Analysis of a Urinary Biomarker Panel for Incident Kidney Disease and Clinical Outcomes

Journal of the American Society of Nephrology

Volumn 24, Issue 11, 2013, Pages 1880-1888

  O'Seaghdha, Conall M ^a,b,c,d   Hwang, Shih Jen ^a,b   Larson, Martin G ^a   Meigs, James B ^c   Vasan, Ramachandran S ^a,e   Fox, Caroline S ^a,b,c  

^a FRAMINGHAM HEART STUDY   (United States)

^b Center for Population Studies   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BEAUMONT HOSPITAL   (Ireland)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 MICROGLOBULIN; BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER; CALBINDIN; CLUSTERIN; CONNECTIVE TISSUE GROWTH FACTOR; CYSTATIN C; GLUTATHIONE TRANSFERASE ALPHA; INTESTINAL TREFOIL FACTOR; KIDNEY INJURY MOLECULE 1; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; OSTEOPONTIN; PROTEIN TFF 3; TAMM HORSFALL GLYCOPROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADULT; ALBUMINURIA; ARTICLE; CARDIOVASCULAR DISEASE; CAUSE OF DEATH; CHRONIC KIDNEY DISEASE; CONGESTIVE HEART FAILURE; FEMALE; FOLLOW UP; HUMAN; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEOPLASM; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK FACTOR; SURVIVAL;

EID: 84887042938     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2013010019     Document Type: Article

References (46)

1. Alpert JS, Thygesen K, Jaffe A., White HD: The universal definition of myocardial infarction: A consensusdocument: Ischaemic heart disease. Heart 94: 1335-1341, 2008
2. Bonventre JV, Vaidya VS, Schmouder R, Feig P., Dieterle F: Next-generation biomarkers for detecting kidney toxicity. Nat Biotechnol 28: 436-440, 2010
3. Wu I, Parikh CR: Screening for kidney diseases: Older measures versus novel biomarkers. Clin J Am Soc Nephrol 3: 1895-1901, 2008
4. Parikh CR, Devarajan P: New biomarkers of acute kidney injury. Crit Care Med 36[Suppl]: S159-S165, 2008 (Pubitemid 351483046)
5. Endre ZH, Westhuyzen J: Early detection of acute kidney injury: Emerging new biomarkers. Nephrology (Carlton) 13: 91-98, 2008 (Pubitemid 351229631)
6. Coons SJ: The FDA's critical path initiative: A brief introduction. Clin Ther 31: 2572-2573, 2009
7. O'Seaghdha C.M., Hwang SJ, Bhavsar N.A., Köttgen A, Coresh J., Astor BC, Fox CS: Lower urinary connective tissue growth factor levels and incident CKD stage 3 in the general population. Am J Kidney Dis 57: 841-849, 2011
8. Olsen MH, Hansen TW, Christensen M.K., Gustafsson F., Rasmussen S, Wachtell K, Ibsen H., Torp-Pedersen C, Hildebrandt PR: N-terminal probrain natriuretic peptide, but not high sensitivity C-reactive protein, improves cardiovascular risk prediction in the general population. Eur Heart J 28: 1374-1381, 2007 (Pubitemid 47355969)
9. Ridker PM, Buring JE, Rifai N, Cook NR: Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: The Reynolds Risk Score. JAMA 297: 611-619, 2007
10. Fox CS, Gona P, Larson M.G., Selhub J., Tofler G, Hwang SJ, Meigs J.B., Levy D., Wang TJ, Jacques PF, Benjamin EJ, Vasan RS: A multi-marker approach to predict incident CKD and microalbuminuria. J Am Soc Nephrol 21: 2143-2149, 2010
11. Wang TJ, Gona P, Larson M.G., Tofler GH, Levy D, Newton-Cheh C, Jacques PF, Rifai N, Selhub J., Robins SJ, Benjamin EJ, D'Agostino RB, Vasan RS: Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med 355: 2631-2639, 2006 (Pubitemid 44969122)
12. Zethelius B, Berglund L, Sundström J, Ingelsson E., Basu S, Larsson A, Venge P., Arnlöv J: Use of multiple biomarkers to improve the prediction of death from cardiovascular causes. N Engl J Med 358: 2107-2116, 2008 (Pubitemid 351679597)
13. van Timmeren M.M., van den Heuvel MC, Bailly V, Bakker SJ, van Goor H, Stegeman CA: Tubular kidney injury molecule-1 (KIM-1) in human renal disease. J Pathol 212: 209-217, 2007 (Pubitemid 46852099)
14. Koyner JL, Vaidya VS, Bennett M.R., Ma Q., Worcester E, Akhter SA, Raman J, Jeevanandam V., O'Connor MF, Devarajan P, Bonventre J.V., Murray PT: Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury. Clin J Am Soc Nephrol 5: 2154-2165, 2010
15. Ko GJ, Grigoryev DN, Linfert D, Jang HR, Watkins T, Cheadle C, Racusen L, Rabb H: Transcriptional analysis of kidneys during repair from AKI reveals possible roles for NGAL and KIM-1 as biomarkers of AKI-to-CKD transition. Am J Physiol Renal Physiol 298: F1472-F1483, 2010
16. Damman K, Van Veldhuisen DJ, Navis G, Vaidya VS, Smilde T.D., Westenbrink BD, Bonventre JV, Voors AA, Hillege HL: Tubular damage in chronic systolic heart failure is associated with reduced survival independent of glomerular filtration rate. Heart 96: 1297-1302, 2010
17. Jungbauer CG, Birner C, Jung B., Buchner S, Lubnow M, von Bary C, Endemann D, Banas B., Mack M, Böger CA, Riegger G., Luchner A: Kidney injury molecule-1 and N-acetyl-β-D-glucosaminidase in chronic heart failure: Possible biomarkers of cardiorenal syndrome. Eur J Heart Fail 13: 1104-1110, 2011
18. Astor BC, Köttgen A, Hwang S.J., Bhavsar N., Fox CS, Coresh J: Trefoil factor 3 predicts incident chronic kidney disease: A case-control study nested within the Atherosclerosis Risk in Communities (ARIC) study. Am J Nephrol 34: 291-297, 2011
19. Rinnert M, Hinz M, Buhtz P., Reiher F, Lessel W, Hoffmann W: Synthesis and localization of trefoil factor family (TFF) peptides in the human urinary tract and TFF2 excretion into the urine. Cell Tissue Res 339: 639-647, 2010
20. Hoffmann W: Trefoil factors TFF (trefoil factor family) peptide-triggered signals promoting mucosal restitution. Cell Mol Life Sci 62: 2932-2938, 2005 (Pubitemid 43004746)
21. Pawar S, Kartha S, Toback FG: Differential gene expression in migrating renal epithelial cells after wounding. J Cell Physiol 165: 556-565, 1995 (Pubitemid 26004313)
22. Bonventre JV: Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J Am Soc Nephrol 14[Suppl 1]: S55-S61, 2003 (Pubitemid 36687041)
23. Romih R, Koprivec D, Martincic D.S., Jezernik K: Restoration of the rat urothelium after cyclophosphamide treatment. Cell Biol Int 25: 531-537, 2001 (Pubitemid 32595151)
24. Veranic P, Romih R, Jezernik K: What determines differentiation of urothelial umbrella cells? Eur J Cell Biol 83: 27-34, 2004 (Pubitemid 38455604)
25. Hoffmann W: Regeneration of the gastric mucosa and its glands from stem cells. Curr Med Chem 15: 3133-3144, 2008
26. Mhawech-Fauceglia P., Wang D, Samrao D., Liu S, Dupont NC, Pejovic T: Trefoil factor family 3 (TFF3) expression and its interaction with estrogen receptor (ER) in endometrial adenocarcinoma. Gynecol Oncol 130: 174-180, 2013
27. Im S, Yoo C, Jung J.H., Choi HJ, Yoo J, Kang CS: Reduced expression of TFF1 and increased expression of TFF3 in gastric cancer: Correlation with clinicopathological parameters and prognosis. Int J Med Sci 10: 133-140, 2013
28. Qu Y, Yang Y, Ma D., Xiao W: Increased trefoil factor 3 levels in the serum of patients with three major histological subtypes of lung cancer. Oncol Rep 27: 1277-1283, 2012
29. Roderick PJ, Atkins RJ, Smeeth L, Mylne A., Nitsch DD, Hubbard RB, Bulpitt CJ, Fletcher AE: CKD and mortality risk in older people: A community-based population study in the United Kingdom. Am J Kidney Dis 53: 950-960, 2009
30. Emberson JR, Haynes R, Dasgupta T., Mafham M, Landray MJ, Baigent C, Clarke R: Cystatin C and risk of vascular and nonvascular mortality: A prospective cohort study of older men. J Intern Med 268: 145-154, 2010
31. Fried LF, Katz R, Sarnak M.J., Shlipak MG, Chaves PH, Jenny NS, Stehman-Breen C, Gillen D., Bleyer AJ, Hirsch C, Siscovick D, Newman AB: Kidney function as a predictor of noncardiovascular mortality. J Am Soc Nephrol 16: 3728-3735, 2005 (Pubitemid 46211295)
32. James MT, Quan H, Tonelli M., Manns BJ, Faris P, Laupland KB, Hemmelgarn BR; Alberta Kidney Disease Network: CKD and risk of hospitalization and death with pneumonia. Am J Kidney Dis 54: 24-32, 2009
33. Di Angelantonio E., Chowdhury R, Sarwar N., Aspelund T, Danesh J, Gudnason V: Chronic kidney disease and risk of major cardiovascular disease and non-vascular mortality: Prospective population based cohort study. BMJ 341: c4986, 2010
34. Hillege HL, Fidler V, Diercks G.F., van Gilst WH, de Zeeuw D, van Veldhuisen DJ, Gans RO, Janssen WM, Grobbee DE, de Jong PE; Prevention of Renal and Vascular End Stage Disease (PREVEND) Study Group: Urinary albumin excretion predicts cardiovascular and non-cardiovascular mortality in general population. Circulation 106: 1777-1782, 2002
35. Wakefield LM, Stuelten C: Keeping order in the neighborhood: New roles for TGFbeta in maintaining epithelial homeostasis. Cancer Cell 12: 293-295, 2007 (Pubitemid 47539313)
36. Han WK, Wagener G, Zhu Y., Wang S, Lee HT: Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery. Clin J Am Soc Nephrol 4: 873-882, 2009
37. Juraschek SP, Coresh J, Inker L.A., Rynders GP, Eckfeldt JH, Selvin E: The effects of freeze-thaw on β-trace protein and β2-microglobulin assays after long-term sample storage. Clin Biochem 45: 694-696, 2012
38. Kannel WB, Feinleib M, McNamara P.M., Garrison RJ, Castelli WP: An investigation of coronary heart disease in families. The Framingham offspring study. Am J Epidemiol 110: 281-290, 1979 (Pubitemid 10204328)
39. National Kidney Foundation: K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Am J Kidney Dis 39[Suppl 1]: S1-S266, 2002
40. Fox CS, Larson MG, Leip E.P., Culleton B., Wilson PW, Levy D: Predictors of new-onset kidney disease in a community-based population. JAMA 291: 844-850, 2004 (Pubitemid 38543772)
41. Mattix HJ, Hsu CY, Shaykevich S, Curhan G: Use of the albumin/creatinine ratio to detect microalbuminuria: Implications of sex and race. J Am Soc Nephrol 13: 1034-1039, 2002 (Pubitemid 34274100)
42. McKee PA, Castelli WP, McNamara P.M., Kannel WB: The natural history of congestive heart failure: The Framingham study. N Engl J Med 285: 1441-1446, 1971
43. O'Seaghdha CM, Lyass A, Massaro J.M., Meigs JB, Coresh J, D'Agostino RB Sr, Astor BC, Fox CS: A risk score for chronic kidney disease in the general population. Am J Med 125: 270-277, 2012
44. Cox DR: Regression models and life-tables. J R Stat Soc Ser A 34: 187-220, 1972
45. Pencina MJ, D'Agostino RB Sr, D'Agostino RB Jr, Vasan RS: Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond. Stat Med 27: 157-172, 2008 (Pubitemid 351193639)
46. Pencina MJ, D'Agostino RB Sr, Steyerberg EW: Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers. Stat Med 30: 11-21, 2011