Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases

Journal of Hepatology

Volumn 64, Issue 4, 2016, Pages 860-871

  Ghallab, Ahmed ^a,b   Cellière, Géraldine ^c   Henkel, Sebastian G ^d   Driesch, Dominik ^d   Hoehme, Stefan ^e   Hofmann, Ute ^f   Zellmer, Sebastian ^e   Godoy, Patricio ^a   Sachinidis, Agapios ^g   Blaszkewicz, Meinolf ^a   Reif, Raymond ^a   Marchan, Rosemarie ^a   Kuepfer, Lars ^h   Häussinger, Dieter ⁱ   Drasdo, Dirk ^c,e   Gebhardt, Rolf ^e   Hengstler, Jan G ^a  

^a LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

^b South Valley University   (Egypt)

^c INRIA   (France)

^d BIOCONTROL JENA GMBH   (Germany)

^e UNIVERSITY OF LEIPZIG   (Germany)

^f UNIVERSITY OF TÜBINGEN   (Germany)

^g UNIVERSITY OF COLOGNE   (Germany)

^h BAYER AG   (Germany)

ⁱ HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Ammonia; Liver damage; Liver regeneration; Spatio temporal model; Systems biology

Indexed keywords

2 OXOGLUTARIC ACID; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; ALPHA-KETOGLUTARIC ACID;

ACUTE DISEASE; AMIDATION; AMMONIA BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DETOXIFICATION; DRUG MECHANISM; GENE EXPRESSION; HYPERAMMONEMIA; IMMUNOHISTOCHEMISTRY; LIVER CELL DAMAGE; LIVER DISEASE; LIVER INJURY; LIVER VEIN; MALE; MATHEMATICAL MODEL; METABOLISM; MOUSE; NITROGEN METABOLISM; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; SIMULATION; VENOUS BLOOD; ANIMAL; C57BL MOUSE; LIVER DISEASES; PHYSIOLOGY;

ANIMALS; GLUTAMATE DEHYDROGENASE; HYPERAMMONEMIA; KETOGLUTARIC ACIDS; LIVER DISEASES; MALE; MICE; MICE, INBRED C57BL;

EID: 84955247895     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.11.018     Document Type: Article

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