Caffeine Impact on Metabolic Syndrome Components Is Modulated by a CYP1A2 Variant

Annals of Nutrition and Metabolism

Volumn 68, Issue 1, 2016, Pages 1-11

  Platt, Daniel E ^g   Ghassibe Sabbagh, Michella ^a   Salameh, Pascale ^a   Salloum, Angelique K ^a   Haber, Marc ^a   Mouzaya, Francis ^a   Gauguier, Dominique ^c   Al Sarraj, Yasser ^d   El Shanti, Hatem ^d,e   Zalloua, Pierre A ^a,f   Abchee, Antoine B ^b  

^a LEBANESE AMERICAN UNIVERSITY   (Lebanon)

^b AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^c SORBONNE UNIVERSITÉ   (France)

^d HAMAD BIN KHALIFA UNIVERSITY   (Qatar)

^e UNIVERSITY OF IOWA   (United States)

^f HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^g IBM T J WATSON RESEARCH CENTER   (United States)

Author keywords

Diabetes; Diet and foods; Gene nutrient interaction

Indexed keywords

CAFFEINE; COFFEE; CYP1A2 PROTEIN, HUMAN; CYTOCHROME P450 1A2; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

AGED; ALLELE; BLOOD; BODY MASS; CHEMISTRY; COFFEE; COHORT ANALYSIS; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC ASSOCIATION STUDY; GENETICS; HUMAN; HYPERTENSION; LEBANON; MALE; METABOLIC SYNDROME X; MIDDLE AGED; RISK FACTOR; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL;

AGED; ALLELES; BODY MASS INDEX; CAFFEINE; CHOLESTEROL, HDL; CHOLESTEROL, LDL; COFFEE; COHORT STUDIES; CYTOCHROME P-450 CYP1A2; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC ASSOCIATION STUDIES; HUMANS; HYPERTENSION; LEBANON; LOGISTIC MODELS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SEX FACTORS; TRIGLYCERIDES;

EID: 84955709326     PISSN: 02506807     EISSN: 14219697     Source Type: Journal    
DOI: 10.1159/000441481     Document Type: Article

References (27)

1. International Diabetes Federation: International Diabetes Federation. IDF Diabetes Atlas, ed 6. Brussels, International Diabetes Federation, 2013.
2. Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE: Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract 2014;103:137-149.
3. Al-Khudairy L, Stranges S, Kumar S, Al-Daghri N, Rees K: Dietary factors and type 2 diabetes in the middle east: what is the evidence for an association?-a systematic review. Nutrients 2013;5:3871-3897.
4. Ghassibe-Sabbagh M, Deeb M, Salloum AK, et al. Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population. Diabetol Metab Syndr 2014;6:89.
5. Nasreddine L, Hwalla N, Sibai A, Hamze M, Parent-Massin D: Food consumption patterns in an adult urban population in Beirut, Lebanon. Public Health Nutr 2006;9:194-203.
6. Bhupathiraju SN, Pan A, Malik VS, et al. Caffeinated and caffeine-free beverages and risk of type 2 diabetes. Am J Clin Nutr 2013;97:155-166.
7. Ding M, Bhupathiraju SN, Chen M, van Dam RM, Hu FB: Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: a systematic review and a dose-response meta-analysis. Diabetes Care 2014;37:569-586.
8. Huxley R, Lee CM, Barzi F, et al. Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis. Arch Intern Med 2009;169:2053-2063.
9. Jiang X, Zhang D, Jiang W: Coffee and caffeine intake and incidence of type 2 diabetes mellitus: a meta-analysis of prospective studies. Eur J Nutr 2014;53:25-38.
10. van Dam RM, Hu FB: Coffee consumption and risk of type 2 diabetes: a systematic review. JAMA 2005;294:97-104.
11. Mostofsky E, Rice MS, Levitan EB, Mittleman MA: Habitual coffee consumption and risk of heart failure: a dose-response meta-analysis. Circ Heart Fail 2012;5:401-405.
12. Regal KA, Kunze KL, Peter RM, Nelson SD: Oxidation of caffeine by CYP1A2: isotope effects and metabolic switching. Drug Metab Dispos 2005;33:1837-1844.
13. Han XM, Ou-Yang DS, Lu PX, et al. Plasma caffeine metabolite ratio (17X/137X) in vivo associated with G-2964A and C734A polymorphisms of human CYP1A2. Pharmacogenetics 2001;11:429-435.
14. Guessous I, Dobrinas M, Kutalik Z, et al. Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension. Hum Mol Genet 2012;21:3283-3292.
15. Cornelis MC, Monda KL, Yu K, et al. Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. PLoS Genet 2011;7:e1002033.
16. Yang A, Palmer AA, de Wit H: Genetics of caffeine consumption and responses to caffeine. Psychopharmacology (Berl) 2010;211:245-257.
17. Palatini P, Benetti E, Mos L, et al. Association of coffee consumption and CYP1A2 polymorphism with risk of impaired fasting glucose in hypertensive patients. Eur J Epidemiol 2015;30:209-217.
18. Chang CC, Chow CC, Tellier LC, Vattikuti S, Purcell SM, Lee JJ: Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience 2015;4:7.
19. R Development Core Team: R: A Language and Environment for Statistical Computing. Vienna, R Foundation for Statistical Computing, 2014.
20. Freedman ND, Park Y, Abnet CC, Hollenbeck AR, Sinha R: Association of coffee drinking with total and cause-specific mortality. N Engl J Med 2012;366:1891-1904.
21. Cornelis MC, El-Sohemy A, Kabagambe EK, Campos H: Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA 2006;295:1135-1141.
22. Boekschoten MV, Hofman MK, Buytenhek R, Schouten EG, Princen HM, Katan MB: Coffee oil consumption increases plasma levels of 7alpha-hydroxy-4-cholesten-3-one in humans. J Nutr 2005;135:785-789.
23. Ricketts ML, Boekschoten MV, Kreeft AJ, et al. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Mol Endocrinol 2007;21:1603-1616.
24. Post SM, de Roos B, Vermeulen M, et al. Cafestol increases serum cholesterol levels in apolipoprotein E∗3-Leiden transgenic mice by suppression of bile acid synthesis. Arterioscler Thromb Vasc Biol 2000;20:1551-1556.
25. Godos J, Pluchinotta FR, Marventano S, et al. Coffee components and cardiovascular risk: beneficial and detrimental effects. Int J Food Sci Nutr 2014;65:925-936.
26. Onakpoya IJ, Spencer EA, Thompson MJ, Heneghan CJ: The effect of chlorogenic acid on blood pressure: a systematic review and meta-analysis of randomized clinical trials. J Hum Hypertens 2015;29:77-81.
27. Gavrieli A, Fragopoulou E, Mantzoros CS, Yannakoulia M: Gender and body mass index modify the effect of increasing amounts of caffeinated coffee on postprandial glucose and insulin concentrations; a randomized, controlled, clinical trial. Metabolism 2013;62:1099-1106.