Autoimmune vitiligo is associated with gain-offunction by a transcriptional regulator that elevates expression of HLA-A∗02:01 in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 5, 2016, Pages 1357-1362

  Hayashi, Masahiro ^a   Jin, Ying ^a,b   Yorgov, Daniel ^c   Santorico, Stephanie A ^a,c   Hagman, James ^a,d   Ferrara, Tracey M ^a,b   Jones, Kenneth L ^a   Cavalli, Giulio ^a,e   Dinarello, Charles A ^a   Spritz, Richard A ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b University of Colorado Denver and Children s Hospital Colorado   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d DEPARTMENT OF MEDICINE   (United States)

^e VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

Autoimmune disease; Enhancer; HLA; Transcription; Vitiligo

Indexed keywords

HLA A ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MESSENGER RNA;

ALLELE; ARTICLE; CELL SURFACE; CONTROLLED STUDY; DNA FLANKING REGION; ENHANCER REGION; GAIN OF FUNCTION MUTATION; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC TRANSFECTION; HAPLOTYPE; HIGH RISK PATIENT; HOMOZYGOTE; HUMAN; HUMAN CELL; IN VIVO STUDY; MAJOR CLINICAL STUDY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROMOTER REGION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RISK FACTOR; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION; VITILIGO; AUTOIMMUNE DISEASE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY;

AUTOIMMUNE DISEASES; GENE EXPRESSION REGULATION; HAPLOTYPES; HLA-A ANTIGENS; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; TRANSCRIPTION, GENETIC; VITILIGO;

EID: 84956679693     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1525001113     Document Type: Article

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