PPARγ expression in t cells as a prognostic marker of sepsis

Shock

Volumn 45, Issue 6, 2016, Pages 591-597

  Brenneis, Marco ^a   Aghajaanpour, Ramin ^a   Knape, Tilo ^b   Sha, Lisa K ^a   Neb, Holger ^c   Meybohm, Patrick ^c   Zacharowski, Kai ^c   Hauser, Ingeborg A ^c   Buttner, Stefan ^c   Parnham, Michael J ^b   Brune, Bernhard ^a   Von Knethen, Andreas ^a  

^a GOETHE UNIVERSITY   (Germany)

^b FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

^c UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Blood; ICU; IL 6; Immune paralysis; Patient survival; T cell depletion

Indexed keywords

MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; BIOLOGICAL MARKER; CD3 ANTIGEN;

ADULT; AGED; ARTICLE; CD3+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; LYMPHOCYTE COUNT; MALE; PILOT STUDY; PROGNOSIS; PROTEIN EXPRESSION; SEPSIS; T LYMPHOCYTE; ADOLESCENT; BLOOD; CASE CONTROL STUDY; FOLLOW UP; INTENSIVE CARE UNIT; METABOLISM; MIDDLE AGED; MORTALITY; PREDICTIVE VALUE; SENSITIVITY AND SPECIFICITY; SURVIVAL ANALYSIS; UNIVERSITY HOSPITAL;

ADOLESCENT; ADULT; AGED; BIOMARKERS; CASE-CONTROL STUDIES; CD3 COMPLEX; FEMALE; FOLLOW-UP STUDIES; HOSPITALS, UNIVERSITY; HUMANS; INTENSIVE CARE UNITS; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PPAR GAMMA; PREDICTIVE VALUE OF TESTS; PROGNOSIS; SENSITIVITY AND SPECIFICITY; SEPSIS; SURVIVAL ANALYSIS; T-LYMPHOCYTES;

EID: 84954555894     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000568     Document Type: Article

References (26)

1. Cohen J, Vincent JL, Adhikari NK, Machado FR, Angus DC, Calandra T, Jaton K, Giulieri S, Delaloye J, Opal S, et al.: Sepsis: a roadmap for future research. Lancet Infect Dis 15(5):581-614, 2015.
2. Wheeler DS, Zingarelli B, Wheeler WJ, Wong HR: Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory response. Recent Pat Inflamm Allergy Drug Discov 3(2):96-112, 2009.
3. Schmidt MV, Paulus P, Kuhn AM, Weigert A, Morbitzer V, Zacharowski K, Kempf VA, Brune B, von Knethen A: Peroxisome proliferator-activated receptor gamma-induced T cell apoptosis reduces survival during polymicrobial sepsis. Am J Respir Crit Care Med 184(1):64-74, 2011.
4. Szabo G, Romics L Jr, Frendl G: Liver in sepsis and systemic inflammatory response syndrome. Clin Liver Dis 6(4):1045-1066, 2002.
5. Wesche DE, Lomas-Neira JL, Perl M, Chung CS, Ayala A: Leukocyte apoptosis and its significance in sepsis and shock. J Leukoc Biol 78(2):325-337, 2005.
6. Soller M, Tautenhahn A, Brune B, Zacharowski K, John S, Link H, von Knethen A: Peroxisome proliferator-activated receptor gamma contributes to T lymphocyte apoptosis during sepsis. J Leukoc Biol 79(1):235-243, 2006.
7. Le Tulzo Y, Pangault C, Gacouin A, Guilloux V, Tribut O, Amiot L, Tattevin P, Thomas R, Fauchet R, Drenou B: Early circulating lymphocyte apoptosis in human septic shock isassociated with poor outcome. Shock 18(6):487-494, 2002.
8. Hotchkiss RS, Nicholson DW: Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol 6(11):813-822, 2006.
9. Reim D, Westenfelder K, Kaiser-Moore S, Schlautkotter S, Holzmann B, Weighardt H: Role of T cells for cytokine production and outcome in a model of acute septic peritonitis. Shock 31(3):245-250, 2009.
10. Fitzgerald ML, Moore KJ, Freeman MW: Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home. J Mol Med (Berl) 80(5):271-281, 2002.
11. Harris SG, Phipps RP: The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis. Eur J Immunol 31(4):1098-1105, 2001.
12. Tautenhahn A, Brune B, von Knethen A: Activation-induced PPARgamma expression sensitizes primary human T cells toward apoptosis. J Leukoc Biol 73(5):665-672, 2003.
13. Li D, Qu Y, Mao M, Zhang X, Li J, Ferriero D, Mu D: Involvement of the PTEN-AKT-FOXO3a pathway in neuronal apoptosis in developing rat brain after hypoxia-ischemia. J Cereb Blood Flow Metab 29(12):1903-1913, 2009.
14. Hotchkiss RS, Swanson PE, Knudson CM, Chang KC, Cobb JP, Osborne DF, Zollner KM, Buchman TG, Korsmeyer SJ, Karl IE: Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J Immunol 162(7):4148-4156, 1999.
15. Angus DC, van der Poll T: Severe sepsis and septic shock. N Engl J Med 369(9):840-851, 2013.
16. Patel L, Pass I, Coxon P, Downes CP, Smith SA, Macphee CH: Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN. Curr Biol 11(10):764-768, 2001.
17. Bloos F, Reinhart K: Rapid diagnosis of sepsis. Virulence 5(1):154-160, 2014.
18. Uusitalo-Seppala R, Koskinen P, Leino A, Peuravuori H, Vahlberg T, Rintala EM: Early detection of severe sepsis in the emergency room: diagnostic value of plasma C-reactive protein, procalcitonin, and interleukin-6. Scand J Infect Dis 43(11-12):883-890, 2011.
19. Wang YL, Frauwirth KA, Rangwala SM, Lazar MA, Thompson CB: Thiazo-lidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival. J Biol Chem 277(35):31781-31788, 2002.
20. Kaplan JM, Denenberg A, Monaco M, Nowell M, Wong H, Zingarelli B: Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock. Intensive Care Med 36(1):123-130, 2010.
21. Harbarth S, Holeckova K, Froidevaux C, Pittet D, Ricou B, Grau GE, Vadas L, Pugin J, Geneva Sepsis N: Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med 164(3):396-402, 2001.
22. Lin S, Huang Z, Wang M, Weng Z, Zeng D, Zhang Y, Zhu Y, Jiang J: Interleukin-6 as an early diagnostic marker for bacterial sepsis in patients with liver cirrhosis. J Crit Care 30(4):732-738, 2015.
23. Castelli GP, Pognani C, Meisner M, Stuani A, Bellomi D, Sgarbi L: Procalci-tonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction. Crit Care 8(4):R234-R242, 2004.
24. Wang X, Li ZY, Zeng L, Zhang AQ, Pan W, Gu W, Jiang JX. Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis. Crit Care 19:245, 2015.
25. + T cells by peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: involvement of physical association between PPAR-gamma and the nuclear factor of activated T cells transcription factor. Mol Pharmacol 64(5):1169-1179, 2003.
26. Yang XY, Wang LH, Mihalic K, Xiao W, Chen T, Li P, Wahl LM, Farrar WL: Interleukin (IL)-4 indirectly suppresses IL-2 production by human T lymphocytes via peroxisome proliferator-activated receptor gamma activated by macro-phage-derived 12/15-lipoxygenase ligands. J Biol Chem 277(6):3973-3978, 2002.