Impact of rapid organism identification via matrix-assisted laser desorption/ionization time-of-flight combined with antimicrobial stewardship team intervention in adult patients with bacteremia and candidemia

Clinical Infectious Diseases

Volumn 57, Issue 9, 2013, Pages 1237-1245

  Huang, Angela M ^a,b   Newton, Duane ^b   Kunapuli, Anjly ^a,b   Gandhi, Tejal N ^c   Washer, Laraine L ^c,d   Isip, Jacqueline ^a,b   Collins, Curtis D ^a,b   Nagel, Jerod L ^a,b  

^a Box 0008   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c Division of Infectious Diseases   (United States)

^d Department of Infection Control and Epidemiology ^*  (United States)

Author keywords

antimicrobial stewardship; bacteremia; candidemia; MALDI TOF

Indexed keywords

ANTIBIOTIC AGENT; BETA LACTAMASE; CARBAPENEMASE; VANCOMYCIN;

ACHROMOBACTER; ACINETOBACTER; ADULT; AGED; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ANTIMICROBIAL STEWARDSHIP TEAM INTERVENTION; ARTICLE; BACTEREMIA; BACTERIUM IDENTIFICATION; BLOOD CULTURE; CANDIDA; CANDIDEMIA; CITROBACTER; COMPUTER PROGRAM; CONTROLLED STUDY; CRYPTOCOCCUS; ENTEROBACTER; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; EVIDENCE BASED MEDICINE; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING ENTEROBACTERIACEAE; FEMALE; FUNGUS IDENTIFICATION; GRAM NEGATIVE SEPSIS; GRAM STAINING; HEALTH PROGRAM; HUMAN; INTENSIVE CARE UNIT; INTERVENTION STUDY; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE CARBAPENEMASE; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETER; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MEDICAL INFORMATION SYSTEM; MEDICAL STAFF; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MICROBIOLOGICAL EXAMINATION; MORTALITY; MULTIDRUG RESISTANCE; MULTIDRUG RESISTANT PSEUDOMONAS AERUGINOSA; NEUTROPENIA; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; QUASI EXPERIMENTAL STUDY; RECURRENT DISEASE; SERRATIA; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ANTIMICROBIAL STEWARDSHIP; BACTEREMIA; CANDIDEMIA; MALDI-TOF;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BACTEREMIA; BACTERIA; CANDIDA; CANDIDEMIA; DRUG PRESCRIPTIONS; DRUG UTILIZATION; FEMALE; HUMANS; MALE; MICROBIOLOGICAL TECHNIQUES; MIDDLE AGED; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS; TREATMENT OUTCOME;

EID: 84886911636     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cit498     Document Type: Article

References (20)

1. Wisplinghoff H, Bischoff T, Tallent SM, Seifert H,Wenzel RP, Edmond MB. Nosocomial bloodstream infections in US hospitals: Analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 2004; 39:309-17.
2. Forrest GN, Roghmann MC, Toombs LS, et al. Peptide nucleic acid fluorescent in situ hybridization for hospital-acquired enterococcal bacteremia: Delivering earlier effective antimicrobial therapy. Antimicrob Agents Chemother 2008; 52:3558-63.
3. Bauer KA, West JE, Balada-Llasat JM, Pancholi P, Stevenson KB, Goff DA. An antimicrobial stewardship program?s impact with rapid polymerase chain reaction methicillin-resistant Staphylococcus aureus/S. aureus blood culture test in patients with S. aureus bacteremia. Clin Infect Dis 2010; 51:1076-80.
4. Lodise TP, McKinnon PS, Swiderski L, Rybak MJ. Outcomes analysis of delayed antibiotic treatment for hospital-acquired Staphylococcus aureus bacteremia. Clin Infect Dis 2003; 36:1418-23.
5. Kang CI, Kim SH, Park WB, et al. Bloodstream infections caused by antibiotic- resistant gram-negative bacilli: Risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome. Antimicrob Agents Chemother 2005; 49:760-6.
6. Perez KK, Olsen RJ, Musick WL, et al. Integrating rapid pathogen identification and antimicrobial stewardship significantly decreases hospital costs [published online ahead of print 6 December 2012]. Arch Pathol Lab Med 2012; doi:10.5858/arpa.2012-0651-OA.
7. Barenfanger J, Graham DR, Kolluri L, et al. Decreased mortality associated with prompt Gram staining of blood cultures. Am J Clin Pathol 2008; 130:870-6.
8. Gaynes R. The impact of antimicrobial use on the emergence of antimicrobial- resistant bacteria in hospitals. Infect Dis Clin North Am 1997; 11:757-65.
9. Stevenson LG, Drake SK, Murray PR. Rapid identification of bacteria in positive blood culture broths by matrix-assisted laser desorption ionization- time of flight mass spectrometry. J Clin Microbiol 2010; 48:444-7.
10. Marklein G, Josten M, Klanke U, et al. Matrix-assisted laser desorption ionization- time of flight mass spectrometry for fast and reliable identification of clinical yeast isolates. J Clin Microbiol 2009; 47:2912-7.
11. Tan KE, Ellis BC, Lee R, Stamper PD, Zhang SX, Carroll KC. Prospective evaluation of a matrix-assisted laser desorption ionization-time of flight mass spectrometry system in a hospital clinical microbiology laboratory for identification of bacteria and yeasts: A bench-by-bench study for assessing the impact on time to identification and cost-effectiveness. J Clin Microbiol 2012; 50:3301-8.
12. Vlek AL, Bonten MJ, Boel CH. Direct matrix-assisted laser desorption ionization time-of-flight mass spectrometry improves appropriateness of antibiotic treatment of bacteremia. PLoS One 2012; 7:e32589.
13. Ly T, Gulia J, Pyrgos V, Waga M, Shoham S. Impact upon clinical outcomes of transplant of PNA FISH-generated laboratory data from the clinical microbiology bench to bedside in real time. Ther Clin Risk Manag 2008; 4:637-40.
14. Carver PL, Lin S, DePestel DD, Newton DW. Impact of mecA gene testing and intervention by infectious disease clinical pharmacists on time to optimal antimicrobial therapy for Staphylococcus aureus bacteremia at a university hospital. J Clin Microbiol 2008; 46:2381-3.
15. Holtzman C, Whitney D, Barlam T, Miller NS. Assessment of impact of peptide nucleic Acid fluorescence in situ hybridization for rapid identification of coagulase-negative staphylococci in the absence of antimicrobial stewardship intervention. J Clin Microbiol 2011; 49:1581-82.
16. Saffert RT, Cunningham SA, Ihde SM, Jobe KE, Mandrekar J, Patel R. Comparison of Bruker Biotyper matrix-assisted laser desorption ionization- time of flight mass spectrometer to BD Phoenix automated microbiology system for identification of gram-negative bacilli. J Clin Microbiol 2011; 49:887-92.
17. Antworth A, Collins CD, Kunapuli A, et al. Impact of an antimicrobial stewardship program comprehensive care bundle on management of candidemia. Pharmacotherapy 2013; 33:137-43.
18. Goff DA, Jankowski C, Tenover FC. Using rapid diagnostic tests to optimize antimicrobial selection in antimicrobial stewardship programs. Pharmacotherapy 2012; 32:677-687.
19. Clerc O, Prodhom G, Vogne C, Bizzini A, Calandra T, Greub G. Impact of matrix-assisted laser desorption ionization time-of-flight mass spectrometry on the clinical management of patients with gram-negative bacteremia: A prospective observational study. Clin Infect Dis 2013; 56:1101-7.
20. Dellit TH, Owens RC, McGowan JE Jr, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis 2007; 44:159-77.