Klebsiella pneumoniae: Characteristics of carbapenem resistance and virulence factors

Acta Biochimica Polonica

Volumn 62, Issue 4, 2015, Pages 867-874

  Candan, Esra Deniz ^a   Aksöz, Nilüfer ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Klebsiella pneumoniae; Multidrug carbapenem resistance; Virulence factors

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; CARBAPENEM DERIVATIVE; CARBAPENEMASE;

BACTERIAL GENE; DRUG EFFECTS; GENETICS; KLEBSIELLA PNEUMONIAE; PATHOGENICITY; VIRULENCE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CARBAPENEMS; GENES, BACTERIAL; KLEBSIELLA PNEUMONIAE; VIRULENCE;

EID: 84956636443     PISSN: 0001527X     EISSN: 1734154X     Source Type: Journal    
DOI: 10.18388/abp.2015_1148     Document Type: Article

References (34)

1. Abouddihaj B, El Otmani F, El Yaagoubi Fouzia L, Zerouali Khalid TM, Timinouni M (2012) First report of a Klebsiella pneumoniae strain coproducing NDM-1, VIM-1 and OXA-48 carbapenemases isolated in Morocco. APMIS 121: 675-677. http://dx.doi.org/10.1111/apm.12034.
2. Alp E, Perçin D, Colakoğlu S, Durmaz S, Kürkcü CA, Ekincioğlu P, Güneş T (2013) Molecular characterisation of carbapenem-resistant Klebsiella pneumoniae in a tertiary university hospital in Turkey. J Hosp Infect 84: 178-180. http://dx.doi.org/10.1016/j.jhin.2013.03.002.
3. Arisoy M, Yousefi Rad A, Akin A, Akar N (2008) Relationship between susceptibility to antimicrobials and virulence factors in pediatric Escherichia coli isolates. Int J Antimicrob Agents 31: 4-8. http://dx.doi.org/10.1016/j.ijantimicag.2007.07.030.
4. Azap Ö, Otlu B, Yesilkaya A, Yakupogullari Y (2013) Detection of OXA-48-like carbapenemase-producing Klebsiella pneumoniae in a tertiary care center in Turkey: molecular characterization and epidemiology. Balkan Med J 30: 259-260. http://dx.doi.org/10.5152/balkanmedj.2013.7499.
5. Balm MND, La MV, Krishnan P, Jureen R, Lin RTP and Teo JWP (2013) Emergence of Klebsiella pneumoniae co-producing NDM-type and OXA-181 carbapenemases. Clin Microbiol Infec 19: E421-E423. http://dx.doi.org/10.1111/1469-0691.12247.
6. Beceiro A, Tomás M, Bou G (2013) Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world? Clin Microbiol Rev 26: 185-230. http://dx.doi.org/10.1128/CMR.00059-12.
7. Chou Huei-Chi, Lee Cha-Ze, Ma Li-Chen, Fang Chi-Tai, Chang Shan-Chwen and Wang Jin-Town (2004). Isolation of a chromosomal region of Klebsiella pneumoniae associated with allantoin metabolism and liver infection. Infect Immun 72: 3783-3792. http://dx.doi.org/10.1128/IAI.72.7.3783-3792.2004.
8. Compain F, Babosan A, Brisse S, Genel N, Audo J, Ailloud F, Kassis-Chikhani N, Arlet G, Decré D (2014) Multiplex PCR for detection of seven virulence factors and K1/K2 capsular serotypes of Klebsiella pneumoniae. J Clin Microbiol 52: 4377-4380. http://dx.doi.org/10.1128/JCM.02316-14.
9. Cortés G, Borrell N, de Astorza B, Gómez C, Sauleda J, Albertí S (2002). Molecular analysis of the contribution of the capsular polysaccharide and the lipopolysaccharide O side chain to the virulence of Klebsiella pneumoniae in a murine model of pneumonia. Infect Immun 70: 2583-2590. http://dx.doi.org/10.1128/IAI.70.5.2583-2590.2002.
10. Doi Y, O'Hara JA, Lando JF, Querry AM, Townsend BM, Pasculle AW, Muto CA (2014). Co-Production of NDM-1 and OXA-232 by Klebsiella pneumoniae. Emerg Infec Dis 20: 163-164. http://dx.doi.org/10.3201/eid2001.130904.
11. Dortet L, Poirel L, Al Yaqoubi F, Nordmann P (2012) NDM-1, OXA-48 and OXA-181 carbapenemase-producing Enterobacteriaceae in Sultanate of Oman. Clin Microbiol Infec 18: E144-E148. http://dx.doi.org/10.1111/j.1469-0691.2012.03796.x.
12. El Fertas-Aissani R, Messai Y, Alouache S, Bakour R (2013). Virulence profiles and antibiotic susceptibility patterns of Klebsiella pneumoniae strains isolated from different clinical specimens. Pathol Biol 61: 209-216. http://dx.doi.org/10.1016/j.patbio.2012.10.004.
13. Fang, Chi-Tai, Chuang, Yi-Ping, Shun, Chia-Tung, Chang, Shan-Chwen and Wang, Jin-Town, A (2004) Novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications. J Exp Med 199: 697-705. http://dx.doi.org/10.1084/jem.20030857.
14. Guiral E, Bosch J, Vila J, Soto SM (2011) Prevalence of Escherichia coli among samples collected from the genital tract in pregnant and nonpregnant women: relationship with virulence. FEMS Microbiol Lett 314: 170-173. http://dx.doi.org/10.1111/j.1574-6968.2010.02160.x.
15. Hartman LJ, Selby EB, Whitehouse CA, Coyne SR, Jaissle JG, Twenhafel NA, Burke RL, Kulesh DA (2009) Rapid Real-Time PCR assays for detection of Klebsiella pneumoniae with the rmpA or magA genes associated with the hypermucoviscosity phenotype. J Mol Diagn 11: 464-471. http://dx.doi.org/10.2353/jmoldx.2009.080136.
16. Ku YH, Chuang YC, Yu WL (2008) Clinical spectrum and molecular characteristics of Klebsiella pneumoniae causing community-acquired extrahepatic abscess. J Microbiol Immunol Infect 41: 311-317.
17. Mamlouk K, Boutiba-Ben Boubaker I, Gautier V, Vimont S, Picard B, Ben Redjeb S (2006) Emergence and outbreaks of CTX-M beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae strains in a Tunisian hospital. J Clin Microbiol 44: 4049-4056. http://dx.doi.org/10.1128/JCM.01076-06.
18. May T and Okabe S (2011) Enterobactin is required for biofilm development in reduced-genome Escherichia coli. Environ Microbiol 13: 3149-3162. http://dx.doi.org/10.1111/j.1462-2920.2011.02607.x.
19. Nordmann P, Naas T, Poirel L (2011) Global Spread of Carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis 17: 1791-1798. http://dx.doi.org/10.3201/eid1710.110655.
20. TM KPC for the detection of carbapenemase-producing Enterobacteriaceae in rectal surveillance cultures. Int J Antimicrob Agents 37: 124-128. http://dx.doi.org/10.1016/j.ijantimicag.2010.10.010.
21. Pfeifer Y, Schlatterer K, Engelmann E, Schiller RA, Frangenberg HR, Stiewe D, Holfelder M, Witte W, Nordmann P, Poirel L (2012) Emergence of OXA-48-type carbapenemase-producing Enterobacteriaceae in German hospitals. Antimicrob Agents Chemother 56: 2125-2128. http://dx.doi.org/10.1128/AAC.05315-11.
22. Podschun R and Ullmann U (1998) Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods and pathogenicity factors. Clin Microbiol Rev 11: 589-603.
23. Poirel L, Heritier C, Tolun V, Nordmann P (2004) Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae. Antimicrob Agents Chemother 48: 15-22. http://dx.doi.org/10.1128/AAC.48.1.15-22.2004.
24. Poirel L, Walsh Timothy R, Cuvillier V, Nordmann P (2011) Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis 70: 119-123. http://dx.doi.org/10.1016/j.diagmicrobio.2010.12.002
25. Sebghati TAS, Korhonen TK, Hornick DB, Clegg S (1998) Characterization of the type 3 fimbrial adhesins of Klebsiella strains. Infect Immun 66: 2887-2894.
26. Shibl A, Al-Agamy M, Memish Z, Senok A, Khader SA, Assiri A (2013) The emergence of OXA-48- and NDM-1-positive Klebsiella pneumoniae in Riyadh, Saudi Arabia. Int J Infect Dis 17: e1130-e1133. http://dx.doi.org/10.1016/j.ijid.2013.06.016.
27. Struve C, Bojer M, Krogfelt KA (2009) Identification of a conserved chromosomal region encoding Klebsiella pneumoniae type 1 and type 3 fimbriae and assessment of the role of fimbriae in pathogenicity. Infect Immun 77: 5016-5024. http://dx.doi.org/10.1128/IAI.00585-09.
28. Turton JF, Perry C, Elgohari S, Hampton CV (2010) PCR characterization and typing of Klebsiella pneumoniae using capsular type-specific, variable number tandem repeat and virulence gene targets. J Med Microbiol 9: 541-547. http://dx.doi.org/10.1099/jmm.0.015198-0.
29. Wang H, Tu F, Gui Z, Lu X, Chu W (2013) Antibiotic resistance profiles and quorum sensing-dependent virulence factors in clinical isolates of Pseudomonas aeruginosa, Indian J Microbiol 53: 163-167. http://dx.doi.org/10.1007/s12088-013-0370-7.
30. Yang YX, Xu ZH, Zhang YQ, Tian J, Weng LX, Wang LH (2012) A new quorum-sensing inhibitor attenuates virulence and decreases antibiotic resistance in Pseudomonas aeruginosa. J Microbiol 50: 987-993. http://dx.doi.org/10.1007/s12275-012-2149-7.
31. Yong D, Toleman MA, Giske CG (2009) Characterization of a new metallo-β-lactamase gene, bla NDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India, Antimicrob Agents Chemother 53: 12, 5046-5054. http://dx.doi.org/10.1128/AAC.00774-09.
32. Yu WL, Fung CP, Ko WC, Cheng KC, Lee CC, Chuang YC (2007) Polymerase chain reaction analysis for detecting capsule serotypes K1 and K2 of Klebsiella pneumoniae causing abscesses of the liver and other sites. J Infect Dis 195: 1235-1236. http://dx.doi.org/10.1086/512686.
33. Yu WL, Ko WC, Cheng KC, Lee HC, Ke DS, Lee CC, Fung CP, Chuang YC (2006) Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan. Clin Infect Dis 42: 1351-1358. http://dx.doi.org/10.1086/503420.
34. Yu WL, Ko WC, Cheng KC, Lee CC, Lai CC, Chuang YC (2008) Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes. Diagn Microbiol Infect Dis 62: 1-6. http://dx.doi.org/10.1016/j.diagmicrobio.2008.04.007.