Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors

Chemical Biology and Drug Design

Volumn 87, Issue 1, 2016, Pages 112-120

  Savi, Lida ^a   Brindisi, Margherita ^b   Alfano, Gloria ^b   Butini, Stefania ^b   La Pietra, Valeria ^b,c   Novellino, Ettore ^b,c   Marinelli, Luciana ^b,c   Lossani, Andrea ^a   Focher, Federico ^a   Cavella, Caterina ^b   Campiani, Giuseppe ^b   Gemma, Sandra ^b  

^a CNR   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

adenosine kinase; Ala scan mutagenesis; allosteric binding site; allosteric inhibitors; drug discovery; non nucleoside human AK inhibitors; small molecule

Indexed keywords

ADENOSINE KINASE; AZEPINE DERIVATIVE; NUCLEOSIDE;

ANTAGONISTS AND INHIBITORS; BINDING SITE; HUMAN; METABOLISM; SITE DIRECTED MUTAGENESIS;

ADENOSINE KINASE; ALLOSTERIC SITE; AZEPINES; HUMANS; MUTAGENESIS, SITE-DIRECTED; NUCLEOSIDES;

EID: 84955664471     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12630     Document Type: Article

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