Homocysteine level is associated with white matter hyperintensity locations in patients with acute ischemic stroke

PLoS ONE

Volumn 10, Issue 12, 2015, Pages

  Gao, Yuan ^a   Wei, Sen ^a   Song, Bo ^a   Qin, Jie ^a   Fang, Hui ^a   Ji, Yan ^a   Zhang, Rui ^a   Sun, Shilei ^a   Xu, Yuming ^a  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HOMOCYSTEINE;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; BLOOD ANALYSIS; BRAIN ISCHEMIA; CLINICAL ASSESSMENT; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FRONTAL LOBE; HUMAN; MAJOR CLINICAL STUDY; MALE; OCCIPITAL LOBE; PARIETAL LOBE; POPULATION RESEARCH; SEX RATIO; WHITE MATTER; BLOOD; FOLLOW UP; METABOLISM; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PROGNOSIS; PROSPECTIVE STUDY; STROKE;

BRAIN ISCHEMIA; FEMALE; FOLLOW-UP STUDIES; HOMOCYSTEINE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; STROKE; WHITE MATTER;

EID: 84955563675     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0144431     Document Type: Article

References (31)

1. Valdes Hernandez MC, Piper RJ, Bastin ME, Royle NA, Maniega SM, Aribisala BS, et al. (2014) Morphologic, distributional, volumetric, and intensity characterization of periventricular hyperintensities. AJNR. American journal of neuroradiology 35:55-62 doi: 10.3174/ajnr.A3612 PMID: 23811980
2. Schmidt R, Fazekas F, Kleinert G, Offenbacher H, Gindl K, Payer F, et al. (1992) Magnetic resonance imaging signal hyperintensities in the deep and subcortical white matter. A comparative study between stroke patients and normal volunteers. Archives of neurology 49:825-827 PMID: 1524515
3. Erten-Lyons D, Woltjer R, Kaye J, Mattek N, Dodge HH, D'Agostino RB, et al. (2013) Neuropathologic basis of white matter hyperintensity accumulation with advanced age. Neurology 81:977-983 doi: 10. 1212/WNL.0b013e3182a43e45 PMID: 23935177
4. Vermeer SE, van Dijk EJ, Koudstaal PJ, Oudkerk M, Hofman A, Green S, et al. (2002) Homocysteine, silent brain infarcts, and white matter lesions: The rotterdam scan study. Annals of neurology 51:285-289 PMID: 11891822
5. Tseng YL, Chang YY, Liu JS, Su CS, Lai SL, Clarke R, et al. (2009) Association of plasma homocysteine concentration with cerebral white matter hyperintensity on magneticresonance images in stroke patients. J Neurol Sci 15; 284(1-2):36-9. doi: 10.1016/j.jns.2009.03.030 PMID: 19398115
6. Seshadri S, Wolf PA, Beiser AS, Selhub J, Au R, Jacques PF, et al. (2008) Association of plasma total homocysteine levels with subclinical brain injury: Cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the framingham offspring study. Archives of neurology 65:642-649 doi: 10.1001/archneur.65.5.642 PMID: 18474741
7. Hooshmand B, Polvikoski T, Kivipelto M, Tanskanen M, Myllykangas L, Erkinjuntti T, et al. (2013) Plasma homocysteine, alzheimer and cerebrovascular pathology: A population-based autopsy study. Brain: a journal of neurology 136:2707-2716
8. Chou PS, Chen CH, Wu MN, Lin YH, Lai CL, Lin RT, et al. (2015) Determinants of cerebral white matter changes in patients with stroke. Internal medicine journal 45:390-395 doi: 10.1111/imj.12704 PMID: 25644475
9. Sachdev P, Parslow R, Salonikas C, Lux O, Wen W, Kumar R, et al. (2004) Homocysteine and the brain in midadult life: Evidence for an increased risk of leukoaraiosis in men. Archives of neurology 61:1369-1376 PMID: 15364682
10. Raz N, Yang Y, Dahle CL, Land S. (2012) Volume of white matter hyperintensities in healthy adults: Contribution of age, vascular risk factors, and inflammation-related genetic variants. Biochimica et biophysica acta 1822:361-369 doi: 10.1016/j.bbadis.2011.08.007 PMID: 21889590
11. Fazekas F, Niederkorn K, Schmidt R, Offenbacher H, Horner S, Bertha G, et al. (1988) White matter signal abnormalities in normal individuals: Correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors. Stroke; a journal of cerebral circulation 19:1285-1288 PMID: 3051534
12. Wahlund LO, Barkhof F, Fazekas F, Bronge L, Augustin M, Sjogren M, et al. (2001) A new rating scale for age-related white matter changes applicable to mri and ct. Stroke; a journal of cerebral circulation 32:1318-1322 PMID: 11387493
13. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of diet in renal disease study group. Annals of internal medicine 130:461-470 PMID: 10075613
14. Pantoni L, Garcia JH. (1997) Pathogenesis of leukoaraiosis: A review. Stroke; a journal of cerebral circulation 28:652-659 PMID: 9056627
15. Olszewski AJ, McCully KS. (1993) Homocysteine metabolism and the oxidative modification of proteins and lipids. Free radical biology & medicine. 14:683-693
16. Tsai JC, Perrella MA, Yoshizumi M, Hsieh CM, Haber E, Schlegel R, et al. (1994) Promotion of vascular smooth muscle cell growth by homocysteine: A link to atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America 91:6369-6373 PMID: 8022789
17. Eikelboom JW, Hankey GJ, Anand SS, Lofthouse E, Staples N, Baker RI. (2000) Association between high homocyst(e)ine and ischemic stroke due to large- and small-artery disease but not other etiologic subtypes of ischemic stroke. Stroke; a journal of cerebral circulation 31:1069-1075 PMID: 10797167
18. Evers S, Koch HG, Grotemeyer KH, Lange B, Deufel T, Ringelstein EB. (1997) Features, symptoms, and neurophysiological findings in stroke associated with hyperhomocysteinemia. Archives of neurology 54:1276-1282 PMID: 9341574
19. Fazekas F, Kleinert R, Offenbacher H, Schmidt R, Kleinert G, Payer F, et al. (1993) Pathologic correlates of incidental mri white matter signal hyperintensities. Neurology 43:1683-1689 PMID: 8414012
20. Waldemar G, Christiansen P, Larsson HB, Hogh P, Laursen H, Lassen NA, et al. (1994) White matter magnetic resonance hyperintensities in dementia of the alzheimer type: Morphological and regional cerebral blood flow correlates. Journal of neurology, neurosurgery, and psychiatry 57:1458-1465 PMID: 7798973
21. Raz N, Rodrigue KM, Acker JD. (2003) Hypertension and the brain: Vulnerability of the prefrontal regions and executive functions. Behavioral neuroscience 117:1169-1180 PMID: 14674838
22. Yoshita M, Fletcher E, Harvey D, Ortega M, Martinez O, Mungas DM, et al. (2006) Extent and distribution of white matter hyperintensities in normal aging, mci, and ad. Neurology 67:2192-2198 PMID: 17190943
23. Gouw AA, van der Flier WM, Fazekas F, van Straaten EC, Pantoni L, Poggesi A, et al. (2008) Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: The leukoaraiosis and disability study. Stroke; a journal of cerebral circulation 39:1414-1420 doi: 10.1161/STROKEAHA.107.498535 PMID: 18323505
24. Payabvash S, Souza LC, Wang Y, Schaefer PW, Furie KL, Halpern EF, et al. (2011) Regional ischemic vulnerability of the brain to hypoperfusion: The need for location specific computed tomography perfusion thresholds in acute stroke patients. Stroke; a journal of cerebral circulation 42:1255-1260 doi: 10. 1161/STROKEAHA.110.600940 PMID: 21493917
25. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, et al. (2002) Plasma homocysteine as a risk factor for dementia and alzheimer's disease. The New England journal of medicine 346:476-483 PMID: 11844848
26. Smith EE, Salat DH, Jeng J, McCreary CR, Fischl B, Schmahmann JD, et al. (2011) Correlations between mri white matter lesion location and executive function and episodic memory. Neurology 76:1492-1499 doi: 10.1212/WNL.0b013e318217e7c8 PMID: 21518999
27. Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH, Selhub J. (2001) Determinants of plasma total homocysteine concentration in the framingham offspring cohort. The American journal of clinical nutrition 73:613-621 PMID: 11237940
28. Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH. (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA: the journal of the American Medical Association 270:2693-2698 PMID: 8133587
29. Szolnoki Z. (2007) Pathomechanism of leukoaraiosis. Neuromolecular Med 9:21-33 PMID: 17114822
30. Tran T, Cotlarciuc I, Yadav S, Hasan N, Bentley P, Freidl W, et al. (2015)Candidate-gene analysis of white matter hyperintensities on neuroimaging. J Neurol Neurosurg Psychiatr 0:1-7.
31. Kapeller P, Barber R, Vermeulen RJ, Ader H, Scheltens P, Freidl W, et al. (2003) Visual rating of agerelated white matter changes on magnetic resonance imaging: Scale comparison, interrater agreement, and correlations with quantitative measurements. Stroke; a journal of cerebral circulation 34:441-445 PMID: 12574557