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Volumn 9, Issue , 2015, Pages

Phase II trial of metformin and paclitaxel for patients with gemcitabine-refractory advanced adenocarcinoma of the pancreas

Author keywords

Metformin; Pancreas adenocarcinoma

Indexed keywords

BILIRUBIN; GEMCITABINE; METFORMIN; PACLITAXEL;

EID: 84955256688     PISSN: None     EISSN: 17546605     Source Type: Journal    
DOI: 10.3332/ecancer.2015.563     Document Type: Article
Times cited : (37)

References (20)
  • 1
    • 79955921754 scopus 로고    scopus 로고
    • FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
    • PMID: 21561347
    • Conroy T et al (2011) FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer N Engl J Med (2011) 364(19) 1817-25 DOI: 10.1056/NEJMoa1011923 PMID: 21561347
    • (2011) N Engl J Med , vol.364 , Issue.19 , pp. 1817-1825
    • Conroy, T.1
  • 2
    • 84905817411 scopus 로고    scopus 로고
    • Second-line oxaliplatin, folinic acid, and fluorouracil versus folinic acid and fluorouracil alone for gemcitabine-refractory pancreatic cancer: Outcomes from the CONKO-003 Trial
    • PMID: 24982456
    • Oettle H et al (2014) Second-Line Oxaliplatin, Folinic Acid, and Fluorouracil Versus Folinic Acid and Fluorouracil Alone for Gemcitabine-Refractory Pancreatic Cancer: Outcomes From the CONKO-003 Trial J Clin Oncol 32(23) 2423-9 DOI: 10.1200/JCO.2013.53.6995 PMID: 24982456
    • (2014) J Clin Oncol , vol.32 , Issue.23 , pp. 2423-2429
    • Oettle, H.1
  • 3
    • 85084273951 scopus 로고    scopus 로고
    • NAPOLI-1 Randomized phase 3 study of mm-398 (nal-iri), with or without 5-fluorouracil and leucovorin, versus 5-fluorouracil and leucovorin, in metastatic pancreatic cancer progressed on or following gemcitabine-based therapy
    • ed
    • Von Hoff D et al ed (2014) NAPOLI-1 Randomized phase 3 study of mm-398 (nal-iri), with or without 5-fluorouracil and leucovorin, versus 5-fluorouracil and leucovorin, in metastatic pancreatic cancer progressed on or following gemcitabine-based therapy. ESMO 16th World Congress on Gastrointestinal Cancer Barcelona Spain Ann Oncol DOI: 10.1093/annonc/mdu193.3
    • (2014) ESMO 16th World Congress on Gastrointestinal Cancer Barcelona Spain Ann Oncol
    • Von Hoff, D.1
  • 4
    • 84890016628 scopus 로고    scopus 로고
    • Metformin is associated with survival benefit in cancer patients with concurrent type 2 diabetes: A systematic review and meta-analysis
    • PMID: 24258613 PMCID: 3868417
    • Yin M et al (2013) Metformin is associated with survival benefit in cancer patients with concurrent type 2 diabetes: A systematic review and meta-analysis Oncologist 18(12) 1248-55 DOI: 10.1634/theoncologist.2013-0111 PMID: 24258613 PMCID: 3868417
    • (2013) Oncologist , vol.18 , Issue.12 , pp. 1248-1255
    • Yin, M.1
  • 5
    • 0029819936 scopus 로고    scopus 로고
    • Metabolic effects of metformin on glucose and lactate metabolism in noninsulindependent diabetes mellitus
    • PMID: 8923861
    • Cusi K, Consoli A and DeFronzo RA (1996) Metabolic effects of metformin on glucose and lactate metabolism in noninsulindependent diabetes mellitus J Clin Endocrinol Metab 81(11) 4059-67 PMID: 8923861
    • (1996) J Clin Endocrinol Metab , vol.81 , Issue.11 , pp. 4059-4067
    • Cusi, K.1    Consoli, A.2    DeFronzo, R.A.3
  • 6
    • 36348950449 scopus 로고    scopus 로고
    • Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
    • PMID: 18006825
    • Dowling RJ et al (2007) Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells Cancer Res 67(22) 10804-12 DOI: 10.1158/0008-5472.CAN-07-2310 PMID: 18006825
    • (2007) Cancer Res , vol.67 , Issue.22 , pp. 10804-10812
    • Dowling, R.J.1
  • 7
    • 84889011636 scopus 로고    scopus 로고
    • Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors
    • PMID: 23803693 PMCID: 3845888
    • Nair V et al (2013) Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors Carcinogenesis 34(12) 2870-9 DOI: 10.1093/carcin/bgt231 PMID: 23803693 PMCID: 3845888
    • (2013) Carcinogenesis , vol.34 , Issue.12 , pp. 2870-2879
    • Nair, V.1
  • 8
    • 84877251996 scopus 로고    scopus 로고
    • Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells
    • Karnevi E et al (2012) Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells BMC Cancer 13 235 DOI: 10.1186/1471-2407-13-235
    • (2012) BMC Cancer , vol.13 , pp. 235
    • Karnevi, E.1
  • 9
    • 69249162223 scopus 로고    scopus 로고
    • Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth
    • PMID: 19679549 PMCID 2753241
    • Kisfalvi K et al (2009) Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth Cancer Res 69(16) 6539-45 DOI: 10.1158/0008-5472.CAN-09-0418 PMID: 19679549 PMCID: 2753241
    • (2009) Cancer Res , vol.69 , Issue.16 , pp. 6539-6545
    • Kisfalvi, K.1
  • 10
    • 84876334434 scopus 로고    scopus 로고
    • Association of metformin use with cancer incidence and mortality: A meta-analysis
    • PMID: 23352629
    • Zhang P et al (2013) Association of metformin use with cancer incidence and mortality: A meta-analysis Cancer Epidemiol 37(3) 207-18 DOI: 10.1016/j.canep.2012.12.009 PMID: 23352629
    • (2013) Cancer Epidemiol , vol.37 , Issue.3 , pp. 207-218
    • Zhang, P.1
  • 11
    • 84861127026 scopus 로고    scopus 로고
    • Metformin use is associated with better survival of diabetic patients with pancreatic cancer
    • PMID: 22465831 PMCID: 3381457
    • Sadeghi N et al (2012) Metformin use is associated with better survival of diabetic patients with pancreatic cancer Clin Cancer Res 18(10) 2905-12 DOI: 10.1158/1078-0432.CCR-11-2994 PMID: 22465831 PMCID: 3381457
    • (2012) Clin Cancer Res , vol.18 , Issue.10 , pp. 2905-2912
    • Sadeghi, N.1
  • 12
    • 84858745832 scopus 로고    scopus 로고
    • Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway
    • PMID: 22252099 PMCID: 3322276
    • Hanna RK et al (2012) Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway Gynecol Oncol 125(2) 458-69 DOI: 10.1016/j.ygyno.2012.01.009 PMID: 22252099 PMCID: 3322276
    • (2012) Gynecol Oncol , vol.125 , Issue.2 , pp. 458-469
    • Hanna, R.K.1
  • 13
    • 79959207505 scopus 로고    scopus 로고
    • Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth
    • PMID: 21543517
    • Rocha GZ et al (2011) Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth Clin Cancer Res 17(12) 3993-4005 DOI: 10.1158/1078-0432.CCR-10-2243 PMID: 21543517
    • (2011) Clin Cancer Res , vol.17 , Issue.12 , pp. 3993-4005
    • Rocha, G.Z.1
  • 14
    • 84881239893 scopus 로고    scopus 로고
    • Second-line treatment in advanced pancreatic cancer: A comprehensive analysis of published clinical trials
    • PMID: 23670093 PMCID: 3718508
    • Rahma OE et al (2013) Second-line treatment in advanced pancreatic cancer: A comprehensive analysis of published clinical trials Ann Oncol 24(8) 1972-9 DOI: 10.1093/annonc/mdt166 PMID: 23670093 PMCID: 3718508
    • (2013) Ann Oncol , vol.24 , Issue.8 , pp. 1972-1979
    • Rahma, O.E.1
  • 15
    • 84886741654 scopus 로고    scopus 로고
    • Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
    • PMID: 24131140
    • Von Hoff DD et al (2013) Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine N Engl J Med 369(18) 1691-703 DOI: 10.1056/NEJMoa1304369 PMID: 24131140
    • (2013) N Engl J Med , vol.369 , Issue.18 , pp. 1691-1703
    • Von Hoff, D.D.1
  • 16
    • 79953789546 scopus 로고    scopus 로고
    • Second-line chemotherapy with capecitabine (Xeloda) and docetaxel (Taxotere) in previously treated, unresectable adenocarcinoma of pancreas: The final results of a phase II trial
    • Katopodis O et al (2011) Second-line chemotherapy with capecitabine (Xeloda) and docetaxel (Taxotere) in previously treated, unresectable adenocarcinoma of pancreas: The final results of a phase II trial Cancer Chemother Pharmacol 67(2) 361-8 DOI: 10.1007/s00280-010-1329-6
    • (2011) Cancer Chemother Pharmacol , vol.67 , Issue.2 , pp. 361-368
    • Katopodis, O.1
  • 17
    • 84876159000 scopus 로고    scopus 로고
    • A phase II trial of nab-Paclitaxel as second-line therapy in patients with advanced pancreatic cancer
    • Hosein PJ et al (2013) A phase II trial of nab-Paclitaxel as second-line therapy in patients with advanced pancreatic cancer Am J Clin Oncol 36(2) 151-6 DOI: 10.1097/COC.0b013e3182436e8c
    • (2013) Am J Clin Oncol , vol.36 , Issue.2 , pp. 151-156
    • Hosein, P.J.1
  • 18
    • 84958777421 scopus 로고    scopus 로고
    • A phase II randomized, placebo controlled study to evaluate the efficacy of the combination of gemcitabine erlotinib, and metformin in patients with locally advanced or metastatic pancreatic cancer ASCO Annual Meeting Chicago
    • ed
    • Wilmink J et al ed (2014) A phase II randomized, placebo controlled study to evaluate the efficacy of the combination of gemcitabine, erlotinib, and metformin in patients with locally advanced or metastatic pancreatic cancer ASCO Annual Meeting Chicago J Clin Oncol
    • (2014) J Clin Oncol
    • Wilmink, J.1
  • 19
    • 84885742331 scopus 로고    scopus 로고
    • Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells
    • PMID: 24204632 PMCID: 3799760
    • Lonardo E et al (2013) Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells PLoS One 8(10) e76518 DOI: 10.1371/journal.pone.0076518 PMID: 24204632 PMCID: 3799760
    • (2013) PLoS One , vol.8 , Issue.10 , pp. e76518
    • Lonardo, E.1
  • 20
    • 79952279828 scopus 로고    scopus 로고
    • DAXX/ATRX MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors
    • PMID: 21252315 PMCID: 3144496
    • Jiao Y et al (2011) DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors Science 331(6021) 1199-203 DOI: 10.1126/science.1200609 PMID: 21252315 PMCID: 3144496
    • (2011) Science , vol.331 , Issue.6021 , pp. 1199-1203
    • Jiao, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.