Metabolic alterations in adolescents with obstructive sleep apnea

International Journal of Pediatric Otorhinolaryngology

Volumn 79, Issue 12, 2015, Pages 2368-2373

  Bhushan, Bharat ^a,b   Ayub, Bushra ^a   Loghmanee, Darius A ^c   Billings, Kathleen R ^a,b  

^a CHILDREN'S MEMORIAL HOSPITAL   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c Lutheran General Hospital   (United States)

Author keywords

Adolescents; Metabolic alterations; Metabolic syndrome; Obesity; Obstructive sleep apnea

Indexed keywords

CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; GLUCOSE BLOOD LEVEL; LIPID;

ADOLESCENT; ADOLESCENT HEALTH; ADOLESCENT OBESITY; AGE; APNEA HYPOPNEA INDEX; ARTICLE; BODY MASS; CASE CONTROL STUDY; CHILD; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GENDER; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; METABOLISM; POLYSOMNOGRAPHY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SLEEP DISORDERED BREATHING; SLEEP TIME; TRIACYLGLYCEROL BLOOD LEVEL; ANALYSIS; BLOOD; COMPLICATION; METABOLIC SYNDROME X; OBESITY; PHYSIOLOGY; SLEEP APNEA, OBSTRUCTIVE;

ADOLESCENT; BLOOD GLUCOSE; BODY MASS INDEX; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; LIPIDS; MALE; METABOLIC SYNDROME X; OBESITY; POLYSOMNOGRAPHY; RETROSPECTIVE STUDIES; SLEEP APNEA, OBSTRUCTIVE;

EID: 84955188324     PISSN: 01655876     EISSN: 18728464     Source Type: Journal    
DOI: 10.1016/j.ijporl.2015.10.046     Document Type: Article

References (23)

1. Center for Disease Control Prevention Status Reports 2013.
2. Punjabi N.M. The epidemiology of adult obstructive sleep apnea. Proc. Am. Thorac. Soc. 2008, 5:136-143.
3. Redline S., Storfer-Isser A., Rosen C.L., Johnson N.L., Kirchner H.L., Emancipator J., et al. Association between metabolic syndrome and sleep-disordered breathing in adolescents. Am. J. Respir. Crit. Care Med. 2007, 176:401-408.
4. Penn E.B., French A., Bhushan B., Schroeder J.W. Access to care for children with symptoms of sleep disordered breathing. Int. J. Pediatr. Otorhinolaryngol. 2012, 76:1671-1673.
5. Lanfranco F., Motta G., Minetto M.A., Baldi M., Balbo M., Ghigo E., et al. Neuroendocrine alterations in obese patients with sleep apnea syndrome. Int. J. Endocrinol. 2010, 2010:474-518.
6. Gozal D., Capdevila O.S., Kheirandish-Gozal L. Metabolic alterations and systemic inflammation in obstructive sleep apnea among nonobese and obese prepubertal children. Am. J. Respir. Crit. Care Med. 2008, 177:1142-1149.
7. Punjabi N.M., Shahar E., Redline S., Gottlieb D.J., Givelber R., Resnick H.E., et al. Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study. Am. J. Epidemiol. 2004, 160:521-530. Sleep Heart Health Study.
8. Nakra N., Bhargava S., Dzuira J., Caprio S., Bazzy-Asaad A. Sleep-disordered breathing in children with metabolic syndrome: the role of leptin and sympathetic nervous system activity and the effect of continuous positive airway pressure. Pediatrics 2008, 122:e634-e642.
9. Expert Committee on the Classification of Diabetes Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003, 26(1):S5-S20.
10. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419.
11. Kurtoglu S., Hatipoglu N., Mazicioglu M., Kendirici M., Keskin M., Kondolot M. Insulin resistance in obese children and adolescents: HOMA-IR cut-off levels in the prepubertal and pubertal periods. J. Clin. Res. Pediatr. Endocrinol. 2010, 2:100-106.
12. Berry R.B., Budhiraja R., Gottlieb D.J., Gozal D., Iber C., Kapur V.K., et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events. Deliberations of the sleep apnea definitions task force of the American Academy of Sleep Medicine. J. Clin. Sleep Med. 2012, 8:597-619. American Academy of Sleep Medicine.
13. Bhushan B., Maddalozzo J., Sheldon S.H., Haymond S., Rychlik K., Lales G.C., et al. Metabolic alterations in children with obstructive sleep apnea. Int. J. Pediatr. Otorhinolaryngol. 2014, 78:854-859.
14. Canapari C.A., Hoppin A.G., Kinane T.B., Thomas B.J., Torriani M., Katz E.S., et al. Relationship between sleep apnea, fat distribution, and insulin resistance in obese children. J. Clin. Sleep Med. 2011, 7:268-273.
15. Tauman R., O'Brien L.M., Ivanenko A., Gozal D. Obesity rather than severity of sleep-disordered breathing as the major determinant of insulin resistance and altered lipidemia in snoring children. Pediatrics 2005, 116:e66-e73.
16. Grassi G., Facchini A., Trevano F.Q., Dell'Oro R., Arenare F., Tana F., et al. Obstructive sleep apnea-dependent and -independent adrenergic activation in obesity. Hypertension 2005, 46:321-325.
17. Floras J.S. Obstructive sleep apnea syndrome, continuous positive airway pressure and treatment of hypertension. Eur. J. Pharmacol. 2015, 15:28-37.
18. Jelic S., Lederer D.J., Adams T., Padeletti M., Colombo P.C., Factor P.H., et al. Vascular inflammation in obesity and sleep apnea. Circulation 2010, 210:1014-1021.
19. Narkiewicz K., Somers V.K. Sympathetic nerve activity in obstructive sleep apnoea. Acta Physiol. Scand. 2003, 177:385-390.
20. Kohler M., Stradling J.R. Mechanisms of vascular damage in obstructive sleep apnea. Nat. Rev. Cardiol. 2010, 7:677-685.
21. Bhushan B., Khalyfa A., Spruyt K., Kheirandish-Gozal L., Capdevila O.S., Bhattacharjee R., et al. Fatty-acid binding protein 4 gene polymorphisms and plasma levels in children with obstructive sleep apnea. Sleep Med. 2011, 12:666-671.
22. Bhushan B., Sheldon S., Wang E., Schroeder J.W. Clinical indicators that predict the presence of moderate to severe obstructive sleep apnea after adenotonsillectomy in children. Am. J. Otolaryngol. 2014, 35:487-495.
23. O'Brien L.M., Sitha S., Baur L.A., Waters K.A. Obesity increases the risk for persisting obstructive sleep apnea after treatment in children. Int. J. Pediatr. Otorhinolaryngol. 2006, 70:1555-1560.