Clozapine: Gold standard treatment for refractory schizophrenia: Now or never?

Treatment-Refractory Schizophrenia: A Clinical Conundrum

Volumn , Issue , 2014, Pages 81-92

  Schulte, P ^a   MacCabe, James H ^b  

^a Mental Health Service Noord Holland Noord and The Netherlands Clozapine Collaboration Group   (Netherlands)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84956748430     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-45257-4_6     Document Type: Chapter

References (58)

1. Aitken AE, Richardsen TA, Morgan ET (2006) Regulation of drug-metabolizing enzymes. Annu Rev Pharmacol Toxicol 46:123-149
2. Arbouw ME, Movig KL, Koopmann M, Poels PJ, Guchelaar HJ, Egberts TC, Neef C, van Vugt JP (2010) Glycopyrrolate for sialorrhea in Parkinson disease: a randomized, double-blind, crossover trial. Neurology 74(15):1203-1207
3. Borer JS (2008) Heart rate: from risk marker to risk factor. Eur Heart J Suppl 10:F2-F6
4. Calderon J, Rubin E, Sobota W (2000) Potential use of ipratropium bromide for the treatment of clozapine-induced hypersalivation: a preliminary report. Int Clin Psychopharmacol 15:49-52
5. Chen CH, Huang MC, Kao CF, Lin SK, Kuo PH, Chiu CC, Lu ML (2013) Effects of adjunctive metformin on metabolic traits in nondiabetic clozapine-treated patients with schizophrenia and the effect of metformin discontinuation on body weight: a 24-week, randomized, double-blind, placebo-controlled study. J Clin Psychiatry 74(5):e424-e430
6. Christiaens V, Pieters G (2005) Hypersalivatie door clozapine: oorzaken en behandelmogelijkheden. Tijdschr Psychiatr 47:39-44
7. Cohen D, Bogers JPM, van Dijk D, Bakker B, Schulte PFJ (2012) Beyond white blood cell monitoring: screening in the initial phase of clozapine therapy. J Clin Psychiatry 73:1307-1312
8. Comley C, Gallelty C, Ash D (2000) Use of atropine eye drops for clozapine induced hypersalivation. Aust N Z J Psychiatry 34:1033-1034
9. Conus P, Nanzer N, Baumann P (2001) An alternative to interruption of treatment in recurrent clozapine-induced severe neutropenia. Br J Psychiatry 179:180
10. Crawford JH, Yang S, Zhou M, Simms HH, Wang P (2004) Down-regulation of hepatic CYP1A2 plays an important role in inflammatory responses in sepsis. Crit Care Med 32(2):502-508
11. Crespel A, Genton P, Berramdane M, Coubes P, Monicard C, Baldy-Moulinier M, Gelisse P (2005) Lamotrigine associated wiThexacerbation or de novo myoclonus in idiopathic generalized epilepsies. Neurology 65(5):762-764
12. Crews MP, Dhillon GS, MacCabe JH (2010) Clozapine rechallenge following clozapine-induced pericarditis. J Clin Psychiatry 71(7):959-961
13. De Leon J (2004) Respiratory infections rather than antibiotics may increase clozapine levels: a critical review of the literature. J Clin Psychiatry 65:1144-1145
14. Essali A, Al-Haj Haasan N, Li C, Rathbone J (2009) Clozapine versus typical neuroleptic medication for schizophrenia. Cochrane Database Syst Rev 1, CD000059. doi:10.1002/14651858.CD000059.pub2
15. Fan X, Borba CP, Copeland P, Hayden D, Freudenreich O, GoffDC, Henderson DC (2013) Metabolic effects of adjunctive aripiprazole in clozapine-treated patients with schizophrenia. Acta Psychiatr Scand 127(3):217-226
16. Fischer RB, Eichhorn M (2001) Was tun bei neuroleptikainduzierter hypersalivation? Psychiatr Prax 28:249-250
17. Fleischhacker WW, Heikkinen ME, Olié JP, Landsberg W, Dewaele P, McQuade RD, Loze JY, Hennicken D, Kerselaers W (2010) Effects of adjunctive treatment with aripiprazole on body weight and clinical efficacy in schizophrenia patients treated with clozapine: a randomized, double-blind, placebo-controlled trial. Int J Neuropsychopharmacol 13(8):1115-1125. doi:10.1017/S1461145710000490
18. Freudenreich O, Beebe M, Goff DC (2004) Clozapine-induced sialorrhea treated with sublingual ipratropium spray: a case-series. J Clin Psychopharmacol 24:98-100
19. Gaftanyuk O, Trestman RL (2004) Scopolamine patch for clozapine-induced sialorrhea. Psychiatr Serv 55:318
20. Ghaznavi S, Nakic M, Rao P, Hu J, Brewer JA et al (2008) Rechallenging with clozapine following neutropenia: treatment options for refractory schizophrenia. Am J Psychiatry 165 (7):813-818
21. Hägg S, Rosenius S, Spigset O (2003) Long-term combination with clozapine and filgrastim in patients with clozapine-induced agranulocytosis. Int Clin Psychopharmacol 18:173-174
22. Hockstein NG, Samadi DS, Gendron K, Handler SD (2004) Sialorrhea: a management challenge. Am Fam Physician 69(11):2628-2634
23. Hyson HC, Johnson AM, Jog MJ (2002) Sublingual atropine for sialorrhea secondary to Parkinsonism: a pilot study. Mov Disord 17:1318-1320
24. Kane JM, Correll CU (2010) Past and present progress in the pharmacologic treatment of schizophrenia. J Clin Psychiatry 71(9):1115-1124. doi:10.4088/JCP.10r06264yel
25. Kanaan R, Kerwin RW (2006) Lithium and clozapine re-challenge: a retrospective case analysis. J Clin Psychiatry 67:756-760
26. Kluge M, Schuld A, Himmerich H et al (2007) Clozapine and olanzapine are associated with food craving and binge eating. Results from a randomized double-blind study. J Clin Psychopharmacol 27:662-666
27. Lally J, Brook J, Dixon T, Gaughran F, Shergill S, Melikian N, MacCabe JH. Ivabradine, a novel treatment for clozapine induced sinus tachycardia: a case series. Ther Adv Psychopharmacol. doi:10.1177/2045125313512325. Published online 20 November 2013
28. Liang CS, Ho PS, Shen LJ, Lee WK, Yang FW, Chiang KT (2010) Comparison of the efficacy and impact on cognition of glycopyrrolate and biperiden for clozapine-induced sialorrhea in schizophrenic patients: a randomized, double-blind, crossover study. Schizophr Res 119(1-3):138-144
29. Manu P et al (2012) Schizophr Res 134(2-3):180-186. doi:10.1016/j.schres.2011.10.014
30. Meltzer HY, Alphs L, Green AI, Altamura AC, Anand R et al (2003) Clozapine treatment for suicidality in schizophrenia: international suicide prevention trial (InterSePT). Arch Gen Psychiatry 60(1):82-91
31. Moisan J, Turgeon M, Desjardins O, Grégoire JP (2013) Comparative safety of antipsychotics: another look at the risk of diabetes. Can J Psychiatry 58:218-224
32. Mortimer AM, Singh P, Shepherd CJ, Puthiryackal J (2010) Clozapine for treatment-resistant schizophrenia: National Institute of Clinical Excellence (NICE) guidance in the real world. Clin Schizophr Relat Psychoses 4(1):49-55. doi:10.3371/CSRP.4.1.4
33. Pacia SV, Devinsky O (1994) Clozapine-related seizures: experience with 5,629 patients. Neurology 44:2247
34. Petrini M, Azzará A (2012) Lithium in the treatment of neutropenia. Curr Opin Hematol 19:52-57
35. Raaska K, Raitasuo V, Neuvonen PJ (2001) Effect of influenza vaccination on serum clozapine and its main metabolite concentrations in patients with schizophrenia. Eur J Clin Pharmacol 57 (10):705-708
36. Raaska K, Raitasuo V, Arstila M, Neuvonen PJ (2002) Bacterial pneumonia can increase serumconcentration of clozapine. Eur J Clin Pharmacol 58:321-322
37. Rajagopal S (2005) Clozapine, agranulocytosis, and benign ethnic neutropenia. Postgrad Med J 81:545-546
38. Rajagopal G, Graham JG, Haut FF(2007) Prevention of clozapine-induced granulocytopenia/agranulocytosis with granulocyte-colony stimulating factor (G-CSF) in an intellectually disabled patient with schizophrenia. J Intellect Disabil Res 51:82-85
39. Renton KW (2004) Cytochrome P450 regulation and biotransformation during inflammation and infection. Curr Drug Metab 5:235-243
40. Ronaldson KJ, Fitzgerald PB, Taylor AJ, Topliss DJ, McNeil JJ (2011) A new monitoring protocol for clozapine-induced myocarditis based on an analysis of 75 cases and 94 controls. Aust N Z J Psychiatry 45(6):458-465
41. Rostami-Hodjegan A, Amin AM, Spencer EP et al (2004) Influence of dose, cigarette smoking, age, sex, and metabolic activity on plasma clozapine concentrations: a predictive model and nomograms to aid clozapine dose adjustment and to assess compliance in individual Patients. J Clin Psychopharmacol 24:70-78
42. Sajatovic M, Meltzer HY (1996) Clozapine-induced myoclonus and generalized seizures. Biol Psychiatry 39:367-370
43. Schulte PFJ (2003) What is an adequate trial with clozapine? Therapeutic drug monitoring and time to response in treatment-refractory schizophrenia. Clin Pharmacokinet 42:607-618
44. Simon V, van Winkel R, De Hert M (2009) Are weight gain and metabolic side effects of atypical antipsychotics dose dependent? A literature review. J Clin Psychiatry 70(7):1041-1050
45. Sockalingam S, Shammi C, Remington G (2007) Clozapine-induced hypersalivation: a review of treatment strategies. Can J Psychiatry 52(6):377-384
46. Sperner-Unterweger B, Czeipek I, Gaggl S, Geissler D, Spiel G et al (1998) Treatment of severe clozapine-induced neutropenia with granulocyte colony-stimulating factor (G-CSF): remission despite continuous treatment with clozapine. Br J Psychiatry 172:82-84
47. Syed R, Au K, Cahill C, Duggan L, He Y, et al (2009) Pharmacological interventions for clozapine-induced hypersalivation. Cochrane Database Syst Rev 1
48. Taylor D, Paton C, Kapur S (2012) The maudsley prescribing guidelines in psychiatry. Wiley-Blackwell, Oxford. ISBN 9780470979488
49. Tessier P, Antonello C (2001) Clozapine and sialorrhea: update. J Psychiatry Neurosci 26:253
50. Tiihonen J, Lönnqvist J, Wahlbeck K, Klaukka T, Niskanen L, Tanskanen A, Haukka J (2009) 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study). Lancet 374:620-627
51. Van der Burg JJW, Didden R, Jongerius PH, Rotteveel JJ (2007) A descriptive analysis of studies on behavioural treatment of drooling (1970-2005). Dev Med Child Neurol 49:390-394
52. Van der Burg JJW, Didden R, Engbers N, Jongerius PH, Rotteveel JJ (2009) Self-management treatment of drooling: a case series. J Behav Ther Exp Psychiatry 40:106-119
53. Van der Molen-Eijgenraam M, Blanken-Meijs JTHM, Heeringa M et al (2001) Delirium door stijging van clozapinespiegels tijdens ontstekingsreactie. Ned Tijdschr Geneesk 145:427-430
54. Walker AM, Lanza LL, Arellano F, Rothman KJ (1997) Mortality in current and former users of clozapine. Epidemiology 8:671-677
55. Whiskey E, Taylor D (2007) Restarting clozapine after neutropenia: evaluating the possibilities and practicalities. CNS Drugs 21(1):25-35
56. Whiskey E, Olofinjana O, Taylor D (2011) The importance of the recognition of benign ethnic neutropenia in black patients during treatment with clozapine: case reports and database study. J Psychopharmacol 25(6):842-845
57. Wong J, Delva N (2007) Clozapine-induced seizures: recognition and treatment. Can J Psychiatry 52:457-463
58. Yusufi B, Mukherjee S, Flanagan R et al (2007) Prevalence and nature of side effects during clozapine maintenance treatment and the relationship with clozapine dose and plasma concentration. Int Clin Psychopharmacol 22:238-243