3-Deoxyglucosone Induced Acute Glucose Intolerance in Sprague-Dawley Rats: Involvement of Insulin Resistance and Impaired β-cell Function

Experimental and Clinical Endocrinology and Diabetes

Volumn 124, Issue 7, 2016, Pages 431-436

  Liang, G ^a   Song, X ^a   Xu, H ^a   Wang, F ^a   Zhang, L ^a   Zhou, L ^a   Jiang, G ^a  

^a Suzhou Hospital of Traditional Chinese Medicine   (China)

Author keywords

3 deoxyglucosone; aminoguanidine; diabetes; glucose intolerance

Indexed keywords

3 DEOXYGLUCOSONE; AMINOGUANIDINE; GLUCOSE; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; 3-DEOXYGLUCOSONE; DEOXYGLUCOSE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETES MELLITUS; DRUG TARGETING; GLUCOSE INTOLERANCE; GLUCOSE TRANSPORT; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; LIVER; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PANCREATIC TISSUE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; DEOXYGLUCOSE; GLUCOSE INTOLERANCE; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84956892333     PISSN: 09477349     EISSN: 14393646     Source Type: Journal    
DOI: 10.1055/s-0035-1565193     Document Type: Article

References (26)

1. Kusunoki H., Miyata S., Ohara T. et al. Relation between serum 3-deoxyglucosone and development of diabetic microangiopathy. Diabetes Care: 2003; 26 1889 1894
2. Eriksson U. J., Wentzel P., Minhas H. S. et al. Teratogenicity of 3-deoxyglucosone and diabetic embryopathy. Diabetes: 1998; 47 1960 1966
3. Beisswenger P. J., Howell S., Stevens R. et al. The role of 3-deoxyglucosone and the activity of its degradative pathways in the etiology of diabetic microvasculardisease. In: O'Brien J., Nursten H., Crabbe M., Ames J. (eds.). The maillard reaction in foods and medicine. Cambridge Royal Society of Chemistry Press: 1998; 298 303
4. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature: 2001; 414 813 820
5. Maessen D. E., Hanssen N. M., Scheijen J. L. et al. Post-glucose load plasma α-dicarbonyl concentrations are increased in individuals with impaired glucose metabolism and type 2 diabetes: the CODAM study. Diabetes Care: 2015; 38 913 920
6. Degen J., Beyer H., Heymann B. et al. Dietary influence on urinary excretion of 3-deoxyglucosone and its metabolite 3-deoxyfructose. J Agric Food Chem: 2014; 19 2449 2456
7. Hamada Y., Nakamura J., Fujisawa H. et al. Effects of glycemic control on plasma 3-deoxyglucosone levels in NIDDM patients. Diabetes Care: 1997; 20 1466 1469
8. Beisswenger P. J., Howell S. K., O'Dell R. M. et al. Alpha-Dicarbonyls increase in the postprandial period and reflect the degree of hyperglycemia. Diabetes Care: 2001; 24 726 732
9. Lal S., Kappler F., Walker M. et al. Quantitation of 3-deoxyglucosone levels in human plasma. Arch Biochem Biophys: 1997; 342 254 260
10. Jiang G., Zhang L., Ji Q. et al. Accumulation of plasma 3-deoxyglucosone impaired glucose regulation in Chinese seniors: implication for senile diabetes? Diabetes Metab Syndr: 2012; 6 140 145
11. Niwa T. 3-Deoxyglucosone: metabolism, analysis, biological activity, and clinical implication. J Chromatogr B Biomed Sci Appl: 1999; 731 23 36
12. Kato H., van Chuyen N., Shinoda T. et al. Metabolism of 3-deoxyglucosone, an intermediate compound in the Maillard reaction, administered orally or intravenously to rats. Biochim Biophys Acta: 1990; 1035 71 76
13. Jiang G. L., Zhang L. V., Wang F. et al. Synthesis and structure analysis of the 3-deoxyglucosone(3-DG). J Soochow Univ: 2011; 27 60 68
14. Zhang L., Jiang G., Yao F. et al. Growth inhibition and apoptosis induced by osthole, a natural coumarin, in hepatocellular carcinoma. PLoS One: 2012; 7 e37865
15. Kahn S. E., Cooper M. E., Del Prato S. Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet: 2014; 383 1068 1083
16. Yamada H., Miyata S., Igaki N. et al. Increase in 3-deoxyglucosone levels in diabetic rat plasma. Specific in vivo determination of intermediate in advanced Maillard reaction. J Biol Chem: 1994; 269 20275 20280
17. Reaven G. M. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes: 1988; 37 1595 1607
18. Sakiyama H., Takahashi M., Yamamoto T. et al. The internalization and metabolism of 3-deoxyglucosone in human umbilical vein endothelial cells. J Biochem: 2006; 139 245 253
19. Sassi-Gaha S., Loughlin D. T., Kappler F. et al. Two dicarbonyl compounds, 3-deoxyglucosone and methylglyoxal, differentially modulate dermal fibroblasts. Matrix Biol: 2010; 29 127 134
20. Pan Y., Qiao Q. Y., Pan L. H. et al. Losartan reduces insulin resistance by inhibiting oxidative stress and enhancing insulin signaling transduction. Exp Clin Endocrinol Diabetes: 2015; 123 170 177
21. Nomura M., Takahashi T., Nagata N. et al. Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells. Biol Pharm Bull: 2008; 31 1403 1409
22. Li Z., Shangguan Z., Liu Y. et al. Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway. J Mol Endocrinol: 2014; 53 71 79
23. Nogueira T. C., Anhê G. F., Carvalho C. R. et al. Involvement of phosphatidylinositol-3 kinase/AKT/PKCzeta/lambda pathway in the effect of palmitate on glucose-induced insulin secretion. Pancreas: 2008; 37 309 315
24. Kikuchi S., Shinpo K., Moriwaka F. et al. Neurotoxicity of methylglyoxal and 3-deoxyglucosone on cultured cortical neurons: Synergism between glycation and oxidative stress, possibly involved in neurodegenerative diseases. J Neurosci Res: 1999; 57 280 289
25. Dhar A., Desai K. L. Alagebrium attenuates acute methylglyoxal-induced glucose intolerance in Sprague-Dawley rats. Br J Pharmacol: 2010; 159 166 175
26. Kato H., van Chuyen N., Shinoda T. et al. Metabolism of 3-deoxyglucosone, an intermediate compound in the Maillard reaction, administered orally or intravenously to rats. Biochim Biophys Acta: 1990; 1035 71 76