A key role of insulin receptors in memory

Diabetes

Volumn 64, Issue 11, 2015, Pages 3653-3655

  De Felice, Fernanda G ^a,b,c   Benedict, Christian ^d  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b D OR INSTITUTE FOR RESEARCH AND EDUCATION IDOR   (Brazil)

^c QUEEN S UNIVERSITY   (Canada)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; INSULIN RECEPTOR;

ALZHEIMER DISEASE; BRAIN FUNCTION; COGNITIVE DEFECT; ENERGY BALANCE; GENE DELETION; HIPPOCAMPAL NEURONAL CULTURE; HIPPOCAMPUS; HUMAN; INSULIN RESISTANCE; MEMORY; MEMORY DISORDER; NERVE CELL PLASTICITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ANIMAL; GENETICS; MALE; METABOLISM; PHYSIOLOGY; SPATIAL LEARNING;

ANIMALS; HIPPOCAMPUS; INSULIN RESISTANCE; MALE; NEURONAL PLASTICITY; RECEPTOR, INSULIN; SPATIAL LEARNING;

EID: 84956850153     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/dbi15-0011     Document Type: Note

References (19)

1. Banting FG, Best CH. The internal secretion of the pancreas. 1922. Indian J Med Res 2007;125:251-266
2. Cahill GF Jr. The Banting Memorial Lecture 1971. Physiology of insulin in man. Diabetes 1971;20:785-799
3. Porte D Jr, Baskin DG, Schwartz MW. Insulin signaling in the central nervous system: a critical role in metabolic homeostasis and disease from C. elegans to humans. Diabetes 2005;54:1264-1276
4. Sara VR, Hall K, Von Holtz H, Humbel R, Sjögren B, Wetterberg L. Evidence for the presence of specific receptors for insulin-like growth factors 1 (IGE-1) and 2 (IGF-2) and insulin throughout the adult human brain. Neurosci Lett 1982;34:39-44
5. De Felice FG. Alzheimer's disease and insulin resistance: translating basic science into clinical applications. J Clin Invest 2013;123:531-539
6. De Felice FG, Vieira MN, Bomfim TR, et al. Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc Natl Acad Sci U S A 2009;106:1971-1976
7. Chapman CD, Frey WH 2nd, Craft S, et al. Intranasal treatment of central nervous system dysfunction in humans. Pharm Res 2013;30:2475-2484
8. Shemesh E, Rudich A, Harman-Boehm I, Cukierman-Yaffe T. Effect of intranasal insulin on cognitive function: a systematic review. J Clin Endocrinol Metab 2012;97:366-376
9. Kleinridders A, Cai W, Cappellucci L, et al. Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. Proc Natl Acad Sci U S A 2015;112:3463-3468
10. Schubert M, Gautam D, Surjo D, et al. Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A 2004;101:3100-3105
11. Grillo CA, Piroli GG, Lawrence RC, et al. Hippocampal insulin resistance impairs spatial learning and synaptic plasticity. Diabetes 2015;64:3927-3936
12. Freiherr J, Hallschmid M, Frey WH 2nd, et al. Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence. CNS Drugs 2013;27:505-514
13. De Felice FG, Ferreira ST. Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease. Diabetes 2014;63:2262-2272
14. Biessels GJ, Reijmer YD. Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI? Diabetes 2014;63:2244-2252
15. Benedict C, Brooks SJ, Kullberg J, et al. Impaired insulin sensitivity as indexed by the HOMA score is associated with deficits in verbal fluency and temporal lobe gray matter volume in the elderly. Diabetes Care 2012;35:488-494
16. Willette AA, Bendlin BB, Starks EJ, et al. Association of insulin resistance with cerebral glucose uptake in late middle-aged adults at risk for alzheimer disease. JAMA Neurol. 27 July 2015 [Epub ahead of print]. DOI: 10.1001/jamaneurol.2015.0613
17. Talbot K, Wang HY, Kazi H, et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest 2012;122:1316-1338
18. Bomfim TR, Forny-Germano L, Sathler LB, et al. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Ab oligomers. J Clin Invest 2012;122:1339-1353
19. Lourenco MV, Clarke JR, Frozza RL, et al. TNF- A mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys. Cell Metab 2013;18:831-843