczynski, S , Boesen, A. M., and Jensen, O M. Antibody-induced modulation and intracellular transport of CD10 and CD19 antigens in human B-cell lines: an immunofluorescence and immunoelectron microscopy study. Blood, 81: 1549-1557, 1993.
25. Caron, P. C., Laird, W., Co, M S., Avdalovic, N. M , Queen, C., and Scheinberg, D A. Engineered humanized dimeric forms of IgG are more effective antibodies J. Exp. Med , 176 1191-1195, 1992
26. Wolff, E. A., Schreiber, G. J., Cosand, W L , and Raff, H V. Monoclonal antibody homodimers: enhanced antitumor activity in nude mice. Cancer Res , 53. 2560-2565, 1993
27. King, D. J , Turner, A., Farnsworth, A. P. H., Adair, J. R , Owens, R. J , Pedley, R. B., Baldock, D., Proudfoot, K. A., Lawson, A. D. G , Beeley, N R A , Millar, K., Millican, T. A. B , Boyce, A , Antoniw, P., Mountain, A., Begent, R. H J., Shochat, D., and Yarranton, G. T Improved tumor targeting with chemically cross-linked recombinant antibody fragments. Cancer Res., 54: 6176-6185, 1994.
28. Smith, R I. F., Coloma, M. J , and Morrison, S. L Addition of a μ-tailpiece to IgG results in polymeric antibodies with enhanced effector functions including complement-mediated cytolysis by IgG4. J Immunol., 154. 2226-2236, 1995.
29. Ghetie, M-A., May, R. D , Till, M., Uhr, J. W., Ghetie, V , Knowles, P. P., Reif, M. Brown, A., Wallace, P. M., Janossy, G , Amlot, P., Vitetta, E. S , and Thorpe, P E Evaluation of ricin Ab chain-containing immunotoxins directed against CD19 and CD22 antigens on normal and malignant human B-cells as potential reagents for in vivo therapy. Cancer Res., 48: 2610-2617, 1988.
30. Bonardi, M. A , French, R. R., Amlot, P., Gromo, G., Modena, D., and Glennie, M. J Delivery of saporin to human B-cell lymphoma using bispecific antibody: targeting via CD22 but not CD19, CD37, or immunoglobulin results in efficient killing Cancer Res , 53: 3015-3021, 1993.
31. Vervoordeldonk, S F , Merle, P. A., van Leeuwen, E. F., van der Schoot, C. E., von dem Borne, A E. G Kr , and Slaper-Cortenbach, C. M. Fcγ receptor II (CD32) on malignant B cells influences modulation induced by anti-CD 19 monoclonal antibody. Blood, 83. 1632-1639, 1994.
32. Ong, G. L., and Mattes, M. J. Re-evaluation of the concept of functional affinity as applied to bivalent antibody binding to cell surface antigens. Mol. Immunol., 30: 1455-1462, 1993.
33. Kaufman, E. N , and Jain, R. K. Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays Cancer Res., 52: 4157-4167, 1992.
34. Dower, S K , DeLisi, C., Titus, J. A , and Segal, D M. Mechanism of binding of multivalent immune complexes to Fc receptors. 1 Equilibrium binding Biochemistry, 20: 6326-6334, 1981.
35. Ben-Bassat, H., Polliack, A , Mitrani-Rosenbaum, S., Reichert, F., Froimovici, M , and Goldblum, N. A comparative study of human cell lines derived from patients with lymphoma, leukemia and infectious mononucleosis. Cancer (Phila ), 40: 1481-1491, 1977.