메뉴 건너뛰기




Volumn 20, Issue 8, 2016, Pages 825-834

Novel therapy of hyperhomocysteinemia in mild cognitive impairment, Alzheimer’s disease, and other dementing disorders

Author keywords

B vitamins; cognitive impairment; Homocysteine; L methylfolate; methylcobalamin; N acetyl cysteine

Indexed keywords

ASCORBIC ACID PLUS VITAMIN B COMPLEX; CHOLINESTERASE INHIBITOR; HOMOCYSTEINE; MEMANTINE;

EID: 84955576945     PISSN: 12797707     EISSN: 17604788     Source Type: Journal    
DOI: 10.1007/s12603-016-0688-z     Document Type: Article
Times cited : (16)

References (43)
  • 1
    • 84876239476 scopus 로고    scopus 로고
    • Homocysteine, Frailty, and All-Cause Mortality in Older Men: The Health in Men Study
    • COI: 1:CAS:528:DC%2BC3sXmt1SjtLw%3D, PID: 23070880
    • Wong YY, Almeida OP, McCaul KA et al. Homocysteine, Frailty, and All-Cause Mortality in Older Men: The Health in Men Study. J Gerontol A Biol Sci Med Sci. 2013;68(5):590–598.
    • (2013) J Gerontol A Biol Sci Med Sci. , vol.68 , Issue.5 , pp. 590-598
    • Wong, Y.Y.1    Almeida, O.P.2    McCaul, K.A.3
  • 2
    • 80053201724 scopus 로고    scopus 로고
    • Vitamin B-12 and homocysteine status in a folate-replete population: results from the Canadian Health Measures Survey
    • COI: 1:CAS:528:DC%2BC3MXht1OgurrF, PID: 21900461
    • MacFarlane AJ, Greene-Finestone LS, Shi Y. Vitamin B-12 and homocysteine status in a folate-replete population: results from the Canadian Health Measures Survey. Am J Clin Nutr. 2011;94(4):1079–1087.
    • (2011) Am J Clin Nutr. , vol.94 , Issue.4 , pp. 1079-1087
    • MacFarlane, A.J.1    Greene-Finestone, L.S.2    Shi, Y.3
  • 3
    • 0034445732 scopus 로고    scopus 로고
    • Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortification
    • COI: 1:STN:280:DC%2BD3MzkvVKisA%3D%3D, PID: 11411265
    • Selhub J, Jacques PF, Bostom AG et al. Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortification. Public Health Rev. 2000;28(1–4):117–145.
    • (2000) Public Health Rev. , vol.28 , Issue.1-4 , pp. 117-145
    • Selhub, J.1    Jacques, P.F.2    Bostom, A.G.3
  • 4
    • 84866654274 scopus 로고    scopus 로고
    • Sydney Memory and Ageing Study Team. Risk profiles for mild cognitive impairment vary by age and sex: the sydney memory and ageing study
    • PID: 22673190
    • Sachdev PS, Lipnicki DM, Crawford J et al. Sydney Memory and Ageing Study Team. Risk profiles for mild cognitive impairment vary by age and sex: the sydney memory and ageing study. Am J Geriatr Psychiatry. 2012;20(10):854–865.
    • (2012) Am J Geriatr Psychiatry. , vol.20 , Issue.10 , pp. 854-865
    • Sachdev, P.S.1    Lipnicki, D.M.2    Crawford, J.3
  • 5
    • 84910060881 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and risk of cognitive decline: a meta-analysis of prospective cohort studies
    • COI: 1:CAS:528:DC%2BC2cXhslGktL%2FJ, PID: 25277537
    • Nie T, Lu T, Xie L, Huang P, Lu Y, Jiang M. Hyperhomocysteinemia and risk of cognitive decline: a meta-analysis of prospective cohort studies. Eur Neurol. 2014;72(3–4):241–248.
    • (2014) Eur Neurol. , vol.72 , Issue.3-4 , pp. 241-248
    • Nie, T.1    Lu, T.2    Xie, L.3    Huang, P.4    Lu, Y.5    Jiang, M.6
  • 6
    • 84894030246 scopus 로고    scopus 로고
    • Lifetime requirement of the methionine cycle for neuronal development and maintenance
    • PID: 24445402
    • Shea TB, Rogers E. Lifetime requirement of the methionine cycle for neuronal development and maintenance. Curr Opin Psychiatry. 2014;27(2):138–142.
    • (2014) Curr Opin Psychiatry. , vol.27 , Issue.2 , pp. 138-142
    • Shea, T.B.1    Rogers, E.2
  • 8
    • 79954533286 scopus 로고    scopus 로고
    • Epigenetic priming of the metabolic syndrome
    • COI: 1:CAS:528:DC%2BC3MXkvVWjtrc%3D, PID: 21495873
    • Bruce KD, Cagampang FR. Epigenetic priming of the metabolic syndrome. Toxicol Mech Methods. 2011;21(4):353–361.
    • (2011) Toxicol Mech Methods. , vol.21 , Issue.4 , pp. 353-361
    • Bruce, K.D.1    Cagampang, F.R.2
  • 9
    • 77956058729 scopus 로고    scopus 로고
    • Epigenetics and cardiovascular disease
    • PID: 20603647
    • Ordovás JM, Smith CE. Epigenetics and cardiovascular disease. Nat Rev Cardiol. 2010;7(9):510–519.
    • (2010) Nat Rev Cardiol. , vol.7 , Issue.9 , pp. 510-519
    • Ordovás, J.M.1    Smith, C.E.2
  • 10
    • 84862182267 scopus 로고    scopus 로고
    • Epigenetic regulation in obesity
    • COI: 1:CAS:528:DC%2BC38Xos1Wktbo%3D
    • Lavebratt C, Almgren M, Ekström TJ. Epigenetic regulation in obesity. Int J Obes (Lond). 2012;36(6):757–765.
    • (2012) Int J Obes (Lond). , vol.36 , Issue.6 , pp. 757-765
    • Lavebratt, C.1    Almgren, M.2    Ekström, T.J.3
  • 12
    • 84907527197 scopus 로고    scopus 로고
    • Regulated DNA methylation and the circadian clock: implications in cancer
    • COI: 1:CAS:528:DC%2BC2cXhvFKgu7rF, PID: 25198253
    • Joska TM, Zaman R, Belden WJ. Regulated DNA methylation and the circadian clock: implications in cancer. Biology (Basel). 2014;3(3):560–577.
    • (2014) Biology (Basel). , vol.3 , Issue.3 , pp. 560-577
    • Joska, T.M.1    Zaman, R.2    Belden, W.J.3
  • 13
    • 41549090375 scopus 로고    scopus 로고
    • A pilot study for circadian gene disturbance in dementia patients
    • COI: 1:CAS:528:DC%2BD1cXks1ejsrg%3D, PID: 18358604
    • Liu HC, Hu CJ, Tang YC, Chang JG. A pilot study for circadian gene disturbance in dementia patients. Neurosci Lett. 2008;435(3):229–233.
    • (2008) Neurosci Lett. , vol.435 , Issue.3 , pp. 229-233
    • Liu, H.C.1    Hu, C.J.2    Tang, Y.C.3    Chang, J.G.4
  • 15
    • 84856593034 scopus 로고    scopus 로고
    • Proteomic analysis of brain proteins in APP/ PS-1 human double mutant knock-in mice with increasing amyloid beta-peptide deposition: insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild cognitive impairment and Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3MXhtleqs7jJ, PID: 21954051
    • Robinson RA, Joshi G, Huang Q, Sultana R, Baker AS, Cai J, Pierce W, St Clair DK, Markesbery WR, Butterfield DA. Proteomic analysis of brain proteins in APP/ PS-1 human double mutant knock-in mice with increasing amyloid beta-peptide deposition: insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild cognitive impairment and Alzheimer’s disease. Proteomics. 2011;11(21):4243–4256.
    • (2011) Proteomics. , vol.11 , Issue.21 , pp. 4243-4256
    • Robinson, R.A.1    Joshi, G.2    Huang, Q.3    Sultana, R.4    Baker, A.S.5    Cai, J.6    Pierce, W.7    St Clair, D.K.8    Markesbery, W.R.9    Butterfield, D.A.10
  • 16
    • 29744433830 scopus 로고    scopus 로고
    • Economic impact of hyperhomocysteinemia in Switzerland
    • PID: 16382299
    • Szucs TD, Käser A, Riesen WF. Economic impact of hyperhomocysteinemia in Switzerland. Cardiovasc Drugs Ther. 2005;19(5):365–369.
    • (2005) Cardiovasc Drugs Ther. , vol.19 , Issue.5 , pp. 365-369
    • Szucs, T.D.1    Käser, A.2    Riesen, W.F.3
  • 17
    • 79957547981 scopus 로고    scopus 로고
    • A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people
    • COI: 1:CAS:528:DC%2BC3MXmvVWqsLc%3D, PID: 21216507
    • Kwok T, Lee J, Law CB, Pan PC, Yung CY, Choi KC, Lam LC. A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people. Clin Nutr. 2011;30(3):297–302.
    • (2011) Clin Nutr. , vol.30 , Issue.3 , pp. 297-302
    • Kwok, T.1    Lee, J.2    Law, C.B.3    Pan, P.C.4    Yung, C.Y.5    Choi, K.C.6    Lam, L.C.7
  • 19
    • 84990042708 scopus 로고    scopus 로고
    • Impact of Hyperhomocysteinemia Treatment on Cognitive Decline due to Alzheimer’s Disease and Related Disorders
    • Shankle WR, Hara J, Rafii MS, Russell J. Impact of Hyperhomocysteinemia Treatment on Cognitive Decline due to Alzheimer’s Disease and Related Disorders. JARCP. 2013;2(4): 319–324.
    • (2013) JARCP. , vol.2 , Issue.4 , pp. 319-324
    • Shankle, W.R.1    Hara, J.2    Rafii, M.S.3    Russell, J.4
  • 20
    • 67649828026 scopus 로고    scopus 로고
    • Development and Validation of the Memory Performance Index: Reducing Measurement Error in Recall Tests
    • Shankle WR, Mangrola T, Chan T, Hara J. Development and Validation of the Memory Performance Index: Reducing Measurement Error in Recall Tests. Alzheimer’s & Dementia. 2009;5:295–306.
    • (2009) Alzheimer’s & Dementia. , vol.5 , pp. 295-306
    • Shankle, W.R.1    Mangrola, T.2    Chan, T.3    Hara, J.4
  • 21
    • 16344396588 scopus 로고    scopus 로고
    • Method to improve the detection of mild cognitive impairment
    • COI: 1:CAS:528:DC%2BD2MXjt1OhsLY%3D, PID: 15781874
    • Shankle WR, Romney AK, Hara J, et al. Method to improve the detection of mild cognitive impairment. Proc Natl Acad Sci USA. 2005;102(13):4919–4924.
    • (2005) Proc Natl Acad Sci^USA. , vol.102 , Issue.13 , pp. 4919-4924
    • Shankle, W.R.1    Romney, A.K.2    Hara, J.3
  • 22
    • 79955840168 scopus 로고    scopus 로고
    • Comparison of the memory performance index with standard neuropsychological measures of cognition
    • PID: 21406427
    • Rafii M, Taylor C, Coutinho A, Kim K, Galasko D. Comparison of the memory performance index with standard neuropsychological measures of cognition. Am J Alzheimers Dis Other Demen. 2011;26(3):235–239.
    • (2011) Am J Alzheimers Dis Other Demen. , vol.26 , Issue.3 , pp. 235-239
    • Rafii, M.1    Taylor, C.2    Coutinho, A.3    Kim, K.4    Galasko, D.5
  • 23
    • 0022919259 scopus 로고
    • Dementia: a systematic approach to identifying reversible causes
    • COI: 1:STN:280:DyaL287jslCgtw%3D%3D, PID: 3949165
    • Reisberg B. Dementia: a systematic approach to identifying reversible causes. Geriatrics. 1986;41(4):30–46.
    • (1986) Geriatrics. , vol.41 , Issue.4 , pp. 30-46
    • Reisberg, B.1
  • 24
    • 85027941531 scopus 로고    scopus 로고
    • Conversion from mild cognitive impairment to dementia: influence of folic acid and vitamin B12 use in the VITA cohort
    • COI: 1:CAS:528:DC%2BC38XhsFygtLfK, PID: 23076510
    • Blasko I, Hinterberger M, Kemmler G, Jungwirth S, Krampla W, Leitha T, Heinz Tragl K, Fischer P. Conversion from mild cognitive impairment to dementia: influence of folic acid and vitamin B12 use in the VITA cohort. J Nutr Health Aging 2012;16(8):687–694.
    • (2012) J Nutr Health Aging , vol.16 , Issue.8 , pp. 687-694
    • Blasko, I.1    Hinterberger, M.2    Kemmler, G.3    Jungwirth, S.4    Krampla, W.5    Leitha, T.6    Heinz Tragl, K.7    Fischer, P.8
  • 25
    • 84859889194 scopus 로고    scopus 로고
    • Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial
    • PID: 21780182
    • de Jager CA, Oulhaj A, Jacoby R et al. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry. 2012;27(6):592–600.
    • (2012) Int J Geriatr Psychiatry. , vol.27 , Issue.6 , pp. 592-600
    • de Jager, C.A.1    Oulhaj, A.2    Jacoby, R.3
  • 27
    • 84866980554 scopus 로고    scopus 로고
    • The relationship between associative learning, transfer generalization, and homocysteine levels in mild cognitive impairment
    • Moustafa AA, Hewedi DH, Eissa AM et al. The relationship between associative learning, transfer generalization, and homocysteine levels in mild cognitive impairment. PLoS One. 2012;7(9):e46496.
    • (2012) PLoS One.
    • Moustafa, A.A.1    Hewedi, D.H.2    Eissa, A.M.3
  • 29
    • 84899698132 scopus 로고    scopus 로고
    • Interactions between plasma concentrations of folate and markers of vitamin B(12) status with cognitive performance in elderly people not exposed to folic acid fortification: the Hordaland Health Study
    • COI: 1:CAS:528:DC%2BC2cXkt1ynu7g%3D, PID: 24229560
    • Doets EL, Ueland PM, Tell GS, Vollset SE, Nygård OK, Van’t Veer P, de Groot LC, Nurk E, Refsum H, Smith AD, Eussen SJ. Interactions between plasma concentrations of folate and markers of vitamin B(12) status with cognitive performance in elderly people not exposed to folic acid fortification: the Hordaland Health Study. Br J Nutr. 2014;111(6):1085–1095
    • (2014) Br J Nutr. , vol.111 , Issue.6 , pp. 1085-1095
    • Doets, E.L.1    Ueland, P.M.2    Tell, G.S.3    Vollset, S.E.4    Nygård, O.K.5    Van’t Veer, P.6    de Groot, L.C.7    Nurk, E.8    Refsum, H.9    Smith, A.D.10    Eussen, S.J.11
  • 30
    • 72749091720 scopus 로고    scopus 로고
    • Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate
    • COI: 1:CAS:528:DC%2BD1MXhsV2lt73K, PID: 19726595
    • Miller JW, Garrod MG, Allen LH, Haan MN, Green R. Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate. Am J Clin Nutr. 2009 Dec;90(6):1586–92.
    • (2009) Am J Clin Nutr. , vol.90 , Issue.6 , pp. 1586-1592
    • Miller, J.W.1    Garrod, M.G.2    Allen, L.H.3    Haan, M.N.4    Green, R.5
  • 31
    • 45749153825 scopus 로고    scopus 로고
    • Homocysteine, folate and cognition in a large community-based sample of elderly people—the 3C Dijon Study
    • PID: 18424901
    • Vidal JS, Dufouil C, Ducros V, Tzourio C. Homocysteine, folate and cognition in a large community-based sample of elderly people—the 3C Dijon Study. Neuroepidemiology. 2008;30(4):207–214.
    • (2008) Neuroepidemiology. , vol.30 , Issue.4 , pp. 207-214
    • Vidal, J.S.1    Dufouil, C.2    Ducros, V.3    Tzourio, C.4
  • 32
    • 55549117471 scopus 로고    scopus 로고
    • Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2-dependent cyclin E expression
    • COI: 1:CAS:528:DC%2BD1cXhtlCgtrbK, PID: 18703672
    • Rabaneda LG, Carrasco M, Lopez-Toledano MA, Murillo-Carretero M, Ruiz FA, Estrada C, Castro C. Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2-dependent cyclin E expression. FASEB J. 2008;22(11):3823–3835.
    • (2008) FASEB J. , vol.22 , Issue.11 , pp. 3823-3835
    • Rabaneda, L.G.1    Carrasco, M.2    Lopez-Toledano, M.A.3    Murillo-Carretero, M.4    Ruiz, F.A.5    Estrada, C.6    Castro, C.7
  • 33
    • 84901190217 scopus 로고    scopus 로고
    • Impaired one carbon metabolism and DNA methylation in alcohol toxicity
    • COI: 1:CAS:528:DC%2BC2cXotFentLs%3D, PID: 24521073
    • Kruman II, Fowler AK. Impaired one carbon metabolism and DNA methylation in alcohol toxicity. J Neurochem. 2014;129(5):770–780.
    • (2014) J Neurochem. , vol.129 , Issue.5 , pp. 770-780
    • Kruman, I.I.1    Fowler, A.K.2
  • 34
    • 20144375857 scopus 로고    scopus 로고
    • Neuroprotective effect of N-acetyl cysteine on hypoxia-induced oxidative stress in primary hippocampal culture
    • COI: 1:CAS:528:DC%2BD2MXltVOltLo%3D, PID: 15919066
    • Jayalakshmi K, Sairam M, Singh SB, Sharma SK, Ilavazhagan G, Banerjee PK. Neuroprotective effect of N-acetyl cysteine on hypoxia-induced oxidative stress in primary hippocampal culture. Brain Res. 2005;1046(1–2):97–104.
    • (2005) Brain Res. , vol.1046 , Issue.1-2 , pp. 97-104
    • Jayalakshmi, K.1    Sairam, M.2    Singh, S.B.3    Sharma, S.K.4    Ilavazhagan, G.5    Banerjee, P.K.6
  • 35
    • 84864189699 scopus 로고    scopus 로고
    • Rescue from a two hit, high-throughput model of neurodegeneration with N-acetyl cysteine
    • COI: 1:CAS:528:DC%2BC38Xht1Kku7fN, PID: 22691629
    • Unnithan AS, Choi HJ, Titler AM, Posimo JM, Leak RK. Rescue from a two hit, high-throughput model of neurodegeneration with N-acetyl cysteine. Neurochem Int. 2012;61(3):356–368.
    • (2012) Neurochem Int. , vol.61 , Issue.3 , pp. 356-368
    • Unnithan, A.S.1    Choi, H.J.2    Titler, A.M.3    Posimo, J.M.4    Leak, R.K.5
  • 39
    • 35448970996 scopus 로고    scopus 로고
    • Molecular targeting of proteins by L-homocysteine: mechanistic implications for vascular disease
    • COI: 1:CAS:528:DC%2BD2sXht1ajtbjO, PID: 17760510
    • Glushchenko AV, Jacobsen DW. Molecular targeting of proteins by L-homocysteine: mechanistic implications for vascular disease. Antioxid Redox Signal. 2007;9(11):1883–1898.
    • (2007) Antioxid Redox Signal. , vol.9 , Issue.11 , pp. 1883-1898
    • Glushchenko, A.V.1    Jacobsen, D.W.2
  • 41
    • 41249098662 scopus 로고    scopus 로고
    • B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice.31
    • COI: 1:CAS:528:DC%2BD1cXktlGgs70%3D, PID: 18243734
    • Fuso A, Nicolia V, Cavallaro RA, Ricceri L, D’Anselmi F, Coluccia P, Calamandrei G, Scarpa S. B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice.31. Mol Cell Neurosci. 2008;37(4):731–746.
    • (2008) Mol Cell Neurosci. , vol.37 , Issue.4 , pp. 731-746
    • Fuso, A.1    Nicolia, V.2    Cavallaro, R.A.3    Ricceri, L.4    D’Anselmi, F.5    Coluccia, P.6    Calamandrei, G.7    Scarpa, S.8
  • 42
    • 84876664251 scopus 로고    scopus 로고
    • Chronic homocysteine exposure causes changes in the intrinsic electrophysiological properties of cultured hippocampal neurons
    • COI: 1:CAS:528:DC%2BC3sXktFeluro%3D, PID: 23307157
    • Schaub C, Uebachs M, Beck H, Linnebank M. Chronic homocysteine exposure causes changes in the intrinsic electrophysiological properties of cultured hippocampal neurons. Exp Brain Res. 2013;225(4):527–534.
    • (2013) Exp Brain Res. , vol.225 , Issue.4 , pp. 527-534
    • Schaub, C.1    Uebachs, M.2    Beck, H.3    Linnebank, M.4
  • 43
    • 0842305029 scopus 로고    scopus 로고
    • Implications for hyperhomocysteinemia: not homocysteine but its oxidized forms strongly inhibit neuronal network activity
    • PID: 14759642
    • Görtz P, Hoinkes A, Fleischer W, Otto F, Schwahn B, Wendel U, Siebler M. Implications for hyperhomocysteinemia: not homocysteine but its oxidized forms strongly inhibit neuronal network activity. J Neurol Sci. 2004 Mar 15;218(1–2):109–14.
    • (2004) J Neurol Sci. , vol.218 , Issue.1-2 , pp. 109-114
    • Görtz, P.1    Hoinkes, A.2    Fleischer, W.3    Otto, F.4    Schwahn, B.5    Wendel, U.6    Siebler, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.