Clinical utility of rapid pathogen identification using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in ventilated patients with pneumonia: A pilot study

Respirology

Volumn 21, Issue 2, 2016, Pages 321-328

  Mok, Jeong Ha ^a   Eom, Jung Seop ^a   Jo, Eun Jung ^a   Kim, Mi Hyun ^a   Lee, Kwangha ^a,b   Kim, Ki Uk ^a   Park, Hye Kyung ^a   Yi, Jongyoun ^a   Lee, Min Ki ^a  

^a Pusan National University School of Medicine   (South Korea)

^b Pusan National University Hospital   (South Korea)

Author keywords

bronchoalveolar lavage; identification; matrix assisted laser desorption mass spectrometry; pneumonia; ventilator

Indexed keywords

AMINOGLYCOSIDE; ANTIBIOTIC AGENT; CARBAPENEM; CEPHALOSPORIN; COLISTIN; GLYCOPEPTIDE; MACROLIDE; MINOCYCLINE; PENICILLIN DERIVATIVE; QUINOLONE; ANTIINFECTIVE AGENT;

AGED; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; BRONCHOALVEOLAR LAVAGE FLUID; COMMUNITY ACQUIRED PNEUMONIA; CONTROLLED STUDY; FEMALE; HOSPITAL ACQUIRED PNEUMONIA; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MICROBIAL IDENTIFICATION; MICROORGANISM; PRIORITY JOURNAL; QUASI EXPERIMENTAL STUDY; VENTILATED PATIENT; VENTILATOR ASSOCIATED PNEUMONIA; ADVERSE EFFECTS; ARTIFICIAL VENTILATION; BACTERIUM; ISOLATION AND PURIFICATION; LENGTH OF STAY; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MIDDLE AGED; PILOT STUDY; PNEUMONIA; TIME FACTOR; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BACTERIA; BRONCHOALVEOLAR LAVAGE FLUID; FEMALE; HUMANS; INTENSIVE CARE UNITS; LENGTH OF STAY; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; PILOT PROJECTS; PNEUMONIA; RESPIRATION, ARTIFICIAL; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS;

EID: 84955401587     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/resp.12677     Document Type: Article

References (28)

1. Houck PM, Bratzler DW, Nsa W, Ma A, Bartlett JG,. Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia. Arch. Intern. Med. 2004; 164: 637-644.
2. Meehan TP, Fine MJ, Krumholz HM, Scinto JD, Galusha DH, Mockalis JT, Weber GF, Petrillo MK, Houck PM, Fine JM,. Quality of care, process, and outcomes in elderly patients with pneumonia. JAMA 1997; 278: 2080-2084.
3. Battleman DS, Callahan M, Thaler HT,. Rapid antibiotic delivery and appropriate antibiotic selection reduce length of hospital stay of patients with community-acquired pneumonia: link between quality of care and resource utilization. Arch. Intern. Med. 2002; 162: 682-688.
4. Esperatti M, Ferrer M, Theessen A, Liapikou A, Valencia M, Saucedo LM, Zavala E, Welte T, Torres A,. Nosocomial pneumonia in the intensive care unit acquired by mechanically ventilated versus nonventilated patients. Am. J. Respir. Crit. Care Med. 2010; 182: 1533-1539.
5. Celis R, Torres A, Gatell JM, Almela M, Rodriguez-Roisin R, Agustí-Vidal A,. Nosocomial pneumonia: a multivariate analysis of risk and prognosis. Chest 1988; 93: 318-324.
6. Luna CM, Vujacich P, Niederman MS, Vay C, Gherardi C, Matera J, Jolly EC,. Impact of BAL data on therapy and outcome of ventilator associated pneumonia. Chest 1997; 111: 676-687.
7. Kollef MH, Ward S,. The influence of mini-BAL cultures on patient outcomes: implications for the antibiotic management of ventilator associated pneumonia. Chest 1998; 113: 412-420.
8. Alvarez-Lerma F,. Modification of empiric antibiotic treatment in patients with pneumonia acquired in the intensive care unit. ICU-acquired Pneumonia Study Group. Intensive Care Med. 1996; 22: 387-394.
9. Kerremans JJ, Verboom P, Stijnen T, Hakkaart-van Roijen L, Goessens W, Verbrugh HA, Vos MC,. Rapid identification and antimicrobial susceptibility testing reduce antibiotic use and accelerate pathogen-directed antibiotic use. J. Antimicrob. Chemother. 2008; 61: 428-435.
10. Seng P, Drancourt M, Gouriet F, La Scola B, Fournier PE, Rolain JM, Raoult D,. Ongoing revolution in bacteriology: routine identification of bacteria by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Clin. Infect. Dis. 2009; 49: 543-551.
11. La Scola B, Raoult D,. Direct identification of bacteria in positive blood culture bottles by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. PLoS ONE 2009; 4: e8041.
12. Endimiani A, Hujer KM, Hujer AM, Kurz S, Jacobs MR, Perlin DS, Bonomo RA,. Are we ready for novel detection methods to treat respiratory pathogens in hospital-acquired pneumonia? Clin. Infect. Dis. 2011; 52 (S4): S373-383.
13. Patel R,. Matrix-assisted laser desorption ionization-time of flight mass spectrometry in clinical microbiology. Clin. Infect. Dis. 2013; 57: 564-572.
14. Tan KE, Ellis BC, Lee R, Stamper PD, Zhang SX, Carroll KC,. Prospective evaluation of a matrix-assisted laser desorption ionization-time of flight mass spectrometry system in a hospital clinical microbiology laboratory for identification of bacteria and yeasts: a bench-by-bench study for assessing the impact on time to identification and cost-effectiveness. J. Clin. Microbiol. 2012; 50: 3301-3308.
15. Vlek AL, Bonten MJ, Boel CH,. Direct matrix-assisted laser desorption ionization time-of-flight mass spectrometry improves appropriateness of antibiotic treatment of bacteremia. PLoS ONE 2012; 7: e32589.
16. Perez KK, Olsen RJ, Musick WL, Cernoch PL, Davis JR, Land GA, Peterson LE, Musser JM,. Integrating rapid pathogen identification and antimicrobial stewardship significantly decreases hospital costs. Arch. Pathol. Lab. Med. 2013; 137: 1247-1254.
17. Huang AM, Newton D, Kunapuli A, Gandhi TN, Washer LL, Isip J, Collins CD, Nagel JL,. Impact of rapid organism identification via matrix-assisted laser desorption/ionization time-of-flight combined with antimicrobial stewardship team intervention in adult patients with bacteremia and candidemia. Clin. Infect. Dis. 2013; 57: 1237-1245.
18. Degand N, Carbonnelle E, Dauphin B, Beretti JL, Le Bourgeois M, Sermet-Gaudelus I, Segonds C, Berche P, Nassif X, Ferroni A,. Matrix-assisted laser desorption ionization-time of flight mass spectrometry for identification of nonfermenting gram-negative bacilli isolated from cystic fibrosis patients. J. Clin. Microbiol. 2008; 46: 3361-3367.
19. Luyt CE, Chastre J, Fagon JY,. Value of the clinical pulmonary infection score for the identification and management of ventilator-associated pneumonia. Intensive Care Med. 2004; 30: 844-852.
20. Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, Dowell SF, File TM Jr, Musher DM, Niederman MS, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin. Infect. Dis. 2007; 44 (Suppl. 2): S27-72.
21. American Thoracic Society, Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am. J. Respir. Crit. Care Med. 2005; 171: 388-416.
22. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med. 2008; 34: 17-60.
23. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N. Engl. J. Med. 2000; 342: 1301-1308.
24. Charlson ME, Pompei P, Ales KL, MacKenzie CR,. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J. Chronic Dis. 1987; 40: 373-383.
25. Rubin LG, Levin MJ, Ljungman P, Davies EG, Avery R, Tomblyn M, Bousvaros A, Dhanireddy S, Sung L, Keyserling H, et al. 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host. Clin. Infect. Dis. 2014; 58: 309-318.
26. Knaus WA, Draper EA, Wagner DP, Zimmerman JE,. APACHE II: a severity of disease classification system. Crit. Care Med. 1985; 13: 818-829.
27. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, Reinhart CK, Suter PM, Thijs LG,. The SOFA (Sepsis-Related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996; 22: 707-710.
28. Prabaker K, Weinstein RA,. Trends in antimicrobial resistance in intensive care units in the United States. Curr. Opin. Crit. Care 2011; 17: 472-479.