Cytochrome P450 2C8*2 allele in Botswana: Human genetic diversity and public health implications

Acta Tropica

Volumn 157, Issue , 2016, Pages 54-58

  Motshoge, Thato ^a,b   Tawe, Leabaneng ^b,c   Muthoga, Charles Waithaka ^b,c   Allotey, Joel ^d   Romano, Rita ^e   Quaye, Isaac ^f   Paganotti, Giacomo Maria ^b,c,g  

^a Department of HIV AIDS Prevention and Care   (Botswana)

^b Medical Education Partnership Initiative (MEPI) Laboratory   (Botswana)

^c BOTSWANA UPENN PARTNERSHIP   (Botswana)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f UNIVERSITY OF NAMIBIA   (Namibia)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Bantu ethnic group; Botswana; CYP2C8; Pharmacogenetics; San ethnic group

Indexed keywords

CYTOCHROME P450 2C8; CYTOCHROME P450;

ALLELE; CYTOCHROME; DNA; ETHNIC GROUP; ETHNICITY; GENETIC ANALYSIS; GENETIC VARIATION; GENOTYPE; PUBLIC HEALTH;

ARTICLE; BANTU PEOPLE; BLOOD SAMPLING; BOTSWANA; CHILD; CYP2C8 GENE; DNA EXTRACTION; ETHNIC DIFFERENCE; GENE FREQUENCY; GENETIC LINKAGE; GENETIC MARKER; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE; HARDY WEINBERG EQUILIBRIUM; HIGH RISK POPULATION; HUMAN; POLYMERASE CHAIN REACTION; PREVALENCE; PRIMARY SCHOOL; PUBLIC HEALTH; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SAN PEOPLE; SCHOOL CHILD; ADOLESCENT; ALLELE; BLACK PERSON; ETHNIC GROUP; FEMALE; GENETIC POLYMORPHISM; GENETICS; MALE; PHARMACOGENETICS;

BOTSWANA;

ADOLESCENT; AFRICAN CONTINENTAL ANCESTRY GROUP; ALLELES; BOTSWANA; CHILD; CYTOCHROME P-450 CYP2C8; CYTOCHROME P-450 ENZYME SYSTEM; ETHNIC GROUPS; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; PHARMACOGENETICS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 84956645530     PISSN: 0001706X     EISSN: 18736254     Source Type: Journal    
DOI: 10.1016/j.actatropica.2016.01.028     Document Type: Article

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