IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 2, 2016, Pages 386-391

  Vivar, Omar I ^a   Masi, Giulia ^b,e   Carpier, Jean Marie ^a,c   Magalhaes, Joao G ^a   Galgano, Donatella ^b   Pazour, Gregory J ^d   Amigorena, Sebastian ^a   Hivroz, Claire ^a   Baldari, Cosima T ^b  

^a PSL RESEARCH UNIVERSITY   (France)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Adoptive transfer; CD4+ T cell; Colitis; Intraflagellar transport; Vesicular traffic

Indexed keywords

INTRAFLAGELLAR TRANSPORT PROTEIN 20; LAT PROTEIN; MEMBRANE PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; CARRIER PROTEIN; IFT20 PROTEIN, HUMAN; IFT20 PROTEIN, MOUSE; LAT PROTEIN, HUMAN; LAT PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL COMMUNICATION; CELL SPREADING; CENTROSOME; COLITIS; CONTROLLED STUDY; EX VIVO STUDY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE ACTIVATION; ANIMAL; CD4 LYMPHOCYTE COUNT; GENE SILENCING; IMMUNOBLOTTING; IMMUNOLOGICAL SYNAPSE; IMMUNOLOGY; JURKAT CELL LINE; LYMPHOCYTE ACTIVATION; METABOLISM; SIGNAL TRANSDUCTION; THYMOCYTE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARRIER PROTEINS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOBLOTTING; IMMUNOLOGICAL SYNAPSES; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MICE; PHOSPHOPROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; THYMOCYTES;

EID: 84954570850     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1513601113     Document Type: Article

References (29)

1. Soares H, Lasserre R, Alcover A (2013) Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses. Immunol Rev 256(1): 118-132.
2. Finetti F, Baldari CT (2013) Compartmentalization of signaling by vesicular trafficking: A shared building design for the immune synapse and the primary cilium. Immunol Rev 251(1):97-112.
3. Das V, et al. (2004) Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes. Immunity 20(5):577-588.
4. Ehrlich LI, Ebert PJ, Krummel MF, Weiss A, Davis MM (2002) Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity 17(6):809-822.
5. Bonello G, et al. (2004) Dynamic recruitment of the adaptor protein LAT: LAT exists in two distinct intracellular pools and controls its own recruitment. J Cell Sci 117(Pt 7): 1009-1016.
6. Fooksman DR, et al. (2010) Functional anatomy of T cell activation and synapse formation. Annu Rev Immunol 28:79-105.
7. Follit JA, Tuft RA, Fogarty KE, Pazour GJ (2006) The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly. Mol Biol Cell 17(9):3781-3792.
8. Pedersen LB, Rosenbaum JL (2008) Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling. Curr Top Dev Biol 85:23-61.
9. Finetti F, et al. (2009) Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse. Nat Cell Biol 11(11):1332-1339.
10. Finetti F, et al. (2014) Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system. J Cell Sci 127(Pt 9):1924-1937.
11. Jonassen JA, San Agustin J, Follit JA, Pazour GJ (2008) Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol 183(3):377-384.
12. Yuan X, Garrett-Sinha LA, Sarkar D, Yang S (2014) Deletion of IFT20 in early stage T lymphocyte differentiation inhibits the development of collagen-induced arthritis. Bone Res 2:14038-14049.
13. Wang H, et al. (2010) ZAP-70: An essential kinase in T-cell signaling. Cold Spring Harb Perspect Biol 2(5):a002279.
14. Dustin ML, Cooper JA (2000) The immunological synapse and the actin cytoskeleton: Molecular hardware for T cell signaling. Nat Immunol 1(1):23-29.
15. Zhang W, et al. (1999) Essential role of LAT in T cell development. Immunity 10(3): 323-332.
16. Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE (1998) LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92(1): 83-92.
17. Purbhoo MA, et al. (2010) Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse. Sci Signal 3(121):ra36.
18. Williamson DJ, et al. (2011) Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events. Nat Immunol 12(7):655-662.
19. Larghi P, et al. (2013) VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites. Nat Immunol 14(7): 723-731.
20. Blanchard N, Di Bartolo V, Hivroz C (2002) In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern. Immunity 17(4):389-399.
21. Griseri T, Asquith M, Thompson C, Powrie F (2010) OX40 is required for regulatory T cell-mediated control of colitis. J Exp Med 207(4):699-709.
22. Yen D, et al. (2006) IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 116(5):1310-1316.
23. Balagopalan L, Barr VA, Kortum RL, Park AK, Samelson LE (2013) Cutting edge: Cell surface linker for activation of T cells is recruited to microclusters and is active in signaling. J Immunol 190(8):3849-3853.
24. Soares H, et al. (2013) Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse. J Exp Med 210(11): 2415-2433.
25. Onnis A, et al. (2015) The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis. Cell Death Differ 22(10):1687-1699.
26. Finetti F, et al. (2015) The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse. J Cell Sci 128(14): 2541-2552.
27. Winzler C, et al. (1997) Maturation stages of mouse dendritic cells in growth factordependent long-term cultures. J Exp Med 185(2):317-328.
28. Tourret M, et al. (2010) T cell polarity at the immunological synapse is required for CD154-dependent IL-12 secretion by dendritic cells. J Immunol 185(11):6809-6818.
29. Pazour GJ, et al. (2002) The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance. J Cell Biol 157(1):103-113.