메뉴 건너뛰기




Volumn 23, Issue 1, 2016, Pages e151-e158

Atypical HemolyticUremic Syndrome: A Clinical Review

Author keywords

atypical hemolyticuremic syndrome; complements; eculizumab; endothelial cells; kidney

Indexed keywords

COMPLEMENT;

EID: 84955676758     PISSN: 10752765     EISSN: 15363686     Source Type: Journal    
DOI: 10.1097/MJT.0b013e31829b59dc     Document Type: Review
Times cited : (15)

References (34)
  • 1
    • 70350279315 scopus 로고    scopus 로고
    • Atypical hemolytic-uremic syndrome
    • Noris M, Remuzzi G. Atypical hemolytic-uremic syndrome. N Engl J Med. 2009;361:1676-1687.
    • (2009) N Engl J Med , vol.361 , pp. 1676-1687
    • Noris, M.1    Remuzzi, G.2
  • 3
    • 84883049968 scopus 로고    scopus 로고
    • Atypical hemolytic uremic syndrome (aHUS): Making the diagnosis
    • Laurence J. Atypical hemolytic uremic syndrome (aHUS): making the diagnosis. Clin Adv Hematol Oncol. 2012;10:3-9.
    • (2012) Clin Adv Hematol Oncol , vol.10 , pp. 3-9
    • Laurence, J.1
  • 4
    • 84867997580 scopus 로고    scopus 로고
    • STEC-HUS, atypical HUS and TTP are all diseases of complement activation
    • Noris M, Mescia F, Remuzzi G. STEC-HUS, atypical HUS and TTP are all diseases of complement activation. Nat Rev Nephrol. 2012;8:622-633.
    • (2012) Nat Rev Nephrol , vol.8 , pp. 622-633
    • Noris, M.1    Mescia, F.2    Remuzzi, G.3
  • 5
    • 79151471122 scopus 로고    scopus 로고
    • AHUS caused by complement dysregulation: New therapies on the horizon
    • Waters AM, Licht C. aHUS caused by complement dysregulation: new therapies on the horizon. Pediatr Nephrol. 2011;26:41-57.
    • (2011) Pediatr Nephrol , vol.26 , pp. 41-57
    • Waters, A.M.1    Licht, C.2
  • 6
    • 78649451637 scopus 로고    scopus 로고
    • The role of endothelial cell injury in thrombotic microangiopathy
    • Goldberg RJ, Nakagawa T, Johnson RJ, et al. The role of endothelial cell injury in thrombotic microangiopathy. Am J Kidney Dis. 2010;56:1168-1174.
    • (2010) Am J Kidney Dis , vol.56 , pp. 1168-1174
    • Goldberg, R.J.1    Nakagawa, T.2    Johnson, R.J.3
  • 7
    • 0022022077 scopus 로고
    • Renal involvement in thrombotic microangiopathies
    • Churg J, Strauss L. Renal involvement in thrombotic microangiopathies. Semin Nephrol. 1985;5:46-56.
    • (1985) Semin Nephrol , vol.5 , pp. 46-56
    • Churg, J.1    Strauss, L.2
  • 8
    • 77955883153 scopus 로고    scopus 로고
    • Complement: A key system for immune surveillance and homeostasis
    • Ricklin D, Hajishengallis G, Yang K, et al. Complement: a key system for immune surveillance and homeostasis. Nat Immunol. 2010;11:785-797.
    • (2010) Nat Immunol , vol.11 , pp. 785-797
    • Ricklin, D.1    Hajishengallis, G.2    Yang, K.3
  • 9
    • 70349437186 scopus 로고    scopus 로고
    • Complement regulators and inhibitory proteins
    • Zipfel PF, Skerka C. Complement regulators and inhibitory proteins. Nat Rev Immunol. 2009;9:729-740.
    • (2009) Nat Rev Immunol , vol.9 , pp. 729-740
    • Zipfel, P.F.1    Skerka, C.2
  • 10
    • 77958587405 scopus 로고    scopus 로고
    • Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype
    • Noris M, Caprioli J, Bresin E, et al. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Clin J Am Soc Nephrol. 2010;5:1844-1859.
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 1844-1859
    • Noris, M.1    Caprioli, J.2    Bresin, E.3
  • 11
    • 0242570482 scopus 로고    scopus 로고
    • Familial haemolytic uraemic syndrome and an MCP mutation
    • International Registry of Recurrent and Familial HUS/TTP
    • Noris M, Brioschi S, Caprioli J, et al; International Registry of Recurrent and Familial HUS/TTP. Familial haemolytic uraemic syndrome and an MCP mutation. Lancet. 2003;362:1542-1547.
    • (2003) Lancet , vol.362 , pp. 1542-1547
    • Noris, M.1    Brioschi, S.2    Caprioli, J.3
  • 12
    • 84874610717 scopus 로고    scopus 로고
    • Combined complement gene mutations in atypical hemolytic uremic syndrome influence clinical phenotype
    • European Working Party on Complement Genetics in Renal Diseases
    • Bresin E, Rurali E, Caprioli J, et al; European Working Party on Complement Genetics in Renal Diseases. Combined complement gene mutations in atypical hemolytic uremic syndrome influence clinical phenotype. J Am Soc Nephrol. 2013;24:475-486.
    • (2013) J Am Soc Nephrol , vol.24 , pp. 475-486
    • Bresin, E.1    Rurali, E.2    Caprioli, J.3
  • 13
    • 77952071017 scopus 로고    scopus 로고
    • Endothelial von Willebrand factor release due to eNOS deficiency predisposes to thrombotic microangiopathy in mouse aging kidney
    • Nakayama T, Sato W, Yoshimura A, et al. Endothelial von Willebrand factor release due to eNOS deficiency predisposes to thrombotic microangiopathy in mouse aging kidney. Am J Pathol. 2010;176:2198-2208.
    • (2010) Am J Pathol , vol.176 , pp. 2198-2208
    • Nakayama, T.1    Sato, W.2    Yoshimura, A.3
  • 14
    • 0037370325 scopus 로고    scopus 로고
    • Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
    • Eremina V, Sood M, Haigh J, et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest. 2003;111:707-716.
    • (2003) J Clin Invest , vol.111 , pp. 707-716
    • Eremina, V.1    Sood, M.2    Haigh, J.3
  • 15
    • 40849130173 scopus 로고    scopus 로고
    • VEGF inhibition and renal thrombotic microangiopathy
    • Eremina V, Jefferson JA, Kowalewska J, et al. VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med. 2008;358:1129-1136.
    • (2008) N Engl J Med , vol.358 , pp. 1129-1136
    • Eremina, V.1    Jefferson, J.A.2    Kowalewska, J.3
  • 16
    • 0034791188 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF121) protects rats from renal infarction in thrombotic microangiopathy
    • Suga S, Kim YG, Joly A, et al. Vascular endothelial growth factor (VEGF121) protects rats from renal infarction in thrombotic microangiopathy. Kidney Int. 2001;60:1297-1308.
    • (2001) Kidney Int , vol.60 , pp. 1297-1308
    • Suga, S.1    Kim, Y.G.2    Joly, A.3
  • 17
    • 77957602545 scopus 로고    scopus 로고
    • Transplantation in atypical hemolytic uremic syndrome
    • Kavanagh D, Richards A, Goodship T, et al. Transplantation in atypical hemolytic uremic syndrome. Semin Thromb Hemost. 2010;36:653-659.
    • (2010) Semin Thromb Hemost , vol.36 , pp. 653-659
    • Kavanagh, D.1    Richards, A.2    Goodship, T.3
  • 18
    • 84955703228 scopus 로고    scopus 로고
    • Solaris (Eculizumab) [Prescribing Information]. Cheshire, CT: Alexion Pharmaceuticals; 2012
    • Solaris (Eculizumab) [Prescribing Information]. Cheshire, CT: Alexion Pharmaceuticals; 2012.
  • 19
    • 0006567214 scopus 로고    scopus 로고
    • Mechanism by which quinapril improves vascular function in coronary artery disease
    • Koh KK, Bui MN, Hathaway L, et al. Mechanism by which quinapril improves vascular function in coronary artery disease. Am J Cardiol. 1999;83:327-331.
    • (1999) Am J Cardiol , vol.83 , pp. 327-331
    • Koh, K.K.1    Bui, M.N.2    Hathaway, L.3
  • 20
    • 33644653151 scopus 로고    scopus 로고
    • Anti-inflammatory and metabolic effects of candesartan in hypertensive patients
    • Koh KK, Quon MJ, Han SH, et al. Anti-inflammatory and metabolic effects of candesartan in hypertensive patients. Int J Cardiol. 2006;108:96-100.
    • (2006) Int J Cardiol , vol.108 , pp. 96-100
    • Koh, K.K.1    Quon, M.J.2    Han, S.H.3
  • 22
    • 0031032831 scopus 로고    scopus 로고
    • Simvastatin, an HMGcoenzyme A reductase inhibitor, improves endothelial function within 1 month
    • O'Driscoll G, Green D, Taylor RR. Simvastatin, an HMGcoenzyme A reductase inhibitor, improves endothelial function within 1 month. Circulation. 1997;95:1126-1131.
    • (1997) Circulation , vol.95 , pp. 1126-1131
    • O'Driscoll, G.1    Green, D.2    Taylor, R.R.3
  • 23
    • 44349148871 scopus 로고    scopus 로고
    • Allopurinol improves endothelial function and reduces oxidant-inflammatory enzyme of myeloperoxidase in metabolic syndrome
    • Yiginer O, Ozcelik F, Inanc T, et al. Allopurinol improves endothelial function and reduces oxidant-inflammatory enzyme of myeloperoxidase in metabolic syndrome. Clin Res Cardiol. 2008;97:334-340.
    • (2008) Clin Res Cardiol , vol.97 , pp. 334-340
    • Yiginer, O.1    Ozcelik, F.2    Inanc, T.3
  • 24
    • 0034065857 scopus 로고    scopus 로고
    • Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension
    • Butler R, Morris AD, Belch JJ, et al. Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension. Hypertension. 2000;35:746-751.
    • (2000) Hypertension , vol.35 , pp. 746-751
    • Butler, R.1    Morris, A.D.2    Belch, J.J.3
  • 25
    • 77957587756 scopus 로고    scopus 로고
    • Treatment of typical (enteropathic) hemolytic uremic syndrome
    • Bitzan M, Schaefer F, Reymond D. Treatment of typical (enteropathic) hemolytic uremic syndrome. Semin Thromb Hemost. 2010;36:594-610.
    • (2010) Semin Thromb Hemost , vol.36 , pp. 594-610
    • Bitzan, M.1    Schaefer, F.2    Reymond, D.3
  • 26
    • 59449107473 scopus 로고    scopus 로고
    • Eculizumab for atypical hemolytic-uremic syndrome
    • Nürnberger J, Philipp T, Witzke O, et al. Eculizumab for atypical hemolytic-uremic syndrome. N Engl J Med. 2009; 360:542-544.
    • (2009) N Engl J Med , vol.360 , pp. 542-544
    • Nürnberger, J.1    Philipp, T.2    Witzke, O.3
  • 27
    • 83155172386 scopus 로고    scopus 로고
    • Eculizumab in atypical hemolytic uremic syndrome: Long-term clinical course and histological findings
    • Tschumi S, GuggerM, Bucher BS, et al. Eculizumab in atypical hemolytic uremic syndrome: long-term clinical course and histological findings. Pediatr Nephrol. 2011;26:2085-2088.
    • (2011) Pediatr Nephrol , vol.26 , pp. 2085-2088
    • Tschumi, S.1    Gugge, M.2    Bucher, B.S.3
  • 28
    • 70350130833 scopus 로고    scopus 로고
    • Safety and long-term efficacy of eculizumab in a renal transplant patient with recurrent atypical hemolytic-uremic syndrome
    • Chatelet V, Fremeaux-Bacchi V, Lobbedez T, et al. Safety and long-term efficacy of eculizumab in a renal transplant patient with recurrent atypical hemolytic-uremic syndrome. Am J Transplant. 2009;9:2644-2645.
    • (2009) Am J Transplant , vol.9 , pp. 2644-2645
    • Chatelet, V.1    Fremeaux-Bacchi, V.2    Lobbedez, T.3
  • 29
    • 70349907791 scopus 로고    scopus 로고
    • Complement inhibitor eculizumab in atypical hemolytic uremic syndrome
    • Mache CJ, Acham-Roschitz B, Fremeaux-Bacchi V, et al. Complement inhibitor eculizumab in atypical hemolytic uremic syndrome. Clin J Am Soc Nephrol. 2009;4:1312-1316.
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 1312-1316
    • Mache, C.J.1    Acham-Roschitz, B.2    Fremeaux-Bacchi, V.3
  • 30
    • 77957602105 scopus 로고    scopus 로고
    • New treatment options for atypical hemolytic uremic syndrome with the complement inhibitor eculizumab
    • Köse O, Zimmerhackl LB, Jungraithmayr T, et al. New treatment options for atypical hemolytic uremic syndrome with the complement inhibitor eculizumab. Semin Thromb Hemost. 2010;36:669-672.
    • (2010) Semin Thromb Hemost , vol.36 , pp. 669-672
    • Köse, O.1    Zimmerhackl, L.B.2    Jungraithmayr, T.3
  • 31
    • 79952287861 scopus 로고    scopus 로고
    • Production of biologically active recombinant human factor H in Physcomitrella
    • Büttner-Mainik A, Parsons J, Jerôme H, et al. Production of biologically active recombinant human factor H in Physcomitrella. Plant Biotechnol J. 2011;9:373-383.
    • (2011) Plant Biotechnol J , vol.9 , pp. 373-383
    • Büttner-Mainik, A.1    Parsons, J.2    Jerôme, H.3
  • 32
    • 33845447368 scopus 로고    scopus 로고
    • High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid
    • George J, Carr E, Davies J, et al. High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid. Circulation. 2006;114:2508-2516.
    • (2006) Circulation , vol.114 , pp. 2508-2516
    • George, J.1    Carr, E.2    Davies, J.3
  • 33
    • 0035957267 scopus 로고    scopus 로고
    • Ascorbate restores endothelium-dependent vasodilation impaired by acute hyperglycemia in humans
    • Beckman JA, Goldfine AB, Gordon MB, et al. Ascorbate restores endothelium-dependent vasodilation impaired by acute hyperglycemia in humans. Circulation. 2001; 103:1618-1623.
    • (2001) Circulation , vol.103 , pp. 1618-1623
    • Beckman, J.A.1    Goldfine, A.B.2    Gordon, M.B.3
  • 34
    • 49349112382 scopus 로고    scopus 로고
    • Hemolytic uremic syndrome recurrence after renal transplantation
    • Loirat C, Fremeaux-Bacchi V. Hemolytic uremic syndrome recurrence after renal transplantation. Pediatr Transplant. 2008;12:619-629.
    • (2008) Pediatr Transplant , vol.12 , pp. 619-629
    • Loirat, C.1    Fremeaux-Bacchi, V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.