Clinico‑microbiological study and antibiotic resistance profile of meca and ESBL gene prevalence in patients with diabetic foot infections

Experimental and Therapeutic Medicine

Volumn 11, Issue 3, 2016, Pages 1031-1038

  Chaudhry, Waqas Nasir ^a   Badar, Rabia ^a   Jamal, Muhsin ^a   Jeong, Jason ^a   Zafar, Jamal ^a   Andleeb, Saadia ^a  

^a NATIONAL UNIVERSITY OF SCIENCES AND TECHNOLOGY   (Pakistan)

Author keywords

Antibiotic resistance; Diabetic foot ulcer; Extended spectrum lactamase; Prevalence

Indexed keywords

CEFOTAXIME; CLAVULANIC ACID; EXTENDED SPECTRUM BETA LACTAMASE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM CULTURE; BACTERIUM ISOLATION; CONTROLLED STUDY; DIABETIC FOOT; DNA EXTRACTION; ENTEROCOCCUS; ESBL GENE; ESCHERICHIA COLI; GENE; GENETIC ANALYSIS; HUMAN; KLEBSIELLA PNEUMONIAE; MECA GENE; MOLECULAR DIAGNOSIS; NONHUMAN; PROTEUS; PSEUDOMONAS AERUGINOSA; RISK ASSESSMENT; SEQUENCE ANALYSIS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS;

EID: 84955600471     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2016.2996     Document Type: Article

References (57)

1. Singh N, Armstrong DG and Lipsky BA: Preventing foot ulcers in patients with diabetes. JAMA 293: 217-228, 2005.
2. Mutlu F, Bener A, Eliyan A, Delghan H, Nofal E, Shalabi L and Wadi N: Projection of Diabetes Burden through 2025 and Contributing Risk Factors of Changing Disease Prevalence: An Emerging Public Health Problem. J Diabetes Metab 5: 341, 2014.
3. Forouhi NG and Wareham NJ: Epidemiology of diabetes. Medicine 38: 602-606, 2010.
4. Cusick M, Meleth AD, Agrón E, Fisher MR, Reed GF, Knatterud GL, Barton FB, Davis MD, Ferris FL and Chew EY; Early Treatment Diabetic Retinopathy Study Research Group: Associations of mortality and diabetes complications in patients with type 1 and type 2 diabetes: Early treatment diabetic retinopathy study report no. 27. Diabetes Care 28: 617-625, 2005.
5. Clayton W and Elasy TA: A Review of the Pathophysiology, Classification, and Treatment of Foot Ulcers in Diabetic Patients. Clin Diabetes: 27, 52-58, 2009.
6. Fowler MJ: Microvascular and macrovascular complications of diabetes. Clinical diabetes 26: 77-82, 2008.
7. Bowler PG, Duerden BI and Armstrong DG: Wound microbiology and associated approaches to wound management. Clin Microbiol Rev 14: 244-269, 2001.
8. Argoff CE, Cole BE, Fishbain DA and Irving GA: Diabetic peripheral neuropathic pain: Clinical and quality-of-life issues. Mayo Clin Proc 81 (Suppl 4): S3-S11, 2006.
9. Podwall D and Gooch C: Diabetic neuropathy: Clinical features, etiology, and therapy. Curr Neurol Neurosci Rep 4: 55-61, 2004.
10. Delamaire M, Maugendre D, Moreno M, Le Goff MC, Allannic H and Genetet B: Impaired leucocyte functions in diabetic patients. Diabet Med 14: 29-34, 1997.
11. Siitonen OI, Niskanen LK, Laakso M, Siitonen JT and Pyörälä K: Lower-extremity amputations in diabetic and nondiabetic patients: A population-based study in eastern Finland. Diabetes care 16: 16-20, 1993.
12. Trautner C, Haastert B, Giani G and Berger M: Incidence of lower limb amputations and diabetes. Diabetes care 19: 1006-1009, 1996.
13. Paneni F, Beckman JA, Creager MA and Cosentino F: Diabetes and vascular disease: Pathophysiology, clinical consequences, and medical therapy. Eur Heart J 34: 2436-2443, 2013.
14. Reiber GE: Epidemiology of foot ulcers and amputations in the diabetic foot. The diabetic foot 6: 13-32, 2001.
15. Tiwari S, Pratyush DD, Dwivedi A, Gupta SK, Rai M and Singh SK: Microbiological and clinical characteristics of diabetic foot infections in northern India. J Infec Dev Ctries 6: 329-332, 2012.
16. Lipsky B, Pecoraro R and Wheat L: The diabetic foot. Soft tissue and bone infection. Infect Dis Clin North Am 4: 409-432, 1990.
17. Frykberg RG: An evidence-based approach to diabetic foot infections. Am J Surg 186 (Suppl): S44-S54, 2003.
18. Benwan K, Al Mulla A and Rotimi VO: A study of the microbiology of diabetic foot infections in a teaching hospital in Kuwait. J Infect Public Health 5: 1-8, 2012.
19. Roberts RR, Hota B, Ahmad I, Scott RD 2nd, Foster SD, Abbasi F, Schabowski S, Kampe LM, Ciavarella GG, Supino M, et al: Hospital and societal costs of antimicrobial-resistant infections in a Chicago teaching hospital: Implications for antibiotic stewardship. Clin Infect Dis 49: 1175-1184, 2009.
20. Cosgrove SE, Sakoulas G, Perencevich EN, Schwaber MJ, Karchmer AW and Carmeli Y: Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: A meta-analysis. Clin Infect Dis 36: 53-59, 2003.
21. Grundmann H, Aires-de-Sousa M, Boyce J and Tiemersma E: Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat. Lancet 368: 874-885, 2006.
22. Askari E, Soleymani F, Arianpoor A, Tabatabai SM, Amini A and Naderi Nasab M: Epidemiology of mecA-methicillin resistant Staphylococcus aureus (MRSA) in Iran: A systematic review and meta-analysis. Iran J Basic Med Sci 15: 1010-1019, 2012.
23. Poole K: Resistance to beta-lactam antibiotics. Cell Mol Life Sci 61: 2200-2223, 2004.
24. Bonnet R: Growing group of extended-spectrum beta-lactamases: The CTX-M enzymes. Antimicrob Agents Chemother 48: 1-14, 2004.
25. Perez F, Endimiani A, Hujer KM and Bonomo RA: The continuing challenge of ESBLs. Curr Opin Pharmacol 7: 459-469, 2007.
26. Walsh TR, Toleman MA, Poirel L and Nordmann P: Metallo-beta-lactamases: The quiet before the storm? Clin Microbiol Rev 18: 306-325, 2005.
27. Shahi SK, Singh VK and Kumar A: Detection of Escherichia coli and associated β-lactamases genes from diabetic foot ulcers by multiplex PCR and molecular modeling and docking of SHV-1, TEM-1, and OXA-1 β-lactamases with clindamycin and piperacillin-tazobactam. PLoS One 8: e68234, 2013.
28. Oyibo SO, Jude EB, Tarawneh I, Nguyen HC, Harkless LB and Boulton AJ: A comparison of two diabetic foot ulcer classification systems: The Wagner and the University of Texas wound classification systems. Diabetes care 24: 84-88, 2001.
29. Bauer AW, Perry DM and Kirby WM: Single-disk antibiotic-sensitivity testing of Staphylococci: An analysis of technique and results. AMA Arch Intern Med 104: 208-216, 1959.
30. Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing: Twenty-first Informational Supplement (M100-S21). CLSI, Wayne, PA, 2011.
31. Singhal S, Mathur T, Khan S, Upadhyay DJ, Chugh S, Gaind R and Rattan A: Evaluation of methods for AmpC beta-lactamase in gram negative clinical isolates from tertiary care hospitals. Indian J Med Microbiol 23: 120-124, 2005.
32. Yong D, Lee K, Yum JH, Shin HB, Rossolini GM and Chong Y: Imipenem-EDTA disk method for differentiation of metallo-beta-lactamase-producing clinical isolates of Pseudomonas spp. and Acinetobacter spp. J Clin Microbiol 40: 3798-3801, 2002.
33. Shahcheraghi F, Nikbin VS and Feizabadi MM: Prevalence of ESBLs genes among multidrug-resistant isolates of Pseudomonas aeruginosa isolated from patients in Tehran. Microb Drug Resist 15: 37-39, 2009.
34. Fang H, Ataker F, Hedin G and Dornbusch K: Molecular epidemiology of extended-spectrum beta-lactamases among Escherichia coli isolates collected in a Swedish hospital and its associated health care facilities from 2001 to 2006. J Clin Microbiol 46: 707-712, 2008.
35. Dallenne C, Da Costa A, Decré D, Favier C and Arlet G: Development of a set of multiplex PCR assays for the detection of genes encoding important beta-lactamases in Enterobacteriaceae. J Antimicrob Chemother 65: 490-495, 2010.
36. Boyd DA, Tyler S, Christianson S, McGeer A, Muller MP, Willey BM, Bryce E, Gardam M, Nordmann P and Mulvey MR: Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum beta-lactamase involved in an outbreak in long-term-care facilities in Toronto, Canada. Antimicrob Agents Chemother 48: 3758-3764, 2004.
37. Monstein HJ, Ostholm-Balkhed A, Nilsson M, Nilsson M, Dornbusch K and Nilsson L: Multiplex PCR amplification assay for the detection of blaSHV, blaTEM and blaCTX-M genes in Enterobacteriaceae. APMIS 115: 1400-1408, 2007.
38. Rodrigues BT, Gilhotra RA, Vangaveti VN and Malabu UH: Prevalence and risk factors of lower limb amputation amongst diabetic food ulcer patients at the Townsville Hospital. Annals of the ACTM 15: 57, 2014.
39. Stockl K, Vanderplas A, Tafesse E and Chang E: Costs of lower-extremity ulcers among patients with diabetes. Diabetes Care 27: 2129-2134, 2004.
40. Gardner SE, Hillis SL, Heilmann K, Segre JA and Grice EA: The neuropathic diabetic foot ulcer microbiome is associated with clinical factors. Diabetes 62: 923-930, 2013.
41. Lipsky BA, Berendt AR, Deery HG, Embil JM, Joseph WS, Karchmer AW, LeFrock JL, Lew DP, Mader JT, Norden C, et al: Diagnosis and treatment of diabetic foot infections. Clin Infect Dis 39: 885-910, 2004.
42. Monteiro-Soares M, Boyko EJ, Ribeiro J, Ribeiro I and Dinis-Ribeiro M: Risk stratification systems for diabetic foot ulcers: A systematic review. Diabetologia 54: 1190-1199, 2011.
43. James GA, Swogger E, Wolcott R, Pulcini ED, Secor P, Sestrich J, Costerton JW and Stewart PS: Biofilms in chronic wounds. Wound Repair Regen 16: 37-44, 2008.
44. Mantey I, Hill R, Foster A, Wilson S, Wade JJ and Edmonds ME: Infection of foot ulcers with Staphylococcus aureus associated with increased mortality in diabetic patients. Commun Dis Public Health 3: 288-290, 2000.
45. Dang CN, Prasad YD, Boulton AJ and Jude EB: Methicillin-resistant Staphylococcus aureus in the diabetic foot clinic: A worsening problem. Diabet Med 20: 159-161, 2003.
46. Gadepalli R, Dhawan B, Sreenivas V, Kapil A, Ammini AC and Chaudhry R: A clinico-microbiological study of diabetic foot ulcers in an Indian tertiary care hospital. Diabetes care 29: 1727-1732, 2006.
47. Trivedi U, Parameswaran S, Armstrong A, Burgueno-Vega D, Griswold J, Dissanaike S and Rumbaugh KP: Prevalence of Multiple Antibiotic Resistant Infections in Diabetic versus Nondiabetic Wounds. J Pathog 2014: 173053, 2014.
48. Richard JL, Sotto A and Lavigne JP: New insights in diabetic foot infection. World J Diabetes 2: 24-32, 2011.
49. Satola SW, Lessa FC, Ray SM, Bulens SN, Lynfield R, Schaffner W, Dumyati G, Nadle J and Patel JB; Active Bacterial Core surveillance (ABCs) MRSA Investigators: Clinical and laboratory characteristics of invasive infections due to methicillin-resistant Staphylococcus aureus isolates demonstrating a vancomycin MIC of 2 micrograms per milliliter: Lack of effect of heteroresistant vancomycin-intermediate S. aureus phenotype. J Clin Microbiol 49: 1583-1587, 2011.
50. Harish BN, Menezes GA, Shekatkar S and Parija SC: Extended-spectrum beta-lactamase-producing Klebsiella pneumoniae from blood culture. J Med Microbiol 56: 999-1000, 2007.
51. Parveen RM, Khan MA, Menezes GA, Harish BN, Parija SC and Hays JP: Extended-spectrum β-lactamase producing Klebsiella pneumoniae from blood cultures in Puducherry, India. Indian J Med Res 134: 392-395, 2011.
52. Umadevi S, Joseph NM, Kumari K, Easow JM, Kumar S, Stephen S, Srirangaraj S and Raj S: Detection of extended spectrum beta lactamases, AmpC beta lactamases and metallobetalactamases in clinical isolates of ceftazidime resistant Pseudomonas aeruginosa. Braz J Microbiol 42: 1284-1288, 2011.
53. Saderi H, Karimi Z, Owlia P, Bahar MA and Rad SMBA: phenotypic detection of metallo-beta-lactamase producing Pseudomonas aeruginosa strains isolated from burned patients. Iranian Journal of Pathology 3: 20-24, 2008.
54. Bukhari SZ, Ahmed S and Zia N: Antimicrobial susceptibility pattern of Staphylococcus aureus on clinical isolates and efficacy of laboratory tests to diagnose MRSA: A multi-centre study. J Ayub Med Coll Abbottabad 23: 139-142, 2011.
55. Šeputienė V, Linkevičius M, Bogdaitė A, Povilonis J, Plančiūnienė R, Giedraitiene A, Pavilonis A and Sužiedėlienė E: Molecular characterization of extended-spectrum β -lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates from hospitals in Lithuania. J Med Microbiol 59: 1263-1265, 2010.
56. Bali EB, Accedil L and Sultan N: Phenotypic and molecular characterization of SHV, TEM, CTX-M and extended-spectrum-lactamase produced by Escherichia coli, Acinobacter baumannii and Klebsiella isolates in a Turkish hospital. African Journal of Microbiology Research 4: 650-654, 2010.
57. Umadevi S, Kandhakumari G, Joseph NM, Kumar S, Easow JM, Stephen S and Singh UK: Prevalence and antimicrobial susceptibility pattern of ESBL producing gram negative bacilli. J Clin Diagn Res 5: 236-239, 2011.