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Volumn 21, Issue 1, 2016, Pages 208-216

Miniaturization of High-Throughput Epigenetic Methyltransferase Assays with Acoustic Liquid Handling

Author keywords

ADE (acoustic droplet ejection); AlphaLISA; epigenetics; HTRF; liquid handling; methyltransferase

Indexed keywords

ASSAYS; COST REDUCTION; DRUG PRODUCTS; LIQUIDS; MINIATURE INSTRUMENTS; OPERATING COSTS;

EID: 84955494911     PISSN: 22110682     EISSN: 22110690     Source Type: Journal    
DOI: 10.1177/2211068215610861     Document Type: Article
Times cited : (10)

References (25)
  • 1
    • 84924283495 scopus 로고    scopus 로고
    • Garland Science, Taylor & Francis Group, New York:, ; pp,, 80–86.
    • L.ArmstrongEpigenetics; Garland Science, Taylor & Francis Group: New York, 2014; pp 1–2, 80–86.
    • (2014) Epigenetics , pp. 1-2
    • Armstrong, L.1
  • 2
    • 64249135764 scopus 로고    scopus 로고
    • Novel Agents on the Horizon for Cancer Therapy
    • W.W.MaA.A.AdjeiNovel Agents on the Horizon for Cancer Therapy. CA Cancer J. Clin. 2009, 59, 111–137.
    • (2009) CA Cancer J. Clin , vol.59 , pp. 111-137
    • Ma, W.W.1    Adjei, A.A.2
  • 3
    • 84857326801 scopus 로고    scopus 로고
    • Development of Homogeneous Nonradioactive Methyltransferase and Demethylase Assays Targeting Histone H3 Lysine 4
    • N.GauthierM.CaronL.Pedro. Development of Homogeneous Nonradioactive Methyltransferase and Demethylase Assays Targeting Histone H3 Lysine 4. J. Biomol. Screen. 2012, 17 (1), 49–58.
    • (2012) J. Biomol. Screen , vol.17 , Issue.1 , pp. 49-58
    • Gauthier, N.1    Caron, M.2    Pedro, L.3
  • 4
    • 69949148388 scopus 로고    scopus 로고
    • Protein Methyltransferases as a Target Class for Drug Discovery
    • R.A.CopelandM.E.SolomonV.M.Richon. Protein Methyltransferases as a Target Class for Drug Discovery. Nat. Rev. Drug Discov. 2009, 8, 724–732.
    • (2009) Nat. Rev. Drug Discov , vol.8 , pp. 724-732
    • Copeland, R.A.1    Solomon, M.E.2    Richon, V.M.3
  • 5
    • 51949111451 scopus 로고    scopus 로고
    • Chemical Probes for Histone-Modifying Enzymes
    • P.A.ColeChemical Probes for Histone-Modifying Enzymes. Nat. Chem. Biol. 2008, 4, 590–597.
    • (2008) Nat. Chem. Biol , vol.4 , pp. 590-597
    • Cole, P.A.1
  • 7
    • 84889684498 scopus 로고    scopus 로고
    • Histone H3 Methyltransferase G9A Epigenetically Activates the Serine-Glycine Synthesis Pathway to Sustain Cancer Cell Survival and Proliferation
    • J.DingT.LiX.Wang. Histone H3 Methyltransferase G9A Epigenetically Activates the Serine-Glycine Synthesis Pathway to Sustain Cancer Cell Survival and Proliferation. Cell. Metab. 2013, 18 (6), 896–907.
    • (2013) Cell. Metab , vol.18 , Issue.6 , pp. 896-907
    • Ding, J.1    Li, T.2    Wang, X.3
  • 8
    • 73249124141 scopus 로고    scopus 로고
    • Discovery of a 2,4-Diamino-7-Aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a
    • F.LiuX.ChenA.Allali-Hassani. Discovery of a 2,4-Diamino-7-Aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a. J. Med. Chem. 2009, 52, 7950–7953.
    • (2009) J. Med. Chem , vol.52 , pp. 7950-7953
    • Liu, F.1    Chen, X.2    Allali-Hassani, A.3
  • 9
    • 32244444118 scopus 로고    scopus 로고
    • Structural Basis for the Methylation Site Specificity of SET7/9
    • J.F.CoutureE.CollazoG.Hauk. Structural Basis for the Methylation Site Specificity of SET7/9. Nat. Struct. Mol. Biol. 2006, 13, 140–146.
    • (2006) Nat. Struct. Mol. Biol , vol.13 , pp. 140-146
    • Couture, J.F.1    Collazo, E.2    Hauk, G.3
  • 10
    • 80052591715 scopus 로고    scopus 로고
    • Substrate and Product Specificities of SET Domain Methyltransferases
    • P.A.DelRizzoR.C.TrievelSubstrate and Product Specificities of SET Domain Methyltransferases. Epigenetics2011, 6 (9), 1059–1067.
    • (2011) Epigenetics , vol.6 , Issue.9 , pp. 1059-1067
    • DelRizzo, P.A.1    Trievel, R.C.2
  • 11
    • 80455125845 scopus 로고    scopus 로고
    • Structural Chemistry of Human SET Domain Protein Methyltransferases
    • M.SchapiraStructural Chemistry of Human SET Domain Protein Methyltransferases. Curr. Chem. Genomics2011, 5, 85–94.
    • (2011) Curr. Chem. Genomics , vol.5 , pp. 85-94
    • Schapira, M.1
  • 12
    • 77952504334 scopus 로고    scopus 로고
    • HTRF: A Technology Tailored for Drug Discovery—A Review of Theoretical Aspects and Recent Applications
    • F.DegorceA.CardE.Trinquest. HTRF: A Technology Tailored for Drug Discovery—A Review of Theoretical Aspects and Recent Applications. Curr. Chem. Genomics2009, 3, 22–32.
    • (2009) Curr. Chem. Genomics , vol.3 , pp. 22-32
    • Degorce, F.1    Card, A.2    Trinquest, E.3
  • 13
    • 65349087287 scopus 로고    scopus 로고
    • AlphaLISA Immunoassay Platform— The “No-Wash” High-Throughput Alternative to ELISA
    • B.-S.MartinaAlphaLISA Immunoassay Platform— The “No-Wash” High-Throughput Alternative to ELISA. ASSAY Drug Dev. Technol. 2009, 7 (1), 90–92.
    • (2009) ASSAY Drug Dev. Technol , vol.7 , Issue.1 , pp. 90-92
    • Martina, B.-S.1
  • 15
    • 0842279636 scopus 로고    scopus 로고
    • Transfer of Low Nanoliter Volumes between Microplates Using Focused Acoustics—Automation Considerations
    • R.EllsonM.StearnsM.Mutz. Transfer of Low Nanoliter Volumes between Microplates Using Focused Acoustics—Automation Considerations. J. Assoc. Lab. Automation2003, 8 (5), 29–34.
    • (2003) J. Assoc. Lab. Automation , vol.8 , Issue.5 , pp. 29-34
    • Ellson, R.1    Stearns, M.2    Mutz, M.3
  • 16
    • 33746928816 scopus 로고    scopus 로고
    • The Effects of Small Molecule and Protein Solutes on Acoustic Drop Ejection
    • J.SheihR.N.EllsonJ.OlechnoThe Effects of Small Molecule and Protein Solutes on Acoustic Drop Ejection. J. Assoc. Lab. Automation2006, 11 (4), 227–232.
    • (2006) J. Assoc. Lab. Automation , vol.11 , Issue.4 , pp. 227-232
    • Sheih, J.1    Ellson, R.N.2    Olechno, J.3
  • 17
    • 84955498137 scopus 로고    scopus 로고
    • EPIgeneous Methyltransferase Assay: A New HTRF Universal SAH Detection Assay to Assess Methyltransferase Activity
    • accessed Feb 15, 2015
    • T.RouxN.DouayryS.Junique. EPIgeneous Methyltransferase Assay: A New HTRF Universal SAH Detection Assay to Assess Methyltransferase Activity. Cisbio Bioassays, 2013. http://www.cisbio.com/sites/default/files/ressources/cisbio-pt-EPIgeneous-Methyltransferase-assay-a-new-HTRF-Universal-SAH-detection-assay.pdf (accessed Feb 15, 2015).
    • (2013) Cisbio Bioassays
    • Roux, T.1    Douayry, N.2    Junique, S.3
  • 19
    • 0033003760 scopus 로고    scopus 로고
    • A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays
    • J.-H.ZhangT.D.Y.ChungK.R.OldenburgA Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J. Biomol. Screen. 1999, 4, 67–73.
    • (1999) J. Biomol. Screen , vol.4 , pp. 67-73
    • Zhang, J.-H.1    Chung, T.D.Y.2    Oldenburg, K.R.3
  • 20
    • 84911871039 scopus 로고
    • Identification of 2,4-Diamino-6,7- Dimethoxyquinoline Derivatives as G9a Inhibitors
    • N.SrimongkolpithakS.SundriyalF.Li. Identification of 2,4-Diamino-6,7- Dimethoxyquinoline Derivatives as G9a Inhibitors. Med. Chem. Commun. 2014, 5, 1821.
    • (1821) Med. Chem. Commun , vol.5
    • Srimongkolpithak, N.1    Sundriyal, S.2    Li, F.3
  • 21
    • 84907228225 scopus 로고    scopus 로고
    • (R)-PFI-2 Is a Potent and Selective Inhibitor of SETD7 Methyltransferase Activity in Cells
    • D.Barsyte-LovejoyF.LiM.J.Oudhoff. (R)-PFI-2 Is a Potent and Selective Inhibitor of SETD7 Methyltransferase Activity in Cells. Proc. Natl. Acad. Sci. U.S.A. 2014, 111 (35), 12853–12858.
    • (2014) Proc. Natl. Acad. Sci. U.S.A , vol.111 , Issue.35 , pp. 12853-12858
    • Barsyte-Lovejoy, D.1    Li, F.2    Oudhoff, M.J.3
  • 22
    • 77952234967 scopus 로고    scopus 로고
    • Pharmacological Evaluation of Different Compound Dilution and Transfer Paradigms on an Enzyme Assay in Low Volume 384-Well Format
    • Boston, MA:
    • T.SpicerY.FitzgeraldN.Burford. Pharmacological Evaluation of Different Compound Dilution and Transfer Paradigms on an Enzyme Assay in Low Volume 384-Well Format. Drug Discovery Technology, Boston, MA, 2005.
    • (2005) Drug Discovery Technology
    • Spicer, T.1    Fitzgerald, Y.2    Burford, N.3
  • 23
    • 84877037636 scopus 로고    scopus 로고
    • Impact of Acoustic Dispensing on Data Quality in HTS and Hit Confirmation
    • J.WingfieldImpact of Acoustic Dispensing on Data Quality in HTS and Hit Confirmation. Drug Discovery, Manchester, UK, 2012.
    • (2012) Drug Discovery, Manchester, UK
    • Wingfield, J.1
  • 24
    • 67449108090 scopus 로고    scopus 로고
    • Achieving Accurate Compound Concentration in Cell-Based Screening: Validation of Acoustic Droplet Ejection Technology
    • R.J.GrantK.RobertsC.Pointon. Achieving Accurate Compound Concentration in Cell-Based Screening: Validation of Acoustic Droplet Ejection Technology. J. Biomol. Screen. 2009, 14 (5), 452–459.
    • (2009) J. Biomol. Screen , vol.14 , Issue.5 , pp. 452-459
    • Grant, R.J.1    Roberts, K.2    Pointon, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.