Elevated Serum Brain-Derived Neurotrophic Factor (BDNF) but not BDNF Gene Val66Met Polymorphism Is Associated with Autism Spectrum Disorders

Molecular Neurobiology

Volumn 54, Issue 2, 2017, Pages 1167-1172

  Meng, Wei Dong ^a   Sun, Shao Jun ^a   Yang, Jie ^b   Chu, Rui Xue ^a   Tu, Wenjun ^c   Liu, Qiang ^c  

^a LIAOCHENG PEOPLE'S HOSPITAL   (China)

^b Liaocheng Herbalist Hospital   (China)

^c INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

Autism spectrum disorders; BDNF Val66Met polymorphism; Biomarker; Brain derived neurotrophic factor; Chinese

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; METHIONINE; VALINE; BIOLOGICAL MARKER; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN;

AREA UNDER THE CURVE; ARTICLE; AUTISM; BDNF GENE; BLOOD LEVEL; CHILD; CLINICAL INDICATOR; CONTROLLED STUDY; DISEASE SEVERITY ASSESSMENT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PRESCHOOL CHILD; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; BLOOD; CASE CONTROL STUDY; GENETIC ASSOCIATION STUDY; GENETICS; PHYSIOLOGY; PROCEDURES;

AUTISM SPECTRUM DISORDER; BIOMARKERS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; GENETIC ASSOCIATION STUDIES; HUMANS; MALE; METHIONINE; POLYMORPHISM, GENETIC; VALINE;

EID: 84955564554     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-016-9721-9     Document Type: Article

References (36)

1. Yoo HJ, Yang SY, Cho IH et al (2014) Polymorphisms of BDNF gene and autism spectrum disorders: family based association study with Korean trios. Psychiatry Invest 11(3):319–324
2. Wong VCN, Hui SLH (2008) Epidemiological study of autism spectrum disorder in China. J Child Neurol 23:67–72
3. Tu WJ, Yin CH, Guo YQ, Li SO, Chen H, Zhang Y, Feng YL, Long BH (2013) Serum homocysteine concentrations in Chinese children with autism. Clin Chem Lab Med 51:e19–e22
4. Al-Ayadhi LY (2012) Relationship between Sonic hedgehog protein, brain-derived neurotrophic factor and oxidative stress in autism spectrum disorders. Neurochem Res 37(2):394–400
5. Halepoto DM, Bashir S, AL-Ayadhi L (2014) Possible role of brain-derived neurotrophic factor (BDNF) in autism spectrum disorder: current status. J College Physicians Surgeons Pakistan 24(4):274–278
6. Yan CL, Zhang J, Hou Y (2015) Decreased plasma levels of lipoxin A4 in children with autism spectrum disorders. NeuroReport 26:341–345
7. Taurines R, Segura M, Schecklmann M et al (2014) Altered peripheral BDNF mRNA expression and BDNF protein concentrations in blood of children and adolescents with autism spectrum disorder. J Neural Transm 121(9):1117–1128
8. Nelson PG, Kuddo T, Song EY et al (2006) Selected neurotrophins, neuropeptides, and cytokines: developmental trajectory and concentrations in neonatal blood of children with autism or Down syndrome. Int J Dev Neurosci 24(1):73–80
9. Nishimura K, Nakamura K, Anitha A et al (2007) Genetic analyses of the brain-derived neurotrophic factor (BDNF) gene in autism. Biochem Biophys Res Commun 356(1):200–206
10. AL-Ayadhi L (2011) Serum levels of brain-derived neurotrophic factor (BDNF) in autistic children in central Saudi Arabia. Open Conference Proc J 2(1):36–40
11. Ricci S, Businaro R, Ippoliti F et al (2013) Altered cytokine and BDNF levels in autism spectrum disorder. Neurotox Res 24(4):491–501
12. Bryn V, Halvorsen B, Ueland T et al (2015) Brain derived neurotrophic factor (BDNF) and autism spectrum disorders (ASD) in childhood. Eur J Paediatr Neurol 19:411–414
13. Notaras M, Hill R, Van den Buuse M (2015) A role for the BDNF gene Val66Met polymorphism in schizophrenia? A comprehensive review. Neurosci Biobehav Rev 51:15–30
14. Gadow KD, Roohi J, DeVincent CJ, Kirsch S, Hatchwell E (2009) Association of COMT(Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. J Autism Dev Disord 39:1542–1551
15. Hwang JP, Tsai SJ, Hong CJ et al (2006) The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression. Neurobiol Aging 27(12):1834–1837
16. Raznahan A, Toro R, Proitsi P, Powell J, Paus TF, Bolton P et al (2009) A functional polymorphism of the brain derived neurotrophic factor gene and cortical anatomy in autism spectrum disorder. J Neurodev Disord 1:215–223
17. Schopler E, Reichler RJ, DeVellis RF, Daly K (1980) Toward objective classification of childhood autism: childhood autism rating scale (CARS). J Autism Dev Disord 10:91–103
18. Park MH, Chang KD, Hallmayer J et al (2015) Preliminary study of anxiety symptoms, family dysfunction, and the brain-derived neurotrophic factor (BDNF) Val66Met genotype in offspring of parents with bipolar disorder. J Psychiatr Res 61:81–88
19. Fiala JC, Spacek J, Harris KM (2002) Dendritic spine pathology: cause or consequence of neurological disorders? Brain Res Brain Res Rev 39:29–54
20. Tyler WJ, Zhang XL, Hartman K, Winterer J, Muller W, Stanton PK et al (2006) BDNF increases release probability and the size of a rapidly recycling vesicle pool within rat hippocampal excitatory synapses. J Physiol 574:787–803
21. Mansour M, Mohamed A, Azam H, Henedy M (2010) Brain derived neurotrophic factor in autism. Current Psychiatry 17(1):23–29
22. Hashimoto K, Iwata Y, Nakamura K et al (2006) Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism. Prog Neuro-Psychopharmacol Biol Psychiatry 30(8):1529–1531
23. Zhang Q, Jiang L, Lu YJ (2014) Serum brain-derived neurotrophic factor levels in Chinese children with autism spectrum disorders: A pilot study. Int J Dev Neurosci 37:65–68
24. Cheng L, Ge Q, Sun B, Yu P, Ke X, Lu Z (2009) Polyacrylamide gel-based microarray: a novel method applied to the association Study between the polymorphisms of BDNF gene and autism. J Biomed Nanotechnol 5:542–550
25. Egan MF, Kojima M, Callicott JH et al (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112(2):257–269
26. Hariri AR, Goldberg TE, Mattay VS et al (2003) Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neuroscience 23(17):6690–6694
27. Frodl T, Schüle C, Schmitt G et al (2007) Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression. Arch Gen Psychiatry 64(4):410–416
28. Chen ZY, JingD BKG, Ieraci A, KhanT SCJ et al (2006) Genetic variantBDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314:140–143
29. Bus BAA, Arias-Vasquez A, Franke B et al (2012) Increase in serum brain-derived neurotrophic factor in met allele carriers of the BDNF Val66Met polymorphism is specific to males. Neuropsychobiology 65(4):183–187
30. Lang UE, Hellweg R, Sander T et al (2009) The Met allele of the BDNF Val66Met polymorphism is associated with increased BDNF serum concentrations. Mol Psychiatry 14(2):120–122
31. Bashir S, Laila ALA (2013) Role of serum levels of neurotensin in children with autism spectrum disorder. Neurol Psychiatry Brain Res 19(2):59–63
32. Li B, Lang N, Cheng ZF (2015) Serum Levels of Brain-Derived Neurotrophic Factor Are Associated with Diabetes Risk, Complications, and Obesity: a Cohort Study from Chinese Patients with Type 2 Diabetes. Mol Neurobiol. doi:10.1007/s12035-015-9461-2
33. Agilli M, Aydin FN, Kurt YG et al (2015) Evaluation of serum brain-derived neurotrophic factor levels in type 2 diabetes mellitus patients with and without depressive symptoms. Acta Biochim Biophys Sin 47(4):313
34. Klein AB, Williamson R, Santini MA et al (2011) Blood BDNF concentrations reflect brain-tissue BDNF levels across species. Int J Neuropsychopharmacol 14(3):347–353
35. Shi SS, Shao S, Yuan B et al (2010) Acute stress and chronic stress change brain-derived neurotrophic factor (BDNF) and tyrosine kinase-coupled receptor (TrkB) expression in both young and aged rat hippocampus. Yonsei Med J 51(5):661–671
36. Katoh-Semba R, Wakako R, Komori T et al (2007) Age-related changes in BDNF protein levels in human serum: differences between autism cases and normal controls. Int J Dev Neurosci 25(6):367–372