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Volumn 75, Issue 24, 2015, Pages 5187-5193

IL15 and T-cell stemness in T-cell-based cancer immunotherapy

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT INTERLEUKIN 15; INTERLEUKIN 15;

EID: 84955294718     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-1498     Document Type: Review
Times cited : (96)

References (43)
  • 2
    • 84855804372 scopus 로고    scopus 로고
    • Interleukin-15 biology and its therapeutic implications in cancer
    • Steel JC, Waldmann TA, Morris JC. Interleukin-15 biology and its therapeutic implications in cancer. Trends Pharmacol Sci 2012; 33: 35-41.
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 35-41
    • Steel, J.C.1    Waldmann, T.A.2    Morris, J.C.3
  • 3
    • 84920577302 scopus 로고    scopus 로고
    • Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer
    • Conlon KC, Lugli E, Welles HC, Rosenberg SA, Fojo AT, Morris JC, et al. Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer. J Clin Oncol 2015; 33: 74-82.
    • (2015) J Clin Oncol , vol.33 , pp. 74-82
    • Conlon, K.C.1    Lugli, E.2    Welles, H.C.3    Rosenberg, S.A.4    Fojo, A.T.5    Morris, J.C.6
  • 4
    • 0036826914 scopus 로고    scopus 로고
    • IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells
    • Dubois S, Mariner J, Waldmann TA, Tagaya Y. IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity 2002; 17: 537-47.
    • (2002) Immunity , vol.17 , pp. 537-547
    • Dubois, S.1    Mariner, J.2    Waldmann, T.A.3    Tagaya, Y.4
  • 5
    • 84863562572 scopus 로고    scopus 로고
    • Circulating IL-15 exists as heterodimeric complex with soluble IL-15Ralpha in human and mouse serum
    • Bergamaschi C, Bear J, Rosati M, Beach RK, Alicea C, Sowder R, et al. Circulating IL-15 exists as heterodimeric complex with soluble IL-15Ralpha in human and mouse serum. Blood 2012; 120: E1-8.
    • (2012) Blood , vol.120 , pp. e1-8
    • Bergamaschi, C.1    Bear, J.2    Rosati, M.3    Beach, R.K.4    Alicea, C.5    Sowder, R.6
  • 6
    • 78049271031 scopus 로고    scopus 로고
    • Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates
    • Lugli E, Goldman CK, Perera LP, Smedley J, Pung R, Yovandich JL, et al. Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates. Blood 2010; 116: 3238-48.
    • (2010) Blood , vol.116 , pp. 3238-3248
    • Lugli, E.1    Goldman, C.K.2    Perera, L.P.3    Smedley, J.4    Pung, R.5    Yovandich, J.L.6
  • 7
    • 84928591321 scopus 로고    scopus 로고
    • The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
    • Klatzmann D, Abbas AK. The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases. Nat Rev Immunol 2015; 15: 283-94.
    • (2015) Nat Rev Immunol , vol.15 , pp. 283-294
    • Klatzmann, D.1    Abbas, A.K.2
  • 8
    • 70350511426 scopus 로고    scopus 로고
    • Safety and immunologic effects of IL-15 administration in nonhuman primates
    • Berger C, Berger M, Hackman RC, Gough M, Elliott C, Jensen MC, et al. Safety and immunologic effects of IL-15 administration in nonhuman primates. Blood 2009; 114: 2417-26.
    • (2009) Blood , vol.114 , pp. 2417-2426
    • Berger, C.1    Berger, M.2    Hackman, R.C.3    Gough, M.4    Elliott, C.5    Jensen, M.C.6
  • 9
    • 30744458573 scopus 로고    scopus 로고
    • Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells
    • Zhang H, Chua KS, Guimond M, Kapoor V, Brown MV, Fleisher TA, et al. Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells. Nat Med 2005; 11: 1238-43.
    • (2005) Nat Med , vol.11 , pp. 1238-1243
    • Zhang, H.1    Chua, K.S.2    Guimond, M.3    Kapoor, V.4    Brown, M.V.5    Fleisher, T.A.6
  • 10
    • 33644784733 scopus 로고    scopus 로고
    • IL-2 administration increases CD4+ CD25(hi) Foxp3 +regulatory T cells in cancer patients
    • Ahmadzadeh M, Rosenberg SA. IL-2 administration increases CD4+ CD25(hi) Foxp3 +regulatory T cells in cancer patients. Blood 2006; 107: 2409-14.
    • (2006) Blood , vol.107 , pp. 2409-2414
    • Ahmadzadeh, M.1    Rosenberg, S.A.2
  • 11
    • 84858758766 scopus 로고    scopus 로고
    • Adoptive immunotherapy for cancer: Harnessing the T cell response
    • Restifo NP, Dudley ME, Rosenberg SA. Adoptive immunotherapy for cancer: Harnessing the T cell response. Nat Rev Immunol 2012; 12: 269-81.
    • (2012) Nat Rev Immunol , vol.12 , pp. 269-281
    • Restifo, N.P.1    Dudley, M.E.2    Rosenberg, S.A.3
  • 13
    • 25844484607 scopus 로고    scopus 로고
    • Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specificCD8+T cells
    • Gattinoni L, Finkelstein SE, Klebanoff CA, Antony PA, Palmer DC, Spiess PJ, et al. Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specificCD8+T cells. J Exp Med 2005; 202: 907-12.
    • (2005) J Exp Med , vol.202 , pp. 907-912
    • Gattinoni, L.1    Finkelstein, S.E.2    Klebanoff, C.A.3    Antony, P.A.4    Palmer, D.C.5    Spiess, P.J.6
  • 14
    • 55949125601 scopus 로고    scopus 로고
    • Adoptive cell therapy for patients with metastatic melanoma: Evaluation of intensive myeloablative chemoradiation preparative regimens
    • Dudley ME, Yang JC, Sherry R, Hughes MS, Royal R, Kammula U, et al. Adoptive cell therapy for patients with metastatic melanoma: Evaluation of intensive myeloablative chemoradiation preparative regimens. J Clin Oncol 2008; 26: 5233-9.
    • (2008) J Clin Oncol , vol.26 , pp. 5233-5239
    • Dudley, M.E.1    Yang, J.C.2    Sherry, R.3    Hughes, M.S.4    Royal, R.5    Kammula, U.6
  • 22
    • 84922661546 scopus 로고    scopus 로고
    • In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells
    • Biasco L, Scala S, Basso Ricci L, Dionisio F, Baricordi C, Calabria A, et al. In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells. Sci Transl Med 2015; 7: 273ra13.
    • (2015) Sci Transl Med , vol.7 , pp. 273ra13
    • Biasco, L.1    Scala, S.2    Basso Ricci, L.3    Dionisio, F.4    Baricordi, C.5    Calabria, A.6
  • 23
    • 28644437672 scopus 로고    scopus 로고
    • Host-reactiveCD8+memory stem cells in graft-versus-host disease
    • Zhang Y, Joe G, Hexner E, Zhu J, Emerson SG. Host-reactiveCD8+memory stem cells in graft-versus-host disease. Nat Med 2005; 11: 1299-305.
    • (2005) Nat Med , vol.11 , pp. 1299-1305
    • Zhang, Y.1    Joe, G.2    Hexner, E.3    Zhu, J.4    Emerson, S.G.5
  • 24
    • 84873050511 scopus 로고    scopus 로고
    • IL-7 and IL-15 instruct the generation of humanmemory stem T cells from naive precursors
    • Cieri N, Camisa B, Cocchiarella F, Forcato M, Oliveira G, Provasi E, et al. IL-7 and IL-15 instruct the generation of humanmemory stem T cells from naive precursors. Blood 2013; 121: 573-84.
    • (2013) Blood , vol.121 , pp. 573-584
    • Cieri, N.1    Camisa, B.2    Cocchiarella, F.3    Forcato, M.4    Oliveira, G.5    Provasi, E.6
  • 25
    • 84928776502 scopus 로고    scopus 로고
    • Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation
    • Roberto A, Castagna L, Zanon V, Bramanti S, Crocchiolo R, McLaren JE, et al. Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation. Blood 2015; 125: 2855-64.
    • (2015) Blood , vol.125 , pp. 2855-2864
    • Roberto, A.1    Castagna, L.2    Zanon, V.3    Bramanti, S.4    Crocchiolo, R.5    McLaren, J.E.6
  • 26
    • 84928789921 scopus 로고    scopus 로고
    • Generation of human memory stem T cells after haploidentical T-replete hematopoietic stem cell transplantation
    • Cieri N, Oliveira G, Greco R, Forcato M, Taccioli C, Cianciotti B, et al. Generation of human memory stem T cells after haploidentical T-replete hematopoietic stem cell transplantation. Blood 2015; 125: 2865-74.
    • (2015) Blood , vol.125 , pp. 2865-2874
    • Cieri, N.1    Oliveira, G.2    Greco, R.3    Forcato, M.4    Taccioli, C.5    Cianciotti, B.6
  • 27
    • 84927635336 scopus 로고    scopus 로고
    • Long-lasting stem cell-like memory CD8+ T cells with a naive-like profile upon yellow fever vaccination
    • Fuertes Marraco SA, Soneson C, Cagnon L, Gannon PO, Allard M, Maillard SA, et al. Long-lasting stem cell-like memory CD8+ T cells with a naive-like profile upon yellow fever vaccination. Sci Transl Med 2015; 7: 282ra48.
    • (2015) Sci Transl Med , vol.7 , pp. 282ra48
    • Fuertes Marraco, S.A.1    Soneson, C.2    Cagnon, L.3    Gannon, P.O.4    Allard, M.5    Maillard, S.A.6
  • 28
    • 84902590274 scopus 로고    scopus 로고
    • Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15
    • Xu Y, Zhang M,Ramos CA, Durett A, Liu E, Dakhova O, et al. Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15. Blood 2014; 123: 3750-9.
    • (2014) Blood , vol.123 , pp. 3750-3759
    • Xu, Y.1    Zhang, M.2    Ramos, C.A.3    Durett, A.4    Liu, E.5    Dakhova, O.6
  • 29
    • 84869410452 scopus 로고    scopus 로고
    • Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15
    • Ring AM, Lin JX, Feng D,Mitra S, Rickert M, Bowman GR, et al. Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nat Immunol 2012; 13: 1187-95.
    • (2012) Nat Immunol , vol.13 , pp. 1187-1195
    • Ring, A.M.1    Lin, J.X.2    Feng, D.3    Mitra, S.4    Rickert, M.5    Bowman, G.R.6
  • 30
    • 84856183120 scopus 로고    scopus 로고
    • Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
    • van der Windt GJ, Everts B, Chang CH, Curtis JD, Freitas TC, Amiel E, et al. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity 2012; 36: 68-78.
    • (2012) Immunity , vol.36 , pp. 68-78
    • Van Der Windt, G.J.1    Everts, B.2    Chang, C.H.3    Curtis, J.D.4    Freitas, T.C.5    Amiel, E.6
  • 31
    • 84255197274 scopus 로고    scopus 로고
    • IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood
    • Sneller MC, Kopp WC, Engelke KJ, Yovandich JL, Creekmore SP, Waldmann TA, et al. IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood. Blood 2011; 118: 6845-8.
    • (2011) Blood , vol.118 , pp. 6845-6848
    • Sneller, M.C.1    Kopp, W.C.2    Engelke, K.J.3    Yovandich, J.L.4    Creekmore, S.P.5    Waldmann, T.A.6
  • 32
    • 84880078963 scopus 로고    scopus 로고
    • Characterization and favorable in vivo properties of heterodimeric soluble IL-15.IL-15Ralpha cytokine compared to IL-15 monomer
    • Chertova E, Bergamaschi C, Chertov O, Sowder R, Bear J, Roser JD, et al. Characterization and favorable in vivo properties of heterodimeric soluble IL-15.IL-15Ralpha cytokine compared to IL-15 monomer. J Biol Chem 2013; 288: 18093-103.
    • (2013) J Biol Chem , vol.288 , pp. 18093-18103
    • Chertova, E.1    Bergamaschi, C.2    Chertov, O.3    Sowder, R.4    Bear, J.5    Roser, J.D.6
  • 34
    • 84877845953 scopus 로고    scopus 로고
    • IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner
    • Liu RB, Engels B, Schreiber K, Ciszewski C, Schietinger A, Schreiber H, et al. IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner. Proc Natl Acad Sci U S A 2013; 110: 8158-63.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 8158-8163
    • Liu, R.B.1    Engels, B.2    Schreiber, K.3    Ciszewski, C.4    Schietinger, A.5    Schreiber, H.6
  • 35
    • 84861801527 scopus 로고    scopus 로고
    • IL-15 protects NKT cells from inhibition by tumor-associatedmacrophages and enhances antimetastatic activity
    • Liu D, Song L, Wei J, Courtney AN, Gao X,Marinova E, et al. IL-15 protects NKT cells from inhibition by tumor-associatedmacrophages and enhances antimetastatic activity. J Clin Invest 2012; 122: 2221-33.
    • (2012) J Clin Invest , vol.122 , pp. 2221-2233
    • Liu, D.1    Song, L.2    Wei, J.3    Courtney, A.N.4    Gao, X.5    Marinova, E.6
  • 36
    • 84900798699 scopus 로고    scopus 로고
    • Enhanced antitumor immunity is elicited by adenovirus-mediated gene transfer of CCL21 and IL-15 in murine colon carcinomas
    • Zhao DX, Li ZJ, Zhang Y, Zhang XN, Zhao KC, Li YG, et al. Enhanced antitumor immunity is elicited by adenovirus-mediated gene transfer of CCL21 and IL-15 in murine colon carcinomas. Cell Immunol 2014; 289: 155-61.
    • (2014) Cell Immunol , vol.289 , pp. 155-161
    • Zhao, D.X.1    Li, Z.J.2    Zhang, Y.3    Zhang, X.N.4    Zhao, K.C.5    Li, Y.G.6
  • 37
    • 84899050715 scopus 로고    scopus 로고
    • Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients
    • Mlecnik B, Bindea G, Angell HK, Sasso MS,Obenauf AC, Fredriksen T, et al. Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients. Sci Transl Med 2014; 6: 228ra37.
    • (2014) Sci Transl Med , vol.6 , pp. 228ra37
    • Mlecnik, B.1    Bindea, G.2    Angell, H.K.3    Sasso, M.S.4    Obenauf, A.C.5    Fredriksen, T.6
  • 38
    • 84908664534 scopus 로고    scopus 로고
    • Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: A randomized clinical trial
    • Hodi FS, Lee S, McDermott DF, Rao UN, Butterfield LH, Tarhini AA, et al. Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: A randomized clinical trial. JAMA 2014; 312: 1744-53.
    • (2014) JAMA , vol.312 , pp. 1744-1753
    • Hodi, F.S.1    Lee, S.2    McDermott, D.F.3    Rao, U.N.4    Butterfield, L.H.5    Tarhini, A.A.6
  • 39
    • 78650328102 scopus 로고    scopus 로고
    • Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma model
    • Yu P, Steel JC, Zhang M, Morris JC, Waldmann TA. Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma model. Clin Cancer Res 2010; 16: 6019-28.
    • (2010) Clin Cancer Res , vol.16 , pp. 6019-6028
    • Yu, P.1    Steel, J.C.2    Zhang, M.3    Morris, J.C.4    Waldmann, T.A.5
  • 40
    • 84862628705 scopus 로고    scopus 로고
    • Augmented IL-15Ralpha expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice
    • Zhang M, Ju W, Yao Z, Yu P, Wei BR, Simpson RM, et al. Augmented IL-15Ralpha expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice. J Immunol 2012; 188: 6156-64.
    • (2012) J Immunol , vol.188 , pp. 6156-6164
    • Zhang, M.1    Ju, W.2    Yao, Z.3    Yu, P.4    Wei, B.R.5    Simpson, R.M.6
  • 41
    • 84892574356 scopus 로고    scopus 로고
    • Combining antibody-directed presentation of IL-15 and 4-1BBL in a trifunctional fusion protein for cancer immunotherapy
    • Kermer V, Hornig N, Harder M, Bondarieva A, Kontermann RE, Muller D. Combining antibody-directed presentation of IL-15 and 4-1BBL in a trifunctional fusion protein for cancer immunotherapy. Mol Cancer Ther 2014; 13: 112-21.
    • (2014) Mol Cancer Ther , vol.13 , pp. 112-121
    • Kermer, V.1    Hornig, N.2    Harder, M.3    Bondarieva, A.4    Kontermann, R.E.5    Muller, D.6
  • 42
    • 84871939748 scopus 로고    scopus 로고
    • Interleukin 15 provides relief to CTLs from regulatory T cell-mediated inhibition: Implications for adoptive T cell-based therapies for lymphoma
    • Perna SK, De Angelis B, Pagliara D, Hasan ST, Zhang L, Mahendravada A, et al. Interleukin 15 provides relief to CTLs from regulatory T cell-mediated inhibition: Implications for adoptive T cell-based therapies for lymphoma. Clin Cancer Res 2013; 19: 106-17.
    • (2013) Clin Cancer Res , vol.19 , pp. 106-117
    • Perna, S.K.1    De Angelis, B.2    Pagliara, D.3    Hasan, S.T.4    Zhang, L.5    Mahendravada, A.6
  • 43
    • 84928771999 scopus 로고    scopus 로고
    • T cell exclusion, immune privilege, and the tumor microenvironment
    • Joyce JA, Fearon DT. T cell exclusion, immune privilege, and the tumor microenvironment. Science 2015; 348: 74-80.
    • (2015) Science , vol.348 , pp. 74-80
    • Joyce, J.A.1    Fearon, D.T.2


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