A Primer on the Genetics of Comorbid Eating Disorders and Substance Use Disorders

European Eating Disorders Review

Volumn 24, Issue 2, 2016, Pages 91-100

  Munn Chernoff, Melissa A ^a   Baker, Jessica H ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

comorbidity; eating disorders; genetics; substance use disorders

Indexed keywords

ADDICTION; COMORBIDITY; EATING DISORDER; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC PROCEDURES; GENETIC RISK; GENOTYPE ENVIRONMENT INTERACTION; HEREDITY; HERITABILITY; HUMAN; MOLECULAR GENETICS; PREVALENCE; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SUBSTANCE ABUSE; BULIMIA; FEEDING AND EATING DISORDERS; FEEDING BEHAVIOR; GENETIC PREDISPOSITION; GENETICS; PSYCHOLOGY; RISK FACTOR; SUBSTANCE-RELATED DISORDERS;

BULIMIA; COMORBIDITY; FEEDING AND EATING DISORDERS; FEEDING BEHAVIOR; GENETIC PREDISPOSITION TO DISEASE; HUMANS; RISK FACTORS; SUBSTANCE-RELATED DISORDERS;

EID: 84956745321     PISSN: 10724133     EISSN: 10990968     Source Type: Journal    
DOI: 10.1002/erv.2424     Document Type: Review

References (105)

1. Agrawal, A., Verweij, K. J., Gillespie, N. A., Heath, A. C., Lessov-Schlaggar, C. N., Martin, N. G., et al., (2012). The genetics of addiction-A translational perspective. Translational Psychiatry, 2, e140. 10.1038/tp.2012.54.
2. th ed.). Washington, DC: American Psychiatric Press.
3. th ed.). Arlington, Virginia: American Psychiatric Publishing.
4. Avena, N. M., Gearhardt, A. N., Gold, M. S., Wang, G. J., &, Potenza, M. N., (2012). Tossing the baby out with the bathwater after a brief rinse? The potential downside of dismissing food addiction based on limited data. Nature Reviews Neuroscience, 13, 514 author reply 514. 10.1038/nrn3212-c1.
5. Avena, N. M., Rada, P., &, Hoebel, B. G., (2008). Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake. Neuroscience and Biobehavioral Reviews, 32, 20-39. 10.1016/j.neubiorev.2007.04.019.
6. Baker, J. H., Mazzeo, S. E., &, Kendler, K. S., (2007). Association between broadly defined bulimia nervosa and drug use disorders: Common genetic and environmental influences. International Journal of Eating Disorders, 40, 673-678.
7. Baker, J. H., Mitchell, K. S., Neale, M. C., &, Kendler, K. S., (2010). Eating disorder symptomatology and substance use disorders: Prevalence and shared risk in a population based twin sample. International Journal of Eating Disorders, 43, 648-658. 10.1002/eat.20856.
8. Baker, J. H., &, Munn-Chernoff, M. A., (2014). Genetic vulnerability to eating disorders and substance use disorders. In, Brewerton, T. D., &, Dennis, A. B., (Eds.), Eating disorders, addictions and substance use disorders (pp. 91-106). Berlin Heidelberg: Springer-Verlag.
9. Bierut, L. J., Dinwiddie, S. H., Begleiter, H., Crowe, R. R., Hesselbrock, V., Nurnberger, J. I. Jr., et al., (1998). Familial transmission of substance dependence: Alcohol, marijuana, cocaine, and habitual smoking: A report from the Collaborative Study on the Genetics of Alcoholism. Archives of General Psychiatry, 55, 982-988.
10. Boraska, V., Davis, O. S., Cherkas, L. F., Helder, S. G., Harris, J., Krug, I., et al., (2012). Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 159B, 803-811. 10.1002/ajmg.b.32087.
11. Boraska, V., Franklin, C. S., Floyd, J. A., Thornton, L. M., Huckins, L. M., Southam, L., et al., (2014). A genome-wide association study of anorexia nervosa. Molecular Psychiatry, 19, 1085-1094. 10.1038/mp.2013.187.
12. Bouchard, T. J. Jr., &, Loehlin, J. C., (2001). Genes, evolution, and personality. Behavior Genetics, 31, 243-273.
13. Bulik, C. M., Devlin, B., Bacanu, S. A., Thornton, L., Klump, K. L., Fichter, M. M., et al., (2003). Significant linkage on chromosome 10p in families with bulimia nervosa. American Journal of Human Genetics, 72, 200-207.
14. Bulik, C. M., Klump, K. L., Thornton, L., Kaplan, A. S., Devlin, B., Fichter, M. M., et al., (2004). Alcohol use disorder comorbidity in eating disorders: A multicenter study. Journal of Clinical Psychiatry, 65, 1000-1006.
15. Bulik-Sullivan, B. K., Loh, P. R., Finucane, H. K., Ripke, S., Yang, J., Schizophrenia Working Group of the Psychiatric Genomics Consortium, et al. (2015). LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nature Genetics, 47, 291-295. 10.1038/ng.3211.
16. Cadoret, R. J., Winokur, G., Langbehn, D., Troughton, E., Yates, W. R., &, Stewart, M. A., (1996). Depression spectrum disease, I: The role of gene-environment interaction. American Journal of Psychiatry, 153, 892-899.
17. Cassin, S. E., &, von Ranson, K. M., (2007). Is binge eating experienced as an addiction? Appetite, 49, 687-690.
18. Center on Addiction and Substance Abuse (2003). Food for thought: Substance abuse and eating disorders (pp. 1-83)In C. University (Ed.). New York, NY: The National Center on Addiction and Substance Abuse at Columbia University.
19. Cross-Disorder Group of the Psychiatric Genomics Consortium, Lee, S. H., Ripke, S., Neale, B. M., Faraone, S. V., Purcell, S. M., et al., (2013). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics, 45, 984-994. 10.1038/ng.2711.
20. Dani, J. A., &, Harris, R. A., (2005). Nicotine addiction and comorbidity with alcohol abuse and mental illness. Nature Neuroscience, 8, 1465-1470. 10.1038/nn1580.
21. Dansky, B. S., Brewerton, T. D., &, Kilpatrick, D. G., (2000). Comorbidity of bulimia nervosa and alcohol use disorders: Results from the National Women's Study. International Journal of Eating Disorders, 27, 180-190.
22. Davison, K. M., Marshall-Fabien, G. L., &, Gondara, L., (2014). Sex differences and eating disorder risk among psychiatric conditions, compulsive behaviors and substance use in a screened Canadian national sample. General Hospital Psychiatry, 36, 411-414. 10.1016/j.genhosppsych.2014.04.001.
23. Devlin, B., Bacanu, S. A., Klump, K. L., Bulik, C. M., Fichter, M. M., Halmi, K. A., et al., (2002). Linkage analysis of anorexia nervosa incorporating behavioral covariates. Human Molecular Genetics, 11, 689-696.
24. Dick, D. M., &, Kendler, K. S., (2012). The impact of gene-environment interaction on alcohol use disorders. Alcohol Research, 34, 318-324.
25. Dick, D. M., Smith, G., Olausson, P., Mitchell, S. H., Leeman, R. F., O'Malley, S. S., et al., (2010). Understanding the construct of impulsivity and its relationship to alcohol use disorders. Addiction Biology, 15, 217-226. 10.1111/j.1369-1600.2009.00190.x.
26. Duncan, A. E., Neuman, R. J., Kramer, J. R., Kuperman, S., Hesselbrock, V. M., &, Bucholz, K. K., (2006). Lifetime psychiatric comorbidity of alcohol dependence and bulimia nervosa in women. Drug and Alcohol Dependence, 84, 122-132.
27. Enoch, M. A., (2012). The influence of gene-environment interactions on the development of alcoholism and drug dependence. Current Psychiatry Reports, 14, 150-158. 10.1007/s11920-011-0252-9.
28. Falk, D. E., Yi, H. Y., &, Hiller-Sturmhofel, S., (2006). An epidemiologic analysis of co-occurring alcohol and tobacco use and disorders: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions. Alcohol Research & Health, 29, 162-171.
29. Frank, J., Cichon, S., Treutlein, J., Ridinger, M., Mattheisen, M., Hoffmann, P., et al., (2012). Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. Addiction Biology, 17, 171-180. 10.1111/j.1369-1600.2011.00395.x.
30. Franko, D. L., Keshaviah, A., Eddy, K. T., Krishna, M., Davis, M. C., Keel, P. K., et al., (2013). A longitudinal investigation of mortality in anorexia nervosa and bulimia nervosa. American Journal of Psychiatry, 170, 917-925. 10.1176/appi.ajp.2013.12070868.
31. Gadalla, T., &, Piran, N., (2007). Co-occurrence of eating disorders and alcohol use disorders in women: A meta analysis. Archives of Women's Mental Health, 10, 133-140.
32. Gearhardt, A. N., Corbin, W. R., &, Brownell, K. D., (2009). Food addiction: An examination of the diagnostic criteria for dependence. Journal of Addictive Medicine, 3, 1-7. 10.1097/ADM.0b013e318193c993.
33. Gearhardt, A. N., White, M. A., &, Potenza, M. N., (2011). Binge eating disorder and food addiction. Current Drug Abuse Reviews, 4, 201-207.
34. Grant, B. F., Stinson, F. S., Dawson, D. A., Chou, S. P., Dufour, M. C., Compton, W., et al., (2004). Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Archives of General Psychiatry, 61, 807-816. 10.1001/archpsyc.61.8.807.
35. Grice, D. E., Halmi, K. A., Fichter, M. M., Strober, M., Woodside, D. B., Treasure, J. T., et al., (2002). Evidence for a susceptibility gene for anorexia nervosa on chromosome 1. American Journal of Human Genetics, 70, 787-792.
36. Hasin, D. S., Stinson, F. S., Ogburn, E., &, Grant, B. F., (2007). Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Archives of General Psychiatry, 64, 830-842.
37. Holderness, C. C., Brooks-Gunn, J., &, Warren, M. P., (1994). Co-morbidity of eating disorders and substance abuse review of the literature. International Journal of Eating Disorders, 16, 1-34.
38. Hudson, J. I., Hiripi, E., Pope, H. G. Jr., &, Kessler, R. C., (2007). The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biological Psychiatry, 61, 348-358.
39. Hudson, J. I., Lalonde, J. K., Berry, J. M., Pindyck, L. J., Bulik, C. M., Crow, S. J., et al., (2006). Binge-eating disorder as a distinct familial phenotype in obese individuals. Archives of General Psychiatry, 63, 313-319.
40. Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., et al., (2010). Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. American Journal of Psychiatry, 167, 748-751. 10.1176/appi.ajp.2010.09091379.
41. International Schizophrenia Consortium, Purcell, S. M., Wray, N. R., Stone, J. L., Visscher, P. M., O'Donovan, M. C., et al., (2009). Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature, 460, 748-752. 10.1038/nature08185.
42. Jimenez-Murcia, S., Steiger, H., Israel, M., Granero, R., Prat, R., Santamaria, J. J., et al., (2013). Pathological gambling in eating disorders: Prevalence and clinical implications. Comprehensive Psychiatry, 54, 1053-1060. 10.1016/j.comppsych.2013.04.014.
43. Johnson, P. M., &, Kenny, P. J., (2010). Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat Neurosci, 13, 635-641. doi: 10.1038/nn.2519.
44. Kaye, W. H., Lilenfeld, L. R., Plotnicov, K., Merikangas, K. R., Nagy, L., Strober, M., et al., (1996). Bulimia nervosa and substance dependence: Association and family transmission. Alcoholism, Clinical and Experimental Research, 20, 878-881.
45. Kaye, W. H., Wierenga, C. E., Bailer, U. F., Simmons, A. N., Wagner, A., &, Bischoff-Grethe, A., (2013). Does a shared neurobiology for foods and drugs of abuse contribute to extremes of food ingestion in anorexia and bulimia nervosa? Biological Psychiatry, 73, 836-842. 10.1016/j.biopsych.2013.01.002.
46. Kendler, K. S., Chen, X., Dick, D., Maes, H., Gillespie, N., Neale, M. C., et al., (2012). Recent advances in the genetic epidemiology and molecular genetics of substance use disorders. Nature Neuroscience, 15, 181-189. 10.1038/nn.3018.
47. Kendler, K. S., Karkowski, L. M., Neale, M. C., &, Prescott, C. A., (2000). Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population-based sample of male twins. Archives of General Psychiatry, 57, 261-269.
48. Kendler, K. S., Schmitt, E., Aggen, S. H., &, Prescott, C. A., (2008). Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use from early adolescence to middle adulthood. Archives of General Psychiatry, 65, 674-682. 10.1001/archpsyc.65.6.674.
49. Kendler, K. S., Walters, E. E., Neale, M. C., Kessler, R. C., Heath, A. C., &, Eaves, L. J., (1995). The structure of the genetic and environmental risk factors for six major psychiatric disorders in women. Phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism. Archives of General Psychiatry, 52, 374-383.
50. Kessler, R. C., Berglund, P. A., Chiu, W. T., Deitz, A. C., Hudson, J. I., Shahly, V., et al., (2013). The prevalence and correlates of binge eating disorder in the World Health Organization World Mental Health Surveys. Biological Psychiatry, 73, 904-914. 10.1016/j.biopsych.2012.11.020.
51. Klump, K. L., Burt, S. A., McGue, M., &, Iacono, W. G., (2007). Changes in genetic and environmental influences on disordered eating across adolescence: A longitudinal twin study. Archives of General Psychiatry, 64, 1409-1415.
52. Krahn, D., Piper, D., King, M., Olson, L., Kurth, C., &, Moberg, D. P., (1996). Dieting in sixth grade predicts alcohol use in ninth grade. Journal of Substance Abuse, 8, 293-301.
53. Lee, Y. H., Abbott, D. W., Seim, H., Crosby, R. D., Monson, N., Burgard, M., et al., (1999). Eating disorders and psychiatric disorders in the first-degree relatives of obese probands with binge eating disorder and obese non-binge eating disorder controls. International Journal of Eating Disorders, 26, 322-332.
54. Lilenfeld, L. R., Kaye, W. H., Greeno, C. G., Merikangas, K. R., Plotnicov, K., Pollice, C., et al., (1997). Psychiatric disorders in women with bulimia nervosa and their first-degree relatives: Effects of comorbid substance dependence. International Journal of Eating Disorders, 22, 253-264.
55. Lilenfeld, L. R., Kaye, W. H., Greeno, C. G., Merikangas, K. R., Plotnicov, K., Pollice, C., et al., (1998). A controlled family study of anorexia nervosa and bulimia nervosa: Psychiatric disorders in first-degree relatives and effects of proband comorbidity. Archives of General Psychiatry, 55, 603-610.
56. Lilenfeld, L. R., Ringham, R., Kalarchian, M. A., &, Marcus, M. D., (2008). A family history study of binge-eating disorder. Comprehensive Psychiatry, 49, 247-254. 10.1016/j.comppsych.2007.10.001.
57. Meule, A., &, Gearhardt, A. N., (2014). Food addiction in the light of DSM-5. Nutrients, 6, 3653-3671. 10.3390/nu6093653.
58. Munafo, M. R., Matheson, I. J., &, Flint, J., (2007). Association of the DRD2 gene Taq1A polymorphism and alcoholism: A meta-analysis of case-control studies and evidence of publication bias. Molecular Psychiatry, 12, 454-461.
59. Munn-Chernoff, M. A., Duncan, A. E., Grant, J. D., Wade, T. D., Agrawal, A., Bucholz, K. K., et al., (2013). A twin study of the association between alcohol dependence, binge eating, and compensatory behaviors. Journal of Studies on Alcohol and Drugs, 74, 664-673. 10.1002/eat.22001.
60. Munn-Chernoff, M. A., Grant, J. D., Agrawal, A., Sartor, C. E., Werner, K. B., Bucholz, K. K., et al., (2015). Genetic overlap between alcohol use disorder and bulimic behaviors in European American and African American women. Drug and Alcohol Dependence, 153, 335-340. 10.1016/j.drugalcdep.2015.05.043.
61. Munn-Chernoff, M. A., Grant, J. D., Bucholz, K. K., Agrawal, A., Lynskey, M. T., Madden, P. A., et al., (2015). Bulimic behaviors and early substance use: Findings from a cotwin-control study. Alcoholism, Clinical and Experimental Research, 39, 1740-1748. 10.1111/acer.12829.
62. Nakabayashi, K., Komaki, G., Tajima, A., Ando, T., Ishikawa, M., Nomoto, J., et al., (2009). Identification of novel candidate loci for anorexia nervosa at 1q41 and 11q22 in Japanese by a genome-wide association analysis with microsatellite markers. Journal of Human Genetics, 54, 531-537. 10.1038/jhg.
63. Nurnberger, J. I. Jr., Wiegand, R., Bucholz, K., O'Connor, S., Meyer, E. T., Reich, T., et al., (2004). A family study of alcohol dependence: Coaggregation of multiple disorders in relatives of alcohol-dependent probands. Archives of General Psychiatry, 61, 1246-1256.
64. Olfson, E., &, Bierut, L. J., (2012). Convergence of genome-wide association and candidate gene studies for alcoholism. Alcoholism, Clinical and Experimental Research, 36, 2086-2094. 10.1111/j.1530-0277.2012.01843.x.
65. Pearson, C. M., Riley, E. N., Davis, H. A., &, Smith, G. T., (2014). Two pathways toward impulsive action: An integrative risk model for bulimic behavior in youth. Journal of Child Psychology and Psychiatry, 55, 852-864. 10.1111/jcpp.12214.
66. Peveler, R., &, Fairburn, C., (1990). Eating disorders in women who abuse alcohol. British Journal of Addiction, 85, 1633-1638.
67. Psychiatric GWAS Consortium Steering Committee (2009). A framework for interpreting genome-wide association studies of psychiatric disorders. Molecular Psychiatry, 14, 10-17. 10.1038/mp.2008.126.
68. Root, T. L., Pisetsky, E. M., Thornton, L., Lichtenstein, P., Pedersen, N. L., &, Bulik, C. M., (2010). Patterns of co-morbidity of eating disorders and substance use in Swedish females. Psychological Medicine, 40, 105-115. 10.1017/S0033291709005662.
69. Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511, 421-427. 10.1038/nature13595.
70. Schuckit, M. A., Tipp, J. E., Anthenelli, R. M., Bucholz, K. K., Hesselbrock, V. M., &, Nurnberger, J. I. Jr., (1996). Anorexia nervosa and bulimia nervosa in alcohol-dependent men and women and their relatives. American Journal of Psychiatry, 153, 74-82.
71. Schulte, E. M., Avena, N. M., &, Gearhardt, A. N., (2015). Which foods may be addictive? The roles of processing, fat content, and glycemic load. PLoS ONE, 10, e0117959. 10.1371/journal.pone.0117959.
72. Shimada-Sugimoto, M., Otowa, T., &, Hettema, J. M., (2015). Genetics of anxiety disorders: Genetic epidemiological and molecular studies in humans. Psychiatry and Clinical Neurosciences, 69, 388-401. 10.1111/pcn.12291.
73. Siontis, K. C., Patsopoulos, N. A., &, Ioannidis, J. P., (2010). Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies. European Journal of Human Genetics, 18, 832-837. 10.1038/ejhg.2010.26.
74. Slane, J. D., Burt, S. A., &, Klump, K. L., (2012). Bulimic behaviors and alcohol use: Shared genetic influences. Behavior Genetics, 42, 603-613.
75. Slane, J. D., Klump, K. L., McGue, M., &, Iacono, G., (2014). Genetic and environmental factors underlying comorbid bulimic behaviours and alcohol use disorders: A moderating role for the dysregulated personality cluster? European Eating Disorders Review, 22, 159-169. 10.1002/erv.2284.
76. Slutske, W. S., Ellingson, J. M., Richmond-Rakerd, L. S., Zhu, G., &, Martin, N. G., (2013). Shared genetic vulnerability for disordered gambling and alcohol use disorder in men and women: Evidence from a national community-based Australian twin study. Twin Research and Human Genetics, 16, 525-534.
77. Smith, L., Watson, M., Gates, S., Ball, D., &, Foxcroft, D., (2008). Meta-analysis of the association of the Taq1A polymorphism with the risk of alcohol dependency: A HuGE gene-disease association review. American Journal of Epidemiology, 167, 125-138.
78. Smoller, J. W., Craddock, N., Kendler, K., Lee, P. H., Neale, B. M., Nurnberger, J. I., et al., (2013). Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis. Lancet, 381, 1371-1379.
79. Steiger, H., Richardson, J., Joober, R., Gauvin, L., Israel, M., Bruce, K. R., et al,. (2007). The 5HTTLPR polymorphism, prior maltreatment and dramatic-erratic personality manifestations in women with bulimic syndromes. Journal of Psychiatry and Neuroscience, 32, 354-362.
80. Steiger, H., Richardson, J., Joober, R., Israel, M., Bruce, K. R., Ng Ying Kin, N. M., et al,. (2008). Dissocial behavior, the 5HTTLPR polymorphism, and maltreatment in women with bulimic syndromes. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B, 128-130. 10.1002/ajmg.b.30579.
81. Steiger, H., Richardson, J., Schmitz, N., Joober, R., Israel, M., Bruce, K. R., et al,. (2009). Association of trait-defined, eating-disorder sub-phenotypes with (biallelic and triallelic) 5HTTLPR variations. Journal of Psychiatric Research, 43, 1086-1094. 10.1016/j.jpsychires.2009.03.009.
82. Stinson, F. S., Grant, B. F., Dawson, D. A., Ruan, W. J., Huang, B., &, Saha, T., (2005). Comorbidity between DSM-IV alcohol and specific drug use disorders in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Drug and Alcohol Dependence, 80, 105-116. 10.1016/j.drugalcdep.2005.03.009.
83. Strober, M., Freeman, R., Lampert, C., Diamond, J., &, Kaye, W., (2000). Controlled family study of anorexia nervosa and bulimia nervosa: Evidence of shared liability and transmission of partial syndromes. American Journal of Psychiatry, 157, 393-401.
84. Sullivan, P. F., (2007). Spurious genetic associations. Biological Psychiatry, 61, 1121-1126. 10.1016/j.biopsych.2006.11.010.
85. Sullivan, P. F., Neale, M. C., &, Kendler, K. S., (2000). Genetic epidemiology of major depression: Review and meta-analysis. American Journal of Psychiatry, 157, 1552-1562.
86. Tomeo, C. A., Field, A. E., Berkey, C. S., Colditz, G. A., &, Frazier, A. L., (1999). Weight concerns, weight control behaviors, and smoking initiation. Pediatrics, 104, 918-924.
87. Trace, S. E., Baker, J. H., Penas-Lledo, E., &, Bulik, C. M., (2013). The genetics of eating disorders. Annual Review of Clinical Psychology, 9, 589-620. 10.1146/annurev-clinpsy-050212-185546.
88. Trace, S. E., Thornton, L. M., Baker, J. H., Root, T. L., Janson, L. E., Lichtenstein, P., et al., (2013). A behavioral-genetic investigation of bulimia nervosa and its relationship with alcohol use disorder. Psychiatry Research, 208, 232-237. 10.1016/j.psychres.2013.04.030.
89. Treutlein, J., Cichon, S., Ridinger, M., Wodarz, N., Soyka, M., Zill, P., et al., (2009). Genome-wide association study of alcohol dependence. Archives of General Psychiatry, 66, 773-784. 10.1001/archgenpsychiatry.2009.83.
90. Vandereycken, W., (1990). The addiction model in eating disorders-Some critical remarks and a selected bibliography. International Journal of Eating Disorders, 9, 95-101.
91. Volkow, N. D., &, Baler, R. D., (2015). NOW vs LATER brain circuits: Implications for obesity and addiction. Trends in Neuroscience, 38, 345-352. 10.1016/j.tins.2015.04.002.
92. Volkow, N. D., Fowler, J. S., Wang, G. J., Baler, R., &, Telang, F., (2009). Imaging dopamine's role in drug abuse and addiction. Neuropharmacology, 56 (Suppl 1), 3-8. 10.1016/j.neuropharm.2008.05.022.
93. von Ranson, K. M., McGue, M., &, Iacono, W. G., (2003). Disordered eating and substance use in an epidemiological sample: II. Associations within families. Psychology of Addictive Behaviors, 17, 193-201.
94. Wade, T. D., Gordon, S., Medland, S., Bulik, C. M., Heath, A. C., Montgomery, G. W., et al., (2013). Genetic variants associated with disordered eating. International Journal of Eating Disorders, 46, 594-608. 10.1002/eat.22133.
95. Wang, J. C., Kapoor, M., &, Goate, A. M., (2012). The genetics of substance dependence. Annual Review of Genomics and Human Genetics, 13, 241-261. 10.1146/annurev-genom-090711-163844.
96. Wang, K., Zhang, H., Bloss, C. S., Duvvuri, V., Kaye, W., Schork, N. J., et al., (2011). A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa. Molecular Psychiatry, 16, 949-959. 10.1038/mp.2010.107.
97. Wiederman, M. W., &, Pryor, T., (1996). Substance use among women with eating disorders. International Journal of Eating Disorders, 20, 163-168.
98. Wilson, G. T., (2010). Eating disorders, obesity and addiction. European Eating Disorders Review, 18, 341-351. 10.1002/erv.1048.
99. Wolfe, W. L., &, Maisto, S. A., (2000). The relationship between eating disorders and substance use: Moving beyond co-prevalence research. Clinical Psychology Review, 20, 617-631.
100. Wray, N. R., Goddard, M. E., &, Visscher, P. M., (2007). Prediction of individual genetic risk to disease from genome-wide association studies. Genome Research, 17, 1520-1528.
101. Yanovski, S. Z., Nelson, J. E., Dubbert, B. K., &, Spitzer, R. L., (1993). Association of binge eating disorder and psychiatric comorbidity in obese subjects. American Journal of Psychiatry, 150, 1472-1479.
102. Yilmaz, Z., Hardaway, A. J., &, Bulik, C. M., (2015). Genetics and epigenetics of eating disorders. Advances in Genomics and Genetics, 5, 131-150.
103. Zaider, T. I., Johnson, J. G., &, Cockell, S. J., (2002). Psychiatric disorders associated with the onset and persistence of bulimia nervosa and binge eating disorder during adolescence. Journal of Youth and Adolescence, 31, 319-329.
104. Ziauddeen, H., Farooqi, I. S., &, Fletcher, P. C., (2012). Obesity and the brain: How convincing is the addiction model? Nature Review Neuroscience, 13, 279-286. 10.1038/nrn3212.
105. Ziauddeen, H., &, Fletcher, P. C., (2013). Is food addiction a valid and useful concept? Obesity Reviews, 14, 19-28. 10.1111/j.1467-789X.2012.01046.x.