Prevalence and characterization of extended-spectrum beta-lactamases producing Enterobacteriaceae in healthy children and associated risk factors

Annals of Clinical Microbiology and Antimicrobials

Volumn 15, Issue 1, 2016, Pages

  Hijazi, S M ^a   Fawzi, M A ^b   Ali, F M ^c   Abd El Galil, K H ^a,d  

^a BEIRUT ARAB UNIVERSITY   (Lebanon)

^b Alexandria University Faculty of Pharmacy   (Egypt)

^c AIN SHAMS UNIVERSITY   (Egypt)

^d University of Mansoura   (Egypt)

Author keywords

Children; CTX 9; CTX M; Dairy products; Extended spectrum beta lactamase; Lebanon; Meat; SHV; TEM

Indexed keywords

BETA LACTAMASE CTX M; BETA LACTAMASE SHV; BACTERIAL PROTEIN; BETA LACTAMASE;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIUM DETECTION; BLACTX M GENE; BLASHV GENE; BLATEM GENE; CHICKEN MEAT; CHILD; CONTROLLED STUDY; DAIRY PRODUCT; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING ENTEROBACTERIACEAE; FOOD INTAKE; HUMAN; LIFESTYLE; MULTIPLEX POLYMERASE CHAIN REACTION; NONHUMAN; NORMAL HUMAN; RISK FACTOR; CLASSIFICATION; ENTEROBACTERIACEAE; ENZYMOLOGY; EPIDEMIOLOGY; FECES; FEMALE; GENETICS; HETEROZYGOTE; HYGIENE; INFANT; ISOLATION AND PURIFICATION; LEBANON; MALE; METABOLISM; MICROBIOLOGY; PLASMID; PRESCHOOL CHILD; PREVALENCE;

BACTERIAL PROTEINS; BETA-LACTAMASES; CARRIER STATE; CHILD, PRESCHOOL; ENTEROBACTERIACEAE; FECES; FEMALE; HUMANS; HYGIENE; INFANT; LEBANON; MALE; PLASMIDS; PREVALENCE;

EID: 84956917503     PISSN: None     EISSN: 14760711     Source Type: Journal    
DOI: 10.1186/s12941-016-0121-9     Document Type: Article

References (46)

1. Bradford PA. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. Clin Microbiol Rev. 2001;14:933-51.
2. Bush K. Alarming beta-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae. Curr Opin Microbiol. 2010;13:558-64.
3. Livermore DM. Current epidemiology and growing resistance of Gram-negative pathogens. Korean J Intern Med. 2012;27:128-42.
4. Livermore DM, Canton R, Gniadkowski M, Nordman P, Rossolini GM, Arlet G, et al. CTX-M: changing the face of ESBLs in Europe. J Antimicrob Chemother. 2007;59:165-74.
5. Karisik E, Ellington MJ, Pike R, Warren RE, Livermore DM, Woodford N. Molecular characterization of plasmids encoding CTX-M-15 beta-lactamases from Escherichia coli strains in the United Kingdom. J Antimicrob Chemother. 2006;58:665-8.
6. Pitout JD. Infections with extended-spectrum beta-lactamase producing Enterobacteriaceae: changing epidemiology and drug treatment choices. Drugs. 2010;70:313-33.
7. Lewis JS, Herrera M, Wickes B, Patterson JE, Jorgensen JH. First report of the emergence of CTX-M-type extended-spectrum beta-lactamases (ESBLs) as the predominant ESBL isolated in a US health care system. Antimicrob Agents Chemother. 2007;51:4015-21.
8. Paterson DL, Bonomo RA. Extended-spectrum beta-lactamases: a clinical update. Clin Microbiol Rev. 2005;18:657-86.
9. Pitout JDD, Laupland KB. Extended-spectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern. Lancet Infect Dis. 2008;8:159-66.
10. Bauernfeind A, Casellas JM, Goldberg M, Holley M, Jungwirth R, Mangold P, et al. A new plasmidic cefotaximase from patients infected with Salmonella typhimurium. Infection. 1992;20:158-63.
11. Cantón R. Epidemiology and evolution of β-lactamases. In: Baquero F, Nombela C, Casslel GH, Gutierrez-Fuentes JA, editors. Evolutionary biology of bacterial and fungal pathogens. Washington: ASM Press; 2008. p. 249-70.
12. Cantón R, Coque TM. The CTX-M β-lactamase pandemic. Curr Opin Microbiol. 2006;9:466-75.
13. Coque TM, Novais A, Carattoli A, Poirel L, Pitout J, Peixe L, et al. Dissemination of clonally related Escherichia coli strains expressing extended-spectrum beta-lactamase CTX-M-15. Emerg Infect Dis. 2008;14:195-200.
14. Valverde A, Coque TM, Sánchez-Moreno MP, Rollán A, Baquero F, Cantón R. Dramatic increase in prevalence of fecal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae during nonoutbreak situations in Spain. J Clin Microbiol. 2004;42:4769-75.
15. Chandramohan L, Revell PA. Prevalence and molecular characterization of extended-spectrum β-lactamase producing Enterobacteriaceae in a pediatric patient population. Antimicrob Agents Chemother. 2012;56:4765.
16. Clinical and Laboratory Standards Institute. Performance standard for antimicrobial disk susceptibility testing: approved standards. 23rd ed. Wayne, PA: CLSI; 2013 (document M100-S20).
17. Integrated DNA Technologies. http://eu.idtdna.com/site. Accessed 21 Sept 2013.
18. Kim J, Jeon S, Lee B, Park M, Lee H, Lee J, et al. Rapid detection of extended spectrum β-lactamase (ESBL) for Enterobacteriaceae by use of a multiplex PCR-based method. Infect Chemother. 2009;41:181-4.
19. Moissenet D, Salauze B, Clermont O, Bingen E, Arlet G, Denamur E, et al. Meningitis caused by Escherichia coli producing TEM-52 extended-spectrum beta-lactamase within an extensive outbreak in a neonatal ward: epidemiological investigation and characterization of the strain. J Clin Microbiol. 2010;48:2459-63.
20. Emori TG, Gaynes RP. An overview of nosocomial infections, including the role of the microbiology laboratory. Clin Microbiol Rev. 1993;6:428-42.
21. Ahmed SF, Ali MM, Mohamed ZK, Moussa TA, Klena JD. Fecal carriage of extended-spectrum β-lactamases and AmpC-producing Escherichia coli in a Libyan community. Ann Clin Microbiol Antimicrob. 2014;13:22.
22. Guimarães B, Barreto A, Radhouani H, Figueiredo N, Gaspar E, Rodrigues J, et al. Genetic detection of extended-spectrum beta-lactamasecontaining Escherichia coli isolates and vancomycin-resistant enterococci in fecal samples of healthy children. Microb Drug Resist. 2009;15:211-6.
23. Kaarme J, Molin Y, Olsen B, Melhus A. Prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in healthy Swedish preschool children. Acta Paediatr. 2013;102:655-60.
24. Kader AA, Kamath KA. Faecal carriage of extended-spectrum beta-lactamase-producing bacteria in the community. East Mediterr Health J. 2009;15:1365-70.
25. Bassyouni RH, Gaber SN, Wegdan AA. Fecal carriage of extended-spectrum β-lactamase- and AmpC-producing Escherichia coli among healthcare workers. J Infect Dev Ctries. 2015;9:304-8.
26. Moubareck C, Daoud Z, Hakime NI, Hamze M, Mangeney N, Matta H, et al. Countrywide spread of community- and hospital-acquired extended-spectrum betalactamase (CTX-M-15)-producing Enterobacteriaceae in Lebanon. J Clin Microbiol. 2005;43:3309-13.
27. Gómez J, García Vázquez E, Ruiz Gómez J. Clinical relevance of bacterial resistance: a historical approach (1982-2007). Rev Esp Quimioter. 2008;21:115-22.
28. Farah R, Lahoud N, Salameh P, Saleh N. Antibiotic dispensation by Lebanese pharmacists: a comparison of higher and lower socio-economic levels. J Infect Public Health. 2015;8:37-46.
29. Geser Nadine, Stephan Roger, Hächler Herbert. Occurrence and characteristics of extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae in food producing animals, minced meat and raw milk. BMC Vet Res. 2012;8:21-30.
30. Casella T, Rodríguez MM, Takahashi JT, Ghiglione B, Dropa M, Assunção E, et al. Detection of blaCTX-M-type genes in complex class 1 integrons carried by Enterobacteriaceae isolated from retail chicken meat in Brazil. Int J Food Microbiol. 2015;16:88-91.
31. Overdevest I, Willemsen I, Rijnsburger M, Eustace A, Xu L, Hawkey P, et al. Extended-spectrum β-lactamase genes of Escherichia coli in chicken meat and humans, The Netherlands. Emerg Infect Dis. 2011;17:1216-22.
32. Kluytmans JA, Overdevest IT, Willemsen I, Kluytmans-van den Bergh MF, van der Zwaluw K, Heck M, et al. Extended-spectrum β-lactamase producing Escherichia coli from retail chicken meat and humans: comparison of strains, plasmids, resistance genes, and virulence factors. Clin Infect Dis. 2013;56:478-87.
33. Leverstein-van Hall MA, Dierikx CM, Cohen Stuart J, Voets GM, van den Munckhof MP, van Essen-Zandbergen A, et al. Dutch patients, retail chicken meat and poultry share the same ESBL genes, plasmids and strains. Clin Microbiol Infect. 2011;17:873-80.
34. Wu G, Day MJ, Mafura MT, Nunez-Garcia J, Fenner JJ, Sharma M, et al. Comparative analysis of ESBL-positive Escherichia coli isolates from animals and humans from the UK, The Netherlands and Germany. PLoS One. 2013;8:e75392.
35. Königer D, Gastmeier P, Kola A, Schwab F, Meyer E. Vegetarians are not less colonized with extended-spectrum-b-lactamase producing bacteria than meat eaters. J Antimicrob Chemother. 2014. doi: 10.1093/jac/dkt335.
36. Grami R, Dahmen S, Mansour W, Mehri W, Haenni M, Aouni M, Madec JY. BlaCTX-M-15-carrying F2: A-: B-plasmid in Escherichia coli from cattle milk in Tunisia. Microb Drug Resist. 2014;20:344-9.
37. Pournaras S, Ikonomidis A, Kristo I, Tsakris A, Maniatis AN. CTX-M enzymes are the most common extended-spectrum β-lactamases among Escherichia coli in a tertiary Greek hospital. J Antimicrob Chemother. 2004;54:574-5.
38. Yan JJ, Hsueh PR, Lu JJ, Chang FY, Shyr JM, Wan JH, et al. Extended-spectrum beta-lactamases and plasmid-mediated AmpC enzymes among clinical isolates of Escherichia coli and Klebsiella pneumoniae from seven medical centers in Taiwan. Antimicrob Agents Chemother. 2006;50:1861-4.
39. Baraniak A, Fiett J, Sulikowska A, Hryniewicz W, Gniadkowski M. Countrywide spread of CTX-M-3 extended-spectrum beta-lactamase-producing microorganisms of the family Enterobacteriaceae in Poland. Antimicrob Agents Chemother. 2002;46:151-9.
40. Rossolini GM, D'Andrea MM, Mugnaioli C. The spread of CTX-M-type extended-spectrum β-lactamases. Clin Microbiol Infect Rev. 2008;14(Suppl. 1):33-41.
41. Cantón R, Novais A, Valverde A, Machado E, Peixe L, Baquero F, et al. Prevalence and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Europe. Clin Microbiol Infect. 2008;14(Suppl. 1):144-53.
42. Bonnet R. Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes. Antimicrob Agents Chemother. 2004;48:1-14.
43. Roy S, Krishnan R, Mukherjee S, Schneiders T, Niyogi SK, Basu S. Prevalence of ST131 virulence-associated strains among CTX-M-producing Escherichia coli in the gut of hospitalized neonates in India. Diagn Microbiol Infect Dis. 2013;77:158.
44. Memariani M, Najar Peerayeh S, Zahraei Salehi T, Shokouhi Mostafavi SK. Occurrence of SHV, TEM and CTX-M β-lactamase genes among enteropathogenic Escherichia coli strains isolated from children with diarrhea. Jundishapur J Microbiol. 2015;8(4):e15620.
45. Birgy André, Cohen Robert, Levy Corinne, Bidet Philippe, Courroux Céline, Benani Mohamed, et al. Community faecal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae in French children. BMC Infect Dis. 2012;12:315.
46. Lahlaoui H, Ben Haj Khalifa A, Ben Moussa M. Epidemiology of Enterobacteriaceae producing CTX-M type extended spectrum β-lactamase (ESBL). Méd Mal Infect Rev. 2014;44:400-4.