A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation-related DNA halogenation

Bioscience, Biotechnology and Biochemistry

Volumn 80, Issue 2, 2016, Pages 313-317

  Asahi, Takashi ^a,b,j   Wu, Xiaohong ^b,c   Shimoda, Hiroshi ^d   Hisaka, Shinsuke ^e   Harada, Etsuko ^f   Kanno, Tomomi ^g   Nakamura, Yoshimasa ^a   Kato, Yoji ^h   Osawa, Toshihiko ^b,i  

^a OKAYAMA UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c HealthCare Systems Co   (Japan)

^d 1 Numata Kitagata cho   (Japan)

^e MEIJO UNIVERSITY   (Japan)

^f Iwade Research Institute of Mycology   (Japan)

^g HOKKAIDO UNIVERSITY OF EDUCATION   (Japan)

^h UNIVERSITY OF HYOGO   (Japan)

ⁱ AICHI GAKUIN UNIVERSITY   (Japan)

^j DAIICHI SANKYO CO   (Japan)

more..

Author keywords

Anti inflammatory agent; Ergothioneine; Hypobromous acid; Mushroom; Myeloperoxidase

Indexed keywords

FUNGI; HALOGENATION;

ANTI-INFLAMMATORY AGENTS; ERGOTHIONEINE; HYPOBROMOUS ACID; MUSHROOM; MYELOPEROXIDASE;

ASCORBIC ACID;

8-BROMO-2'-DEOXYGUANOSINE; ANTIINFLAMMATORY AGENT; ASCORBIC ACID; BROMATE; DEOXYGUANOSINE; DNA; GLUTATHIONE; HYPOBROMOUS ACID; HYPOCHLOROUS ACID; PEROXIDASE; THIONEINE;

ADVERSE EFFECTS; AGARICALES; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; HAIRLESS MOUSE; HALOGENATION; INFLAMMATION; ISOLATION AND PURIFICATION; MALE; METABOLISM; MOUSE; PATHOLOGY; ULTRAVIOLET RADIATION;

AGARICALES; ANIMALS; ANTI-INFLAMMATORY AGENTS; ASCORBIC ACID; BROMATES; DEOXYGUANOSINE; DNA; ERGOTHIONEINE; GLUTATHIONE; HALOGENATION; HYPOCHLOROUS ACID; INFLAMMATION; MALE; MICE; MICE, HAIRLESS; PEROXIDASE; ULTRAVIOLET RAYS;

EID: 84956622229     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1080/09168451.2015.1083396     Document Type: Article

References (20)

1. Harrison JE, Schultz J. Studies on the chlorinating activity of myeloperoxidase. J. Biol. Chem. 1976; 251: 1371-1374.
2. Gaut JP, Yeh GC, Tran HD, et al. Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis. Proc. Natl. Acad. Sci. USA. 2001; 98: 11961-11966.
3. Henderson JP, Byun J, Heinecke JW. Molecular chlorine generated by the myeloperoxidase-hydrogen peroxide-chloride system of phagocytes produces 5-chlorocytosine in bacterial RNA. J. Biol. Chem. 1999; 274: 33440-33448.
4. Asahi T, Kondo H, Masuda M, et al. Chemical and immunochemical detection of 8-halogenated deoxyguanosines at early stage inflammation. J. Biol. Chem. 2010; 285: 9282-9291.
5. Takeshita J, Byun J, Nhan TQ, et al. Myeloperoxidase generates 5-chlorouracil in human atherosclerotic tissue: A potential pathway for somatic mutagenesis by macrophages. J. Biol. Chem. 2006; 281: 3096-3104.
6. Fisher GJ, Datta SC, Talwar HS, et al. Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature. 1996; 379: 335-339.
7. Bruner SD, Norman DP, Verdine GL. Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA. Nature. 2000; 403: 859-866.
8. Yin Y, Li W, Son YO, et al. Quercitrin protects skin from UVB-induced oxidative damage. Toxicol. Appl. Pharmacol. 2013; 269: 89-99.
9. Irwin KC, Barry H. Ergothioneine; antioxidant potential, physiological function and role in disease. Biochim. Biophys. Acta. 2012; 1822: 784-793.
10. Henderson JP, Byun J, Williams MV, et al. Bromination of deoxycytidine by eosinophil peroxidase: A mechanism for mutagenesis by oxidative damage of nucleotide precursors. Proc. Natl. Acad. Sci. USA. 2001; 98: 1631-1636.
11. Kato Y, Nagao A, Terao J, et al. Inhibition of myeloperoxidasecatalyzed tyrosylation by phenolic antioxidants in vitro. Biosci. Biotechnol. Biochem. 2003; 67: 1136-1139.
12. Ishitsuka Y, Maniwa F, Koide C, et al. Detection of modified tyrosines as an inflammation marker in a photo-aged skin model. Photochem. Photobiol. 2007; 83: 698-705.
13. Ey J, Schömig E, Taubert D. Dietary sources and antioxidant effects of ergothioneine. J. Agric. Food Chem. 2007; 55: 6466-6474.
14. Schauss AG, Beres E, Vertesi A, et al. The effect of ergothioneine on clastogenic potential and mutagenic activity: Genotoxicity evaluation. Int. J. Toxicol. 2011; 30: 405-409.
15. Shiba Y, Kinoshita T, Chuman H, et al. Flavonoids as substrates and inhibitors of myeloperoxidase: Molecular actions of aglycone and metabolites. Chem. Res. Toxicol. 2008; 21: 1600-1609.
16. Kawai Y, Matsui Y, Kondo H, et al. Galloylated catechins as potent inhibitors of hypochlorous acid-induced DNA damage. Chem. Res. Toxicol. 2008; 21: 1407-1414.
17. Hawkins CL, Pattison DI, Davies MJ. Hypochlorite-induced oxidation of amino acids, peptides and proteins. Amino Acids. 2003; 25: 259-274.
18. Grundemann D, Harlfinger S, Golz S, et al. Discovery of the ergothioneine transporter. Proc. Natl. Acad. Sci. USA. 2005; 102: 5256-5261.
19. Kato Y, Kubo Y, Iwata D, et al. Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1. Pharm. Res. 2010; 27: 832-840.
20. Repine JE, Elkins ND. Effect of ergothioneine on acute lung injury and inflammation in cytokine insufflated rats. Prev Med. 2012; 54: S79-S82.