Peroxisome proliferator-activated receptor-α-mediated transcription of miR-301a and miR-454 and their host gene SKA2 regulates endothelin-1 and PAI-1 expression in sickle cell disease

Bioscience Reports

Volumn 35, Issue 6, 2015, Pages

  Gonsalves, Caryn S ^a   Li, Chen ^a   Malik, Punam ^b   Tahara, Stanley M ^a   Kalra, Vijay K ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Endothelin 1 (ET 1); Micro ribonucleic acid (miRNA); Peroxisome proliferator activated receptor (PPAR ); Plasminogen activator inhibitor 1 (PAI 1); Sickle cell disease (SCD); Spindle and kinetochore associated protein 2 (SKA2)

Indexed keywords

ENDOTHELIN 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MICRORNA; MICRORNA 301A; MICRORNA 454; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PLASMINOGEN ACTIVATOR INHIBITOR 1; UNCLASSIFIED DRUG; FENOFIBRATE; HIF1A PROTEIN, HUMAN; MIRN301 MICRORNA, HUMAN; MIRN454 MICRORNA, HUMAN; NONHISTONE PROTEIN; PGF PROTEIN, HUMAN; PGF PROTEIN, MOUSE; PLACENTA PROTEIN; PLACENTAL GROWTH FACTOR; SERPINE1 PROTEIN, HUMAN; SKA2 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHILD; CONTROLLED STUDY; CORRELATIONAL STUDY; FEMALE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; INTRON; MALE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; RNA TRANSCRIPTION; SICKLE CELL ANEMIA; SKA2 GENE; ANEMIA, SICKLE CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; COMPLICATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HYPERTENSION, PULMONARY; METABOLISM; PATHOLOGY; PROMOTER REGION;

ANEMIA, SICKLE CELL; ANIMALS; CELL LINE; CHROMOSOMAL PROTEINS, NON-HISTONE; ENDOTHELIN-1; FENOFIBRATE; GENE EXPRESSION REGULATION; HUMANS; HYPERTENSION, PULMONARY; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICRORNAS; PLACENTA GROWTH FACTOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; PPAR ALPHA; PREGNANCY PROTEINS; PROMOTER REGIONS, GENETIC;

EID: 84956878370     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20150190     Document Type: Article

References (34)

1. Gladwin, M.T., Barst, R.J., Castro, O.L., Gordeuk, V.R., Hillery, C.A., Kato, G.J., Kim-Shapiro, D.B., Machado, R., Morris, C.R., Steinberg, M.H. and Vichinsky, E.P. (2010) Pulmonary hypertension and NO in sickle cell. Blood 116, 852-854 CrossRef PubMed
2. Machado, R.F. and Gladwin, M.T. (2010) Pulmonary hypertension in hemolytic disorders: pulmonary vascular disease: the global perspective. Chest 137, 30S-38S CrossRef PubMed
3. Gladwin, M.T., Sachdev, V., Jison, M.L., Shizukuda, Y., Plehn, J.F., Minter, K., Brown, B., Coles, W.A., Nichols, J.S., Ernst, I. et al. (2004) Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. N. Engl. J. Med. 350, 886-895 CrossRef PubMed
4. Hsu, L.L., Champion, H.C., Campbell-Lee, S.A., Bivalacqua, T.J., Manci, E.A., Diwan, B.A., Schimel, D.M., Cochard, A.E., Wang, X., Schechter, A.N. et al. (2007) Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability. Blood 109, 3088-3098 CrossRef PubMed
5. Bunn, H.F., Nathan, D.G., Dover, G.J., Hebbel, R.P., Platt, O.S., Rosse, W.F. and Ware, R.E. (2010) Pulmonary hypertension and nitric oxide depletion in sickle cell disease. Blood 116, 687-692 CrossRef PubMed
6. Sundaram, N., Tailor, A., Mendelsohn, L., Wansapura, J., Wang, X., Higashimoto, T., Pauciulo, M.W., Gottliebson, W., Kalra, V.K., Nichols, W.C. et al. (2010) High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension. Blood 116, 109-112 CrossRef PubMed
7. Phelan, M.W. and Faller, D.V. (1996) Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial cells. J. Cell. Physiol. 167, 469-476 CrossRef PubMed
8. Patel, N., Gonsalves, C.S., Malik, P. and Kalra, V.K. (2008) Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1 alpha. Blood 112, 856-865 CrossRef PubMed
9. Reiter, C.D., Wang, X., Tanus-Santos, J.E., Hogg, N., Cannon, R.O., Schechter, A.N. and Gladwin, M.T. (2002) Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat. Med. 8, 1383-1389 CrossRef PubMed
10. Rybicki, A.C. and Benjamin, L.J. (1998) Increased levels of endothelin-1 in plasma of sickle cell anemia patients. Blood 92, 2594-2596 PubMed
11. Hu, J., Discher, D.J., Bishopric, N.H. and Webster, K.A. (1998) Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand. Biochem. Biophys. Res. Commun. 245, 894-899 CrossRef PubMed
12. Kourembanas, S., Marsden, P.A., McQuillan, L.P. and Faller, D.V. (1991) Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J. Clin. Invest. 88, 1054-1057 CrossRef PubMed
13. Sabaa, N., de Franceschi, L., Bonnin, P., Castier, Y., Malpeli, G., Debbabi, H., Galaup, A., Maier-Redelsperger, M., Vandermeersch, S., Scarpa, A. et al. (2008) Endothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle-cell disease. J. Clin. Invest. 118, 1924-1933 CrossRef PubMed
14. Key, N.S., Slungaard, A., Dandelet, L., Nelson, S.C., Moertel, C., Styles, L.A., Kuypers, F.A. and Bach, R.R. (1998) Whole blood tissue factor procoagulant activity is elevated in patients with sickle cell disease. Blood 91, 4216-4223 PubMed
15. Nsiri, B., Gritli, N., Mazigh, C., Ghazouani, E., Fattoum, S. and Machghoul, S. (1997) Fibrinolytic response to venous occlusion in patients with homozygous sickle cell disease. Hematol. Cell. Ther. 39, 229-232 CrossRef PubMed
16. Ataga, K.I., Moore, C.G., Hillery, C.A., Jones, S., Whinna, H.C., Strayhorn, D., Sohier, C., Hinderliter, A., Praise, L.V. and Oringer, E.P. (2008) Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension. Hematologica 93, 20-2617 CrossRef
17. Hillery, C.A. and Panepinto, J.A. (2004) Pathophysiology of stroke in sickle cell disease. Microcirculation 11, 195-208 CrossRef PubMed
18. Keeton, M.R., Curriden, S.A., van Zonneveld, A.J. and Loskutoff, D.J. (1991) Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta. J. Biol. Chem. 266, 23048-23052 PubMed
19. Fink, T., Kazlauskas, A., Poellinger, L., Ebbesen, P. and Zachar, V. (2002) Identification of a tightly regulated hypoxia-response element in the promoter of human plasminogen activator inhibitor-1. Blood 99, 2077-2083 CrossRef PubMed
20. Arndt, P.G., Young, S.K. and Worthen, G.S. (2005) Regulation of lipopolysaccharide-induced lung inflammation by plasminogen activator inhibitor-1 through a JNK-mediated pathway. J. Immunol. 175, 4049-4059 CrossRef PubMed
21. Perelman, N., Selvaraj, S.K., Batra, S., Luck, L.R., Erdreich-Epstein, A., Coates, T.D., Kalra, V.K. and Malik, P. (2003) Placenta growth factor activates monocytes and correlates with sickle cell disease severity. Blood 102, 1506-1514 CrossRef PubMed
22. Brittain, J.E., Hulkower, B., Jones, S.K., Strayhorn, D., De Castro, L., Telen, M.J., Orringer, E.P., Hinderliter, A. and Ataga, K.I. (2010) Placenta growth factor in sickle cell disease: association with hemolysis and inflammation. Blood 115, 2014-2020 CrossRef PubMed
23. Patel, N., Sundaram, N., Yang, M., Madigan, C., Kalra, V.K. and Malik, P. (2010) Placenta growth factor (PlGF), a novel inducer of plasminogen activator inhibitor-1 (PAI-1) in sickle cell disease (SCD). J. Biol. Chem. 285, 16713-16722 CrossRef PubMed
24. Patel, N., Tahara, S.M., Malik, P. and Kalra, V.K. (2011) Involvement of miR-30c and miR-301a in immediate induction of plasminogen activator inhibitor-1 by placenta growth factor in human pulmonary endothelial cells. Biochem. J. 434, 473-482 CrossRef PubMed
25. Li, C., Mpollo, M.-S.E.M., Gonsalves, C.S., Tahara, S.M., Malik, P. and Kalra, V.K. (2014) Peroxisome proliferator-activated receptor-α-mediated transcription of miR-199a2 attenuates endothelin-1 expression via hypoxia-inducible factor-1α. J. Biol. Chem. 289, 36031-36047 CrossRef PubMed
26. Kim, K.S., Rajagopal, V., Gonsalves, C., Johnson, C. and Kalra, V.K. (2006) A novel role of hypoxia-inducible factor in cobalt chloride-and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells. J. Immunol. 177, 7211-7224 CrossRef PubMed
27. Pászty, C., Brion, C.M., Manci, E., Witkowska, H.E., Stevens, M.E., Mohandas, N. and Rubin, E.M. (1997) Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease. Science 278, 876-878 CrossRef PubMed
28. Patel, N., Gonsalves, C.S., Yang, M., Malik, P. and Kalra, V.K. (2009) Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease. Blood 113, 1129-1138 CrossRef PubMed
29. Schanen, B.C. and Li, X. (2011) Transcriptional regulation of mammalian miRNA genes. Genomics 97, 1-6 CrossRef PubMed
30. Xiao, Z.-D., Diao, L.-T., Yang, J.-H., Xu, H., Huang, M.-B., Deng, Y.-J., Zhou, H. and Qu, L.-H. (2013) Deciphering the transcriptional regulation of microRNA genes in humans with ACTLocater. Nucleic Acids Res. 41, e5 CrossRef PubMed
31. Guo, Z., Maki, M., Ding, R., Yang, Y., zhang, B. and Xiong, L. (2014) Genome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues. Sci. Rep. 4, 5150 PubMed
32. Lee, Y.-B., Bantounas, I., Lee, D.-Y., Phylactou, L., Caldwell, M.A. and Uney, J.B. (2009) Twist-1 regulates the miR-199a/214 cluster during development. Nucleic Acids Res. 37, 123-128 CrossRef PubMed
33. Cao, G., Huang, B., Liu, Z., Zhang, J., Xu, H., Xia, W., Li, J., Li, S., Chen, L., Ding, H. et al. (2010) Intronic miR-301 feedback regulates its host gene, ska2, in A549 cells by targeting MEOX2 to affect ERK/CREB pathways. Biochem. Biophys. Res. Commun. 396, 978-982 CrossRef PubMed
34. Lalloyer, F. and Staels, B. (2010) Fibrates, glitazones, and peroxisome proliferator-activated receptors. Atertio. Thromb. Vasc. Biol. 30, 894-899 CrossRef