Ageing/menopausal status in healthy women and ageing in healthy men differently affect cardiometabolic parameters

International Journal of Medical Sciences

Volumn 13, Issue 2, 2016, Pages 124-132

  Campesi, Ilaria ^a,b   Occhioni, Stefano ^a   Tonolo, Giancarlo ^c   Cherchi, Sara ^c   Basili, Stefania ^d   Carru, Ciriaco ^a,e   Zinellu, Angelo ^a   Franconi, Flavia ^a,f  

^a UNIVERSITY OF SASSARI   (Italy)

^b NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

^c San Giovanni di Dio Hospital   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e UNIVERSITY HOSPITAL OF SASSARI   (Italy)

^f Assessorato alle Politiche per la Persona of Basilicata Region   (Italy)

Author keywords

Ageing; Ageing menopausal status; Endothelial function; Gender; Inflammation; Oxidative stress

Indexed keywords

6 N,N' DIMETHYLARGININE; CARBONYL DERIVATIVE; CHOLESTEROL; CREATININE; HEMOGLOBIN; INTERLEUKIN 6; MALONALDEHYDE; N(G),N(G) DIMETHYLARGININE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; ARGININE; IL6 PROTEIN, HUMAN; N,N-DIMETHYLARGININE; TUMOR NECROSIS FACTOR;

ADULT; AGING; ARTICLE; BODY WEIGHT; CARDIOVASCULAR PARAMETERS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CREATININE BLOOD LEVEL; ENDOTHELIAL DYSFUNCTION; ERYTHROCYTE; FEMALE; HEMOGLOBIN BLOOD LEVEL; HUMAN; MALE; MENOPAUSE; METABOLIC PARAMETERS; NORMAL HUMAN; OXIDATIVE STRESS; POSTMENOPAUSE; PREMENOPAUSE; PROTEIN BLOOD LEVEL; SEX DIFFERENCE; TRIACYLGLYCEROL BLOOD LEVEL; ANALOGS AND DERIVATIVES; BLOOD; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PROTEIN CARBONYLATION; RISK FACTOR;

ADULT; AGING; ARGININE; BLOOD; BODY WEIGHT; FEMALE; HUMANS; INTERLEUKIN-6; MALE; MALONDIALDEHYDE; MIDDLE AGED; OXIDATIVE STRESS; POSTMENOPAUSE; PREMENOPAUSE; PROTEIN CARBONYLATION; RISK FACTORS; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84956913213     PISSN: 14491907     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijms.14163     Document Type: Article

References (36)

1. Legato MJ. Principles of Gender-Specific Medicine: 2.2. Academic Press, Elsevier; 2009.
2. Franconi F, Campesi I. Pharmacogenomics, pharmacokinetics and pharmacodynamics: interaction with biological differences between men and women. Br J Pharmacol. 2014; 171: 580-94.
3. Regitz-Zagrosek V. Sex and Gender Differences in Pharmacology: Springer; 2012.
4. Vrachnis N, Zygouris D, Iliodromiti Z, Daniilidis A, Valsamakis G, Kalantaridou S. Probing the impact of sex steroids and menopause-related sex steroid deprivation on modulation of immune senescence. Maturitas. 2014; 78: 174-8.
5. Arenas IA, Armstrong SJ, Xu Y, Davidge ST. Chronic tumor necrosis factor- alpha inhibition enhances NO modulation of vascular function in estrogen- deficient rats. Hypertension. 2005; 46: 76-81.
6. Csiszar A, Labinskyy N, Smith K, Rivera A, Orosz Z, Ungvari Z. Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging. Am J Pathol. 2007; 170: 388-98.
7. Starkweather AR. The effects of exercise on perceived stress and IL-6 levels among older adults. Biol Res Nurs. 2007; 8: 186-94.
8. Kim OY, Chae JS, Paik JK, Seo HS, Jang Y, Cavaillon JM, et al. Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women. Age (Dordr). 2012; 34: 415-25.
9. Cioffi M, Esposito K, Vietri MT, Gazzerro P, D'Auria A, Ardovino I, et al. Cytokine pattern in postmenopause. Maturitas. 2002; 41: 187-92.
10. Malutan AM, Mihu D, Costin N, Mihu C. Proinflammatory and anti- inflammatory cytokine changes related to menopause. Prz Menopauzalny. 2014; 13: 162-8.
11. Stowe RP, Peek MK, Cutchin MP, Goodwin JS. Plasma cytokine levels in a population-based study: relation to age and ethnicity. J Gerontol A Biol Sci Med Sci. 2010; 65: 429-33.
12. Goy B, Atmaca M, Aslan M, Ucler R, Alay M, Seven I, et al. Relationship between serum DHEAS and oxidative stress levels of body mass index in healthy postmenopausal women. Redox Rep. 2015.
13. Kolesnikova L, Semenova N, Madaeva I, Suturina L, Solodova E, Grebenkina L, et al. Antioxidant status in peri- and postmenopausal women. Maturitas. 2015; 81: 83-7.
14. Mata-Granados JM, Cuenca-Acebedo R, Luque de Castro MD, Quesada Gomez JM. Lower vitamin E serum levels are associated with osteoporosis in early postmenopausal women: a cross-sectional study. J Bone Miner Metab. 2013; 31: 455-60.
15. Bacon SL, Lavoie KL, Arsenault A, Dupuis J, Pilote L, Laurin C, et al. The research on endothelial function in women and men at risk for cardiovascular disease (REWARD) study: methodology. BMC Cardiovasc Disord. 2011; 11: 50.
16. Edirisinghe I, Rahman I. Cigarette smoke-mediated oxidative stress, shear stress, and endothelial dysfunction: role of VEGFR2. Ann N Y Acad Sci. 2010; 1203: 66-72.
17. Schepers E, Barreto DV, Liabeuf S, Glorieux G, Eloot S, Barreto FC, et al. Symmetric dimethylarginine as a proinflammatory agent in chronic kidney disease. Clin J Am Soc Nephrol. 2011; 6: 2374-83.
18. Tanahashi K, Akazawa N, Miyaki A, Choi Y, Ra SG, Matsubara T, et al. Plasma ADMA concentrations associate with aerobic fitness in postmenopausal women. Life Sci. 2014; 108: 30-3.
19. Sverdlov AL, Ngo DT, Chan WP, Chirkov YY, Horowitz JD. Aging of the nitric oxide system: are we as old as our NO? J Am Heart Assoc. 2014; 3.
20. Campesi I, Galistu A, Carru C, Franconi F, Fois M, Zinellu A. Glutamyl cycle in the rat liver appears to be sex-gender specific. Exp Toxicol Pathol. 2013; 65: 585-9.
21. Campesi I, Straface E, Occhioni S, Montella A, Franconi F. Protein oxidation seems to be linked to constitutive autophagy: a sex study. Life Sci. 2013; 93: 145-52.
22. Zinellu A, Sotgia S, Usai MF, Pintus G, Deiana L, Carru C. Improved method for plasma ADMA, SDMA, and arginine quantification by field-amplified sample injection capillary electrophoresis UV detection. Anal Bioanal Chem. 2011; 399: 1815-21.
23. Wang K, Li M, Bucan M. Pathway-based approaches for analysis of genomewide association studies. Am J Hum Genet. 2007; 81: 1278-83.
24. Sibal L, Agarwal SC, Home PD, Boger RH. The role of asymmetric dimethylarginine (ADMA) in endothelial dysfunction and cardiovascular disease. Curr Cardiol Rev. 2010; 6: 82-90.
25. Campesi I, Carru C, Zinellu A, Occhioni S, Sanna M, Palermo M, et al. Regular cigarette smoking influences the transsulfuration pathway, endothelial function, and inflammation biomarkers in a sex-gender specific manner in healthy young humans. Am J Transl Res. 2013; 5: 497-509.
26. van Bussel BC, Schouten F, Henry RM, Schalkwijk CG, de Boer MR, Ferreira I, et al. Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period. Hypertension. 2011; 58: 588-95.
27. Maurel S, Hamon B, Taillandier J, Rudant E, Bonhomme-Faivre L, Trivalle C. Prognostic value of serum interleukin-6 (IL-6) levels in long term care. Arch Gerontol Geriatr. 2007; 45: 65-71.
28. Bruunsgaard H, Pedersen BK. Age-related inflammatory cytokines and disease. Immunol Allergy Clin North Am. 2003; 23: 15-39.
29. Ahluwalia N, Mastro AM, Ball R, Miles MP, Rajendra R, Handte G. Cytokine production by stimulated mononuclear cells did not change with aging in apparently healthy, well-nourished women. Mech Ageing Dev. 2001; 122: 1269-79.
30. Forsey RJ, Thompson JM, Ernerudh J, Hurst TL, Strindhall J, Johansson B, et al. Plasma cytokine profiles in elderly humans. Mech Ageing Dev. 2003; 124: 487-93.
31. O'Brien SM, Fitzgerald P, Scully P, Landers A, Scott LV, Dinan TG. Impact of gender and menstrual cycle phase on plasma cytokine concentrations. Neuroimmunomodulation. 2007; 14: 84-90.
32. Ferrucci L, Corsi A, Lauretani F, Bandinelli S, Bartali B, Taub DD, et al. The origins of age-related proinflammatory state. Blood. 2005; 105: 2294-9.
33. Tousoulis D, Kampoli AM, Tentolouris C, Papageorgiou N, Stefanadis C. The role of nitric oxide on endothelial function. Curr Vasc Pharmacol. 2012; 10: 4-18.
34. Palmieri B, Sblendorio V. Oxidative stress detection: what for? Part II. Eur Rev Med Pharmacol Sci. 2007; 11: 27-54.
35. Sanchez-Rodriguez MA, Zacarias-Flores M, Arronte-Rosales A, Correa-Munoz E, Mendoza-Nunez VM. Menopause as risk factor for oxidative stress. Menopause. 2012; 19: 361-7.
36. Elias-Smale SE, Gunal A, Maas AH. Gynecardiology: Distinct patterns of ischemic heart disease in middle-aged women. Maturitas. 2015; 81: 348-52.