Are ERAD components involved in cross-presentation?

Molecular Immunology

Volumn 68, Issue 2, 2015, Pages 112-115

  Grotzke, JeffE ^a   Cresswell, Peter ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antigen processing; Cross presentation; Dendritic cells; ERAD; MHC

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CHAPERONE; EXOTOXIN; FAT DROPLET; HLA ANTIGEN CLASS 2; MEMBRANE PROTEIN; OVALBUMIN; OXIDOREDUCTASE; PROTEASOME; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE E3; ANTIGEN; HLA ANTIGEN CLASS 1; NUCLEAR PROTEIN; NUCLEAR PROTEIN IMPORT FACTOR P97; UBIQUITIN PROTEIN LIGASE;

ANTIGEN PRESENTING CELL; CD8+ T LYMPHOCYTE; CROSS PRESENTATION; CYTOSOL; DENDRITIC CELL; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENDOSOME; HUMAN; INTERNALIZATION; LIPID TRANSPORT; MACROPHAGE; PHAGOSOME; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; PSEUDOMONAS AERUGINOSA; REVIEW; ANIMAL; ANTIGEN PRESENTATION; CYTOLOGY; ENDOPLASMIC RETICULUM; GENETICS; IMMUNOLOGY; METABOLISM; PROTEIN TRANSPORT;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; CROSS-PRIMING; CYTOSOL; DENDRITIC CELLS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; NUCLEAR PROTEINS; PROTEIN TRANSPORT; UBIQUITIN-PROTEIN LIGASES;

EID: 84955637673     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2015.05.002     Document Type: Review

References (34)

1. Ackerman, A.L., Giodini, A., Cresswell, P., 2006. A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells. Immunity 25, 607-617.
2. Ackerman, A.L., Kyritsis, C., Tampe, R., Cresswell, P., 2003. Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens. Proc. Natl. Acad. Sci. U. S. A. 100, 12889-12894.
3. Becker, T., Volchuk, A., Rothman, J.E., 2005. Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages. Proc. Natl. Acad. Sci. U. S. A. 102, 4022-4026.
4. Bougneres, L., Helft, J., Tiwari, S., Vargas, P., Chang, B.H., Chan, L., Campisi, L., Lauvau, G., Hugues, S., Kumar, P., Kamphorst, A.O., Dumenil, A.M., Nussenzweig, M., MacMicking, J.D., Amigorena, S., Guermonprez, P., 2009. A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells. Immunity 31, 232-244.
5. Carvalho, P., Stanley, A.M., Rapoport, T.A., 2010. Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell 143, 579-591.
6. Cebrian, I., Visentin, G., Blanchard, N., Jouve, M., Bobard, A., Moita, C., Enninga, J., Moita, L.F., Amigorena, S., Savina, A., 2011. Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells. Cell 147, 1355-1368.
7. Christianson, J.C., Shaler, T.A., Tyler, R.E., Kopito, R.R., 2008. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nat. Cell Biol. 10, 272-282.
8. Giodini, A., Cresswell, P., 2008. Hsp90-mediated cytosolic refolding of exogenous proteins internalized by dendritic cells. EMBO J. 27, 201-211.
9. Goldszmid, R.S., Coppens, I., Lev, A., Caspar, P., Mellman, I., Sher, A., 2009. Host ERparasitophorous vacuole interaction provides a route of entry for antigen crosspresentation in Toxoplasma gondii-infected dendritic cells. J. Exp. Med. 206, 399-410.
10. Grotzke, J.E., Harriff, M.J., Siler, A.C., Nolt, D., Delepine, J., Lewinsohn, D.A., Lewinsohn, D.M., 2009. The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle. PLoS Pathog. 5, e1000374.
11. Grotzke, J.E., Lu, Q., Cresswell, P., 2013. Deglycosylation-dependent fluorescent proteins provide unique tools for the study of ER-associated degradation. Proc. Natl. Acad. Sci. U. S. A. 110, 3393-3398.
12. Guermonprez, P., Saveanu, L., Kleijmeer, M., Davoust, J., Van Endert, P., Amigorena, S., 2003. ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells. Nature 425, 397-402.
13. Hosokawa, N., Wada, I., Hasegawa, K., Yorihuzi, T., Tremblay, L.O., Herscovics, A., Nagata, K., 2001. A novel ER alpha-mannosidase-like protein accelerates ERassociated degradation. EMBO Rep. 2, 415-422.
14. Houde, M., Bertholet, S., Gagnon, E., Brunet, S., Goyette, G., Laplante, A., Princiotta, M.F., Thibault, P., Sacks, D., Desjardins, M., 2003. Phagosomes are competent organelles for antigen cross-presentation. Nature 425, 402-406.
15. Imai, J., Hasegawa, H., Maruya, M., Koyasu, S., Yahara, I., 2005. Exogenous antigens are processed through the endoplasmic reticulum-associated degradation (ERAD) in cross-presentation by dendritic cells. Int. Immunol. 17, 45-53.
16. Imai, T., Kato, Y., Kajiwara, C., Mizukami, S., Ishige, I., Ichiyanagi, T., Hikida, M., Wang, J.Y., Udono, H., 2011. Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells. Proc. Natl. Acad. Sci. U. S. A. 108, 16363-16368.
17. Kikkert, M., Doolman, R., Dai, M., Avner, R., Hassink, G., van Voorden, S., Thanedar, S., Roitelman, J., Chau, V., Wiertz, E., 2004. Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. J. Biol. Chem. 279, 3525-3534.
18. Koopmann, J.O., Albring, J., Huter, E., Bulbuc, N., Spee, P., Neefjes, J., Hammerling, G.J., Momburg, F., 2000. Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec61p channel. Immunity 13, 117-127.
19. Kovacsovics-Bankowski, M., Rock, K.L., 1995. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science 267, 243-246.
20. Leitman, J., Shenkman, M., Gofman, Y., Shtern, N.O., Ben-Tal, N., Hendershot, L.M., Lederkremer, G.Z., 2014. Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD. Mol. Biol. Cell 25, 1050-1060.
21. Lilley, B.N., Ploegh, H.L., 2004. A membrane protein required for dislocation of misfolded proteins from the ER. Nature 429, 834-840.
22. Lin, M.L., Zhan, Y., Proietto, A.I., Prato, S., Wu, L., Heath, W.R., Villadangos, J.A., Lew, A.M., 2008. Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset. Proc. Natl. Acad. Sci. U. S. A. 105, 3029-3034.
23. McNew, J.A., Parlati, F., Fukuda, R., Johnston, R.J., Paz, K., Paumet, F., Sollner, T.H., Rothman, J.E., 2000. Compartmental specificity of cellular membrane fusion encoded in SNARE proteins. Nature 407, 153-159.
24. Mehnert, M., Sommer, T., Jarosch, E., 2010. ERAD ubiquitin ligases: multifunctional tools for protein quality control and waste disposal in the endoplasmic reticulum. Bioessays 32, 905-913.
25. Menager, J., Ebstein, F., Oger, R., Hulin, P., Nedellec, S., Duverger, E., Lehmann, A., Kloetzel, P.M., Jotereau, F., Guilloux, Y., 2014. Cross-presentation of synthetic long peptides by human dendritic cells: a process dependent on ERAD component p97/VCP but Not sec61 and/or Derlin-1. PLOS ONE 9, e89897.
26. Mueller, B., Klemm, E.J., Spooner, E., Claessen, J.H., Ploegh, H.L., 2008. SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. Proc. Natl. Acad. Sci. U. S. A. 105, 12325-12330.
27. Olzmann, J.A., Kopito, R.R., 2011. Lipid droplet formation is dispensable for endoplasmic reticulum-associated degradation. J. Biol. Chem. 286, 27872-27874.
28. Pilon, M., Schekman, R., Romisch, K., 1997. Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation. EMBO J. 16, 4540-4548.
29. Ploegh, H.L., 2007. A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum. Nature 448, 435-438.
30. Stein, A., Ruggiano, A., Carvalho, P., Rapoport, T.A., 2014. Key steps in ERAD of luminal ER proteins reconstituted with purified components. Cell 158, 1375-1388.
31. Turk, B., Turk, V., 2009. Lysosomes as "suicide bags" in cell death: myth or reality? J. Biol. Chem. 284, 21783-21787.
32. Ye, Y., Meyer, H.H., Rapoport, T.A., 2001. The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature 414, 652-656.
33. Ye, Y., Shibata, Y., Yun, C., Ron, D., Rapoport, T.A., 2004. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature 429, 841-847.
34. Zehner, M., Chasan, A.I., Schuette, V., Embgenbroich, M., Quast, T., Kolanus, W., Burgdorf, S., 2011. Mannose receptor polyubiquitination regulates endosomal recruitment of p97 and cytosolic antigen translocation for cross-presentation. Proc. Natl. Acad. Sci. U. S. A. 108, 9933-9938.