Associations of urinary uromodulin with clinical characteristics and markers of tubular function in the general population

Clinical Journal of the American Society of Nephrology

Volumn 11, Issue 1, 2016, Pages 70-80

  Pruijm, Menno ^a   Ponte, Belen ^a   Ackermann, Daniel ^a   Paccaud, Fred ^a   Guessous, Idris ^a   Ehret, Georg ^a   Pechére Bertschi, Antoinette ^a   Vogt, Bruno ^a   Mohaupt, Markus G ^a   Martin, Pierre Yves ^a   Youhanna, Sonia C ^a   Nägele, Nadine ^a   Vollenweider, Peter ^a   Waeber, Gérard ^a   Burnier, Michel ^a   Devuyst, Olivier ^a   Bochud, Murielle ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

TAMM HORSFALL GLYCOPROTEIN; BIOLOGICAL MARKER; ELECTROLYTE;

ADULT; ARTICLE; BIOCHEMICAL ANALYSIS; CREATININE CLEARANCE; CREATININE URINE LEVEL; DISEASE ASSOCIATION; ECHOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLOMERULUS FILTRATION; HUMAN; HYPERTENSION; KIDNEY TUBULE FUNCTION; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; MIDDLE AGED; MULTIVARIATE ANALYSIS; URINE VOLUME; AGED; ALBUMINURIA; GLOMERULUS FILTRATION RATE; KIDNEY TUBULE; OSMOLARITY; PHYSIOLOGY; URINE;

ADULT; AGED; ALBUMINURIA; BIOMARKERS; ELECTROLYTES; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY TUBULES; MALE; MIDDLE AGED; OSMOLAR CONCENTRATION; UROMODULIN;

EID: 84954435534     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.04230415     Document Type: Article

References (33)

1. Olden M, Corre T, Hayward C, Toniolo D, Ulivi S, Gasparini P, Pistis G, Hwang SJ, Bergmann S, Campbell H, Cocca M, Gandin I, Girotto G, Glaudemans B, Hastie ND, Loffing J, Polasek O, Rampoldi L, Rudan I, Sala C, Traglia M, Vollenweider P, Vuckovic D, Youhanna S, Weber J, Wright AF, Kutalik Z, Bochud M, Fox CS, Devuyst O: Common variants in UMOD associate with urinary uromodulin levels: A meta-analysis. J Am Soc Nephrol 25: 1869-1882, 2014
2. Rampoldi L, Scolari F, Amoroso A, Ghiggeri G, Devuyst O: The rediscovery of uromodulin (Tamm-Horsfall protein): From tubulointerstitial nephropathy to chronic kidney disease. Kidney Int 80: 338-347, 2011
3. Bachmann S, Mutig K, Bates J, Welker P, Geist B, Gross V, Luft FC, Alenina N, Bader M, Thiele BJ, Prasadan K, Raffi HS, Kumar S: Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice. Am J Physiol Renal Physiol 288: F559-F567, 2005
4. Renigunta A, Renigunta V, Saritas T, Decher N, Mutig K, Waldegger S: Tamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function. J Biol Chem 286: 2224-2235, 2011
5. Hart TC, Gorry MC, Hart PS, Woodard AS, Shihabi Z, Sandhu J, Shirts B, Xu L, Zhu H, Barmada MM, Bleyer AJ: Mutations of theUMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy. J Med Genet 39: 882-892, 2002
6. Kottgen A, Pattaro C, Boger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, O’Connell JR, Li M, Schmidt H, Tanaka T, Isaacs A, Ketkar S, Hwang SJ, Johnson AD, Dehghan A, Teumer A, Paré G, Atkinson EJ, Zeller T, Lohman K, Cornelis MC, Probst-Hensch NM, Kronenberg F, Tonjes A, Hayward C, Aspelund T, Eiriksdottir G, Launer LJ, Harris TB, Rampersaud E, Mitchell BD, Arking DE, Boerwinkle E, Struchalin M, Cavalieri M, Singleton A, Giallauria F, Metter J, de Boer IH, Haritunians T, Lumley T, Siscovick D, Psaty BM, Zillikens MC, Oostra BA, Feitosa M, Province M, de Andrade M, Turner ST, Schillert A, Ziegler A, Wild PS, Schnabel RB, Wilde S, Munzel TF, Leak TS, Illig T, Klopp N, Meisinger C, Wichmann HE, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Schreiber S, Aulchenko YS, Felix JF, Rivadeneira F, Uitterlinden AG, Hofman A, Imboden M, Nitsch D, Brandstatter A, Kollerits B, Kedenko L, Magi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, Volzke H, Kroemer HK, Nauck M, Volker U, Polasek O, Vitart V, Badola S, Parker AN, Ridker PM, Kardia SL, Blankenberg S, Liu Y, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Shlipak MG, van Duijn CM, Borecki I, Kramer BK, Rudan I, Gyllensten U, Wilson JF, Witteman JC, Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM, Fox CS: New loci associated with kidney function and chronic kidney disease. Nat Genet 42: 376-384, 2010
7. Pattaro C, Kottgen A, Teumer A, Garnaas M, Boger CA, Fuchsberger C, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O’Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O’Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa M, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tonjes A, Dehghan A, Chouraki V, Holliday EG, Sorice R, Kutalik Z, Lehtimaki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G, Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu FB, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Koenig W, Illig T, Doring A, Wichmann HE, Kolcic I, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nothlings U, Jacobs G, Biffar R, Endlich K, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Volker U, Volzke H, Kovacs P, Stumvoll M, Magi R, Hofman A, Uitterlinden AG, Rivadeneira F, Aulchenko YS, Polasek O, Hastie N, Vitart V, Helmer C, Wang JJ, Ruggiero D, Bergmann S, Kahonen M, Viikari J, Nikopensius T, Province M, Ketkar S, Colhoun H, Doney A, Robino A, Giulianini F, Kramer BK, Portas L, Ford I, Buckley BM, Adam M, Thun GA, Paulweber B, Haun M, Sala C, Metzger M, Mitchell P, Ciullo M, Kim SK, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema JW, Probst-Hensch NM, Kronenberg F, Toniolo D, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Siscovick DS, van Duijn CM, Borecki I, Kardia SL, Liu Y, Curhan GC, Rudan I, Gyllensten U, Wilson JF, Franke A, Pramstaller PP, Rettig R, Prokopenko I, Witteman JC, Hayward C, Ridker P, Parsa A, Bochud M, Heid IM, Goessling W, Chasman DI, Kao WH, Fox CS, Goessling W, Chasman DI, Kao WH, Fox CS; CARDIoGRAM Consortium; ICBP Consortium; CARe Consortium. Wellcome Trust Case Control Consortium 2 (WTCCC2): Genome-wide as- sociation and functional follow-up reveals new loci for kidney function. PLoS Genet 8: e1002584, 2012
8. Kottgen A, Yang Q, Shimmin LC, Tin A, Schaeffer C, Coresh J, Liu X, Rampoldi L, Hwang SJ, Boerwinkle E, Hixson JE, Kao WH, Fox CS: Association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants iden- tified by UMOD gene region sequencing. PLoS One 7: e38311, 2012
9. Kottgen A, Hwang SJ, Larson MG, Van Eyk JE, Fu Q, Benjamin EJ, Dehghan A, Glazer NL, Kao WH, Harris TB, Gudnason V, Shlipak MG, Yang Q, Coresh J, Levy D, Fox CS: Uromodulin levels as- sociate with a common UMOD variant and risk for incident CKD. J Am Soc Nephrol 21: 337-344, 2010
10. Trudu M, Janas S, Lanzani C, Debaix H, Schaeffer C, Ikehata M, Citterio L, Demaretz S, Trevisani F, Ristagno G, Glaudemans B, Laghmani K, Dell’Antonio G, Loffing J, Rastaldi MP, Manunta P, Devuyst O, Rampoldi L; Swiss Kidney Project on Genes in Hypertension (SKIPOGH) team: Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression. Nat Med 19: 1655-1660, 2013
11. Thornley C, Dawnay A, Cattell WR: Human Tamm-Horsfall glycoprotein: urinary and plasma levels in normal subjects and patients with renal disease determined by a fully validated ra- dioimmunoassay. Clin Sci (Lond) 68: 529-535, 1985
12. Ollier-Hartmann MP, Pouget-Abadie C, Bouillie J, Hartmann L: Variations of urinary Tamm-Horsfall protein in humans during the first thirty years of life. Nephron 38: 163-166, 1984
13. Reinhart HH, Obedeanu N, Robinson R, Korzeniowski O, Kaye D, Sobel JD: Urinary excretion of Tamm-Horsfall protein in el- derly women. J Urol 146: 806-808, 1991
14. Ponte B, Pruijm M, Ackermann D, Vuistiner P, Eisenberger U, Guessous I, Rousson V, Mohaupt MG, Alwan H, Ehret G, Pechere-Bertschi A, Paccaud F, Staessen JA, Vogt B, Burnier M, Martin PY, Bochud M: Reference values and factors associated with renal resistive index in a family-based population study. Hypertension 63: 136-142, 2014
15. Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, Kusek JW, Manzi J, Van Lente F, Zhang YL, Coresh J, Levey AS; CKD-EPI Investigators: Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med 367: 20-29, 2012
16. Firmann M, Mayor V, Vidal PM, Bochud M, Pécoud A, Hayoz D, Paccaud F, Preisig M, Song KS, Yuan X, Danoff TM, Stirnadel HA, Waterworth D, Mooser V, Waeber G, Vollenweider P: The CoLaus study: A population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome. BMC Cardiovasc Disord 8: 6, 2008
17. Pruijm M, Ponte B, Ackermann D, Vuistiner P, Paccaud F, Guessous I, Ehret G, Eisenberger U, Mohaupt M, Burnier M, Martin PY, Bochud M: Heritability, determinants and reference values of renal length: A family-based population study. Eur Radiol 23: 2899-2905, 2013
18. Ponte B, Pruijm M, Ackermann D, Vuistiner P, Guessous I, Ehret G, Alwan H, Youhanna S, Paccaud F, Mohaupt M, Péchère Bertschi A, Vogt B, Burnier M, Martin PY, Devuyst O, Bochud M: Copeptin is associated with kidney length, renal function, and prevalence of simple cysts in a population-based study. J Am Soc Nephrol 26: 1415-1425, 2015
19. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J; CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration): A new equation to estimate glomerular filtration rate. Ann Intern Med 150: 604-612, 2009
20. Staessen J, Bulpitt C, Fagard R, Joossens JV, Lijnen P, Amery A: Four urinary cations and blood pressure. A population study in two Belgian towns. Am J Epidemiol 117: 676-687, 1983
21. Bankir L, Bochud M, Maillard M, Bovet P, Gabriel A, Burnier M: Nighttime blood pressure and nocturnal dipping are associated with daytime urinary sodium excretion in African subjects. Hypertension 51: 891-898, 2008
22. Youhanna S, Weber J, Beaujean V, Glaudemans B, Sobek J, Devuyst O: Determination of uromodulin in human urine: influence of storage and processing. Nephrol Dial Transplant 29: 136-145, 2014
23. Jones TB, Riddick LR, Harpen MD, Dubuisson RL, Samuels D: Ultrasonographic determination of renal mass and renal volume. J Ultrasound Med 2: 151-154, 1983
24. Waikar SS, Sabbisetti VS, Bonventre JV: Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate. Kidney Int 78: 486-494, 2010
25. Bernard AM, Ouled AA, Lauwerys RR, Lambert A, Vandeleene B: Pronounced decrease of Tamm-Horsfall proteinuria in diabetics. Clin Chem 33: 1264, 1987
26. Thulesen J, Jørgensen PE, Torffvit O, Nexø E, Poulsen SS: Urinary excretion of epidermal growth factor and Tamm-Horsfall protein in three rat models with increased renal excretion of urine. Regul Pept 72: 179-186, 1997
27. Bachmann S, Dawnay AB, Bouby N, Bankir L: Tamm-Horsfall protein excretion during chronic alterations in urinary concentration and protein intake in the rat. Ren Physiol Biochem 14: 236-245, 1991
28. Torffvit O, Melander O, Hultén UL: Urinary excretion rate of Tamm-Horsfall protein is related to salt intake in humans. Nephron, Physiol 97: 31-36, 2004
29. Mutig K, Kahl T, Saritas T, Godes M, Persson P, Bates J, Raffi H, Rampoldi L, Uchida S, Hille C, Dosche C, Kumar S, Castaneda-Bueno M, Gamba G, Bachmann S: Activation of the bumetanide- sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner. J Biol Chem 286: 30200-30210, 2011
30. Seyberth HW, Schlingmann KP: Bartter- and Gitelman-like syn- dromes: salt-losing tubulopathies with loop or DCT defects. Pediatr Nephrol 26: 1789-1802, 2011
31. Hoy WE, Douglas-Denton RN, Hughson MD, Cass A, Johnson K, Bertram JF: A stereological study of glomerular number and volume: preliminary findings in a multiracial study of kidneys at autopsy. Kidney Int Suppl (83 Suppl): S31-S37, 2003
32. Textor SC, Gloviczki ML, Flessner MF, Calhoun DA, Glockner J, Grande JP, McKusick MA, Cha SS, Lerman LO: Association of filtered sodium load with medullary volumes and medullary hypoxia in hypertensive African Americans as compared with whites. Am J Kidney Dis 59: 229-237, 2012
33. O’Seaghdha CM, Hwang SJ, Larson MG, Meigs JB, Vasan RS, Fox CS: Analysis of a urinary biomarker panel for incident kidneydisease and clinical outcomes. J Am Soc Nephrol 24: 1880-1888, 2013