Exocytosis of endothelial lysosome-related organelles hair-triggers a patchy loss of glycocalyx at the onset of sepsis

American Journal of Pathology

Volumn 186, Issue 2, 2016, Pages 248-258

  Zullo, Joseph A ^a   Fan, Jie ^b   Azar, Tala T ^b   Yen, Wanyi ^b   Zeng, Min ^b   Chen, Jun ^a   Ratliff, Brian B ^a   Song, Jun ^a,c   Tarbell, John M ^b   Goligorsky, Michael S ^a   Fu, Bingmei M ^b  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b City University of New York   (United States)

^c Medical College   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CATHEPSIN; LIPOPOLYSACCHARIDE; NG HYDROXY L ARGININE; SUPEROXIDE; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; CAPILLARY ENDOTHELIAL CELL; CELL MOTILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CULTURE MEDIUM; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIAL SURFACE GLYCOCALYX; EXOCYTOSIS; GLYCOCALYX; HUMAN; HUMAN CELL; HYDROGEL; LYSOSOME; MALE; MOUSE; MULTIPLE ORGAN FAILURE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; STOCHASTIC OPTICAL RECONSTRUCTION MICROSCOPY; TIME-LAPSE VIDEO MICROSCOPY; UMBILICAL VEIN ENDOTHELIAL CELL; WEIBEL PALADE BODY; ANIMAL; C57BL MOUSE; CAPILLARY PERMEABILITY; CELL CULTURE; CELL LINE; DRUG EFFECTS; ENDOTHELIUM CELL; HAIR; METABOLISM; VASCULAR ENDOTHELIUM;

ANIMALS; CAPILLARY PERMEABILITY; CELL LINE; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; EXOCYTOSIS; GLYCOCALYX; HAIR; HUMANS; LIPOPOLYSACCHARIDES; LYSOSOMES; MALE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE TYPE III; SEPSIS;

EID: 84955242015     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2015.10.001     Document Type: Article

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