Role of nephrin in podocyte injury induced by angiotension II

Journal of Receptors and Signal Transduction

Volumn 36, Issue 1, 2016, Pages 1-5

  Yu, Shengyou ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Losartan; molecular mechanisms; nephrin; podocyte

Indexed keywords

ANGIOTENSIN II; LOSARTAN; MESSENGER RNA; NEPHRIN; ANTIARRHYTHMIC AGENT; MEMBRANE PROTEIN; VASOCONSTRICTOR AGENT;

APOPTOSIS; ARTICLE; CELL BODY; CELL DAMAGE; CELL PROTECTION; CELL STRUCTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; GENE EXPRESSION; IMAGE PROCESSING; IMAGING SOFTWARE; KIDNEY DISEASE; MOLECULAR DYNAMICS; PHASE CONTRAST MICROSCOPY; PODOCYTE; PROTEIN EXPRESSION; PROTEINURIA; REAL TIME POLYMERASE CHAIN REACTION; RENAL PROTECTION; WESTERN BLOTTING; CELL CULTURE; CELL PROLIFERATION; DRUG EFFECTS; GENETICS; GLOMERULUS; HUMAN; KIDNEY DISEASES; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANGIOTENSIN II; ANTI-ARRHYTHMIA AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; HUMANS; KIDNEY DISEASES; KIDNEY GLOMERULUS; LOSARTAN; MEMBRANE PROTEINS; PODOCYTES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; VASOCONSTRICTOR AGENTS;

EID: 84955062958     PISSN: 10799893     EISSN: 15324281     Source Type: Journal    
DOI: 10.3109/10799893.2014.963872     Document Type: Article

References (15)

1. Foster RR, Saleem MA, Mathieson PW, et al. Vascular endothelial growth factor and nephrin interact and reduce apoptosis in human podocytes. Am J Physiol Renal Physiol 2005;288:48-57.
2. Huber TB, Kottgen M, Schilling B, et al. Interaction with podocin facilitates nephrin signaling. J Biol Chem 2001;276:41543-6.
3. Schwarz K, Simons M, Reiser J, et al. Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. J Clin Invest 2001;108:1621-9.
4. Hughes J, Savill JS. Apoptosis in glomerulonephritis. Curr Opin Nephrol Hypertens 2005;14:389-95.
5. Yu SY, Qi R, Zhao H. Losartan reverses glomerular podocytes injury induced by AngII via stabilizing the expression of GLUT1. Mol Biol Rep 2013;40:6295-301.
6. Qi R, Li W. FK506 inhibits the mice glomerular mesangial cells proliferation by affecting the transforming growth factor-β and smads signal pathways. Ren Fail 2014;36:589-92.
7. Gavin I Welsh, Moin A Saleem. Nephrin-signature molecule of the glomerular podocyte? J Pathol 2010;220:328-37
8. Yu SY, Qi R. Role of bad in podocyte apoptosis induced by puromycin aminonucleoside. Transplant Proceed 2013;45:569-73.
9. Facemire CS, Mohler PJ, Arendshorst WJ, et al. Expression and relative abundance of short transient receptor potential channels in the rat renal microcirculation. Am J Physiol Renal Physiol 2004;28:546-51.
10. Limbourg FP, Huang Z, Plumier JC, et al. Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids. J Clin Invest 2002;110:1729-38.
11. Huang L, You YS, Wu W. Role of CD2-associated protein in podocyte apoptosis and proteinuria induced by angiotensin II. Ren Fail 2014;36:1328-32.
12. Bonnet F, Cooper ME, Kawachi H, et al. Irbesartan normalizes the deficiency in glomerular nephrin expression in a model of diabetes and hypertension. Diabetologia 2001;44:874-7.
13. Doublier S, Salvidio G, Lupia E, et al. Nephrin expression is reduced in human diabetic nephropathy: evidence for a distinct role for glycated albumin and angiotensin II. Diabetes 2003;52:1023-30.
14. Davis BJ, Cao Z, de Gasparo M, et al. Disparate effects of angiotensin II antagonists and calcium channel blockers on albuminuria in experimental diabetes and hypertension: potential role of nephrin. J Hypertens 2003;21:209-16.
15. Benigni A, Gagliardini E, Tomasoni S, et al. Selective impairment of gene expression and assembly of nephrin in human diabetic nephropathy. Kidney Int 2004;65:2193-200.