메뉴 건너뛰기




Volumn 36, Issue 2, 2016, Pages 327-340

Biotechnological approaches to the production of shikonins: A critical review with recent updates

Author keywords

Alkannin; Boraginaceae; Cell culture; In vitro culture; Naphthoquinones; Natural products; Pigments; Secondary metabolites

Indexed keywords

BIOTECHNOLOGY; CELL CULTURE; KETONES; METABOLIC ENGINEERING; METABOLITES; NUCLEIC ACIDS; PIGMENTS;

EID: 84954568175     PISSN: 07388551     EISSN: 15497801     Source Type: Journal    
DOI: 10.3109/07388551.2014.961003     Document Type: Review
Times cited : (69)

References (122)
  • 1
    • 84891019987 scopus 로고    scopus 로고
    • Pharmacological properties of shikonin-A review of literature since 2002
    • Andújar I, Ros JL, Giner RM, Recio MC. (2013). Pharmacological properties of shikonin-a review of literature since 2002. Planta Med, 79, 1685-97.
    • (2013) Planta Med , vol.79 , pp. 1685-1697
    • Andújar, I.1    Ros, J.L.2    Giner, R.M.3    Recio, M.C.4
  • 2
    • 58649114353 scopus 로고    scopus 로고
    • Noteworthy secondary metabolites naphthoquinones-their occurrence, pharmacological properties and analysis
    • Babula P, Adam V, Havel L, Kizek R. (2009). Noteworthy secondary metabolites naphthoquinones-their occurrence, pharmacological properties and analysis. Curr Pharm Anal, 5, 47-68.
    • (2009) Curr Pharm Anal , vol.5 , pp. 47-68
    • Babula, P.1    Adam, V.2    Havel, L.3    Kizek, R.4
  • 3
    • 0033818031 scopus 로고    scopus 로고
    • Genetic engineering on shikonin biosynthesis: Expression of the bacterial ubiA gene in Lithospermum erythrorhizon
    • Boehm R, Sommer S, Li SM, Heide L. (2000). Genetic engineering on shikonin biosynthesis: expression of the bacterial ubiA gene in Lithospermum erythrorhizon. Plant Cell Physiol, 41, 911-19.
    • (2000) Plant Cell Physiol , vol.41 , pp. 911-919
    • Boehm, R.1    Sommer, S.2    Li, S.M.3    Heide, L.4
  • 4
    • 0026124850 scopus 로고
    • Solvent selection strategies for extractive biocatalysis
    • Bruce LJ, Daugulis AJ. (1991). Solvent selection strategies for extractive biocatalysis. Biotechnol Prog, 7, 116-24.
    • (1991) Biotechnol Prog , vol.7 , pp. 116-124
    • Bruce, L.J.1    Daugulis, A.J.2
  • 5
    • 0034982016 scopus 로고    scopus 로고
    • Shikonin production by p-fluorophenylalanine resistant cells of Lithospermum erythrorhizon
    • Bulgakov VP, Kozyrenko MM, Fedoreyev SA, et al. (2001). Shikonin production by p-fluorophenylalanine resistant cells of Lithospermum erythrorhizon. Fitoterapia, 72, 394-401.
    • (2001) Fitoterapia , vol.72 , pp. 394-401
    • Bulgakov, V.P.1    Kozyrenko, M.M.2    Fedoreyev, S.A.3
  • 6
    • 0009343415 scopus 로고
    • Influence of jasmonic acid and 12-oxophytodienoic acid on the biosynthesis of shikonin in a cell culture of Arnebia euchroma
    • Bychkova TP, Nanenina EB, Berzin VB. Miroshnikov AI. (1993). Influence of jasmonic acid and 12-oxophytodienoic acid on the biosynthesis of shikonin in a cell culture of Arnebia euchroma. Bioorganicheskaya Khimiya, 19, 1008-12.
    • (1993) Bioorganicheskaya Khimiya , vol.19 , pp. 1008-1012
    • Bychkova, T.P.1    Nanenina, E.B.2    Berzin, V.B.3    Miroshnikov, A.I.4
  • 7
    • 0004453489 scopus 로고
    • Microspectrophotometric evaluation of rosmarinic acid accumulation in single cultured plant cells
    • Chaprin N, Ellis BE. (1984). Microspectrophotometric evaluation of rosmarinic acid accumulation in single cultured plant cells. Can J Bot, 62, 2278-82.
    • (1984) Can J Bot , vol.62 , pp. 2278-2282
    • Chaprin, N.1    Ellis, B.E.2
  • 8
    • 0036402654 scopus 로고    scopus 로고
    • Manipulation of natural product accumulation in plants through genetic engineering
    • Charlwood BV, Pletsch M. (2002). Manipulation of natural product accumulation in plants through genetic engineering. J Herbs Spices Med Plants, 9, 139-51.
    • (2002) J Herbs Spices Med Plants , vol.9 , pp. 139-151
    • Charlwood, B.V.1    Pletsch, M.2
  • 9
    • 84867100524 scopus 로고    scopus 로고
    • Induction of Shikonin production in hairy root cultures of Arnebia hispidissima via Agrobacterium rhizogenesmediated genetic transformation
    • Chaudhury A, Pal M. (2010). Induction of Shikonin production in hairy root cultures of Arnebia hispidissima via Agrobacterium rhizogenesmediated genetic transformation. J Crop Sci Biotechnol, 13, 99-106.
    • (2010) J Crop Sci Biotechnol , vol.13 , pp. 99-106
    • Chaudhury, A.1    Pal, M.2
  • 11
    • 33746068611 scopus 로고    scopus 로고
    • Effects of low-dose gammairradiation on production of shikonin derivatives in callus cultures of Lithospermum erythrorhizon S
    • Chung BY, Lee YB, Baek MH, et al. (2006). Effects of low-dose gammairradiation on production of shikonin derivatives in callus cultures of Lithospermum erythrorhizon S. Radiat Phys Chem, 75, 1018-23.
    • (2006) Radiat Phys Chem , vol.75 , pp. 1018-1023
    • Chung, B.Y.1    Lee, Y.B.2    Baek, M.H.3
  • 12
    • 84871591582 scopus 로고    scopus 로고
    • Antimicrobial and cytotoxic isohexenylnaphthazarins from Arnebia euchroma (Royle) Jonst (Boraginaceae) callus and cell suspension culture
    • Damianakos H, Kretschmer N, Syk?owska-Baranek K, et al. (2012). Antimicrobial and cytotoxic isohexenylnaphthazarins from Arnebia euchroma (Royle). Jonst. (Boraginaceae). callus and cell suspension culture. Molecules, 17, 14310-22.
    • (2012) Molecules , vol.17 , pp. 14310-14322
    • Damianakos, H.1    Kretschmer, N.2    Sykowska-Baranek, K.3
  • 13
    • 0011365720 scopus 로고
    • Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon: VI Production of shikonin derivatives by a two-layer culture containing an organic solvent
    • Deno H, Suga C, Morimoto T, Fujita Y. (1987). Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon: VI. Production of shikonin derivatives by a two-layer culture containing an organic solvent. Plant Cell Rep, 6, 197-9.
    • (1987) Plant Cell Rep , vol.6 , pp. 197-199
    • Deno, H.1    Suga, C.2    Morimoto, T.3    Fujita, Y.4
  • 15
    • 0345806111 scopus 로고
    • Cell line selection
    • In: Yeoman MM, ed.. Oxford, London: Blackwell Scientific Publications
    • Dix P. (1986). Cell line selection. In: Yeoman MM, ed. Plant cell culture technology. Oxford, London: Blackwell Scientific Publications, 143-201.
    • (1986) Plant Cell Culture Technology , pp. 143-201
    • Dix, P.1
  • 16
    • 0345538857 scopus 로고
    • Studies on cell suspension culture and fermentation culture of Arnebia euchroma
    • Dong JW, Ye HC, Wu X, et al. (1993). Studies on cell suspension culture and fermentation culture of Arnebia euchroma. Acta Bot Sin, 35, 57-61.
    • (1993) Acta Bot Sin , vol.35 , pp. 57-61
    • Dong, J.W.1    Ye, H.C.2    Wu, X.3
  • 17
    • 0029088428 scopus 로고
    • Strategies for the improvement of secondary metabolite production in plant cell cultures
    • Dö rnenburg H, Knorr D. (1995). Strategies for the improvement of secondary metabolite production in plant cell cultures. Enzyme Microb Technol, 17, 674-84.
    • (1995) Enzyme Microb Technol , vol.17 , pp. 674-684
    • Dö Rnenburg, H.1    Knorr, D.2
  • 18
    • 3042761619 scopus 로고    scopus 로고
    • Evaluation of immobilisation effects on metabolic activities and productivity in plant cell processes
    • Dö rnenburg H. (2004). Evaluation of immobilisation effects on metabolic activities and productivity in plant cell processes. Process Biochem, 39, 1369-75.
    • (2004) Process Biochem , vol.39 , pp. 1369-1375
    • Dö Rnenburg, H.1
  • 19
    • 0032027589 scopus 로고    scopus 로고
    • Enhancement of shikonin production in cell suspension cultures of Arnebia euchroma employing two-liquid-phase systems
    • Fu X, Dewei L. (1998). Enhancement of shikonin production in cell suspension cultures of Arnebia euchroma employing two-liquid-phase systems. Chin J Chem Eng, 6, 1-5.
    • (1998) Chin J Chem Eng , vol.6 , pp. 1-5
    • Fu, X.1    Dewei, L.2
  • 20
    • 0033120814 scopus 로고    scopus 로고
    • Stimulation of shikonin production by combined fungal elicitation and in situ extraction in suspension cultures of Arnebia euchroma
    • Fu XQ, Lu DW. (1999). Stimulation of shikonin production by combined fungal elicitation and in situ extraction in suspension cultures of Arnebia euchroma. Enzyme Microb Technol, 24, 243-6.
    • (1999) Enzyme Microb Technol , vol.24 , pp. 243-246
    • Fu, X.Q.1    Lu, D.W.2
  • 21
    • 0002714732 scopus 로고
    • Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon i Effects of nitrogen source on the production of shikonin derivatives
    • Fujita Y, Hara Y, Ogino T, Suga C. (1981a). Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon. I. Effects of nitrogen source on the production of shikonin derivatives. Plant Cell Rep, 1, 59-60.
    • (1981) Plant Cell Rep , vol.1 , pp. 59-60
    • Fujita, Y.1    Hara, Y.2    Ogino, T.3    Suga, C.4
  • 22
    • 0002714734 scopus 로고
    • Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon II A new medium for the production of shikonin derivates
    • Fujita Y, Hara Y, Suga C, Morimoto T. (1981b). Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon II. A new medium for the production of shikonin derivates. Plant Cell Rep, 1, 613.
    • (1981) Plant Cell Rep , vol.1 , pp. 613
    • Fujita, Y.1    Hara, Y.2    Suga, C.3    Morimoto, T.4
  • 23
    • 0001483958 scopus 로고
    • Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon III Comparison of shikonin derivatives of cultured cells and Ko-shikon
    • Fujita Y, Maeda Y, Suga C, Morimoto T. (1983). Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon III. Comparison of shikonin derivatives of cultured cells and Ko-shikon. Plant Cell Rep, 2, 192-3.
    • (1983) Plant Cell Rep , vol.2 , pp. 192-193
    • Fujita, Y.1    Maeda, Y.2    Suga, C.3    Morimoto, T.4
  • 24
    • 0001686427 scopus 로고
    • Industrial production of shikonin and berberine
    • In: Bock G, Marsh J, eds.. Chichester, UK: John Wiley & Sons Ltd
    • Fujita Y. (1988a). Industrial production of shikonin and berberine. In: Bock G, Marsh J, eds. Applications of plant cell and tissue culture. Chichester, UK: John Wiley & Sons Ltd., 228-35.
    • (1988) Applications of Plant Cell and Tissue Culture , pp. 228-235
    • Fujita, Y.1
  • 25
    • 0000565707 scopus 로고
    • Shikonin production by plant (Lithospermum erythrorhizon). Cell cultures
    • In: Bajaj YPS, ed.. Berlin, Heidelberg: Springer-Verlag
    • Fujita Y. (1988b). Shikonin production by plant (Lithospermum erythrorhizon). cell cultures. In: Bajaj YPS, ed. Biotechnology in agriculture and forestry, Vol 4. Medicinal and aromatic plants. Berlin, Heidelberg: Springer-Verlag, 225 p.
    • (1988) Biotechnology in Agriculture and Forestry, Vol 4. Medicinal and Aromatic Plants
    • Fujita, Y.1
  • 26
    • 0012266078 scopus 로고
    • Formation of stereoisomeric mixtures of naphthoquinone derivatives in Echium lycopsis callus cultures
    • Fukui H, Tsukada M, Mizukami H, Tabata M. (1983). Formation of stereoisomeric mixtures of naphthoquinone derivatives in Echium lycopsis callus cultures. Phytochemistry, 22, 453-6.
    • (1983) Phytochemistry , vol.22 , pp. 453-456
    • Fukui, H.1    Tsukada, M.2    Mizukami, H.3    Tabata, M.4
  • 27
    • 0001513503 scopus 로고
    • Two phenolic acids from Lithospermum erythrorhizon cell suspension cultures
    • Fukui H, Yazaki K, Tabata M. (1984). Two phenolic acids from Lithospermum erythrorhizon cell suspension cultures. Phytochemistry, 23, 2398-9.
    • (1984) Phytochemistry , vol.23 , pp. 2398-2399
    • Fukui, H.1    Yazaki, K.2    Tabata, M.3
  • 28
    • 0002434273 scopus 로고
    • Induction of shikonin biosynthesis by endogenous polysaccharides in Lithospermum erythrorhizon cell suspension cultures
    • Fukui H, Tani M, Tabata M. (1990). Induction of shikonin biosynthesis by endogenous polysaccharides in Lithospermum erythrorhizon cell suspension cultures. Plant Cell Rep, 9, 73-6.
    • (1990) Plant Cell Rep , vol.9 , pp. 73-76
    • Fukui, H.1    Tani, M.2    Tabata, M.3
  • 29
    • 0345596441 scopus 로고    scopus 로고
    • Formation and secretion of a new brown benzoquinone by hairy root cultures of Lithospermum erythrorhizon
    • Fukui H, Feroz Hasan AFM, Ueoka T, Kyo M. (1998). Formation and secretion of a new brown benzoquinone by hairy root cultures of Lithospermum erythrorhizon. Phytochemistry, 47, 1037-9.
    • (1998) Phytochemistry , vol.47 , pp. 1037-1039
    • Fukui, H.1    Feroz Hasan, A.F.M.2    Ueoka, T.3    Kyo, M.4
  • 30
    • 0030019335 scopus 로고    scopus 로고
    • Inhibition and regulation of shikonin biosynthesis in suspension cultures of Lithospermum
    • Gaisser S, Heide L. (1996). Inhibition and regulation of shikonin biosynthesis in suspension cultures of Lithospermum. Phytochemistry, 41, 1065-72.
    • (1996) Phytochemistry , vol.41 , pp. 1065-1072
    • Gaisser, S.1    Heide, L.2
  • 31
    • 33645881339 scopus 로고    scopus 로고
    • Cell growth and shikonin production of Arnebia euchroma in a periodically submerged airlift bioreactor
    • Ge F, Yuan X, Wang X, et al. (2006). Cell growth and shikonin production of Arnebia euchroma in a periodically submerged airlift bioreactor. Biotechnol Lett, 28, 525-9.
    • (2006) Biotechnol Lett , vol.28 , pp. 525-529
    • Ge, F.1    Yuan, X.2    Wang, X.3
  • 32
    • 84949529760 scopus 로고    scopus 로고
    • Enhanced production of napthoquinone metabolite (shikonin). from cell suspension culture of Arnebia sp. and its up-scaling through bioreactor
    • Gupta K, Garg S, Singh J, Kumar M. (2013). Enhanced production of napthoquinone metabolite (shikonin). from cell suspension culture of Arnebia sp. and its up-scaling through bioreactor. 3 Biotech, 4, 263-73.
    • (2013) 3 Biotech , vol.4 , pp. 263-273
    • Gupta, K.1    Garg, S.2    Singh, J.3    Kumar, M.4
  • 33
    • 0002021540 scopus 로고
    • Temporal and spatial heterogeneity in the accumulation of anthocyanins in cell culture of Catharanthus roseus (L.). G. Don
    • Hall RD, Yeoman MM. (1986). Temporal and spatial heterogeneity in the accumulation of anthocyanins in cell culture of Catharanthus roseus (L.). G. Don. J Exp Bot, 37, 48-60.
    • (1986) J Exp Bot , vol.37 , pp. 48-60
    • Hall, R.D.1    Yeoman, M.M.2
  • 34
    • 2642638229 scopus 로고
    • Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon v Differences in the production between callus and suspension cultures
    • Hara Y, Morimoto T, Fujita Y. (1987). Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon V. Differences in the production between callus and suspension cultures. Plant Cell Rep, 6, 8-11.
    • (1987) Plant Cell Rep , vol.6 , pp. 8-11
    • Hara, Y.1    Morimoto, T.2    Fujita, Y.3
  • 36
    • 0001712926 scopus 로고
    • Enzyme activities in cell-free extracts of shikonin-producing Lithospermum erythrorhizon cell suspension cultures
    • Heide L, Tabata M. (1987a). Enzyme activities in cell-free extracts of shikonin-producing Lithospermum erythrorhizon cell suspension cultures. Phytochemistry, 26, 1645-50.
    • (1987) Phytochemistry , vol.26 , pp. 1645-1650
    • Heide, L.1    Tabata, M.2
  • 37
    • 0000083514 scopus 로고
    • Geranylpyrophosphate: P-hydroxybenzoate geranyltransferase activity in extracts of Lithospermum erythrorhizon cell cultures
    • Heide L, Tabata M. (1987b). Geranylpyrophosphate: p-hydroxybenzoate geranyltransferase activity in extracts of Lithospermum erythrorhizon cell cultures. Phytochemistry, 26, 1651-5.
    • (1987) Phytochemistry , vol.26 , pp. 1651-1655
    • Heide, L.1    Tabata, M.2
  • 38
    • 0001051043 scopus 로고
    • Enzymatic regulation of shikonin biosynthesis in Lithospermum erythrorhizon cell cultures
    • Heide L, Nishioka N, Fukui H, Tabata M. (1989). Enzymatic regulation of shikonin biosynthesis in Lithospermum erythrorhizon cell cultures. Phytochemistry, 28, 1873-77.
    • (1989) Phytochemistry , vol.28 , pp. 1873-1877
    • Heide, L.1    Nishioka, N.2    Fukui, H.3    Tabata, M.4
  • 39
    • 0000359304 scopus 로고
    • Two quinines from callus cultures of Echium lycopsis
    • Inouye H, Matsumura H, Kawasaki M, et al. (1981). Two quinines from callus cultures of Echium lycopsis. Phytochemistry, 20, 1701-5.
    • (1981) Phytochemistry , vol.20 , pp. 1701-1705
    • Inouye, H.1    Matsumura, H.2    Kawasaki, M.3
  • 40
    • 0033630151 scopus 로고    scopus 로고
    • Arnebins and antimicrobial activities of Arnebia hispidissima (Lehm.) DC cell cultures
    • Jain SC, Singh B, Jain R. (1999). Arnebins and antimicrobial activities of Arnebia hispidissima (Lehm.). DC cell cultures. Phytomedicine, 6, 474-6.
    • (1999) Phytomedicine , vol.6 , pp. 474-476
    • Jain, S.C.1    Singh, B.2    Jain, R.3
  • 41
    • 27844450373 scopus 로고    scopus 로고
    • Asexual propagation of Arnebia euchroma and exploration of hereditary stability in regenerated plantlets
    • Ji QL, Wang WG. (2001). Asexual propagation of Arnebia euchroma and exploration of hereditary stability in regenerated plantlets. Plant Physiol Commun, 37, 499-502.
    • (2001) Plant Physiol Commun , vol.37 , pp. 499-502
    • Ji, Q.L.1    Wang, W.G.2
  • 42
    • 28144459382 scopus 로고    scopus 로고
    • Thidiazuron-induced in vitro shoot organogenesis of the medicinal plant Arnebia euchroma (Royle)
    • Jiang B, Yang YG, Guo YM, Chen YZ. (2005). Thidiazuron-induced in vitro shoot organogenesis of the medicinal plant Arnebia euchroma (Royle). Johnst. In Vitro Cell Dev Biol Plant, 41, 677-81.
    • (2005) Johnst. in Vitro Cell Dev Biol Plant , vol.41 , pp. 677-681
    • Jiang, B.1    Yang, Y.G.2    Guo, Y.M.3    Chen, Y.Z.4
  • 43
    • 0024999960 scopus 로고
    • Effect of growth hormone modifications on shikonin production from Lithospermum erythrorhizon cell cultures with in situ extraction
    • Kim DJ, Chang HN. (1990a). Effect of growth hormone modifications on shikonin production from Lithospermum erythrorhizon cell cultures with in situ extraction. Biotechnol Lett, 12, 289-94.
    • (1990) Biotechnol Lett , vol.12 , pp. 289-294
    • Kim, D.J.1    Chang, H.N.2
  • 44
    • 0025471001 scopus 로고
    • Enhanced shikonin production from Lithospermum erythrorhizon by in situ extraction and calcium alginate immobilization
    • Kim DJ, Chang HN. (1990b). Enhanced shikonin production from Lithospermum erythrorhizon by in situ extraction and calcium alginate immobilization. Biotechnol Bioeng, 36, 460-6.
    • (1990) Biotechnol Bioeng , vol.36 , pp. 460-466
    • Kim, D.J.1    Chang, H.N.2
  • 45
    • 0036670036 scopus 로고    scopus 로고
    • High level expression of chorismate pyruvate-lyase (ubiC) and HMG-CoA reductase in hairy root cultures of Lithospermum erythrorhizon
    • Kohle A, Sommer S, Yazaki K, et al. (2002). High level expression of chorismate pyruvate-lyase (ubiC). and HMG-CoA reductase in hairy root cultures of Lithospermum erythrorhizon. Plant Cell Physiol, 43, 894-902.
    • (2002) Plant Cell Physiol , vol.43 , pp. 894-902
    • Kohle, A.1    Sommer, S.2    Yazaki, K.3
  • 46
    • 81855226125 scopus 로고    scopus 로고
    • Cell suspension culture of Arnebia euchroma (Royle). Johnston-A potential source of naphthoquinone pigments
    • Kumar R, Sharma N, Malik S, et al. (2011). Cell suspension culture of Arnebia euchroma (Royle). Johnston-a potential source of naphthoquinone pigments. J Med Plants Res, 5, 6048-54.
    • (2011) J Med Plants Res , vol.5 , pp. 6048-6054
    • Kumar, R.1    Sharma, N.2    Malik, S.3
  • 47
    • 2642645430 scopus 로고    scopus 로고
    • Regulatory role of microsomal 3-hydroxy-3-methylglutaryl-coenzymeA reductase for shikonin biosynthesis in Lithospermum erythrorhizon cell suspension cultures
    • Lange BM, Severin K, Bechthold A, Heide L. (1998). Regulatory role of microsomal 3-hydroxy-3-methylglutaryl-coenzymeA reductase for shikonin biosynthesis in Lithospermum erythrorhizon cell suspension cultures. Planta, 204, 234-41.
    • (1998) Planta , vol.204 , pp. 234-241
    • Lange, B.M.1    Severin, K.2    Bechthold, A.3    Heide, L.4
  • 49
    • 0032580385 scopus 로고    scopus 로고
    • Shikonin: A geranyl diphosphatederived plant hemiterpenoid formed via the mevalonate pathway
    • Li SM, Henning S, Heide L. (1998). Shikonin: a geranyl diphosphatederived plant hemiterpenoid formed via the mevalonate pathway. Tetrahedron Lett, 39, 2721-4.
    • (1998) Tetrahedron Lett , vol.39 , pp. 2721-2724
    • Li, S.M.1    Henning, S.2    Heide, L.3
  • 50
    • 0037023673 scopus 로고    scopus 로고
    • Enhancement of shikonin production in single and two-phase suspension cultures of Lithospermum erythorhizon cells using low-energy ultrasound
    • Lin L, Wu J. (2002). Enhancement of shikonin production in single and two-phase suspension cultures of Lithospermum erythorhizon cells using low-energy ultrasound. Biotechnol Bioeng, 78, 81-8.
    • (2002) Biotechnol Bioeng , vol.78 , pp. 81-88
    • Lin, L.1    Wu, J.2
  • 51
    • 84982378007 scopus 로고
    • Organic growth factor requirements of tobacco tissue cultures
    • Linsmaier EM, Skoog F. (1965). Organic growth factor requirements of tobacco tissue cultures. Physiol Plant, 18, 100-27.
    • (1965) Physiol Plant , vol.18 , pp. 100-127
    • Linsmaier, E.M.1    Skoog, F.2
  • 52
    • 33645325405 scopus 로고    scopus 로고
    • Effect of light on gene expression and shikonin formation in cultured Onosma paniculatum cells
    • Liu CZ, Qi JL, Chen L, et al. (2006). Effect of light on gene expression and shikonin formation in cultured Onosma paniculatum cells. Plant Cell Tissue Organ Cult, 84, 39-46.
    • (2006) Plant Cell Tissue Organ Cult , vol.84 , pp. 39-46
    • Liu, C.Z.1    Qi, J.L.2    Chen, L.3
  • 53
    • 84876706171 scopus 로고    scopus 로고
    • Quinones derived from plant secondary metabolites as anti-cancer agents
    • Lu JJ, Bao JL, Wu GS, et al. (2013). Quinones derived from plant secondary metabolites as anti-cancer agents. Anticancer Agents Med Chem, 13,456-63.
    • (2013) Anticancer Agents Med Chem , vol.13 , pp. 456-463
    • Lu, J.J.1    Bao, J.L.2    Wu, G.S.3
  • 54
    • 79959302788 scopus 로고    scopus 로고
    • Cultivation of medicinal and aromatic plants for specialty industrial materials
    • Lubbe A, Verpoorte R. (2011). Cultivation of medicinal and aromatic plants for specialty industrial materials. Ind Crops Prod, 34, 785-801.
    • (2011) Ind Crops Prod , vol.34 , pp. 785-801
    • Lubbe, A.1    Verpoorte, R.2
  • 55
    • 84954544992 scopus 로고    scopus 로고
    • Production of naphthoquinone pigments in cell suspension cultures of Arnebia euchroma (Royle) Johnston: Influence of pH on growth kinetics and acetylshikonin
    • Malik S, Bhushan S, Verma SC, et al. (2008). Production of naphthoquinone pigments in cell suspension cultures of Arnebia euchroma (Royle). Johnston: influence of pH on growth kinetics and acetylshikonin. Med Aromat Plant Sci Biotechnol, 2, 43-9.
    • (2008) Med Aromat Plant Sci Biotechnol , vol.2 , pp. 43-49
    • Malik, S.1    Bhushan, S.2    Verma, S.C.3
  • 57
    • 66449096823 scopus 로고    scopus 로고
    • Regeneration in Rheum emodi Wall.: A step towards conservation of an endangered medicinal plant species
    • Malik S, Kumar R, Vats SK, et al. (2009). Regeneration in Rheum emodi Wall.: a step towards conservation of an endangered medicinal plant species. Eng Life Sci, 9, 130-4.
    • (2009) Eng Life Sci , vol.9 , pp. 130-134
    • Malik, S.1    Kumar, R.2    Vats, S.K.3
  • 58
    • 77950865059 scopus 로고    scopus 로고
    • Qualitative and quantitative analysis of anthraquinone derivatives in rhizomes of tissue culture-raised Rheum emodi Wall plants
    • Malik S, Sharma N, Sharma UK, et al. (2010a). Qualitative and quantitative analysis of anthraquinone derivatives in rhizomes of tissue culture-raised Rheum emodi Wall. plants. J Plant Physiol, 167, 749-56.
    • (2010) J Plant Physiol , vol.167 , pp. 749-756
    • Malik, S.1    Sharma, N.2    Sharma, U.K.3
  • 59
    • 77955282936 scopus 로고    scopus 로고
    • Direct shoot regeneration from intact leaves of Arnebia euchroma (Royle) Johnston using thidiazuron
    • Malik S, Sharma S, Sharma M, Ahuja PS. (2010b). Direct shoot regeneration from intact leaves of Arnebia euchroma (Royle). Johnston using thidiazuron. Cell Biol Int, 34, 537-42.
    • (2010) Cell Biol Int , vol.34 , pp. 537-542
    • Malik, S.1    Sharma, S.2    Sharma, M.3    Ahuja, P.S.4
  • 60
    • 78650254061 scopus 로고    scopus 로고
    • Production of the anticancer drug taxol in Taxus baccata suspension cultures: A review
    • Malik S, Cusido RM, Mirjalili MH, et al. (2011a). Production of the anticancer drug taxol in Taxus baccata suspension cultures: a review. Process Biochem, 46, 23-34.
    • (2011) Process Biochem , vol.46 , pp. 23-34
    • Malik, S.1    Cusido, R.M.2    Mirjalili, M.H.3
  • 61
    • 79955651136 scopus 로고    scopus 로고
    • Physico-chemical factors influencing the shikonin derivatives production in cell suspension cultures of Arnebia euchroma (Royle)
    • Malik S, Bhushan S, Sharma M, Ahuja PS. (2011b). Physico-chemical factors influencing the shikonin derivatives production in cell suspension cultures of Arnebia euchroma (Royle). Johnston, a medicinally important plant species Cell Biol Int, 35, 152-7.
    • (2011) Johnston, A Medicinally Important Plant Species Cell Biol Int , vol.35 , pp. 152-157
    • Malik, S.1    Bhushan, S.2    Sharma, M.3    Ahuja, P.S.4
  • 62
    • 84879320577 scopus 로고    scopus 로고
    • Root-zone temperature alters alkaloid synthesis and accumulation in Catharanthus roseus and Nicotiana tabacum
    • Malik S, Andrade SAL, Sawaya ACHF, et al. (2013a). Root-zone temperature alters alkaloid synthesis and accumulation in Catharanthus roseus and Nicotiana tabacum. Ind Crops Prod, 49, 318-25.
    • (2013) Ind Crops Prod , vol.49 , pp. 318-325
    • Malik, S.1    Andrade, S.A.L.2    Sawaya, A.C.H.F.3
  • 63
    • 84873170639 scopus 로고    scopus 로고
    • Living between two worlds: Two-phase culture systems for producing plant secondary metabolites
    • Malik S, Mirjalili MH, Fett-Neto AG, et al. (2013b). Living between two worlds: two-phase culture systems for producing plant secondary metabolites. Crit Rev Biotechnol, 33, 1-22.
    • (2013) Crit Rev Biotechnol , vol.33 , pp. 1-22
    • Malik, S.1    Mirjalili, M.H.2    Fett-Neto, A.G.3
  • 64
    • 84911995497 scopus 로고    scopus 로고
    • Biotechnological approaches for producing aryltetralin lignans from Linum species
    • Malik S, Biba O, Gruz J, et al. (2014). Biotechnological approaches for producing aryltetralin lignans from Linum species. Phytochem Rev. doi: 10.1007/s11101-014-9345-5.
    • (2014) Phytochem Rev
    • Malik, S.1    Biba, O.2    Gruz, J.3
  • 65
    • 21244501825 scopus 로고    scopus 로고
    • Organogenesis, embryogenesis, and synthetic seed production in Arnebia euchroma-A critically endangered medicinal plant of the Himalaya
    • Manjkhola S, Dhar U, Joshi M. (2005). Organogenesis, embryogenesis, and synthetic seed production in Arnebia euchroma-a critically endangered medicinal plant of the Himalaya. In Vitro Cell Dev Biol Plant, 41, 244-8.
    • (2005) Vitro Cell Dev Biol Plant , vol.41 , pp. 244-248
    • Manjkhola, S.1    Dhar, U.2    Joshi, M.3
  • 66
    • 0000839849 scopus 로고
    • Effect of nutritional factors on shikonin derivative formation in Lithospermum callus cultures
    • Mizukami H, Konoshima M, Tabata M. (1977). Effect of nutritional factors on shikonin derivative formation in Lithospermum callus cultures. Phytochemistry, 16, 1183-6.
    • (1977) Phytochemistry , vol.16 , pp. 1183-1186
    • Mizukami, H.1    Konoshima, M.2    Tabata, M.3
  • 67
    • 0003065212 scopus 로고
    • Variation in pigment production in Lithospermum erythrorhizon callus cultures
    • Mizukami H, Konoshima M, Tabata M. (1978). Variation in pigment production in Lithospermum erythrorhizon callus cultures. Phytochemistry, 17, 95-7.
    • (1978) Phytochemistry , vol.17 , pp. 95-97
    • Mizukami, H.1    Konoshima, M.2    Tabata, M.3
  • 68
    • 0001627693 scopus 로고
    • Induction of rosmarinic acid biosynthesis in Lithospermum erythrorhizon cell suspension cultures by yeast extract
    • Mizukami H, Ogawa T, Ohashi H, Ellis BE. (1992). Induction of rosmarinic acid biosynthesis in Lithospermum erythrorhizon cell suspension cultures by yeast extract. Plant Cell Rep, 11, 480-3.
    • (1992) Plant Cell Rep , vol.11 , pp. 480-483
    • Mizukami, H.1    Ogawa, T.2    Ohashi, H.3    Ellis, B.E.4
  • 69
    • 0001071944 scopus 로고
    • Methyl jasmonateinduced rosmarinic acid biosynthesis in Lithospermum erythrorhizon cell suspension cultures
    • Mizukami H, Tabira Y, Ohashi H, Ellis BE. (1993). Methyl jasmonateinduced rosmarinic acid biosynthesis in Lithospermum erythrorhizon cell suspension cultures. Plant Cell Rep, 12, 706-9.
    • (1993) Plant Cell Rep , vol.12 , pp. 706-709
    • Mizukami, H.1    Tabira, Y.2    Ohashi, H.3    Ellis, B.E.4
  • 70
    • 84982358134 scopus 로고
    • A revised medium for rapid growth and bioassays with tobacco tissue cultures
    • Murashige T, Skoog F. (1962). A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant, 15, 473-97.
    • (1962) Physiol Plant , vol.15 , pp. 473-497
    • Murashige, T.1    Skoog, F.2
  • 71
    • 35948945421 scopus 로고    scopus 로고
    • Plant cell elicitation for production of secondary metabolites: A review
    • Namdeo AG. (2007). Plant cell elicitation for production of secondary metabolites: a review. Pharmacogn Rev, 1, 69-79.
    • (2007) Pharmacogn Rev , vol.1 , pp. 69-79
    • Namdeo, A.G.1
  • 72
    • 0002522798 scopus 로고
    • Effects of fungal elicitor on shikonin derivatives formation in Onosma paniculatum cell cultures
    • Ning W, Zhao Q, Xia Z, Cao R. (1994). Effects of fungal elicitor on shikonin derivatives formation in Onosma paniculatum cell cultures. Acta Phytophysiol Sinica, 20, 325-31.
    • (1994) Acta Phytophysiol Sinica , vol.20 , pp. 325-331
    • Ning, W.1    Zhao, Q.2    Xia, Z.3    Cao, R.4
  • 73
    • 84867973266 scopus 로고    scopus 로고
    • Application of cell technologies for production of plant derived bioactive substances of plant origin
    • Nosov AM. (2012). Application of cell technologies for production of plant derived bioactive substances of plant origin. Appl Biochem Microbiol, 48, 609-24.
    • (2012) Appl Biochem Microbiol , vol.48 , pp. 609-624
    • Nosov, A.M.1
  • 74
    • 79958765012 scopus 로고    scopus 로고
    • High frequency direct plant regeneration, micropropagation and shikonin induction in Arnebia hispidissima
    • Pal M, Chaudhury A. (2010). High frequency direct plant regeneration, micropropagation and shikonin induction in Arnebia hispidissima. J Crop Sci Biotech, 13, 13-20.
    • (2010) J Crop Sci Biotech , vol.13 , pp. 13-20
    • Pal, M.1    Chaudhury, A.2
  • 75
    • 84879795707 scopus 로고    scopus 로고
    • An improved micropropagation of Arnebia hispidissima (Lehm.) DC and assessment of genetic fidelity of micropropagated plants using DNA-based molecular markers
    • Phulwaria M, Rai M, Shekhawat NS. (2013). An improved micropropagation of Arnebia hispidissima (Lehm.). DC and assessment of genetic fidelity of micropropagated plants using DNA-based molecular markers. Appl Biochem Biotechnol, 170, 1163-73.
    • (2013) Appl Biochem Biotechnol , vol.170 , pp. 1163-1173
    • Phulwaria, M.1    Rai, M.2    Shekhawat, N.S.3
  • 76
    • 24444469533 scopus 로고    scopus 로고
    • Some naphthoquinones and pyrolizidine alkaloids in cell culture of Arnebia euchroma (Royle)
    • Pietrosiuk A, Urmantseva V, Furmanowa M. (1999). Some naphthoquinones and pyrolizidine alkaloids in cell culture of Arnebia euchroma (Royle). Jonst. Herba Polonica, 65, 354-61.
    • (1999) Jonst. Herba Polonica , vol.65 , pp. 354-361
    • Pietrosiuk, A.1    Urmantseva, V.2    Furmanowa, M.3
  • 77
    • 33749062384 scopus 로고    scopus 로고
    • The shikonin derivatives and pyrrolizidine alkaloids in hairy root cultures of Lithospermum canescens (Michx.)
    • Pietrosiuk A, Syklowska-Baranek K, Wiedenfeld H, et al. (2006). The shikonin derivatives and pyrrolizidine alkaloids in hairy root cultures of Lithospermum canescens (Michx.). Lehm. Plant Cell Rep, 25, 1052-8.
    • (2006) Lehm. Plant Cell Rep , vol.25 , pp. 1052-1058
    • Pietrosiuk, A.1    Syklowska-Baranek, K.2    Wiedenfeld, H.3
  • 78
    • 0036275284 scopus 로고    scopus 로고
    • Plant cell cultures: Chemical factories of secondary metabolites
    • Rao RS, Ravishankar GA. (2002). Plant cell cultures: chemical factories of secondary metabolites. Biotechnol Adv, 20, 101-53.
    • (2002) Biotechnol Adv , vol.20 , pp. 101-153
    • Rao, R.S.1    Ravishankar, G.A.2
  • 79
    • 6444244303 scopus 로고    scopus 로고
    • Plants and human health in the twenty-first century
    • Raskin I, Ribnicky DM, Komarnytsky S, et al. (2002). Plants and human health in the twenty-first century. Trends Biotechnol, 20, 522-31.
    • (2002) Trends Biotechnol , vol.20 , pp. 522-531
    • Raskin, I.1    Ribnicky, D.M.2    Komarnytsky, S.3
  • 80
    • 0033995670 scopus 로고    scopus 로고
    • Biotechnological production of phytopharmaceuticals
    • Ravishankar GA, Rao RS. (2002). Biotechnological production of phytopharmaceuticals. J Biochem Mol Biol Biophys, 4, 73-102.
    • (2002) J Biochem Mol Biol Biophys , vol.4 , pp. 73-102
    • Ravishankar, G.A.1    Rao, R.S.2
  • 81
    • 84954465739 scopus 로고    scopus 로고
    • Green biotechnology
    • In: Demain AL, ed.. New York: Academic Press
    • Renneberg R. (2008). Green biotechnology. In: Demain AL, ed. Biotechnology for beginners. New York: Academic Press, 210-3.
    • (2008) Biotechnology for Beginners , pp. 210-213
    • Renneberg, R.1
  • 83
    • 41049113299 scopus 로고    scopus 로고
    • Isolation and purification of acetylshikonin and b-acetoxyisovalerylshikonin from cell suspension cultures of Arnebia euchroma (Royle) Johnston using rapid preparative HPLC
    • Sharma N, Sharma UK, Malik S, et al. (2008). Isolation and purification of acetylshikonin and b-acetoxyisovalerylshikonin from cell suspension cultures of Arnebia euchroma (Royle). Johnston using rapid preparative HPLC. J Sep Sci, 31, 629-35.
    • (2008) J Sep Sci , vol.31 , pp. 629-635
    • Sharma, N.1    Sharma, U.K.2    Malik, S.3
  • 84
    • 79958771236 scopus 로고    scopus 로고
    • Micropropagation of Arnebia hispidissima (Lehm).DC and production of alkannin from callus and cell suspension culture
    • Shekhawat MS, Shekhawat NS. (2011). Micropropagation of Arnebia hispidissima (Lehm).DC. and production of alkannin from callus and cell suspension culture. Acta Physiol Plant, 33, 1445-50.
    • (2011) Acta Physiol Plant , vol.33 , pp. 1445-1450
    • Shekhawat, M.S.1    Shekhawat, N.S.2
  • 85
    • 0000182565 scopus 로고
    • Shikonin production and secretion by hairy root cultures of Lithospermum erythrorhizon
    • Shimomura K, Sudo H, Saga H, Kamada H. (1991). Shikonin production and secretion by hairy root cultures of Lithospermum erythrorhizon. Plant Cell Rep, 10, 282-5.
    • (1991) Plant Cell Rep , vol.10 , pp. 282-285
    • Shimomura, K.1    Sudo, H.2    Saga, H.3    Kamada, H.4
  • 86
    • 0027506375 scopus 로고
    • Increased shikonin production by hairy roots of Lithospermum erythrorhizon in two phase bubble column reactor
    • Sim SJ, Chang HN. (1993). Increased shikonin production by hairy roots of Lithospermum erythrorhizon in two phase bubble column reactor. Biotechnol Lett, 15, 145-50.
    • (1993) Biotechnol Lett , vol.15 , pp. 145-150
    • Sim, S.J.1    Chang, H.N.2
  • 87
    • 75649149557 scopus 로고    scopus 로고
    • Production and secretion of alkannin by hairy root cultures of Arnebia hispidissima (Lehm.)
    • Singh B, Sahu PM, Sharma MK, et al. (2002). Production and secretion of alkannin by hairy root cultures of Arnebia hispidissima (Lehm.). D.C. J Plant Biol, 29, 293-300.
    • (2002) D.C. J Plant Biol , vol.29 , pp. 293-300
    • Singh, B.1    Sahu, P.M.2    Sharma, M.K.3
  • 88
    • 78650823447 scopus 로고    scopus 로고
    • Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-mgeranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston]
    • Singh RS, Gara RK, Bhardwaj PK, et al. (2010). Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-mgeranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle). Johnston]. BMC Mol Biol, 11, 88.
    • (2010) BMC Mol Biol , vol.11 , pp. 88
    • Singh, R.S.1    Gara, R.K.2    Bhardwaj, P.K.3
  • 90
    • 0344223307 scopus 로고    scopus 로고
    • Genetic engineering of shikonin biosynthesis hairy root cultures of Lithospermum erythrorhizon transformed with the bacterial ubiC gene
    • Sommer S, Kohle A, Yazaki K, et al. (1999). Genetic engineering of shikonin biosynthesis hairy root cultures of Lithospermum erythrorhizon transformed with the bacterial ubiC gene. Plant Mol Biol, 39, 683-93.
    • (1999) Plant Mol Biol , vol.39 , pp. 683-693
    • Sommer, S.1    Kohle, A.2    Yazaki, K.3
  • 91
    • 0027112478 scopus 로고
    • Enzyme activity and shikonin production in Lithospermum erythrorhizon cell cultures
    • Srinivasan V, Ryu DDY. (1992). Enzyme activity and shikonin production in Lithospermum erythrorhizon cell cultures. Biotechnol Bioeng, 40, 69-74.
    • (1992) Biotechnol Bioeng , vol.40 , pp. 69-74
    • Srinivasan, V.1    Ryu, D.D.Y.2
  • 92
    • 84856016214 scopus 로고    scopus 로고
    • Enhanced production of antitumour naphthoquinones in transgenic hairy root lines of Lithospermum canescens
    • Syk?owska-Baranek K, Pietrosiuk A, Gawron A, et al. (2012). Enhanced production of antitumour naphthoquinones in transgenic hairy root lines of Lithospermum canescens. Plant Cell Tissue Organ Cult, 108, 213-9.
    • (2012) Plant Cell Tissue Organ Cult , vol.108 , pp. 213-219
    • Sykowska-Baranek, K.1    Pietrosiuk, A.2    Gawron, A.3
  • 93
    • 0001355026 scopus 로고
    • Pigment formation in callus culture of Lithospermum erythrorhizon
    • Tabata M, Mizukami H, Hiraoka N. (1974). Pigment formation in callus culture of Lithospermum erythrorhizon. Phytochemistry, 13, 927-32.
    • (1974) Phytochemistry , vol.13 , pp. 927-932
    • Tabata, M.1    Mizukami, H.2    Hiraoka, N.3
  • 94
    • 0002439098 scopus 로고
    • Production of shikonin by plant cell cultures
    • In: Zaitlin M, Day P, Hollaender A, eds.. New York: Academic Press, Inc. Harcourt Brace Jovanovich Publishers
    • Tabata M, Fujita Y. (1985). Production of shikonin by plant cell cultures. In: Zaitlin M, Day P, Hollaender A, eds. Biotechnology in plant science: relevance to agriculture in the eighties. New York: Academic Press, Inc. Harcourt Brace Jovanovich Publishers, 207-18.
    • (1985) Biotechnology in Plant Science: Relevance to Agriculture in the Eighties , pp. 207-218
    • Tabata, M.1    Fujita, Y.2
  • 95
    • 0004919462 scopus 로고
    • Inhibition of shikonin biosynthesis by photodegradation products of FMN
    • Tabata M, Yazaki K, Nishikawa Y, Yoneda F. (1993). Inhibition of shikonin biosynthesis by photodegradation products of FMN. Phytochemistry, 32, 1439-42.
    • (1993) Phytochemistry , vol.32 , pp. 1439-1442
    • Tabata, M.1    Yazaki, K.2    Nishikawa, Y.3    Yoneda, F.4
  • 97
    • 0033711095 scopus 로고    scopus 로고
    • Shikonin derivative formation on the stem of cultured shoots in Lithospermum erythrorhizon
    • Touno K, Harada K, Yoshimatsu K, et al. (2000a). Shikonin derivative formation on the stem of cultured shoots in Lithospermum erythrorhizon. Plant Cell Rep, 19, 1121-6.
    • (2000) Plant Cell Rep , vol.19 , pp. 1121-1126
    • Touno, K.1    Harada, K.2    Yoshimatsu, K.3
  • 98
    • 16344378426 scopus 로고    scopus 로고
    • Histological observation of red pigment formed on shoot stem of Lithospermum erythrorhizon
    • Touno K, Harada K, Yoshimatsu K, et al. (2000b). Histological observation of red pigment formed on shoot stem of Lithospermum erythrorhizon. Plant Biotechnol, 17, 127-30.
    • (2000) Plant Biotechnol , vol.17 , pp. 127-130
    • Touno, K.1    Harada, K.2    Yoshimatsu, K.3
  • 99
    • 16344389786 scopus 로고    scopus 로고
    • Ethylene induced shikonin biosynthesis in shoot culture of Lithospermum erythrorhizon
    • Touno K, Tamaoka J, Ohashi Y, Shimomura K. (2005). Ethylene induced shikonin biosynthesis in shoot culture of Lithospermum erythrorhizon. Plant Physiol Biochem, 43, 101-5.
    • (2005) Plant Physiol Biochem , vol.43 , pp. 101-105
    • Touno, K.1    Tamaoka, J.2    Ohashi, Y.3    Shimomura, K.4
  • 100
    • 0000060238 scopus 로고    scopus 로고
    • Effect of jasmonates and exogenous polysaccharides on production of alkannin pigments in suspension cultures of Alkanna tinctoria
    • Urbanek H, Bergier K, Saniewski M, Patykowski J. (1996). Effect of jasmonates and exogenous polysaccharides on production of alkannin pigments in suspension cultures of Alkanna tinctoria. Plant Cell Rep, 15, 637-41.
    • (1996) Plant Cell Rep , vol.15 , pp. 637-641
    • Urbanek, H.1    Bergier, K.2    Saniewski, M.3    Patykowski, J.4
  • 101
    • 0033240152 scopus 로고    scopus 로고
    • Induction of phenylalanine ammonia-lyase by methyl jasmonate in cultured cells of Arnebia euchroma
    • Urmantseva VV, Karyagina TB, Chertkova RV, et al. (1999). Induction of phenylalanine ammonia-lyase by methyl jasmonate in cultured cells of Arnebia euchroma. Russ J Plant Physiol, 46, 749.
    • (1999) Russ J Plant Physiol , vol.46 , pp. 749
    • Urmantseva, V.V.1    Karyagina, T.B.2    Chertkova, R.V.3
  • 102
    • 0032775330 scopus 로고    scopus 로고
    • Metabolic engineering of plant secondary metabolite pathways for the production of fine chemicals
    • Verpoorte R, ten Hoopen HJG, Memelink J. (1999). Metabolic engineering of plant secondary metabolite pathways for the production of fine chemicals. Biotechnol Lett, 21, 467-79.
    • (1999) Biotechnol Lett , vol.21 , pp. 467-479
    • Verpoorte, R.1    Ten Hoopen, H.J.G.2    Memelink, J.3
  • 103
    • 0001861232 scopus 로고    scopus 로고
    • Secondary metabolism
    • In: Verpoorte R, Alfermann AW, eds.. London: Kluwer Academic Publishers
    • Verpoorte R. (2000). Secondary metabolism. In: Verpoorte R, Alfermann AW, eds. Metabolic engineering of plant secondary metabolism. London: Kluwer Academic Publishers, 1-29.
    • (2000) Metabolic Engineering of Plant Secondary Metabolism , pp. 1-29
    • Verpoorte, R.1
  • 105
    • 58449095429 scopus 로고    scopus 로고
    • Nitric oxide regulates shikonin formation in suspension-cultured Onosma paniculatum cells
    • Wu SJ, Qi JL, Zhang WJ, et al. (2009). Nitric oxide regulates shikonin formation in suspension-cultured Onosma paniculatum cells. Plant Cell Physiol, 50, 118-28.
    • (2009) Plant Cell Physiol , vol.50 , pp. 118-128
    • Wu, S.J.1    Qi, J.L.2    Zhang, W.J.3
  • 106
    • 0033984410 scopus 로고    scopus 로고
    • Geranylhydroquinone 3-hydroxylase, a cytochrome P-450 monooxygenase from Lithospermum erythrorhizon cell suspension cultures
    • Yamamoto H, Inouye K, Li SM, Heide L. (2000). Geranylhydroquinone 3-hydroxylase, a cytochrome P-450 monooxygenase from Lithospermum erythrorhizon cell suspension cultures. Planta, 210, 312-7.
    • (2000) Planta , vol.210 , pp. 312-317
    • Yamamoto, H.1    Inouye, K.2    Li, S.M.3    Heide, L.4
  • 107
    • 0036690360 scopus 로고    scopus 로고
    • Regulation of lithospermic acid B and shikonin production in Lithospermum erythrorhizon cell suspension cultures
    • Yamamoto H, Zhao P, Yazaki K, Inoue K. (2002). Regulation of lithospermic acid B and shikonin production in Lithospermum erythrorhizon cell suspension cultures. Chem Pharm Bull, 50, 1086-90.
    • (2002) Chem Pharm Bull , vol.50 , pp. 1086-1090
    • Yamamoto, H.1    Zhao, P.2    Yazaki, K.3    Inoue, K.4
  • 108
    • 0032751811 scopus 로고    scopus 로고
    • Effect of brassinolide on growth and shikonin formation in cultured Onosma paniculatum cells
    • Yang YH, Zhang H, Cao RQ. (1999). Effect of brassinolide on growth and shikonin formation in cultured Onosma paniculatum cells. J Plant Growth Regul, 18, 89-92.
    • (1999) J Plant Growth Regul , vol.18 , pp. 89-92
    • Yang, Y.H.1    Zhang, H.2    Cao, R.Q.3
  • 109
    • 0001092988 scopus 로고
    • Ruglation of shikonin production by glutamine in Lithospermum erythrorhizon cell cultures
    • Yazaki K, Fukui H, Kikuma M, Tabata M. (1987). Ruglation of shikonin production by glutamine in Lithospermum erythrorhizon cell cultures. Plant Cell Rep, 6, 131-4.
    • (1987) Plant Cell Rep , vol.6 , pp. 131-134
    • Yazaki, K.1    Fukui, H.2    Kikuma, M.3    Tabata, M.4
  • 110
    • 84954495818 scopus 로고    scopus 로고
    • CDNA cloning and functional analysis of LEDI-2, a gene preferentially expressed in the dark in Lithospermum erythrorhizon cell suspension cultures (abstract no.1348)
    • Yazaki K, Matsuoka H, Sato F. (1997a). cDNA cloning and functional analysis of LEDI-2, a gene preferentially expressed in the dark in Lithospermum erythrorhizon cell suspension cultures (abstract no.1348). Plant Physiol, 114, S-261.
    • (1997) Plant Physiol , vol.114 , pp. S-261
    • Yazaki, K.1    Matsuoka, H.2    Sato, F.3
  • 111
    • 0030750664 scopus 로고    scopus 로고
    • Effects of methyl jasmonate on shikonin and dihydroechinofuran production in Lithospermum erythrorhizon cell cultures
    • Yazaki K, Takeda K, Tabata M. (1997b). Effects of methyl jasmonate on shikonin and dihydroechinofuran production in Lithospermum erythrorhizon cell cultures. Plant Cell Physiol, 38, 776-82.
    • (1997) Plant Cell Physiol , vol.38 , pp. 776-782
    • Yazaki, K.1    Takeda, K.2    Tabata, M.3
  • 112
    • 0032465332 scopus 로고    scopus 로고
    • Stable transformation of Lithospermum erythrorhizon by Agrobacterium rhizogenes and shikonin production of the transformants
    • Yazaki K, Tanaka S, Matsuoka H, Sato F. (1998). Stable transformation of Lithospermum erythrorhizon by Agrobacterium rhizogenes and shikonin production of the transformants. Plant Cell Rep, 18, 214-9.
    • (1998) Plant Cell Rep , vol.18 , pp. 214-219
    • Yazaki, K.1    Tanaka, S.2    Matsuoka, H.3    Sato, F.4
  • 113
    • 0001838830 scopus 로고    scopus 로고
    • Shikonin biosynthesis in Lithospermum erythrorhizon: Light-induced negative regulation of secondary metabolism
    • Yazaki K, Matsuoka H, Ujihara T, Sato F. (1999). Shikonin biosynthesis in Lithospermum erythrorhizon: light-induced negative regulation of secondary metabolism. Plant Biotechnol, 16, 335-42.
    • (1999) Plant Biotechnol , vol.16 , pp. 335-342
    • Yazaki, K.1    Matsuoka, H.2    Ujihara, T.3    Sato, F.4
  • 114
    • 0035037873 scopus 로고    scopus 로고
    • A novel darkinducible protein LeDI-2 and its involvement in root specific secondary metabolism in Lithospermum erythrorhizon
    • Yazaki K, Matsuoka H, Shimomura K, et al. (2001). A novel darkinducible protein LeDI-2 and its involvement in root specific secondary metabolism in Lithospermum erythrorhizon. Plant Physiol, 125, 1831-41.
    • (2001) Plant Physiol , vol.125 , pp. 1831-1841
    • Yazaki, K.1    Matsuoka, H.2    Shimomura, K.3
  • 115
    • 0006962827 scopus 로고
    • Effect of gibberellin A on shikonin production in Lithospermum callus cultures
    • Yoshikawa N, Fukui H, Tabata M. (1986). Effect of gibberellin A on shikonin production in Lithospermum callus cultures. Phytochemistry, 25, 621-2.
    • (1986) Phytochemistry , vol.25 , pp. 621-622
    • Yoshikawa, N.1    Fukui, H.2    Tabata, M.3
  • 116
    • 1842370286 scopus 로고    scopus 로고
    • Plant regeneration from callus cultures of Lithospermum erythrorhizon
    • Yu HJ, Oh SK, Oh MH, et al. (1997). Plant regeneration from callus cultures of Lithospermum erythrorhizon. Plant Cell Rep, 16, 261-6.
    • (1997) Plant Cell Rep , vol.16 , pp. 261-266
    • Yu, H.J.1    Oh, S.K.2    Oh, M.H.3
  • 118
    • 84954519287 scopus 로고
    • Comparative characteristics of shikonin accumulating Arnebia euchroma suspension culture and p-fluorophenylalanine-resistant variant
    • Zakhlenjuk OV, Vidmachenko TV, Kunakh VA, et al. (1993). Comparative characteristics of shikonin accumulating Arnebia euchroma suspension culture and p-fluorophenylalanine-resistant variant. Acta Horticult, 330, 293-8.
    • (1993) Acta Horticult , vol.330 , pp. 293-298
    • Zakhlenjuk, O.V.1    Vidmachenko, T.V.2    Kunakh, V.A.3
  • 119
    • 76149132646 scopus 로고    scopus 로고
    • Bioprocess engineering of Echium italicum L.: Induction of shikonin and alkannin derivatives by two-liquid-phase suspension cultures
    • Zare K, Nazemiyeh H, Movafeghi A, et al. (2010). Bioprocess engineering of Echium italicum L.: induction of shikonin and alkannin derivatives by two-liquid-phase suspension cultures. Plant Cell Tissue Organ Cult, 100, 157-64.
    • (2010) Plant Cell Tissue Organ Cult , vol.100 , pp. 157-164
    • Zare, K.1    Nazemiyeh, H.2    Movafeghi, A.3
  • 120
    • 80053089932 scopus 로고    scopus 로고
    • Callus culture of Echium italicum L towards production of a shikonin derivative
    • Zare K, Khosrowshahli M, Nazemiyeh H, et al. (2011). Callus culture of Echium italicum L. towards production of a shikonin derivative. Nat Prod Res, 25, 1480-7.
    • (2011) Nat Prod Res , vol.25 , pp. 1480-1487
    • Zare, K.1    Khosrowshahli, M.2    Nazemiyeh, H.3
  • 121
    • 79751499099 scopus 로고    scopus 로고
    • LeERF-1, a novel AP2/ERF family gene within the B3 subcluster, is down-regulated by light signals in Lithospermum erythrorhizon
    • Zhang W, Zou A, Miao J, et al. (2011). LeERF-1, a novel AP2/ERF family gene within the B3 subcluster, is down-regulated by light signals in Lithospermum erythrorhizon. Plant Biol, 13, 343-8.
    • (2011) Plant Biol , vol.13 , pp. 343-348
    • Zhang, W.1    Zou, A.2    Miao, J.3
  • 122
    • 84875590096 scopus 로고    scopus 로고
    • Influence of fungal elicitor and macroporous resin on shikonin accumulation in hairy roots of Arnebia euchroma (Royle)
    • Zhang P, Wang F, Zhu C. (2013). Influence of fungal elicitor and macroporous resin on shikonin accumulation in hairy roots of Arnebia euchroma (Royle). Johnst. Chinese J Biotechnol, 29, 214-23.
    • (2013) Johnst. Chinese J Biotechnol , vol.29 , pp. 214-223
    • Zhang, P.1    Wang, F.2    Zhu, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.